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Bacterial immunogenic α-galactosylceramide identified in the murine large intestine: dependency on diet and inflammation.

von Gerichten J, Lamprecht D, Opalka L, Soulard D, Marsching C, Pilz R, Sencio V, Herzer S, Galy B, Nordström V, Hopf C, Gröne HJ, Trottein F, Sandhoff R.

J Lipid Res. 2019 Sep 4. pii: jlr.RA119000236. doi: 10.1194/jlr.RA119000236. [Epub ahead of print]


Toll-like receptor 5 agonist flagellin reduces influenza A virus replication independently of type I interferon and interleukin 22 and improves antiviral efficacy of oseltamivir.

Georgel AF, Cayet D, Pizzorno A, Rosa-Calatrava M, Paget C, Sencio V, Dubuisson J, Trottein F, Sirard JC, Carnoy C.

Antiviral Res. 2019 Aug;168:28-35. doi: 10.1016/j.antiviral.2019.05.002. Epub 2019 May 9.


Mechanisms of Bacterial Superinfection Post-influenza: A Role for Unconventional T Cells.

Paget C, Trottein F.

Front Immunol. 2019 Mar 1;10:336. doi: 10.3389/fimmu.2019.00336. eCollection 2019. Review.


TLR9-mediated dendritic cell activation uncovers mammalian ganglioside species with specific ceramide backbones that activate invariant natural killer T cells.

Paget C, Deng S, Soulard D, Priestman DA, Speca S, von Gerichten J, Speak AO, Saroha A, Pewzner-Jung Y, Futerman AH, Mallevaey T, Faveeuw C, Gu X, Platt FM, Sandhoff R, Trottein F.

PLoS Biol. 2019 Mar 1;17(3):e3000169. doi: 10.1371/journal.pbio.3000169. eCollection 2019 Mar.


Semisynthetic glycoconjugate based on dual role protein/PsaA as a pneumococcal vaccine.

Prasanna M, Soulard D, Camberlein E, Ruffier N, Lambert A, Trottein F, Csaba N, Grandjean C.

Eur J Pharm Sci. 2019 Mar 1;129:31-41. doi: 10.1016/j.ejps.2018.12.013. Epub 2018 Dec 17.


Alteration of Flt3-Ligand-dependent de novo generation of conventional dendritic cells during influenza infection contributes to respiratory bacterial superinfection.

Beshara R, Sencio V, Soulard D, Barthélémy A, Fontaine J, Pinteau T, Deruyter L, Ismail MB, Paget C, Sirard JC, Trottein F, Faveeuw C.

PLoS Pathog. 2018 Oct 29;14(10):e1007360. doi: 10.1371/journal.ppat.1007360. eCollection 2018 Oct.


Production of Interleukin-20 cytokines limits bacterial clearance and lung inflammation during infection by Streptococcus pneumoniae.

Madouri F, Barada O, Kervoaze G, Trottein F, Pichavant M, Gosset P.

EBioMedicine. 2018 Nov;37:417-427. doi: 10.1016/j.ebiom.2018.10.031. Epub 2018 Oct 22.


Natural Killer T Cells and Mucosal-Associated Invariant T Cells in Lung Infections.

Trottein F, Paget C.

Front Immunol. 2018 Aug 2;9:1750. doi: 10.3389/fimmu.2018.01750. eCollection 2018. Review.


IL-17-dependent SIgA-mediated protection against nasal Bordetella pertussis infection by live attenuated BPZE1 vaccine.

Solans L, Debrie AS, Borkner L, Aguiló N, Thiriard A, Coutte L, Uranga S, Trottein F, Martín C, Mills KHG, Locht C.

Mucosal Immunol. 2018 Nov;11(6):1753-1762. doi: 10.1038/s41385-018-0073-9. Epub 2018 Aug 16.


Interleukin-22 Immunotherapy during Severe Influenza Enhances Lung Tissue Integrity and Reduces Secondary Bacterial Systemic Invasion.

Barthelemy A, Sencio V, Soulard D, Deruyter L, Faveeuw C, Le Goffic R, Trottein F.

Infect Immun. 2018 Jun 21;86(7). pii: e00706-17. doi: 10.1128/IAI.00706-17. Print 2018 Jul.


CXCR1/2 Antagonism Is Protective during Influenza and Post-Influenza Pneumococcal Infection.

Tavares LP, Garcia CC, Machado MG, Queiroz-Junior CM, Barthelemy A, Trottein F, Siqueira MM, Brandolini L, Allegretti M, Machado AM, de Sousa LP, Teixeira MM.

