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Items: 1 to 50 of 468

1.

Highly Regio-, Diastereo-, and Enantioselective Synthesis of Tetrahydroazepines and Benzo[b]oxepines via Palladium-Catalyzed [4+3] Cycloaddition Reactions.

Trost BM, Zuo Z.

Angew Chem Int Ed Engl. 2019 Oct 14. doi: 10.1002/anie.201911537. [Epub ahead of print]

PMID:
31610098
2.

A large data resource of genomic copy number variation across neurodevelopmental disorders.

Zarrei M, Burton CL, Engchuan W, Young EJ, Higginbotham EJ, MacDonald JR, Trost B, Chan AJS, Walker S, Lamoureux S, Heung T, Mojarad BA, Kellam B, Paton T, Faheem M, Miron K, Lu C, Wang T, Samler K, Wang X, Costain G, Hoang N, Pellecchia G, Wei J, Patel RV, Thiruvahindrapuram B, Roifman M, Merico D, Goodale T, Drmic I, Speevak M, Howe JL, Yuen RKC, Buchanan JA, Vorstman JAS, Marshall CR, Wintle RF, Rosenberg DR, Hanna GL, Woodbury-Smith M, Cytrynbaum C, Zwaigenbaum L, Elsabbagh M, Flanagan J, Fernandez BA, Carter MT, Szatmari P, Roberts W, Lerch J, Liu X, Nicolson R, Georgiades S, Weksberg R, Arnold PD, Bassett AS, Crosbie J, Schachar R, Stavropoulos DJ, Anagnostou E, Scherer SW.

NPJ Genom Med. 2019 Oct 7;4:26. doi: 10.1038/s41525-019-0098-3. eCollection 2019.

3.

Enantioselective Divergent Syntheses of (+)-Bulleyanaline and Related Isoquinoline Alkaloids from the Genus Corydalis.

Trost BM, Hung CJ, Jiao Z.

J Am Chem Soc. 2019 Oct 9;141(40):16085-16092. doi: 10.1021/jacs.9b08441. Epub 2019 Sep 25.

PMID:
31525040
4.

Impact of DNA source on genetic variant detection from human whole-genome sequencing data.

Trost B, Walker S, Haider SA, Sung WWL, Pereira S, Phillips CL, Higginbotham EJ, Strug LJ, Nguyen C, Raajkumar A, Szego MJ, Marshall CR, Scherer SW.

J Med Genet. 2019 Sep 12. pii: jmedgenet-2019-106281. doi: 10.1136/jmedgenet-2019-106281. [Epub ahead of print]

5.

Elaborating Complex Heteroaryl-Containing Cycles via Enantioselective Palladium-Catalyzed Cycloadditions.

Trost BM, Jiao Z, Hung CJ.

Angew Chem Int Ed Engl. 2019 Oct 14;58(42):15154-15158. doi: 10.1002/anie.201910061. Epub 2019 Sep 11. Review.

PMID:
31483926
6.

Dinuclear Metal-ProPhenol Catalysts: Development and Synthetic Applications.

Trost BM, Hung CJ, Mata G.

Angew Chem Int Ed Engl. 2019 Aug 26. doi: 10.1002/anie.201909692. [Epub ahead of print]

PMID:
31452294
7.

Desymmetrization of Phosphinic Acids via Pd-Catalyzed Asymmetric Allylic Alkylation: Rapid Access to P-Chiral Phosphinates.

Trost BM, Spohr SM, Rolka AB, Kalnmals CA.

J Am Chem Soc. 2019 Sep 11;141(36):14098-14103. doi: 10.1021/jacs.9b07340. Epub 2019 Aug 27.

PMID:
31442377
8.

Palladium-Catalyzed Asymmetric Allylic Fluoroalkylation/Trifluoromethylation.

Trost BM, Gholami H, Zell D.

J Am Chem Soc. 2019 Jul 24;141(29):11446-11451. doi: 10.1021/jacs.9b06231. Epub 2019 Jul 10.

PMID:
31280565
9.

Development of Chemo- and Enantioselective Palladium-Catalyzed Decarboxylative Asymmetric Allylic Alkylation of α-Nitroesters.

Trost BM, Schultz JE, Bai Y.

Angew Chem Int Ed Engl. 2019 Aug 19;58(34):11820-11825. doi: 10.1002/anie.201904034. Epub 2019 Jul 16.

