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Repeat-associated non-AUG translation in C9orf72-ALS/FTD is driven by neuronal excitation and stress.

Westergard T, McAvoy K, Russell K, Wen X, Pang Y, Morris B, Pasinelli P, Trotti D, Haeusler A.

EMBO Mol Med. 2019 Jan 7. pii: e9423. doi: 10.15252/emmm.201809423. [Epub ahead of print]


miR126-5p Downregulation Facilitates Axon Degeneration and NMJ Disruption via a Non-Cell-Autonomous Mechanism in ALS.

Maimon R, Ionescu A, Bonnie A, Sweetat S, Wald-Altman S, Inbar S, Gradus T, Trotti D, Weil M, Behar O, Perlson E.

J Neurosci. 2018 Jun 13;38(24):5478-5494. doi: 10.1523/JNEUROSCI.3037-17.2018. Epub 2018 May 17.


Haploinsufficiency leads to neurodegeneration in C9ORF72 ALS/FTD human induced motor neurons.

Shi Y, Lin S, Staats KA, Li Y, Chang WH, Hung ST, Hendricks E, Linares GR, Wang Y, Son EY, Wen X, Kisler K, Wilkinson B, Menendez L, Sugawara T, Woolwine P, Huang M, Cowan MJ, Ge B, Koutsodendris N, Sandor KP, Komberg J, Vangoor VR, Senthilkumar K, Hennes V, Seah C, Nelson AR, Cheng TY, Lee SJ, August PR, Chen JA, Wisniewski N, Hanson-Smith V, Belgard TG, Zhang A, Coba M, Grunseich C, Ward ME, van den Berg LH, Pasterkamp RJ, Trotti D, Zlokovic BV, Ichida JK.

Nat Med. 2018 Mar;24(3):313-325. doi: 10.1038/nm.4490. Epub 2018 Feb 5.


Astrocytes expressing ALS-linked mutant FUS induce motor neuron death through release of tumor necrosis factor-alpha.

Kia A, McAvoy K, Krishnamurthy K, Trotti D, Pasinelli P.

Glia. 2018 May;66(5):1016-1033. doi: 10.1002/glia.23298. Epub 2018 Jan 30.


EAAT2 and the Molecular Signature of Amyotrophic Lateral Sclerosis.

Rosenblum LT, Trotti D.

Adv Neurobiol. 2017;16:117-136. doi: 10.1007/978-3-319-55769-4_6. Review.


Blood-Brain Barrier Driven Pharmacoresistance in Amyotrophic Lateral Sclerosis and Challenges for Effective Drug Therapies.

Mohamed LA, Markandaiah S, Bonanno S, Pasinelli P, Trotti D.

AAPS J. 2017 Nov;19(6):1600-1614. doi: 10.1208/s12248-017-0120-6. Epub 2017 Aug 4. Review.


Mutation of the caspase-3 cleavage site in the astroglial glutamate transporter EAAT2 delays disease progression and extends lifespan in the SOD1-G93A mouse model of ALS.

Rosenblum LT, Shamamandri-Markandaiah S, Ghosh B, Foran E, Lepore AC, Pasinelli P, Trotti D.

Exp Neurol. 2017 Jun;292:145-153. doi: 10.1016/j.expneurol.2017.03.014. Epub 2017 Mar 22.


Pathogenic determinants and mechanisms of ALS/FTD linked to hexanucleotide repeat expansions in the C9orf72 gene.

Wen X, Westergard T, Pasinelli P, Trotti D.

Neurosci Lett. 2017 Jan 1;636:16-26. doi: 10.1016/j.neulet.2016.09.007. Epub 2016 Sep 13. Review.


Cell-to-Cell Transmission of Dipeptide Repeat Proteins Linked to C9orf72-ALS/FTD.

Westergard T, Jensen BK, Wen X, Cai J, Kropf E, Iacovitti L, Pasinelli P, Trotti D.

Cell Rep. 2016 Oct 11;17(3):645-652. doi: 10.1016/j.celrep.2016.09.032.