Front Immunol. 2017 Dec 13;8:1799. doi: 10.3389/fimmu.2017.01799. eCollection 2017.


Critical Role for Very-Long Chain Sphingolipids in Invariant Natural Killer T Cell Development and Homeostasis.

Saroha A, Pewzner-Jung Y, Ferreira NS, Sharma P, Jouan Y, Kelly SL, Feldmesser E, Merrill AH Jr, Trottein F, Paget C, Lang KS, Futerman AH.

Front Immunol. 2017 Nov 1;8:1386. doi: 10.3389/fimmu.2017.01386. eCollection 2017.


Type I IFN Receptor Signaling Controls IL7-Dependent Accumulation and Activity of Protumoral IL17A-Producing γδT Cells in Breast Cancer.

Patin EC, Soulard D, Fleury S, Hassane M, Dombrowicz D, Faveeuw C, Trottein F, Paget C.

Cancer Res. 2018 Jan 1;78(1):195-204. doi: 10.1158/0008-5472.CAN-17-1416. Epub 2017 Oct 25.


Co-delivery of the NKT agonist α-galactosylceramide and tumor antigens to cross-priming dendritic cells breaks tolerance to self-antigens and promotes antitumor responses.

Ghinnagow R, De Meester J, Cruz LJ, Aspord C, Corgnac S, Macho-Fernandez E, Soulard D, Fontaine J, Chaperot L, Charles J, Soncin F, Mami-Chouaib F, Plumas J, Faveeuw C, Trottein F.

Oncoimmunology. 2017 Aug 18;6(9):e1339855. doi: 10.1080/2162402X.2017.1339855. eCollection 2017.


Enhancement of Adjuvant Functions of Natural Killer T Cells Using Nanovector Delivery Systems: Application in Anticancer Immune Therapy.

Ghinnagow R, Cruz LJ, Macho-Fernandez E, Faveeuw C, Trottein F.

Front Immunol. 2017 Jul 27;8:879. doi: 10.3389/fimmu.2017.00879. eCollection 2017. Review.


Solubilization of α-galactosylceramide in aqueous medium: Impact on Natural Killer T cell activation and antitumor responses.

Macho-Fernandez E, Chekkat N, Ehret C, Thomann JS, De Giorgi M, Spanedda MV, Bourel-Bonnet L, Betbeder D, Heurtault B, Faveeuw C, Fournel S, Frisch B, Trottein F.

Int J Pharm. 2017 Sep 15;530(1-2):354-363. doi: 10.1016/j.ijpharm.2017.07.054. Epub 2017 Jul 22.


[Influenza and secondary bacterial infections: threats and treatments].

Roquilly A, Trottein F.

Med Sci (Paris). 2017 May;33(5):528-533. doi: 10.1051/medsci/20173305017. Epub 2017 Jun 14. Review. French.


[iNKT cells: potential therapeutic targets to fight anthrax].

Le Gars M, Haustant M, Klezovich-Benard M, Paget C, Trottein F, Goossens PL, Tournier JN.

Med Sci (Paris). 2017 May;33(5):488-490. doi: 10.1051/medsci/20173305010. Epub 2017 Jun 14. French. No abstract available.


Neutrophilic NLRP3 inflammasome-dependent IL-1β secretion regulates the γδT17 cell response in respiratory bacterial infections.

Hassane M, Demon D, Soulard D, Fontaine J, Keller LE, Patin EC, Porte R, Prinz I, Ryffel B, Kadioglu A, Veening JW, Sirard JC, Faveeuw C, Lamkanfi M, Trottein F, Paget C.

Mucosal Immunol. 2017 Jul;10(4):1056-1068. doi: 10.1038/mi.2016.113. Epub 2017 Jan 4.


Exogenous Activation of Invariant Natural Killer T Cells by α-Galactosylceramide Reduces Pneumococcal Outgrowth and Dissemination Postinfluenza.

Barthelemy A, Ivanov S, Hassane M, Fontaine J, Heurtault B, Frisch B, Faveeuw C, Paget C, Trottein F.

MBio. 2016 Nov 1;7(6). pii: e01440-16. doi: 10.1128/mBio.01440-16.


Pseudomonas aeruginosa proteolytically alters the interleukin 22-dependent lung mucosal defense.

Guillon A, Brea D, Morello E, Tang A, Jouan Y, Ramphal R, Korkmaz B, Perez-Cruz M, Trottein F, O'Callaghan RJ, Gosset P, Si-Tahar M.