PMID:
31231880
10.

New Catalytic Asymmetric Formation of Oxygen Heterocycles Bearing Nucleoside Bases at the Anomeric Carbon.

Trost BM, Xu S, Sharif EU.

J Am Chem Soc. 2019 Jul 3;141(26):10199-10204. doi: 10.1021/jacs.9b06050. Epub 2019 Jun 17.

PMID:
31194521
11.

Sulfones as Chemical Chameleons: Versatile Synthetic Equivalents of Small-Molecule Synthons.

Trost BM, Kalnmals CA.

Chemistry. 2019 Aug 27;25(48):11193-11213. doi: 10.1002/chem.201902019. Epub 2019 Jul 12. Review.

PMID:
31185136
12.

Chemo-, Regio-, Diastereo-, and Enantioselective Palladium Allylic Alkylation of 1,3-Dioxaboroles as Synthetic Equivalents of α-Hydroxyketones.

Trost BM, Schultz JE, Chang T, Maduabum MR.

J Am Chem Soc. 2019 Jun 19;141(24):9521-9526. doi: 10.1021/jacs.9b04658. Epub 2019 Jun 10.

PMID:
31180647
13.

Length of Uninterrupted CAG, Independent of Polyglutamine Size, Results in Increased Somatic Instability, Hastening Onset of Huntington Disease.

Wright GEB, Collins JA, Kay C, McDonald C, Dolzhenko E, Xia Q, Bečanović K, Drögemöller BI, Semaka A, Nguyen CM, Trost B, Richards F, Bijlsma EK, Squitieri F, Ross CJD, Scherer SW, Eberle MA, Yuen RKC, Hayden MR.

Am J Hum Genet. 2019 Jun 6;104(6):1116-1126. doi: 10.1016/j.ajhg.2019.04.007. Epub 2019 May 16.

PMID:
31104771
14.

Glutaminase Deficiency Caused by Short Tandem Repeat Expansion in GLS.

van Kuilenburg ABP, Tarailo-Graovac M, Richmond PA, Drögemöller BI, Pouladi MA, Leen R, Brand-Arzamendi K, Dobritzsch D, Dolzhenko E, Eberle MA, Hayward B, Jones MJ, Karbassi F, Kobor MS, Koster J, Kumari D, Li M, MacIsaac J, McDonald C, Meijer J, Nguyen C, Rajan-Babu IS, Scherer SW, Sim B, Trost B, Tseng LA, Turkenburg M, van Vugt JJFA, Veldink JH, Walia JS, Wang Y, van Weeghel M, Wright GEB, Xu X, Yuen RKC, Zhang J, Ross CJ, Wasserman WW, Geraghty MT, Santra S, Wanders RJA, Wen XY, Waterham HR, Usdin K, van Karnebeek CDM.

N Engl J Med. 2019 Apr 11;380(15):1433-1441. doi: 10.1056/NEJMoa1806627.

PMID:
30970188
15.

Catalytic (3+2) Palladium-Aminoallyl Cycloaddition with Conjugated Dienes.

Trost BM, Huang Z.

Angew Chem Int Ed Engl. 2019 May 6;58(19):6396-6399. doi: 10.1002/anie.201900693. Epub 2019 Apr 4.

PMID:
30946506
16.

Enantioselective Divergent Synthesis of C19-Oxo Eburnane Alkaloids via Palladium-Catalyzed Asymmetric Allylic Alkylation of an N-Alkyl-α,β-unsaturated Lactam.

Trost BM, Bai Y, Bai WJ, Schultz JE.

J Am Chem Soc. 2019 Mar 27;141(12):4811-4814. doi: 10.1021/jacs.9b00788. Epub 2019 Mar 15.

PMID:
30848892
17.

Palladium-Catalyzed Decarboxylative Asymmetric Allylic Alkylation of Dihydroquinolinones.

Trost BM, Nagaraju A, Wang F, Zuo Z, Xu J, Hull KL.

Org Lett. 2019 Mar 15;21(6):1784-1788. doi: 10.1021/acs.orglett.9b00358. Epub 2019 Mar 5.

PMID:
30834753
18.

Synthesis of Chiral, Densely Substituted Pyrrolidones via Phosphine-Catalyzed Cycloisomerization.

