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Metformin Protects the Heart Against Hypertrophic and Apoptotic Remodeling After Myocardial Infarction.

Loi H, Boal F, Tronchere H, Cinato M, Kramar S, Oleshchuk O, Korda M, Kunduzova O.

Front Pharmacol. 2019 Feb 27;10:154. doi: 10.3389/fphar.2019.00154. eCollection 2019.


IL-26 in the induced sputum is associated with the level of systemic inflammation, lung functions and body weight in COPD patients.

Savchenko L, Mykytiuk M, Cinato M, Tronchere H, Kunduzova O, Kaidashev I.

Int J Chron Obstruct Pulmon Dis. 2018 Aug 24;13:2569-2575. doi: 10.2147/COPD.S164833. eCollection 2018.


Differential protein profiling as a potential multi-marker approach for obese patients with heart failure: A retrospective study.

Timotin A, Cinato M, Boal F, Dejean S, Anesia R, Arnaut O, Lagente C, Roncalli J, Desmoulin F, Tronchere H, Kunduzova O.

Sci Rep. 2018 May 21;8(1):7894. doi: 10.1038/s41598-018-26118-9.


Cardioprotective properties of N-terminal galanin fragment (2-15) in experimental ischemia/reperfusion injury.

Pisarenko O, Timotin A, Sidorova M, Studneva I, Shulzhenko V, Palkeeva M, Serebryakova L, Molokoedov A, Veselova O, Cinato M, Boal F, Tronchere H, Kunduzova O.

Oncotarget. 2017 Oct 5;8(60):101659-101671. doi: 10.18632/oncotarget.21503. eCollection 2017 Nov 24.


Inhibition of PIKfyve prevents myocardial apoptosis and hypertrophy through activation of SIRT3 in obese mice.

Tronchere H, Cinato M, Timotin A, Guitou L, Villedieu C, Thibault H, Baetz D, Payrastre B, Valet P, Parini A, Kunduzova O, Boal F.

EMBO Mol Med. 2017 Jun;9(6):770-785. doi: 10.15252/emmm.201607096.


Myocardial protection from ischemia/reperfusion injury by exogenous galanin fragment.

Timotin A, Pisarenko O, Sidorova M, Studneva I, Shulzhenko V, Palkeeva M, Serebryakova L, Molokoedov A, Veselova O, Cinato M, Tronchere H, Boal F, Kunduzova O.

Oncotarget. 2017 Mar 28;8(13):21241-21252. doi: 10.18632/oncotarget.15071.


Septin 9 induces lipid droplets growth by a phosphatidylinositol-5-phosphate and microtubule-dependent mechanism hijacked by HCV.

Akil A, Peng J, Omrane M, Gondeau C, Desterke C, Marin M, Tronchère H, Taveneau C, Sar S, Briolotti P, Benjelloun S, Benjouad A, Maurel P, Thiers V, Bressanelli S, Samuel D, Bréchot C, Gassama-Diagne A.

Nat Commun. 2016 Jul 15;7:12203. doi: 10.1038/ncomms12203.


Expression of myotubularins in blood platelets: Characterization and potential diagnostic of X-linked myotubular myopathy.

Mansour R, Severin S, Xuereb JM, Gratacap MP, Laporte J, Buj-Bello A, Tronchère H, Payrastre B.

Biochem Biophys Res Commun. 2016 Jul 29;476(3):167-73. doi: 10.1016/j.bbrc.2016.04.127. Epub 2016 May 4.


Apelin-13 administration protects against ischaemia/reperfusion-mediated apoptosis through the FoxO1 pathway in high-fat diet-induced obesity.

Boal F, Timotin A, Roumegoux J, Alfarano C, Calise D, Anesia R, Parini A, Valet P, Tronchere H, Kunduzova O.

Br J Pharmacol. 2016 Jun;173(11):1850-63. doi: 10.1111/bph.13485. Epub 2016 Apr 20.


PI5P Triggers ICAM-1 Degradation in Shigella Infected Cells, Thus Dampening Immune Cell Recruitment.

Boal F, Puhar A, Xuereb JM, Kunduzova O, Sansonetti PJ, Payrastre B, Tronchère H.

Cell Rep. 2016 Feb 2;14(4):750-759. doi: 10.1016/j.celrep.2015.12.079. Epub 2016 Jan 14.


Apelin regulates FoxO3 translocation to mediate cardioprotective responses to myocardial injury and obesity.

Boal F, Roumegoux J, Alfarano C, Timotin A, Calise D, Anesia R, Drougard A, Knauf C, Lagente C, Roncalli J, Desmoulin F, Tronchere H, Valet P, Parini A, Kunduzova O.

