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In vitro evaluation of the activity of an essential oil from Pistacia vera L. variety Bronte hull against Candida sp.

D'Arrigo M, Bisignano C, Irrera P, Smeriglio A, Zagami R, Trombetta D, Romeo O, Mandalari G.

BMC Complement Altern Med. 2019 Jan 7;19(1):6. doi: 10.1186/s12906-018-2425-0.


Antioxidant and cytoprotective activities of an ancient Mediterranean citrus (Citrus lumia Risso) albedo extract: Microscopic observations and polyphenol characterization.

Smeriglio A, Cornara L, Denaro M, Barreca D, Burlando B, Xiao J, Trombetta D.

Food Chem. 2019 May 1;279:347-355. doi: 10.1016/j.foodchem.2018.11.138. Epub 2018 Dec 12.


The antioxidant effects of Hydroxytyrosol and Vitamin E on pediatric NAFLD, in a clinical trial: a new treatment?

Nobili V, Alisi A, Mosca A, Crudele A, Zaffina S, Denaro M, Smeriglio A, Trombetta D.

Antioxid Redox Signal. 2018 Dec 27. doi: 10.1089/ars.2018.7704. [Epub ahead of print]


Gene code CD274/PD-L1: from molecular basis toward cancer immunotherapy.

Fabrizio FP, Trombetta D, Rossi A, Sparaneo A, Castellana S, Muscarella LA.

Ther Adv Med Oncol. 2018 Dec 17;10:1758835918815598. doi: 10.1177/1758835918815598. eCollection 2018. Review.


Impact of an innovative pain elective course on student beliefs and attitudes towards opioid medication use.

Franko TS 2nd, Trombetta D.

Curr Pharm Teach Learn. 2018 Sep;10(9):1248-1263. doi: 10.1016/j.cptl.2018.06.002. Epub 2018 Aug 3.


Biochemical Characterization of Clinical Strains of Staphylococcus spp. and Their Sensitivity to Polyphenols-Rich Extracts from Pistachio (Pistacia vera L.).

La Camera E, Bisignano C, Crisafi G, Smeriglio A, Denaro M, Trombetta D, Mandalari G.

Pathogens. 2018 Oct 22;7(4). pii: E82. doi: 10.3390/pathogens7040082.


Targeting ubiquitin-proteasome pathway by natural, in particular polyphenols, anticancer agents: Lessons learned from clinical trials.

Nabavi SF, Atanasov AG, Khan H, Barreca D, Trombetta D, Testai L, Sureda A, Tejada S, Vacca RA, Pittalà V, Gulei D, Berindan-Neagoe I, Shirooie S, Nabavi SM.

Cancer Lett. 2018 Oct 10;434:101-113. doi: 10.1016/j.canlet.2018.07.018. Epub 2018 Jul 17.


Evaluation of biological response induced by molybdenum oxide nanocolloids on in vitro cultured NIH/3T3 fibroblast cells by micro-Raman spectroscopy.

Fazio E, Speciale A, Spadaro S, Bonsignore M, Cimino F, Cristani M, Trombetta D, Saija A, Neri F.

Colloids Surf B Biointerfaces. 2018 Oct 1;170:233-241. doi: 10.1016/j.colsurfb.2018.06.028. Epub 2018 Jun 18.


The problem of misidentification between edible and poisonous wild plants: Reports from the Mediterranean area.

Cornara L, Smeriglio A, Frigerio J, Labra M, Di Gristina E, Denaro M, Mora E, Trombetta D.

Food Chem Toxicol. 2018 Sep;119:112-121. doi: 10.1016/j.fct.2018.04.066. Epub 2018 May 31.


Epigenetic versus Genetic Deregulation of the KEAP1/NRF2 Axis in Solid Tumors: Focus on Methylation and Noncoding RNAs.

Fabrizio FP, Sparaneo A, Trombetta D, Muscarella LA.

Oxid Med Cell Longev. 2018 Mar 13;2018:2492063. doi: 10.1155/2018/2492063. eCollection 2018. Review.


Frequent NRG1 fusions in Caucasian pulmonary mucinous adenocarcinoma predicted by Phospho-ErbB3 expression.

