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Items: 1 to 50 of 453

1.

Enantioselective Divergent Synthesis of C19-Oxo Eburnane Alkaloids via Palladium-Catalyzed Asymmetric Allylic Alkylation of an N-Alkyl-α,β-unsaturated Lactam.

Trost BM, Bai Y, Bai WJ, Schultz JE.

J Am Chem Soc. 2019 Mar 15. doi: 10.1021/jacs.9b00788. [Epub ahead of print]

PMID:
30848892
2.

Palladium-Catalyzed Decarboxylative Asymmetric Allylic Alkylation of Dihydroquinolinones.

Trost BM, Nagaraju A, Wang F, Zuo Z, Xu J, Hull KL.

Org Lett. 2019 Mar 15;21(6):1784-1788. doi: 10.1021/acs.orglett.9b00358. Epub 2019 Mar 5.

PMID:
30834753
3.

Synthesis of Chiral, Densely Substituted Pyrrolidones via Phosphine-Catalyzed Cycloisomerization.

Trost BM, Gnanamani E, Hung CJ, Kalnmals CA.

Org Lett. 2019 Mar 15;21(6):1890-1894. doi: 10.1021/acs.orglett.9b00496. Epub 2019 Mar 4.

PMID:
30829494
4.

Vanadium-Catalyzed Coupling of Allenols with Electrophilic Halide Sources for the Formation of α-Halo-α',β'-unsaturated Ketones.

Trost BM, Tracy JS, Yusoontorn T.

Org Lett. 2019 Feb 15;21(4):1207-1211. doi: 10.1021/acs.orglett.9b00195. Epub 2019 Jan 28.

PMID:
30689391
5.

Direct Enantio- and Diastereoselective Vinylogous Addition of Butenolides to Chromones Catalyzed by Zn-ProPhenol.

Trost BM, Gnanamani E, Kalnmals CA, Hung CJ, Tracy JS.

J Am Chem Soc. 2019 Jan 30;141(4):1489-1493. doi: 10.1021/jacs.8b13367. Epub 2019 Jan 18.

PMID:
30642168
6.

Highly Chemoselective Deprotection of the 2,2,2-Trichloroethoxycarbonyl (Troc) Protecting Group.

Trost BM, Kalnmals CA, Tracy JS, Bai WJ.

Org Lett. 2018 Dec 4. doi: 10.1021/acs.orglett.8b03642. [Epub ahead of print]

PMID:
30511873
7.

Enantioselective Synthesis of des-epoxy-Amphidinolide N.

Trost BM, Bai WJ, Stivala CE, Hohn C, Poock C, Heinrich M, Xu S, Rey J.

J Am Chem Soc. 2018 Nov 20. doi: 10.1021/jacs.8b11827. [Epub ahead of print]

PMID:
30457857
8.

Catalytic palladium-oxyallyl cycloaddition.

Trost BM, Huang Z, Murhade GM.

Science. 2018 Nov 2;362(6414):564-568. doi: 10.1126/science.aau4821.

PMID:
30385573
9.

Propene as an Atom-Economical Linchpin for Concise Total Synthesis of Polyenes: Piericidin A.

Trost BM, Gholami H.

J Am Chem Soc. 2018 Sep 19;140(37):11623-11626. doi: 10.1021/jacs.8b08974. Epub 2018 Sep 5.

PMID:
30173519
10.

Conservation of kinase-phosphorylation site pairings: Evidence for an evolutionarily dynamic phosphoproteome.

McDonald M, Trost B, Napper S.

PLoS One. 2018 Aug 14;13(8):e0202036. doi: 10.1371/journal.pone.0202036. eCollection 2018.

11.

Enantio- and Diastereoselective Synthesis of Chiral Allenes by Palladium-Catalyzed Asymmetric [3+2] Cycloaddition Reactions.

Trost BM, Zell D, Hohn C, Mata G, Maruniak A.

Angew Chem Int Ed Engl. 2018 Sep 24;57(39):12916-12920. doi: 10.1002/anie.201808345. Epub 2018 Sep 5.

PMID:
30073727
12.

Enantioselective Palladium-Catalyzed [3+2] Cycloaddition of Trimethylenemethane and Fluorinated Ketones.

Trost BM, Mata G.

Angew Chem Int Ed Engl. 2018 Sep 17;57(38):12333-12337. doi: 10.1002/anie.201807308. Epub 2018 Aug 23.

PMID:
30071149
13.

Direct Catalytic Asymmetric Vinylogous Additions of α,β- and β,γ-Butenolides to Polyfluorinated Alkynyl Ketimines.

Trost BM, Hung CJ, Scharf MJ.

Angew Chem Int Ed Engl. 2018 Aug 27;57(35):11408-11412. doi: 10.1002/anie.201806249. Epub 2018 Jul 26.