Sci Rep. 2015 Nov 6;5:16104. doi: 10.1038/srep16104.


TOM1 is a PI5P effector involved in the regulation of endosomal maturation.

Boal F, Mansour R, Gayral M, Saland E, Chicanne G, Xuereb JM, Marcellin M, Burlet-Schiltz O, Sansonetti PJ, Payrastre B, Tronchère H.

J Cell Sci. 2015 Feb 15;128(4):815-27. doi: 10.1242/jcs.166314. Epub 2015 Jan 14.


Phosphatidylinositol 5-phosphate: a nuclear stress lipid and a tuner of membranes and cytoskeleton dynamics.

Viaud J, Boal F, Tronchère H, Gaits-Iacovoni F, Payrastre B.

Bioessays. 2014 Mar;36(3):260-72. doi: 10.1002/bies.201300132. Epub 2013 Dec 21. Review.


A Shigella effector dampens inflammation by regulating epithelial release of danger signal ATP through production of the lipid mediator PtdIns5P.

Puhar A, Tronchère H, Payrastre B, Nhieu GT, Sansonetti PJ.

Immunity. 2013 Dec 12;39(6):1121-31. doi: 10.1016/j.immuni.2013.11.013.


The myotubularin-amphiphysin 2 complex in membrane tubulation and centronuclear myopathies.

Royer B, Hnia K, Gavriilidis C, Tronchère H, Tosch V, Laporte J.

EMBO Rep. 2013 Oct;14(10):907-15. doi: 10.1038/embor.2013.119. Epub 2013 Aug 6.


Phosphatase-dead myotubularin ameliorates X-linked centronuclear myopathy phenotypes in mice.

Amoasii L, Bertazzi DL, Tronchère H, Hnia K, Chicanne G, Rinaldi B, Cowling BS, Ferry A, Klaholz B, Payrastre B, Laporte J, Friant S.

PLoS Genet. 2012;8(10):e1002965. doi: 10.1371/journal.pgen.1002965. Epub 2012 Oct 11.


A novel mass assay to quantify the bioactive lipid PtdIns3P in various biological samples.

Chicanne G, Severin S, Boscheron C, Terrisse AD, Gratacap MP, Gaits-Iacovoni F, Tronchère H, Payrastre B.

Biochem J. 2012 Oct 1;447(1):17-23. doi: 10.1042/BJ20120945.


Inhibition of Rac controls NPM-ALK-dependent lymphoma development and dissemination.

Colomba A, Giuriato S, Dejean E, Thornber K, Delsol G, Tronchère H, Meggetto F, Payrastre B, Gaits-Iacovoni F.

Blood Cancer J. 2011 Jun;1(6):e21. doi: 10.1038/bcj.2011.19. Epub 2011 Jun 3.


Phosphoinositides and cellular pathogens.

Payrastre B, Gaits-Iacovoni F, Sansonetti P, Tronchère H.

Subcell Biochem. 2012;59:363-88. doi: 10.1007/978-94-007-3015-1_12. Review.


Genetic interaction between MTMR2 and FIG4 phospholipid phosphatases involved in Charcot-Marie-Tooth neuropathies.

Vaccari I, Dina G, Tronchère H, Kaufman E, Chicanne G, Cerri F, Wrabetz L, Payrastre B, Quattrini A, Weisman LS, Meisler MH, Bolino A.

PLoS Genet. 2011 Oct;7(10):e1002319. doi: 10.1371/journal.pgen.1002319. Epub 2011 Oct 20.


Shigella flexneri infection generates the lipid PI5P to alter endocytosis and prevent termination of EGFR signaling.

Ramel D, Lagarrigue F, Pons V, Mounier J, Dupuis-Coronas S, Chicanne G, Sansonetti PJ, Gaits-Iacovoni F, Tronchère H, Payrastre B.

Sci Signal. 2011 Sep 20;4(191):ra61. doi: 10.1126/scisignal.2001619.


The nucleophosmin-anaplastic lymphoma kinase oncogene interacts, activates, and uses the kinase PIKfyve to increase invasiveness.

Dupuis-Coronas S, Lagarrigue F, Ramel D, Chicanne G, Saland E, Gaits-Iacovoni F, Payrastre B, Tronchère H.

J Biol Chem. 2011 Sep 16;286(37):32105-14. doi: 10.1074/jbc.M111.227512. Epub 2011 Jul 7.


The phosphoinositide phosphatase MTM-1 regulates apoptotic cell corpse clearance through CED-5-CED-12 in C. elegans.

Neukomm LJ, Nicot AS, Kinchen JM, Almendinger J, Pinto SM, Zeng S, Doukoumetzidis K, Tronchère H, Payrastre B, Laporte JF, Hengartner MO.

