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A Dissection of Oligomerization by the TRIM28 Tripartite Motif and the Interaction with Members of the Krab-ZFP Family.

Sun Y, Keown JR, Black MM, Raclot C, Demarais N, Trono D, Turelli P, Goldstone DC.

J Mol Biol. 2019 Jun 28;431(14):2511-2527. doi: 10.1016/j.jmb.2019.05.002. Epub 2019 May 9.


Hominoid-Specific Transposable Elements and KZFPs Facilitate Human Embryonic Genome Activation and Control Transcription in Naive Human ESCs.

Pontis J, Planet E, Offner S, Turelli P, Duc J, Coudray A, Theunissen TW, Jaenisch R, Trono D.

Cell Stem Cell. 2019 May 2;24(5):724-735.e5. doi: 10.1016/j.stem.2019.03.012. Epub 2019 Apr 18.


ZFP30 promotes adipogenesis through the KAP1-mediated activation of a retrotransposon-derived Pparg2 enhancer.

Chen W, Schwalie PC, Pankevich EV, Gubelmann C, Raghav SK, Dainese R, Cassano M, Imbeault M, Jang SM, Russeil J, Delessa T, Duc J, Trono D, Wolfrum C, Deplancke B.

Nat Commun. 2019 Apr 18;10(1):1809. doi: 10.1038/s41467-019-09803-9.


DPPA2 and DPPA4 are necessary to establish a 2C-like state in mouse embryonic stem cells.

De Iaco A, Coudray A, Duc J, Trono D.

EMBO Rep. 2019 May;20(5). pii: e47382. doi: 10.15252/embr.201847382. Epub 2019 Apr 4.


ZNF445 is a primary regulator of genomic imprinting.

Takahashi N, Coluccio A, Thorball CW, Planet E, Shi H, Offner S, Turelli P, Imbeault M, Ferguson-Smith AC, Trono D.

Genes Dev. 2019 Jan 1;33(1-2):49-54. doi: 10.1101/gad.320069.118.


Properties of LINE-1 proteins and repeat element expression in the context of amyotrophic lateral sclerosis.

Pereira GC, Sanchez L, Schaughency PM, Rubio-Roldán A, Choi JA, Planet E, Batra R, Turelli P, Trono D, Ostrow LW, Ravits J, Kazazian HH, Wheelan SJ, Heras SR, Mayer J, García-Pérez JL, Goodier JL.

Mob DNA. 2018 Dec 15;9:35. doi: 10.1186/s13100-018-0138-z. eCollection 2018.


Pharmacological Induction of a Progenitor State for the Efficient Expansion of Primary Human Hepatocytes.

Unzu C, Planet E, Brandenberg N, Fusil F, Cassano M, Perez-Vargas J, Friedli M, Cosset FL, Lutolf MP, Wildhaber BE, Trono D.

Hepatology. 2019 May;69(5):2214-2231. doi: 10.1002/hep.30425. Epub 2019 Feb 14.


Analysis of metabolic and mineral changes in response to salt stress in durum wheat (Triticum turgidum ssp. durum) genotypes, which differ in salinity tolerance.

Borrelli GM, Fragasso M, Nigro F, Platani C, Papa R, Beleggia R, Trono D.

Plant Physiol Biochem. 2018 Dec;133:57-70. doi: 10.1016/j.plaphy.2018.10.025. Epub 2018 Oct 26.


HIV-1 Vpr and p21 restrict LINE-1 mobility.

Kawano K, Doucet AJ, Ueno M, Kariya R, An W, Marzetta F, Kuroki M, Turelli P, Sukegawa S, Okada S, Strebel K, Trono D, Ariumi Y.

Nucleic Acids Res. 2018 Sep 19;46(16):8454-8470. doi: 10.1093/nar/gky688.


KAP1 facilitates reinstatement of heterochromatin after DNA replication.

Jang SM, Kauzlaric A, Quivy JP, Pontis J, Rauwel B, Coluccio A, Offner S, Duc J, Turelli P, Almouzni G, Trono D.

Nucleic Acids Res. 2018 Sep 28;46(17):8788-8802. doi: 10.1093/nar/gky580.


KRAB zinc finger proteins.

Ecco G, Imbeault M, Trono D.