Trost BM, Gnanamani E, Hung CJ, Kalnmals CA.

Org Lett. 2019 Mar 15;21(6):1890-1894. doi: 10.1021/acs.orglett.9b00496. Epub 2019 Mar 4.

PMID:
30829494
19.

Vanadium-Catalyzed Coupling of Allenols with Electrophilic Halide Sources for the Formation of α-Halo-α',β'-unsaturated Ketones.

Trost BM, Tracy JS, Yusoontorn T.

Org Lett. 2019 Feb 15;21(4):1207-1211. doi: 10.1021/acs.orglett.9b00195. Epub 2019 Jan 28.

PMID:
30689391
20.

Direct Enantio- and Diastereoselective Vinylogous Addition of Butenolides to Chromones Catalyzed by Zn-ProPhenol.

Trost BM, Gnanamani E, Kalnmals CA, Hung CJ, Tracy JS.

J Am Chem Soc. 2019 Jan 30;141(4):1489-1493. doi: 10.1021/jacs.8b13367. Epub 2019 Jan 18.

PMID:
30642168
21.

Highly Chemoselective Deprotection of the 2,2,2-Trichloroethoxycarbonyl (Troc) Protecting Group.

Trost BM, Kalnmals CA, Tracy JS, Bai WJ.

Org Lett. 2018 Dec 21;20(24):8043-8046. doi: 10.1021/acs.orglett.8b03642. Epub 2018 Dec 4.

PMID:
30511873
22.

Enantioselective Synthesis of des-Epoxy-Amphidinolide N.

Trost BM, Bai WJ, Stivala CE, Hohn C, Poock C, Heinrich M, Xu S, Rey J.

J Am Chem Soc. 2018 Dec 12;140(49):17316-17326. doi: 10.1021/jacs.8b11827. Epub 2018 Dec 4.

PMID:
30457857
23.

Catalytic palladium-oxyallyl cycloaddition.

Trost BM, Huang Z, Murhade GM.

Science. 2018 Nov 2;362(6414):564-568. doi: 10.1126/science.aau4821.

PMID:
30385573
24.

Propene as an Atom-Economical Linchpin for Concise Total Synthesis of Polyenes: Piericidin A.

Trost BM, Gholami H.

J Am Chem Soc. 2018 Sep 19;140(37):11623-11626. doi: 10.1021/jacs.8b08974. Epub 2018 Sep 5.

PMID:
30173519
25.

Conservation of kinase-phosphorylation site pairings: Evidence for an evolutionarily dynamic phosphoproteome.

McDonald M, Trost B, Napper S.

PLoS One. 2018 Aug 14;13(8):e0202036. doi: 10.1371/journal.pone.0202036. eCollection 2018.

26.

Enantio- and Diastereoselective Synthesis of Chiral Allenes by Palladium-Catalyzed Asymmetric [3+2] Cycloaddition Reactions.

Trost BM, Zell D, Hohn C, Mata G, Maruniak A.

Angew Chem Int Ed Engl. 2018 Sep 24;57(39):12916-12920. doi: 10.1002/anie.201808345. Epub 2018 Sep 5.

PMID:
30073727
27.

Enantioselective Palladium-Catalyzed [3+2] Cycloaddition of Trimethylenemethane and Fluorinated Ketones.

Trost BM, Mata G.

Angew Chem Int Ed Engl. 2018 Sep 17;57(38):12333-12337. doi: 10.1002/anie.201807308. Epub 2018 Aug 23.

PMID:
30071149
28.

Direct Catalytic Asymmetric Vinylogous Additions of α,β- and β,γ-Butenolides to Polyfluorinated Alkynyl Ketimines.

Trost BM, Hung CJ, Scharf MJ.

Angew Chem Int Ed Engl. 2018 Aug 27;57(35):11408-11412. doi: 10.1002/anie.201806249. Epub 2018 Jul 26.

PMID:
29969528
29.

Synthesis of the Aminocyclitol Core of Jogyamycin via an Enantioselective Pd-Catalyzed Trimethylenemethane (TMM) Cycloaddition.

Trost BM, Zhang L, Lam TM.

Org Lett. 2018 Jul 6;20(13):3938-3942. doi: 10.1021/acs.orglett.8b01518. Epub 2018 Jun 25.

PMID:
29939033
30.