Development. 2011 May;138(10):2003-14. doi: 10.1242/dev.060012. Epub 2011 Apr 13.


Myotubularin controls desmin intermediate filament architecture and mitochondrial dynamics in human and mouse skeletal muscle.

Hnia K, Tronchère H, Tomczak KK, Amoasii L, Schultz P, Beggs AH, Payrastre B, Mandel JL, Laporte J.

J Clin Invest. 2011 Jan;121(1):70-85. doi: 10.1172/JCI44021. Epub 2010 Dec 6.


Regulation and roles of PI3Kβ, a major actor in platelet signaling and functions.

Gratacap MP, Guillermet-Guibert J, Martin V, Chicanne G, Tronchère H, Gaits-Iacovoni F, Payrastre B.

Adv Enzyme Regul. 2011;51(1):106-16. doi: 10.1016/j.advenzreg.2010.09.011. Epub 2010 Oct 28. Review.


Matrix metalloproteinase-9 is upregulated in nucleophosmin-anaplastic lymphoma kinase-positive anaplastic lymphomas and activated at the cell surface by the chaperone heat shock protein 90 to promote cell invasion.

Lagarrigue F, Dupuis-Coronas S, Ramel D, Delsol G, Tronchère H, Payrastre B, Gaits-Iacovoni F.

Cancer Res. 2010 Sep 1;70(17):6978-87. doi: 10.1158/0008-5472.CAN-10-0861. Epub 2010 Aug 10.


Evidence for a positive role of PtdIns5P in T-cell signal transduction pathways.

Guittard G, Mortier E, Tronchère H, Firaguay G, Gérard A, Zimmermann P, Payrastre B, Nunès JA.

FEBS Lett. 2010 Jun 3;584(11):2455-60. doi: 10.1016/j.febslet.2010.04.051. Epub 2010 Apr 24.


PtdIns5P protects Akt from dephosphorylation through PP2A inhibition.

Ramel D, Lagarrigue F, Dupuis-Coronas S, Chicanne G, Leslie N, Gaits-Iacovoni F, Payrastre B, Tronchère H.

Biochem Biophys Res Commun. 2009 Sep 11;387(1):127-31. doi: 10.1016/j.bbrc.2009.06.139. Epub 2009 Jul 1.


Cutting edge: Dok-1 and Dok-2 adaptor molecules are regulated by phosphatidylinositol 5-phosphate production in T cells.

Guittard G, Gérard A, Dupuis-Coronas S, Tronchère H, Mortier E, Favre C, Olive D, Zimmermann P, Payrastre B, Nunès JA.

J Immunol. 2009 Apr 1;182(7):3974-8. doi: 10.4049/jimmunol.0804172.


Detection of myotubularin phosphatases activity on phosphoinositides in vitro and ex vivo.

Rohde HM, Tronchère H, Payrastre B, Laporte J.

Methods Mol Biol. 2009;462:265-78. doi: 10.1007/978-1-60327-115-8_18.


Elevated levels of PtdIns5P in NPM-ALK transformed cells: implication of PIKfyve.

Coronas S, Lagarrigue F, Ramel D, Chicanne G, Delsol G, Payrastre B, Tronchère H.

Biochem Biophys Res Commun. 2008 Jul 25;372(2):351-5. doi: 10.1016/j.bbrc.2008.05.062. Epub 2008 May 22.


PtdIns5P: a little phosphoinositide with big functions?

Coronas S, Ramel D, Pendaries C, Gaits-Iacovoni F, Tronchère H, Payrastre B.

Biochem Soc Symp. 2007;(74):117-28. Review.


A novel PtdIns3P and PtdIns(3,5)P2 phosphatase with an inactivating variant in centronuclear myopathy.

Tosch V, Rohde HM, Tronchère H, Zanoteli E, Monroy N, Kretz C, Dondaine N, Payrastre B, Mandel JL, Laporte J.

Hum Mol Genet. 2006 Nov 1;15(21):3098-106. Epub 2006 Sep 28.


PtdIns5P activates the host cell PI3-kinase/Akt pathway during Shigella flexneri infection.

Pendaries C, Tronchère H, Arbibe L, Mounier J, Gozani O, Cantley L, Fry MJ, Gaits-Iacovoni F, Sansonetti PJ, Payrastre B.

EMBO J. 2006 Mar 8;25(5):1024-34. Epub 2006 Feb 16.


Emerging roles of phosphatidylinositol monophosphates in cellular signaling and trafficking.

Pendaries C, Tronchère H, Racaud-Sultan C, Gaits-Iacovoni F, Coronas S, Manenti S, Gratacap MP, Plantavid M, Payrastre B.