Development. 2017 Aug 1;144(15):2719-2729. doi: 10.1242/dev.132605. Review.


Switzerland and the Digital Health Revolution.

Trono D.

Chimia (Aarau). 2016 Dec 21;70(12):851-852. doi: 10.2533/chimia.2016.851.


A KRABsody for Embryo-Placental Development.

Trono D.

Dev Cell. 2017 Jun 19;41(6):578-580. doi: 10.1016/j.devcel.2017.06.005. Review.


Analysis of DNA polymerase ν function in meiotic recombination, immunoglobulin class-switching, and DNA damage tolerance.

Takata KI, Reh S, Yousefzadeh MJ, Zelazowski MJ, Bhetawal S, Trono D, Lowery MG, Sandoval M, Takata Y, Lu Y, Lin K, Shen J, Kusewitt DF, McBride KM, Cole F, Wood RD.

PLoS Genet. 2017 Jun 1;13(6):e1006818. doi: 10.1371/journal.pgen.1006818. eCollection 2017 Jun.


DUX-family transcription factors regulate zygotic genome activation in placental mammals.

De Iaco A, Planet E, Coluccio A, Verp S, Duc J, Trono D.

Nat Genet. 2017 Jun;49(6):941-945. doi: 10.1038/ng.3858. Epub 2017 May 1.


Polyphenic trait promotes liver cancer in a model of epigenetic instability in mice.

Cassano M, Offner S, Planet E, Piersigilli A, Jang SM, Henry H, Geuking MB, Mooser C, McCoy KD, Macpherson AJ, Trono D.

Hepatology. 2017 Jul;66(1):235-251. doi: 10.1002/hep.29182. Epub 2017 May 18.


The mouse genome displays highly dynamic populations of KRAB-zinc finger protein genes and related genetic units.

Kauzlaric A, Ecco G, Cassano M, Duc J, Imbeault M, Trono D.

PLoS One. 2017 Mar 23;12(3):e0173746. doi: 10.1371/journal.pone.0173746. eCollection 2017.


KRAB zinc-finger proteins contribute to the evolution of gene regulatory networks.

Imbeault M, Helleboid PY, Trono D.

Nature. 2017 Mar 23;543(7646):550-554. doi: 10.1038/nature21683. Epub 2017 Mar 8.


SMiLE-seq identifies binding motifs of single and dimeric transcription factors.

Isakova A, Groux R, Imbeault M, Rainer P, Alpern D, Dainese R, Ambrosini G, Trono D, Bucher P, Deplancke B.

Nat Methods. 2017 Mar;14(3):316-322. doi: 10.1038/nmeth.4143. Epub 2017 Jan 16.


Lentiviral vectors, two decades later.

Naldini L, Trono D, Verma IM.

Science. 2016 Sep 9;353(6304):1101-2. doi: 10.1126/science.aah6192. No abstract available.


Molecular Criteria for Defining the Naive Human Pluripotent State.

Theunissen TW, Friedli M, He Y, Planet E, O'Neil RC, Markoulaki S, Pontis J, Wang H, Iouranova A, Imbeault M, Duc J, Cohen MA, Wert KJ, Castanon R, Zhang Z, Huang Y, Nery JR, Drotar J, Lungjangwa T, Trono D, Ecker JR, Jaenisch R.

Cell Stem Cell. 2016 Oct 6;19(4):502-515. doi: 10.1016/j.stem.2016.06.011. Epub 2016 Jul 14.


Transposable Elements and Their KRAB-ZFP Controllers Regulate Gene Expression in Adult Tissues.

Ecco G, Cassano M, Kauzlaric A, Duc J, Coluccio A, Offner S, Imbeault M, Rowe HM, Turelli P, Trono D.

Dev Cell. 2016 Mar 21;36(6):611-23. doi: 10.1016/j.devcel.2016.02.024.


A Large-Scale Functional Screen to Identify Epigenetic Repressors of Retrotransposon Expression.

Ecco G, Rowe HM, Trono D.

Methods Mol Biol. 2016;1400:403-17. doi: 10.1007/978-1-4939-3372-3_25.


Transposable Elements, Polydactyl Proteins, and the Genesis of Human-Specific Transcription Networks.

Trono D.