Barriers to Surgical Care and Health Outcomes: A Prospective Study on the Relation Between Wealth, Sex, and Postoperative Complications in the Republic of Congo.

Lin BM, White M, Glover A, Wamah GP, Trotti DL, Randall K, Alkire BC, Cheney ML, Parker G, Shrime MG.

World J Surg. 2017 Jan;41(1):14-23. doi: 10.1007/s00268-016-3676-x.


Astrocytes drive upregulation of the multidrug resistance transporter ABCB1 (P-Glycoprotein) in endothelial cells of the blood-brain barrier in mutant superoxide dismutase 1-linked amyotrophic lateral sclerosis.

Qosa H, Lichter J, Sarlo M, Markandaiah SS, McAvoy K, Richard JP, Jablonski MR, Maragakis NJ, Pasinelli P, Trotti D.

Glia. 2016 Aug;64(8):1298-313. doi: 10.1002/glia.23003. Epub 2016 May 9.


Regulation of ABC efflux transporters at blood-brain barrier in health and neurological disorders.

Qosa H, Miller DS, Pasinelli P, Trotti D.

Brain Res. 2015 Dec 2;1628(Pt B):298-316. doi: 10.1016/j.brainres.2015.07.005. Epub 2015 Jul 15. Review.


Inhibiting drug efflux transporters improves efficacy of ALS therapeutics.

Jablonski MR, Markandaiah SS, Jacob D, Meng NJ, Li K, Gennaro V, Lepore AC, Trotti D, Pasinelli P.

Ann Clin Transl Neurol. 2014 Dec;1(12):996-1005. doi: 10.1002/acn3.141. Epub 2014 Nov 21.


Antisense proline-arginine RAN dipeptides linked to C9ORF72-ALS/FTD form toxic nuclear aggregates that initiate in vitro and in vivo neuronal death.

Wen X, Tan W, Westergard T, Krishnamurthy K, Markandaiah SS, Shi Y, Lin S, Shneider NA, Monaghan J, Pandey UB, Pasinelli P, Ichida JK, Trotti D.

Neuron. 2014 Dec 17;84(6):1213-25. doi: 10.1016/j.neuron.2014.12.010.


ABC transporter-driven pharmacoresistance in Amyotrophic Lateral Sclerosis.

Jablonski M, Miller DS, Pasinelli P, Trotti D.

Brain Res. 2015 May 14;1607:1-14. doi: 10.1016/j.brainres.2014.08.060. Epub 2014 Aug 28. Review.


Sumoylation of the astroglial glutamate transporter EAAT2 governs its intracellular compartmentalization.

Foran E, Rosenblum L, Bogush A, Pasinelli P, Trotti D.

Glia. 2014 Aug;62(8):1241-53. doi: 10.1002/glia.22677. Epub 2014 Apr 21.


Role of mitochondria in mutant SOD1 linked amyotrophic lateral sclerosis.

Tan W, Pasinelli P, Trotti D.

Biochim Biophys Acta. 2014 Aug;1842(8):1295-301. doi: 10.1016/j.bbadis.2014.02.009. Epub 2014 Feb 22. Review.


Sumoylation of critical proteins in amyotrophic lateral sclerosis: emerging pathways of pathogenesis.

Foran E, Rosenblum L, Bogush AI, Trotti D.

Neuromolecular Med. 2013 Dec;15(4):760-70. doi: 10.1007/s12017-013-8262-x. Epub 2013 Sep 24. Review.


Small peptides against the mutant SOD1/Bcl-2 toxic mitochondrial complex restore mitochondrial function and cell viability in mutant SOD1-mediated ALS.

Tan W, Naniche N, Bogush A, Pedrini S, Trotti D, Pasinelli P.

J Neurosci. 2013 Jul 10;33(28):11588-98. doi: 10.1523/JNEUROSCI.5385-12.2013.


Selective increase of two ABC drug efflux transporters at the blood-spinal cord barrier suggests induced pharmacoresistance in ALS.