Adv Enzyme Regul. 2005;45:201-14. Epub 2005 Jul 15.


Integrin-dependent interaction of lipid rafts with the actin cytoskeleton in activated human platelets.

Bodin S, Soulet C, Tronchère H, Sié P, Gachet C, Plantavid M, Payrastre B.

J Cell Sci. 2005 Feb 15;118(Pt 4):759-69. Epub 2005 Jan 25.


118th ENMC International Workshop on Advances in Myotubular Myopathy. 26-28 September 2003, Naarden, The Netherlands. (5th Workshop of the International Consortium on Myotubular Myopathy).

Bertini E, Biancalana V, Bolino A, Buj Bello A, Clague M, Guicheney P, Jungbluth H, Kress W, Musaro' A, Nandurkar H, Pirola L, Romero N, Senderek J, Suter U, Sewry C, Tronchere H, Wallgren-Pettersson C, Wishart MJ, Laporte J.

Neuromuscul Disord. 2004 Jun;14(6):387-96. No abstract available.


Production of phosphatidylinositol 5-phosphate by the phosphoinositide 3-phosphatase myotubularin in mammalian cells.

Tronchère H, Laporte J, Pendaries C, Chaussade C, Liaubet L, Pirola L, Mandel JL, Payrastre B.

J Biol Chem. 2004 Feb 20;279(8):7304-12. Epub 2003 Dec 1.


Implication of phosphoinositide phosphatases in genetic diseases: the case of myotubularin.

Tronchère H, Buj-Bello A, Mandel JL, Payrastre B.

Cell Mol Life Sci. 2003 Oct;60(10):2084-99. Review.


Expression of myotubularin by an adenoviral vector demonstrates its function as a phosphatidylinositol 3-phosphate [PtdIns(3)P] phosphatase in muscle cell lines: involvement of PtdIns(3)P in insulin-stimulated glucose transport.

Chaussade C, Pirola L, Bonnafous S, Blondeau F, Brenz-Verca S, Tronchère H, Portis F, Rusconi S, Payrastre B, Laporte J, Van Obberghen E.

Mol Endocrinol. 2003 Dec;17(12):2448-60. Epub 2003 Sep 18.


Phosphoinositide signaling disorders in human diseases.

Pendaries C, Tronchère H, Plantavid M, Payrastre B.

FEBS Lett. 2003 Jul 3;546(1):25-31. Review.


Lipid rafts are critical membrane domains in blood platelet activation processes.

Bodin S, Tronchère H, Payrastre B.

Biochim Biophys Acta. 2003 Mar 10;1610(2):247-57. Review.


Muscle-specific alternative splicing of myotubularin-related 1 gene is impaired in DM1 muscle cells.

Buj-Bello A, Furling D, Tronchère H, Laporte J, Lerouge T, Butler-Browne GS, Mandel JL.

Hum Mol Genet. 2002 Sep 15;11(19):2297-307.


Endosomal localization and function of sorting nexin 1.

Zhong Q, Lazar CS, Tronchère H, Sato T, Meerloo T, Yeo M, Songyang Z, Emr SD, Gill GN.

Proc Natl Acad Sci U S A. 2002 May 14;99(10):6767-72. Epub 2002 May 7.


Functional redundancy in the myotubularin family.

Laporte J, Liaubet L, Blondeau F, Tronchère H, Mandel JL, Payrastre B.

Biochem Biophys Res Commun. 2002 Feb 22;291(2):305-12.


RGS12 and RGS14 GoLoco motifs are G alpha(i) interaction sites with guanine nucleotide dissociation inhibitor Activity.

Kimple RJ, De Vries L, Tronchère H, Behe CI, Morris RA, Gist Farquhar M, Siderovski DP.

J Biol Chem. 2001 Aug 3;276(31):29275-81. Epub 2001 May 31.


Activator of G protein signaling 3 is a guanine dissociation inhibitor for Galpha i subunits.

De Vries L, Fischer T, Tronchère H, Brothers GM, Strockbine B, Siderovski DP, Farquhar MG.

Proc Natl Acad Sci U S A. 2000 Dec 19;97(26):14364-9.


Phosphorylation regulates in vivo interaction and molecular targeting of serine/arginine-rich pre-mRNA splicing factors.

Yeakley JM, Tronchère H, Olesen J, Dyck JA, Wang HY, Fu XD.

J Cell Biol. 1999 May 3;145(3):447-55.


Involvement of vicinal dithiols in differential regulation of fMLP and phorbol ester-activated phospholipase D in stimulated human neutrophils.

Planat V, Tronchere H, Record M, Ribbes G, Chap H.

Biochem Biophys Res Commun. 1996 Jan 26;218(3):847-53.


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