Virulence. 2017 Aug 18;8(6):810-820. doi: 10.1080/21505594.2016.1253658. Epub 2016 Oct 28.


Mechanisms of Invariant NKT Cell Activity in Restraining Bacillus anthracis Systemic Dissemination.

Le Gars M, Haustant M, Klezovich-Bénard M, Paget C, Trottein F, Goossens PL, Tournier JN.

J Immunol. 2016 Oct 15;197(8):3225-3232. Epub 2016 Sep 7.


Influenza A virus-induced release of interleukin-10 inhibits the anti-microbial activities of invariant natural killer T cells during invasive pneumococcal superinfection.

Barthelemy A, Ivanov S, Fontaine J, Soulard D, Bouabe H, Paget C, Faveeuw C, Trottein F.

Mucosal Immunol. 2017 Mar;10(2):460-469. doi: 10.1038/mi.2016.49. Epub 2016 May 25.


Interleukin-22 protects against non-typeable Haemophilus influenzae infection: alteration during chronic obstructive pulmonary disease.

Sharan R, Perez-Cruz M, Kervoaze G, Gosset P, Weynants V, Godfroid F, Hermand P, Trottein F, Pichavant M, Gosset P.

Mucosal Immunol. 2017 Jan;10(1):139-149. doi: 10.1038/mi.2016.40. Epub 2016 May 4.


A Toll-Like Receptor 5 Agonist Improves the Efficacy of Antibiotics in Treatment of Primary and Influenza Virus-Associated Pneumococcal Mouse Infections.

Porte R, Fougeron D, Muñoz-Wolf N, Tabareau J, Georgel AF, Wallet F, Paget C, Trottein F, Chabalgoity JA, Carnoy C, Sirard JC.

Antimicrob Agents Chemother. 2015 Oct;59(10):6064-72. doi: 10.1128/AAC.01210-15. Epub 2015 Jul 20.


CD3bright signals on γδ T cells identify IL-17A-producing Vγ6Vδ1+ T cells.

Paget C, Chow MT, Gherardin NA, Beavis PA, Uldrich AP, Duret H, Hassane M, Souza-Fonseca-Guimaraes F, Mogilenko DA, Staumont-Sallé D, Escalante NK, Hill GR, Neeson P, Ritchie DS, Dombrowicz D, Mallevaey T, Trottein F, Belz GT, Godfrey DI, Smyth MJ.

Immunol Cell Biol. 2015 Feb;93(2):198-212. doi: 10.1038/icb.2014.94. Epub 2014 Nov 11.


Role of non-conventional T lymphocytes in respiratory infections: the case of the pneumococcus.

Ivanov S, Paget C, Trottein F.

PLoS Pathog. 2014 Oct 9;10(10):e1004300. doi: 10.1371/journal.ppat.1004300. eCollection 2014 Oct. Review.


Targeted delivery of α-galactosylceramide to CD8α+ dendritic cells optimizes type I NKT cell-based antitumor responses.

Macho-Fernandez E, Cruz LJ, Ghinnagow R, Fontaine J, Bialecki E, Frisch B, Trottein F, Faveeuw C.

J Immunol. 2014 Jul 15;193(2):961-9. doi: 10.4049/jimmunol.1303029. Epub 2014 Jun 9.


Cytokine responses to the anti-schistosome vaccine candidate antigen glutathione-S-transferase vary with host age and are boosted by praziquantel treatment.

Bourke CD, Nausch N, Rujeni N, Appleby LJ, Trottein F, Midzi N, Mduluza T, Mutapi F.

PLoS Negl Trop Dis. 2014 May 8;8(5):e2846. doi: 10.1371/journal.pntd.0002846. eCollection 2014 May.


Optimization of natural killer T cell-mediated immunotherapy in cancer using cell-based and nanovector vaccines.

Faveeuw C, Trottein F.

Cancer Res. 2014 Mar 15;74(6):1632-8. doi: 10.1158/0008-5472.CAN-13-3504. Epub 2014 Mar 5. Review.


Activation of Type 3 innate lymphoid cells and interleukin 22 secretion in the lungs during Streptococcus pneumoniae infection.

Van Maele L, Carnoy C, Cayet D, Ivanov S, Porte R, Deruy E, Chabalgoity JA, Renauld JC, Eberl G, Benecke AG, Trottein F, Faveeuw C, Sirard JC.