Trombetta D, Graziano P, Scarpa A, Sparaneo A, Rossi G, Rossi A, Di Maio M, Antonello D, Mafficini A, Fabrizio FP, Manzorra MC, Balsamo T, Centra F, Simbolo M, Pantalone A, Notarangelo M, Parente P, Lucia Dimitri MC, Bonfitto A, Fiordelisi F, Storlazzi CT, L'Abbate A, Taurchini M, Maiello E, Fazio VM, Muscarella LA.

Oncotarget. 2018 Jan 3;9(11):9661-9671. doi: 10.18632/oncotarget.23800. eCollection 2018 Feb 9.


Understanding the Effect of Particle Size and Processing on Almond Lipid Bioaccessibility through Microstructural Analysis: From Mastication to Faecal Collection.

Mandalari G, Parker ML, Grundy MM, Grassby T, Smeriglio A, Bisignano C, Raciti R, Trombetta D, Baer DJ, Wilde PJ.

Nutrients. 2018 Feb 14;10(2). pii: E213. doi: 10.3390/nu10020213.


Essential oil of Citrus lumia Risso: Phytochemical profile, antioxidant properties and activity on the central nervous system.

Smeriglio A, Alloisio S, Raimondo FM, Denaro M, Xiao J, Cornara L, Trombetta D.

Food Chem Toxicol. 2018 Sep;119:407-416. doi: 10.1016/j.fct.2017.12.053. Epub 2017 Dec 28.


Experimental exposure of blue mussels (Mytilus galloprovincialis) to high levels of benzo[a]pyrene and possible implications for human health.

Speciale A, Zena R, Calabrò C, Bertuccio C, Aragona M, Saija A, Trombetta D, Cimino F, Lo Cascio P.

Ecotoxicol Environ Saf. 2018 Apr 15;150:96-103. doi: 10.1016/j.ecoenv.2017.12.038. Epub 2017 Dec 19.


Polyphenolic profile and biological activities of black carrot crude extract (Daucus carota L. ssp. sativus var. atrorubens Alef.).

Smeriglio A, Denaro M, Barreca D, D'Angelo V, Germanò MP, Trombetta D.

Fitoterapia. 2018 Jan;124:49-57. doi: 10.1016/j.fitote.2017.10.006. Epub 2017 Oct 16.


In vitro and in vivo modeling of lipid bioaccessibility and digestion from almond muffins: The importance of the cell-wall barrier mechanism.

Grassby T, Mandalari G, Grundy MM, Edwards CH, Bisignano C, Trombetta D, Smeriglio A, Chessa S, Ray S, Sanderson J, Berry SE, Ellis PR, Waldron KW.

J Funct Foods. 2017 Oct;37:263-271. doi: 10.1016/j.jff.2017.07.046.


ALK and NRG1 Fusions Coexist in a Patient with Signet Ring Cell Lung Adenocarcinoma.

Muscarella LA, Trombetta D, Fabrizio FP, Scarpa A, Fazio VM, Maiello E, Rossi A, Graziano P.

J Thorac Oncol. 2017 Oct;12(10):e161-e163. doi: 10.1016/j.jtho.2017.05.014. No abstract available.


NRG1-ErbB Lost in Translation: A New Paradigm for Lung Cancer?

Trombetta D, Rossi A, Fabrizio FP, Sparaneo A, Graziano P, Fazio VM, Muscarella LA.

Curr Med Chem. 2017;24(38):4213-4228. doi: 10.2174/0929867324666170911170554. Review.


Antioxidant Effects of a Hydroxytyrosol-Based Pharmaceutical Formulation on Body Composition, Metabolic State, and Gene Expression: A Randomized Double-Blinded, Placebo-Controlled Crossover Trial.

Colica C, Di Renzo L, Trombetta D, Smeriglio A, Bernardini S, Cioccoloni G, Costa de Miranda R, Gualtieri P, Sinibaldi Salimei P, De Lorenzo A.

Oxid Med Cell Longev. 2017;2017:2473495. doi: 10.1155/2017/2473495. Epub 2017 Aug 9.


Exposure to Anisakis extracts can induce inflammation on in vitro cultured human colonic cells.

Speciale A, Trombetta D, Saija A, Panebianco A, Giarratana F, Ziino G, Minciullo PL, Cimino F, Gangemi S.