Jablonski MR, Jacob DA, Campos C, Miller DS, Maragakis NJ, Pasinelli P, Trotti D.

Neurobiol Dis. 2012 Aug;47(2):194-200. doi: 10.1016/j.nbd.2012.03.040. Epub 2012 Apr 11.


An over-oxidized form of superoxide dismutase found in sporadic amyotrophic lateral sclerosis with bulbar onset shares a toxic mechanism with mutant SOD1.

Guareschi S, Cova E, Cereda C, Ceroni M, Donetti E, Bosco DA, Trotti D, Pasinelli P.

Proc Natl Acad Sci U S A. 2012 Mar 27;109(13):5074-9. doi: 10.1073/pnas.1115402109. Epub 2012 Mar 13.


Motor neuron impairment mediated by a sumoylated fragment of the glial glutamate transporter EAAT2.

Foran E, Bogush A, Goffredo M, Roncaglia P, Gustincich S, Pasinelli P, Trotti D.

Glia. 2011 Nov;59(11):1719-31. doi: 10.1002/glia.21218. Epub 2011 Jul 18.


Voltage-dependent inwardly rectifying potassium conductance in the outer membrane of neuronal mitochondria.

Fieni F, Parkar A, Misgeld T, Kerschensteiner M, Lichtman JW, Pasinelli P, Trotti D.

J Biol Chem. 2010 Aug 27;285(35):27411-7. doi: 10.1074/jbc.M110.131243. Epub 2010 Jun 15.


ALS-linked mutant SOD1 damages mitochondria by promoting conformational changes in Bcl-2.

Pedrini S, Sau D, Guareschi S, Bogush M, Brown RH Jr, Naniche N, Kia A, Trotti D, Pasinelli P.

Hum Mol Genet. 2010 Aug 1;19(15):2974-86. doi: 10.1093/hmg/ddq202. Epub 2010 May 11.


Glutamate transporters and the excitotoxic path to motor neuron degeneration in amyotrophic lateral sclerosis.

Foran E, Trotti D.

Antioxid Redox Signal. 2009 Jul;11(7):1587-602. doi: 10.1089/ars.2009.2444. Review.


Nordihydroguaiaretic acid increases glutamate uptake in vitro and in vivo: therapeutic implications for amyotrophic lateral sclerosis.

Boston-Howes W, Williams EO, Bogush A, Scolere M, Pasinelli P, Trotti D.

Exp Neurol. 2008 Sep;213(1):229-37. doi: 10.1016/j.expneurol.2008.06.010. Epub 2008 Jun 24.


A caspase-3-cleaved fragment of the glial glutamate transporter EAAT2 is sumoylated and targeted to promyelocytic leukemia nuclear bodies in mutant SOD1-linked amyotrophic lateral sclerosis.

Gibb SL, Boston-Howes W, Lavina ZS, Gustincich S, Brown RH Jr, Pasinelli P, Trotti D.

J Biol Chem. 2007 Nov 2;282(44):32480-90. Epub 2007 Sep 6.


Caspase-3 cleaves and inactivates the glutamate transporter EAAT2.

Boston-Howes W, Gibb SL, Williams EO, Pasinelli P, Brown RH Jr, Trotti D.

J Biol Chem. 2006 May 19;281(20):14076-84. Epub 2006 Mar 27.


Amyotrophic lateral sclerosis-associated SOD1 mutant proteins bind and aggregate with Bcl-2 in spinal cord mitochondria.

Pasinelli P, Belford ME, Lennon N, Bacskai BJ, Hyman BT, Trotti D, Brown RH Jr.

Neuron. 2004 Jul 8;43(1):19-30.


Modulation of DMT1 activity by redox compounds.

Marciani P, Trotti D, Hediger MA, Monticelli G.

J Membr Biol. 2004 Jan 15;197(2):91-9.


A role for glutamate transporters in neurodegenerative diseases.

Trotti D.

Adv Exp Med Biol. 2002;513:225-48. Review. No abstract available.


Inhibition of the glutamate transporter EAAC1 expressed in Xenopus oocytes by phorbol esters.