Cold Spring Harb Symp Quant Biol. 2015;80:281-8. doi: 10.1101/sqb.2015.80.027573. Epub 2016 Jan 13. Review.


Cloning, expression analysis, and functional characterization of two secretory phospholipases A2 in durum wheat (Triticum durum Desf.).

Mazzucotelli E, Trono D.

Plant Sci. 2015 Dec;241:295-306. doi: 10.1016/j.plantsci.2015.10.009. Epub 2015 Oct 23.


Modulation of Potassium Channel Activity in the Balance of ROS and ATP Production by Durum Wheat Mitochondria-An Amazing Defense Tool Against Hyperosmotic Stress.

Trono D, Laus MN, Soccio M, Alfarano M, Pastore D.

Front Plant Sci. 2015 Dec 1;6:1072. doi: 10.3389/fpls.2015.01072. eCollection 2015. Review.


The evolution of gene expression and binding specificity of the largest transcription factor family in primates.

Kapopoulou A, Mathew L, Wong A, Trono D, Jensen JD.

Evolution. 2016 Jan;70(1):167-80. doi: 10.1111/evo.12819. Epub 2015 Dec 9.


Drawing a fine line on endogenous retroelement activity.

Castro-Diaz N, Friedli M, Trono D.

Mob Genet Elements. 2015 Feb 3;5(1):1-6. eCollection 2015 Jan-Feb.


The developmental control of transposable elements and the evolution of higher species.

Friedli M, Trono D.

Annu Rev Cell Dev Biol. 2015;31:429-51. doi: 10.1146/annurev-cellbio-100814-125514. Epub 2015 Sep 17. Review.


Recombinant Lipases and Phospholipases and Their Use as Biocatalysts for Industrial Applications.

Borrelli GM, Trono D.

Int J Mol Sci. 2015 Sep 1;16(9):20774-840. doi: 10.3390/ijms160920774. Review.


Venus trap in the mouse embryo reveals distinct molecular dynamics underlying specification of first embryonic lineages.

Dietrich JE, Panavaite L, Gunther S, Wennekamp S, Groner AC, Pigge A, Salvenmoser S, Trono D, Hufnagel L, Hiiragi T.

EMBO Rep. 2015 Aug;16(8):1005-21. doi: 10.15252/embr.201540162. Epub 2015 Jul 3.


Release of human cytomegalovirus from latency by a KAP1/TRIM28 phosphorylation switch.

Rauwel B, Jang SM, Cassano M, Kapopoulou A, Barde I, Trono D.

Elife. 2015 Apr 7;4. doi: 10.7554/eLife.06068.


A KAP1 phosphorylation switch controls MyoD function during skeletal muscle differentiation.

Singh K, Cassano M, Planet E, Sebastian S, Jang SM, Sohi G, Faralli H, Choi J, Youn HD, Dilworth FJ, Trono D.

Genes Dev. 2015 Mar 1;29(5):513-25. doi: 10.1101/gad.254532.114.


TRIM28 represses transcription of endogenous retroviruses in neural progenitor cells.

Fasching L, Kapopoulou A, Sachdeva R, Petri R, Jönsson ME, Männe C, Turelli P, Jern P, Cammas F, Trono D, Jakobsson J.

Cell Rep. 2015 Jan 6;10(1):20-8. doi: 10.1016/j.celrep.2014.12.004. Epub 2014 Dec 24.


As time goes by: KRABs evolve to KAP endogenous retroelements.

Imbeault M, Trono D.

Dev Cell. 2014 Nov 10;31(3):257-258. doi: 10.1016/j.devcel.2014.10.019. Epub 2014 Nov 10.


Identification of the transcription factor ZEB1 as a central component of the adipogenic gene regulatory network.

Gubelmann C, Schwalie PC, Raghav SK, Röder E, Delessa T, Kiehlmann E, Waszak SM, Corsinotti A, Udin G, Holcombe W, Rudofsky G, Trono D, Wolfrum C, Deplancke B.

Elife. 2014 Aug 27;3:e03346. doi: 10.7554/eLife.03346.


Evolutionally dynamic L1 regulation in embryonic stem cells.

Castro-Diaz N, Ecco G, Coluccio A, Kapopoulou A, Yazdanpanah B, Friedli M, Duc J, Jang SM, Turelli P, Trono D.