A Deprotonation Approach to the Unprecedented Amino-Trimethylenemethane Chemistry: Regio-, Diastereo-, and Enantioselective Synthesis of Complex Amino Cycles.

Trost BM, Wang Y.

Angew Chem Int Ed Engl. 2018 Aug 20;57(34):11025-11029. doi: 10.1002/anie.201805876. Epub 2018 Jul 18.

PMID:
29924916
31.

Palladium-Catalyzed Asymmetric Allylic Alkylation of 3-Substituted 1 H-Indoles and Tryptophan Derivatives with Vinylcyclopropanes.

Trost BM, Bai WJ, Hohn C, Bai Y, Cregg JJ.

J Am Chem Soc. 2018 May 30;140(21):6710-6717. doi: 10.1021/jacs.8b03656. Epub 2018 May 18.

PMID:
29750514
32.

Direct catalytic enantioselective amination of ketones for the formation of tri- and tetrasubstituted stereocenters.

Trost BM, Tracy JS, Saget T.

Chem Sci. 2018 Feb 14;9(11):2975-2980. doi: 10.1039/c8sc00147b. eCollection 2018 Mar 21.

33.

Sulfones as Synthetic Linchpins: Transition-Metal-Free sp3 -sp2 and sp2 -sp2 Cross-Couplings Between Geminal Bis(sulfones) and Organolithium Compounds.

Trost BM, Kalnmals CA.

Chemistry. 2018 Jun 26;24(36):9066-9074. doi: 10.1002/chem.201800118. Epub 2018 Jun 7.

PMID:
29543985
34.

The Personal Genome Project Canada: findings from whole genome sequences of the inaugural 56 participants.

Reuter MS, Walker S, Thiruvahindrapuram B, Whitney J, Cohn I, Sondheimer N, Yuen RKC, Trost B, Paton TA, Pereira SL, Herbrick JA, Wintle RF, Merico D, Howe J, MacDonald JR, Lu C, Nalpathamkalam T, Sung WWL, Wang Z, Patel RV, Pellecchia G, Wei J, Strug LJ, Bell S, Kellam B, Mahtani MM, Bassett AS, Bombard Y, Weksberg R, Shuman C, Cohn RD, Stavropoulos DJ, Bowdin S, Hildebrandt MR, Wei W, Romm A, Pasceri P, Ellis J, Ray P, Meyn MS, Monfared N, Hosseini SM, Joseph-George AM, Keeley FW, Cook RA, Fiume M, Lee HC, Marshall CR, Davies J, Hazell A, Buchanan JA, Szego MJ, Scherer SW.

CMAJ. 2018 Feb 5;190(5):E126-E136. doi: 10.1503/cmaj.171151.

35.

Transcriptome analysis of response to Plasmodiophora brassicae infection in the Arabidopsis shoot and root.

Irani S, Trost B, Waldner M, Nayidu N, Tu J, Kusalik AJ, Todd CD, Wei Y, Bonham-Smith PC.

BMC Genomics. 2018 Jan 5;19(1):23. doi: 10.1186/s12864-017-4426-7.

36.

A Comprehensive Workflow for Read Depth-Based Identification of Copy-Number Variation from Whole-Genome Sequence Data.

Trost B, Walker S, Wang Z, Thiruvahindrapuram B, MacDonald JR, Sung WWL, Pereira SL, Whitney J, Chan AJS, Pellecchia G, Reuter MS, Lok S, Yuen RKC, Marshall CR, Merico D, Scherer SW.

Am J Hum Genet. 2018 Jan 4;102(1):142-155. doi: 10.1016/j.ajhg.2017.12.007.

37.

Zn-ProPhenol Catalyzed Enantio- and Diastereoselective Direct Vinylogous Mannich Reactions between α,β- and β,γ-Butenolides and Aldimines.

Trost BM, Gnanamani E, Tracy JS, Kalnmals CA.

J Am Chem Soc. 2017 Dec 20;139(50):18198-18201. doi: 10.1021/jacs.7b11361. Epub 2017 Dec 8.

PMID:
29198100
38.

Pd-catalyzed asymmetric allylic alkylations via C-H activation of N-allyl imines with glycinates.

Trost BM, Li X.

Chem Sci. 2017 Oct 1;8(10):6815-6821. doi: 10.1039/c7sc02899g. Epub 2017 Aug 15.