Trotti D, Peng JB, Dunlop J, Hediger MA.

Brain Res. 2001 Sep 28;914(1-2):196-203.


Regulation of glutamate transporters in health and disease.

Gegelashvili G, Robinson MB, Trotti D, Rauen T.

Prog Brain Res. 2001;132:267-86. Review. No abstract available.


Amyotrophic lateral sclerosis-linked glutamate transporter mutant has impaired glutamate clearance capacity.

Trotti D, Aoki M, Pasinelli P, Berger UV, Danbolt NC, Brown RH Jr, Hediger MA.

J Biol Chem. 2001 Jan 5;276(1):576-82.


SOD1 mutants linked to amyotrophic lateral sclerosis selectively inactivate a glial glutamate transporter

Trotti D, Rolfs A, Danbolt NC, Brown RH Jr, Hediger MA.

Nat Neurosci. 1999 Sep;2(9):848. No abstract available.


Inhibitory effect of the neuroprotective agent idebenone on arachidonic acid metabolism in astrocytes.

Civenni G, Bezzi P, Trotti D, Volterra A, Racagni G.

Eur J Pharmacol. 1999 Apr 9;370(2):161-7.


SOD1 mutants linked to amyotrophic lateral sclerosis selectively inactivate a glial glutamate transporter.

Trotti D, Rolfs A, Danbolt NC, Brown RH Jr, Hediger MA.

Nat Neurosci. 1999 May;2(5):427-33. Erratum in: Nat Neurosci 1999 Sep;2(9):848.


Glutamate transporters are oxidant-vulnerable: a molecular link between oxidative and excitotoxic neurodegeneration?

Trotti D, Danbolt NC, Volterra A.

Trends Pharmacol Sci. 1998 Aug;19(8):328-34. Review.


Cloning and characterization of a potassium-coupled amino acid transporter.

Castagna M, Shayakul C, Trotti D, Sacchi VF, Harvey WR, Hediger MA.

Proc Natl Acad Sci U S A. 1998 Apr 28;95(9):5395-400.


Non-synaptic localization of the glutamate transporter EAAC1 in cultured hippocampal neurons.

Coco S, Verderio C, Trotti D, Rothstein JD, Volterra A, Matteoli M.

Eur J Neurosci. 1997 Sep;9(9):1902-10.


Neuronal and glial glutamate transporters possess an SH-based redox regulatory mechanism.

Trotti D, Rizzini BL, Rossi D, Haugeto O, Racagni G, Danbolt NC, Volterra A.

Eur J Neurosci. 1997 Jun;9(6):1236-43.


Symmetry of H+ binding to the intra- and extracellular side of the H+-coupled oligopeptide cotransporter PepT1.

Nussberger S, Steel A, Trotti D, Romero MF, Boron WF, Hediger MA.

J Biol Chem. 1997 Mar 21;272(12):7777-85.


Molecular characteristics of mammalian and insect amino acid transporters: implications for amino acid homeostasis.

Castagna M, Shayakul C, Trotti D, Sacchi VF, Harvey WR, Hediger MA.

J Exp Biol. 1997 Jan;200(Pt 2):269-86. Review.


Peroxynitrite inhibits glutamate transporter subtypes.

Trotti D, Rossi D, Gjesdal O, Levy LM, Racagni G, Danbolt NC, Volterra A.

J Biol Chem. 1996 Mar 15;271(11):5976-9.


Arachidonic acid inhibits a purified and reconstituted glutamate transporter directly from the water phase and not via the phospholipid membrane.

Trotti D, Volterra A, Lehre KP, Rossi D, Gjesdal O, Racagni G, Danbolt NC.

J Biol Chem. 1995 Apr 28;270(17):9890-5.


Reactive oxygen species inhibit high-affinity glutamate uptake: molecular mechanism and neuropathological implications.

Volterra A, Trotti D, Floridi S, Racagni G.

Ann N Y Acad Sci. 1994 Nov 17;738:153-62. Review. No abstract available.


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