J Infect Dis. 2014 Aug 1;210(3):493-503. doi: 10.1093/infdis/jiu106. Epub 2014 Feb 26.


Oxidative stress-mediated iNKT-cell activation is involved in COPD pathogenesis.

Pichavant M, Rémy G, Bekaert S, Le Rouzic O, Kervoaze G, Vilain E, Just N, Tillie-Leblond I, Trottein F, Cataldo D, Gosset P.

Mucosal Immunol. 2014 May;7(3):568-78. doi: 10.1038/mi.2013.75. Epub 2013 Oct 30.


Role of type 1 natural killer T cells in pulmonary immunity.

Paget C, Trottein F.

Mucosal Immunol. 2013 Nov;6(6):1054-67. doi: 10.1038/mi.2013.59. Epub 2013 Oct 9. Review.


Lung inflammation and thymic atrophy after bleomycin are controlled by the prostaglandin D2 receptor DP1.

van den Brule S, Huaux F, Uwambayinema F, Ibouraadaten S, Yakoub Y, Palmai-Pallag M, Trottein F, Renauld JC, Lison D.

Am J Respir Cell Mol Biol. 2014 Jan;50(1):212-22. doi: 10.1165/rcmb.2012-0520OC.


Notch signaling regulates follicular helper T cell differentiation.

Auderset F, Schuster S, Fasnacht N, Coutaz M, Charmoy M, Koch U, Favre S, Wilson A, Trottein F, Alexander J, Luther SA, MacDonald HR, Radtke F, Tacchini-Cottier F.

J Immunol. 2013 Sep 1;191(5):2344-50. doi: 10.4049/jimmunol.1300643. Epub 2013 Aug 5.


Colonic inflammation in mice is improved by cigarette smoke through iNKT cells recruitment.

Montbarbon M, Pichavant M, Langlois A, Erdual E, Maggiotto F, Neut C, Mallevaey T, Dharancy S, Dubuquoy L, Trottein F, Cortot A, Desreumaux P, Gosset P, Bertin B.

PLoS One. 2013 Apr 25;8(4):e62208. doi: 10.1371/journal.pone.0062208. Print 2013.


Interleukin-22 reduces lung inflammation during influenza A virus infection and protects against secondary bacterial infection.

Ivanov S, Renneson J, Fontaine J, Barthelemy A, Paget C, Fernandez EM, Blanc F, De Trez C, Van Maele L, Dumoutier L, Huerre MR, Eberl G, Si-Tahar M, Gosset P, Renauld JC, Sirard JC, Faveeuw C, Trottein F.

J Virol. 2013 Jun;87(12):6911-24. doi: 10.1128/JVI.02943-12. Epub 2013 Apr 17.


Age-related patterns in human myeloid dendritic cell populations in people exposed to Schistosoma haematobium infection.

Nausch N, Louis D, Lantz O, Peguillet I, Trottein F, Chen IY, Appleby LJ, Bourke CD, Midzi N, Mduluza T, Mutapi F.

PLoS Negl Trop Dis. 2012;6(9):e1824. doi: 10.1371/journal.pntd.0001824. Epub 2012 Sep 27.


Scavenger receptors in human airway epithelial cells: role in response to double-stranded RNA.

Dieudonné A, Torres D, Blanchard S, Taront S, Jeannin P, Delneste Y, Pichavant M, Trottein F, Gosset P.

PLoS One. 2012;7(8):e41952. doi: 10.1371/journal.pone.0041952. Epub 2012 Aug 7.


Proportions of CD4+ memory T cells are altered in individuals chronically infected with Schistosoma haematobium.

Nausch N, Bourke CD, Appleby LJ, Rujeni N, Lantz O, Trottein F, Midzi N, Mduluza T, Mutapi F.

Sci Rep. 2012;2:472. doi: 10.1038/srep00472. Epub 2012 Jun 26.


Key role for respiratory CD103(+) dendritic cells, IFN-γ, and IL-17 in protection against Streptococcus pneumoniae infection in response to α-galactosylceramide.

Ivanov S, Fontaine J, Paget C, Macho Fernandez E, Van Maele L, Renneson J, Maillet I, Wolf NM, Rial A, Léger H, Ryffel B, Frisch B, Chabalgoity JA, Sirard JC, Benecke A, Faveeuw C, Trottein F.

J Infect Dis. 2012 Sep 1;206(5):723-34. doi: 10.1093/infdis/jis413. Epub 2012 Jun 21.