PMID:
29969528
14.

Synthesis of the Aminocyclitol Core of Jogyamycin via an Enantioselective Pd-Catalyzed Trimethylenemethane (TMM) Cycloaddition.

Trost BM, Zhang L, Lam TM.

Org Lett. 2018 Jul 6;20(13):3938-3942. doi: 10.1021/acs.orglett.8b01518. Epub 2018 Jun 25.

PMID:
29939033
15.

A Deprotonation Approach to the Unprecedented Amino-Trimethylenemethane Chemistry: Regio-, Diastereo-, and Enantioselective Synthesis of Complex Amino Cycles.

Trost BM, Wang Y.

Angew Chem Int Ed Engl. 2018 Aug 20;57(34):11025-11029. doi: 10.1002/anie.201805876. Epub 2018 Jul 18.

PMID:
29924916
16.

Palladium-Catalyzed Asymmetric Allylic Alkylation of 3-Substituted 1 H-Indoles and Tryptophan Derivatives with Vinylcyclopropanes.

Trost BM, Bai WJ, Hohn C, Bai Y, Cregg JJ.

J Am Chem Soc. 2018 May 30;140(21):6710-6717. doi: 10.1021/jacs.8b03656. Epub 2018 May 18.

PMID:
29750514
17.

Direct catalytic enantioselective amination of ketones for the formation of tri- and tetrasubstituted stereocenters.

Trost BM, Tracy JS, Saget T.

Chem Sci. 2018 Feb 14;9(11):2975-2980. doi: 10.1039/c8sc00147b. eCollection 2018 Mar 21.

18.

Sulfones as Synthetic Linchpins: Transition-Metal-Free sp3 -sp2 and sp2 -sp2 Cross-Couplings Between Geminal Bis(sulfones) and Organolithium Compounds.

Trost BM, Kalnmals CA.

Chemistry. 2018 Jun 26;24(36):9066-9074. doi: 10.1002/chem.201800118. Epub 2018 Jun 7.

PMID:
29543985
19.

The Personal Genome Project Canada: findings from whole genome sequences of the inaugural 56 participants.

Reuter MS, Walker S, Thiruvahindrapuram B, Whitney J, Cohn I, Sondheimer N, Yuen RKC, Trost B, Paton TA, Pereira SL, Herbrick JA, Wintle RF, Merico D, Howe J, MacDonald JR, Lu C, Nalpathamkalam T, Sung WWL, Wang Z, Patel RV, Pellecchia G, Wei J, Strug LJ, Bell S, Kellam B, Mahtani MM, Bassett AS, Bombard Y, Weksberg R, Shuman C, Cohn RD, Stavropoulos DJ, Bowdin S, Hildebrandt MR, Wei W, Romm A, Pasceri P, Ellis J, Ray P, Meyn MS, Monfared N, Hosseini SM, Joseph-George AM, Keeley FW, Cook RA, Fiume M, Lee HC, Marshall CR, Davies J, Hazell A, Buchanan JA, Szego MJ, Scherer SW.

CMAJ. 2018 Feb 5;190(5):E126-E136. doi: 10.1503/cmaj.171151.

20.

Transcriptome analysis of response to Plasmodiophora brassicae infection in the Arabidopsis shoot and root.

Irani S, Trost B, Waldner M, Nayidu N, Tu J, Kusalik AJ, Todd CD, Wei Y, Bonham-Smith PC.

BMC Genomics. 2018 Jan 5;19(1):23. doi: 10.1186/s12864-017-4426-7.

21.

A Comprehensive Workflow for Read Depth-Based Identification of Copy-Number Variation from Whole-Genome Sequence Data.

Trost B, Walker S, Wang Z, Thiruvahindrapuram B, MacDonald JR, Sung WWL, Pereira SL, Whitney J, Chan AJS, Pellecchia G, Reuter MS, Lok S, Yuen RKC, Marshall CR, Merico D, Scherer SW.

Am J Hum Genet. 2018 Jan 4;102(1):142-155. doi: 10.1016/j.ajhg.2017.12.007.

22.

Zn-ProPhenol Catalyzed Enantio- and Diastereoselective Direct Vinylogous Mannich Reactions between α,β- and β,γ-Butenolides and Aldimines.

Trost BM, Gnanamani E, Tracy JS, Kalnmals CA.

J Am Chem Soc. 2017 Dec 20;139(50):18198-18201. doi: 10.1021/jacs.7b11361. Epub 2017 Dec 8.

PMID:
29198100
23.

Pd-catalyzed asymmetric allylic alkylations via C-H activation of N-allyl imines with glycinates.

Trost BM, Li X.

Chem Sci. 2017 Oct 1;8(10):6815-6821. doi: 10.1039/c7sc02899g. Epub 2017 Aug 15.