Genes Dev. 2014 Jul 1;28(13):1397-409. doi: 10.1101/gad.241661.114. Epub 2014 Jun 17.


Expression, purification and refolding of active durum wheat (Triticum durum Desf.) secretory phospholipase A2 from inclusion bodies of Escherichia coli.

Verlotta A, Trono D.

Protein Expr Purif. 2014 Sep;101:28-36. doi: 10.1016/j.pep.2014.05.009. Epub 2014 Jun 9.


Interplay of TRIM28 and DNA methylation in controlling human endogenous retroelements.

Turelli P, Castro-Diaz N, Marzetta F, Kapopoulou A, Raclot C, Duc J, Tieng V, Quenneville S, Trono D.

Genome Res. 2014 Aug;24(8):1260-70. doi: 10.1101/gr.172833.114. Epub 2014 May 30.


Loss of transcriptional control over endogenous retroelements during reprogramming to pluripotency.

Friedli M, Turelli P, Kapopoulou A, Rauwel B, Castro-Díaz N, Rowe HM, Ecco G, Unzu C, Planet E, Lombardo A, Mangeat B, Wildhaber BE, Naldini L, Trono D.

Genome Res. 2014 Aug;24(8):1251-9. doi: 10.1101/gr.172809.114. Epub 2014 May 30.


Dual-regulated lentiviral vector for gene therapy of X-linked chronic granulomatosis.

Chiriaco M, Farinelli G, Capo V, Zonari E, Scaramuzza S, Di Matteo G, Sergi LS, Migliavacca M, Hernandez RJ, Bombelli F, Giorda E, Kajaste-Rudnitski A, Trono D, Grez M, Rossi P, Finocchi A, Naldini L, Gentner B, Aiuti A.

Mol Ther. 2014 Aug;22(8):1472-1483. doi: 10.1038/mt.2014.87. Epub 2014 May 29.


Transport pathways--proton motive force interrelationship in durum wheat mitochondria.

Trono D, Laus MN, Soccio M, Pastore D.

Int J Mol Sci. 2014 May 9;15(5):8186-215. doi: 10.3390/ijms15058186. Review.


[A KRAB/KAP1-miRNA cascade regulates erythropoiesis through stage-specific control of mitophagy].

Barde I, Rauwel B, Marin-Florez RM, Corsinotti A, Laurenti E, Verp S, Offner S, Marquis J, Kapopoulou A, Vanicek J, Trono D.

Med Sci (Paris). 2014 Jan;30(1):12-5. doi: 10.1051/medsci/20143001003. Epub 2014 Jan 24. French. No abstract available.


VEGFR-3 neutralization inhibits ovarian lymphangiogenesis, follicle maturation, and murine pregnancy.

Rutkowski JM, Ihm JE, Lee ST, Kilarski WW, Greenwood VI, Pasquier MC, Quazzola A, Trono D, Hubbell JA, Swartz MA.

Am J Pathol. 2013 Nov;183(5):1596-1607. doi: 10.1016/j.ajpath.2013.07.031. Epub 2013 Sep 13.


Stay-green trait-antioxidant status interrelationship in durum wheat (Triticum durum) flag leaf during post-flowering.

De Simone V, Soccio M, Borrelli GM, Pastore D, Trono D.

J Plant Res. 2014;127(1):159-71. doi: 10.1007/s10265-013-0584-0. Epub 2013 Aug 25.


The uniqueness of the plant mitochondrial potassium channel.

Pastore D, Soccio M, Laus MN, Trono D.

BMB Rep. 2013 Aug;46(8):391-7. Review.


Prototype foamy virus Bet impairs the dimerization and cytosolic solubility of human APOBEC3G.

Jaguva Vasudevan AA, Perkovic M, Bulliard Y, Cichutek K, Trono D, Häussinger D, Münk C.

J Virol. 2013 Aug;87(16):9030-40. doi: 10.1128/JVI.03385-12. Epub 2013 Jun 12.


A switch between topological domains underlies HoxD genes collinearity in mouse limbs.

Andrey G, Montavon T, Mascrez B, Gonzalez F, Noordermeer D, Leleu M, Trono D, Spitz F, Duboule D.

Science. 2013 Jun 7;340(6137):1234167. doi: 10.1126/science.1234167.

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