39.

Controlling Regioselectivity in the Enantioselective N-Alkylation of Indole Analogues Catalyzed by Dinuclear Zinc-ProPhenol.

Trost BM, Gnanamani E, Hung CJ.

Angew Chem Int Ed Engl. 2017 Aug 21;56(35):10451-10456. doi: 10.1002/anie.201705315. Epub 2017 Jul 19.

40.

Carbon-Nitrogen Bond Formation via the Vanadium Oxo Catalyzed Sigmatropic Functionalization of Allenols.

Trost BM, Tracy JS.

Org Lett. 2017 May 19;19(10):2630-2633. doi: 10.1021/acs.orglett.7b00961. Epub 2017 May 3.

41.

Ru-catalyzed sequence for the synthesis of cyclic amido-ethers.

Trost BM, Sharif EU, Cregg JJ.

Chem Sci. 2017 Jan 1;8(1):770-774. doi: 10.1039/c6sc02849g. Epub 2016 Sep 12.

42.

Stereoselective Synthesis of Exocyclic Tetrasubstituted Vinyl Halides via Ru-Catalyzed Halotropic Cycloisomerization of 1,6-Haloenynes.

Trost BM, Kalnmals CA.

Org Lett. 2017 May 5;19(9):2346-2349. doi: 10.1021/acs.orglett.7b00879. Epub 2017 Apr 24.

43.

Isomerization of N-Allyl Amides To Form Geometrically Defined Di-, Tri-, and Tetrasubstituted Enamides.

Trost BM, Cregg JJ, Quach N.

J Am Chem Soc. 2017 Apr 12;139(14):5133-5139. doi: 10.1021/jacs.7b00564. Epub 2017 Apr 4.

44.

Technological advances for interrogating the human kinome.

Baharani A, Trost B, Kusalik A, Napper S.

Biochem Soc Trans. 2017 Feb 8;45(1):65-77. doi: 10.1042/BST20160163. Review.

PMID:
28202660
45.

Development of the Regiodivergent Asymmetric Prenylation of 3-Substituted Oxindoles.

Trost BM, Chan WH, Malhotra S.

Chemistry. 2017 Mar 28;23(18):4405-4414. doi: 10.1002/chem.201605810. Epub 2017 Mar 6.

46.

Efficient Access to Chiral Trisubstituted Aziridines via Catalytic Enantioselective Aza-Darzens Reactions.

Trost BM, Saget T, Hung CJ.

Angew Chem Int Ed Engl. 2017 Feb 20;56(9):2440-2444. doi: 10.1002/anie.201607845. Epub 2017 Jan 23.

47.

De Novo Genome and Transcriptome Assembly of the Canadian Beaver (Castor canadensis).

Lok S, Paton TA, Wang Z, Kaur G, Walker S, Yuen RK, Sung WW, Whitney J, Buchanan JA, Trost B, Singh N, Apresto B, Chen N, Coole M, Dawson TJ, Ho K, Hu Z, Pullenayegum S, Samler K, Shipstone A, Tsoi F, Wang T, Pereira SL, Rostami P, Ryan CA, Tong AH, Ng K, Sundaravadanam Y, Simpson JT, Lim BK, Engstrom MD, Dutton CJ, Kerr KC, Franke M, Rapley W, Wintle RF, Scherer SW.

G3 (Bethesda). 2017 Feb 9;7(2):755-773. doi: 10.1534/g3.116.038208.

48.

Re-Orienting Coupling of Organocuprates with Propargyl Electrophiles from SN2' to SN2 with Stereocontrol.

Trost BM, Debien L.

Chem Sci. 2016;7(8):4985-4989. doi: 10.1039/C6SC01086E. Epub 2016 May 10.

49.

Synthetic Strategies Employed for the Construction of Fostriecin and Related Natural Products.

Trost BM, Knopf JD, Brindle CS.

Chem Rev. 2016 Dec 28;116(24):15035-15088. doi: 10.1021/acs.chemrev.6b00488. Epub 2016 Dec 8. Review.

50.

Indenylmetal Catalysis in Organic Synthesis.

Trost BM, Ryan MC.

Angew Chem Int Ed Engl. 2017 Mar 6;56(11):2862-2879. doi: 10.1002/anie.201609054. Epub 2017 Jan 27. Review.

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