24.

Controlling Regioselectivity in the Enantioselective N-Alkylation of Indole Analogues Catalyzed by Dinuclear Zinc-ProPhenol.

Trost BM, Gnanamani E, Hung CJ.

Angew Chem Int Ed Engl. 2017 Aug 21;56(35):10451-10456. doi: 10.1002/anie.201705315. Epub 2017 Jul 19.

25.

Carbon-Nitrogen Bond Formation via the Vanadium Oxo Catalyzed Sigmatropic Functionalization of Allenols.

Trost BM, Tracy JS.

Org Lett. 2017 May 19;19(10):2630-2633. doi: 10.1021/acs.orglett.7b00961. Epub 2017 May 3.

26.

Ru-catalyzed sequence for the synthesis of cyclic amido-ethers.

Trost BM, Sharif EU, Cregg JJ.

Chem Sci. 2017 Jan 1;8(1):770-774. doi: 10.1039/c6sc02849g. Epub 2016 Sep 12.

27.

Stereoselective Synthesis of Exocyclic Tetrasubstituted Vinyl Halides via Ru-Catalyzed Halotropic Cycloisomerization of 1,6-Haloenynes.

Trost BM, Kalnmals CA.

Org Lett. 2017 May 5;19(9):2346-2349. doi: 10.1021/acs.orglett.7b00879. Epub 2017 Apr 24.

28.

Isomerization of N-Allyl Amides To Form Geometrically Defined Di-, Tri-, and Tetrasubstituted Enamides.

Trost BM, Cregg JJ, Quach N.

J Am Chem Soc. 2017 Apr 12;139(14):5133-5139. doi: 10.1021/jacs.7b00564. Epub 2017 Apr 4.

29.

Technological advances for interrogating the human kinome.

Baharani A, Trost B, Kusalik A, Napper S.

Biochem Soc Trans. 2017 Feb 8;45(1):65-77. doi: 10.1042/BST20160163. Review.

PMID:
28202660
30.

Development of the Regiodivergent Asymmetric Prenylation of 3-Substituted Oxindoles.

Trost BM, Chan WH, Malhotra S.

Chemistry. 2017 Mar 28;23(18):4405-4414. doi: 10.1002/chem.201605810. Epub 2017 Mar 6.

31.

Efficient Access to Chiral Trisubstituted Aziridines via Catalytic Enantioselective Aza-Darzens Reactions.

Trost BM, Saget T, Hung CJ.

Angew Chem Int Ed Engl. 2017 Feb 20;56(9):2440-2444. doi: 10.1002/anie.201607845. Epub 2017 Jan 23.

32.

De Novo Genome and Transcriptome Assembly of the Canadian Beaver (Castor canadensis).

Lok S, Paton TA, Wang Z, Kaur G, Walker S, Yuen RK, Sung WW, Whitney J, Buchanan JA, Trost B, Singh N, Apresto B, Chen N, Coole M, Dawson TJ, Ho K, Hu Z, Pullenayegum S, Samler K, Shipstone A, Tsoi F, Wang T, Pereira SL, Rostami P, Ryan CA, Tong AH, Ng K, Sundaravadanam Y, Simpson JT, Lim BK, Engstrom MD, Dutton CJ, Kerr KC, Franke M, Rapley W, Wintle RF, Scherer SW.

G3 (Bethesda). 2017 Feb 9;7(2):755-773. doi: 10.1534/g3.116.038208.

33.

Re-Orienting Coupling of Organocuprates with Propargyl Electrophiles from SN2' to SN2 with Stereocontrol.

Trost BM, Debien L.

Chem Sci. 2016;7(8):4985-4989. doi: 10.1039/C6SC01086E. Epub 2016 May 10.

34.

Synthetic Strategies Employed for the Construction of Fostriecin and Related Natural Products.

Trost BM, Knopf JD, Brindle CS.

Chem Rev. 2016 Dec 28;116(24):15035-15088. doi: 10.1021/acs.chemrev.6b00488. Epub 2016 Dec 8. Review.

35.

Indenylmetal Catalysis in Organic Synthesis.

Trost BM, Ryan MC.

Angew Chem Int Ed Engl. 2017 Mar 6;56(11):2862-2879. doi: 10.1002/anie.201609054. Epub 2017 Jan 27. Review.

36.

Asymmetric synthesis of chiral β-alkynyl carbonyl and sulfonyl derivatives via sequential palladium and copper catalysis.

Trost BM, Masters JT, Taft BR, Lumb JP.

Chem Sci. 2016 Sep 16;7(9):6217-6231. Epub 2016 Jun 10.

37.

Synthesis of a 1,3-Bridged Macrobicyclic Enyne via Chemoselective Cycloisomerization Using Palladium-Catalyzed Alkyne-Alkyne Coupling.