Interleukin-22 is produced by invariant natural killer T lymphocytes during influenza A virus infection: potential role in protection against lung epithelial damages.

Paget C, Ivanov S, Fontaine J, Renneson J, Blanc F, Pichavant M, Dumoutier L, Ryffel B, Renauld JC, Gosset P, Gosset P, Si-Tahar M, Faveeuw C, Trottein F.

J Biol Chem. 2012 Mar 16;287(12):8816-29. doi: 10.1074/jbc.M111.304758. Epub 2012 Jan 31.


Spleen-resident CD4+ and CD4- CD8α- dendritic cell subsets differ in their ability to prime invariant natural killer T lymphocytes.

Bialecki E, Macho Fernandez E, Ivanov S, Paget C, Fontaine J, Rodriguez F, Lebeau L, Ehret C, Frisch B, Trottein F, Faveeuw C.

PLoS One. 2011;6(10):e26919. doi: 10.1371/journal.pone.0026919. Epub 2011 Oct 31.


Egfl7 promotes tumor escape from immunity by repressing endothelial cell activation.

Delfortrie S, Pinte S, Mattot V, Samson C, Villain G, Caetano B, Lauridant-Philippin G, Baranzelli MC, Bonneterre J, Trottein F, Faveeuw C, Soncin F.

Cancer Res. 2011 Dec 1;71(23):7176-86. doi: 10.1158/0008-5472.CAN-11-1301. Epub 2011 Oct 28.


A detrimental role for invariant natural killer T cells in the pathogenesis of experimental dengue virus infection.

Renneson J, Guabiraba R, Maillet I, Marques RE, Ivanov S, Fontaine J, Paget C, Quesniaux V, Faveeuw C, Ryffel B, Teixeira MM, Trottein F.

Am J Pathol. 2011 Oct;179(4):1872-83. doi: 10.1016/j.ajpath.2011.06.023. Epub 2011 Aug 16.


Activation of invariant Natural Killer T lymphocytes in response to the α-galactosylceramide analogue KRN7000 encapsulated in PLGA-based nanoparticles and microparticles.

Macho Fernandez E, Chang J, Fontaine J, Bialecki E, Rodriguez F, Werkmeister E, Krieger V, Ehret C, Heurtault B, Fournel S, Frisch B, Betbeder D, Faveeuw C, Trottein F.

Int J Pharm. 2012 Feb 14;423(1):45-54. doi: 10.1016/j.ijpharm.2011.04.068. Epub 2011 May 14.


Potential role of invariant NKT cells in the control of pulmonary inflammation and CD8+ T cell response during acute influenza A virus H3N2 pneumonia.

Paget C, Ivanov S, Fontaine J, Blanc F, Pichavant M, Renneson J, Bialecki E, Pothlichet J, Vendeville C, Barba-Spaeth G, Huerre MR, Faveeuw C, Si-Tahar M, Trottein F.

J Immunol. 2011 May 15;186(10):5590-602. doi: 10.4049/jimmunol.1002348. Epub 2011 Apr 13. Erratum in: J Immunol. 2011 Aug 1;187(3):1515. Barba-Speath, Giovanna [corrected to Barba-Spaeth, Giovanna].


Interferon response factor 3 is essential for house dust mite-induced airway allergy.

Marichal T, Bedoret D, Mesnil C, Pichavant M, Goriely S, Trottein F, Cataldo D, Goldman M, Lekeux P, Bureau F, Desmet CJ.

J Allergy Clin Immunol. 2010 Oct;126(4):836-844.e13. doi: 10.1016/j.jaci.2010.06.009. Epub 2010 Jul 31.


Double-stranded RNA exacerbates pulmonary allergic reaction through TLR3: implication of airway epithelium and dendritic cells.

Torres D, Dieudonné A, Ryffel B, Vilain E, Si-Tahar M, Pichavant M, Lassalle P, Trottein F, Gosset P.

J Immunol. 2010 Jul 1;185(1):451-9. doi: 10.4049/jimmunol.0902833. Epub 2010 May 26.


Glycosyltransferase and sulfotransferase gene expression profiles in human monocytes, dendritic cells and macrophages.

Trottein F, Schaffer L, Ivanov S, Paget C, Vendeville C, Cazet A, Groux-Degroote S, Lee S, Krzewinski-Recchi MA, Faveeuw C, Head SR, Gosset P, Delannoy P.

Glycoconj J. 2009 Dec;26(9):1259-74. doi: 10.1007/s10719-009-9244-y.

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