Trost BM, Masters JT, Le Vaillant F, Lumb JP.

J Org Chem. 2016 Oct 21;81(20):10023-10028. Epub 2016 Oct 13.

38.

Chiral cyclopentadienylruthenium sulfoxide catalysts for asymmetric redox bicycloisomerization.

Trost BM, Ryan MC, Rao M.

Beilstein J Org Chem. 2016 Jun 7;12:1136-52. doi: 10.3762/bjoc.12.110. eCollection 2016.

39.

Total Synthesis of (-)-Lasonolide A.

Trost BM, Stivala CE, Fandrick DR, Hull KL, Huang A, Poock C, Kalkofen R.

J Am Chem Soc. 2016 Sep 14;138(36):11690-701. doi: 10.1021/jacs.6b05127. Epub 2016 Sep 1.

40.

DAPPLE 2: a Tool for the Homology-Based Prediction of Post-Translational Modification Sites.

Trost B, Maleki F, Kusalik A, Napper S.

J Proteome Res. 2016 Aug 5;15(8):2760-7. doi: 10.1021/acs.jproteome.6b00304. Epub 2016 Jul 13.

PMID:
27367363
41.

Development of a Coordinatively Unsaturated Chiral Indenylruthenium Catalyst.

Trost BM, Ryan MC, Maurer D.

Org Lett. 2016 Jul 1;18(13):3166-9. doi: 10.1021/acs.orglett.6b01375. Epub 2016 Jun 22.

PMID:
27333303
42.

Transition metal-catalyzed couplings of alkynes to 1,3-enynes: modern methods and synthetic applications.

Trost BM, Masters JT.

Chem Soc Rev. 2016 Apr 21;45(8):2212-38. doi: 10.1039/c5cs00892a. Epub 2016 Feb 1. Review.

43.

Computational Analysis of the Predicted Evolutionary Conservation of Human Phosphorylation Sites.

Trost B, Kusalik A, Napper S.

PLoS One. 2016 Apr 5;11(4):e0152809. doi: 10.1371/journal.pone.0152809. eCollection 2016.

44.

Direct Catalytic Asymmetric Mannich Reactions for the Construction of Quaternary Carbon Stereocenters.

Trost BM, Saget T, Hung CI.

J Am Chem Soc. 2016 Mar 23;138(11):3659-62. doi: 10.1021/jacs.6b01187. Epub 2016 Mar 9.

45.

Investigation of the cause of geographic disparities in IDEXX ELISA sensitivity in serum samples from Mycobacterium bovis-infected cattle.

Trost B, Stuber T, Surujballi O, Nelson J, Robbe-Austerman S, Smith NH, Desautels L, Tikoo SK, Griebel P.

Sci Rep. 2016 Mar 7;6:22763. doi: 10.1038/srep22763.

46.

A Ruthenium/Phosphoramidite-Catalyzed Asymmetric Interrupted Metallo-ene Reaction.

Trost BM, Ryan MC.

J Am Chem Soc. 2016 Mar 9;138(9):2981-4. doi: 10.1021/jacs.6b00983. Epub 2016 Mar 1.

PMID:
26899551
47.

Ruthenium-Catalyzed Multicomponent Reactions: Access to α-Silyl-β-Hydroxy Vinylsilanes, Stereodefined 1,3-Dienes, and Cyclohexenes.

Trost BM, Koester DC, Sharif EU.

Chemistry. 2016 Feb 18;22(8):2634-8. doi: 10.1002/chem.201504981. Epub 2016 Jan 25.

48.

Rapamycin reduces fibroblast proliferation without causing quiescence and induces STAT5A/B-mediated cytokine production.

Gillespie ZE, MacKay K, Sander M, Trost B, Dawicki W, Wickramarathna A, Gordon J, Eramian M, Kill IR, Bridger JM, Kusalik A, Mitchell JA, Eskiw CH.

Nucleus. 2015;6(6):490-506. doi: 10.1080/19491034.2015.1128610.

49.

Broad Spectrum Enolate Equivalent for Catalytic Chemo-, Diastereo-, and Enantioselective Addition to N-Boc Imines.

Trost BM, Hung CI.

J Am Chem Soc. 2015 Dec 23;137(50):15940-6. doi: 10.1021/jacs.5b11248. Epub 2015 Dec 14.

50.

Catalytic Asymmetric Mannich Reactions with Fluorinated Aromatic Ketones: Efficient Access to Chiral β-Fluoroamines.

Trost BM, Saget T, Lerchen A, Hung CI.

Angew Chem Int Ed Engl. 2016 Jan 11;55(2):781-4. doi: 10.1002/anie.201509719. Epub 2015 Nov 26.

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