Parasitol Res. 2017 Sep;116(9):2471-2477. doi: 10.1007/s00436-017-5551-6. Epub 2017 Jul 12.


Dietary Phytochemicals and Endrocrine-related Activities: An Update.

Smeriglio A, Denaro M, Trombetta D.

Mini Rev Med Chem. 2018;18(16):1382-1397. doi: 10.2174/1389557517666170711152406. Review.


Almond Skin Extracts Abrogate HSV-1 Replication by Blocking Virus Binding to the Cell.

Bisignano C, Mandalari G, Smeriglio A, Trombetta D, Pizzo MM, Pennisi R, Sciortino MT.

Viruses. 2017 Jul 10;9(7). pii: E178. doi: 10.3390/v9070178.


In Vitro Evaluation of the Antioxidant, Cytoprotective, and Antimicrobial Properties of Essential Oil from Pistacia vera L. Variety Bronte Hull.

Smeriglio A, Denaro M, Barreca D, Calderaro A, Bisignano C, Ginestra G, Bellocco E, Trombetta D.

Int J Mol Sci. 2017 Jun 6;18(6). pii: E1212. doi: 10.3390/ijms18061212.


Flavanones: Citrus phytochemical with health-promoting properties.

Barreca D, Gattuso G, Bellocco E, Calderaro A, Trombetta D, Smeriglio A, Laganà G, Daglia M, Meneghini S, Nabavi SM.

Biofactors. 2017 Jul 8;43(4):495-506. doi: 10.1002/biof.1363. Epub 2017 May 12. Review.


Analytical Evaluation and Antioxidant Properties of Some Secondary Metabolites in Northern Italian Mono- and Multi-Varietal Extra Virgin Olive Oils (EVOOs) from Early and Late Harvested Olives.

Trombetta D, Smeriglio A, Marcoccia D, Giofrè SV, Toscano G, Mazzotti F, Giovanazzi A, Lorenzetti S.

Int J Mol Sci. 2017 Apr 11;18(4). pii: E797. doi: 10.3390/ijms18040797.


A malignant inflammatory myofibroblastic tumor of the hypopharynx harboring the 3a/b variants of the EML4-ALK fusion gene.

Muscarella LA, Rossi G, Trombetta D, La Torre A, Di Candia L, Mengoli MC, Sparaneo A, Fazio VM, Graziano P.

Oncol Lett. 2017 Feb;13(2):593-598. doi: 10.3892/ol.2016.5504. Epub 2016 Dec 14.


Keap1/Nrf2 pathway in kidney cancer: frequent methylation of KEAP1 gene promoter in clear renal cell carcinoma.

Fabrizio FP, Costantini M, Copetti M, la Torre A, Sparaneo A, Fontana A, Poeta L, Gallucci M, Sentinelli S, Graziano P, Parente P, Pompeo V, De Salvo L, Simone G, Papalia R, Picardo F, Balsamo T, Flammia GP, Trombetta D, Pantalone A, Kok K, Paranita F, Muscarella LA, Fazio VM.

Oncotarget. 2017 Feb 14;8(7):11187-11198. doi: 10.18632/oncotarget.14492.


Proanthocyanidins and hydrolysable tannins: occurrence, dietary intake and pharmacological effects.

Smeriglio A, Barreca D, Bellocco E, Trombetta D.

Br J Pharmacol. 2017 Jun;174(11):1244-1262. doi: 10.1111/bph.13630. Epub 2016 Oct 21. Review.


Food Matrix Effects of Polyphenol Bioaccessibility from Almond Skin during Simulated Human Digestion.

Mandalari G, Vardakou M, Faulks R, Bisignano C, Martorana M, Smeriglio A, Trombetta D.

Nutrients. 2016 Sep 15;8(9). pii: E568. doi: 10.3390/nu8090568.


Phytochemical, Ecological and Antioxidant Evaluation of Wild Sicilian Thyme: Thymbra capitata (L.) Cav.

Saija A, Speciale A, Trombetta D, Leto C, Tuttolomondo T, La Bella S, Licata M, Virga G, Bonsangue G, Gennaro MC, Napoli E, Siracusa L, Ruberto G.

Chem Biodivers. 2016 Dec;13(12):1641-1655. doi: 10.1002/cbdv.201600072. Epub 2016 Nov 19.


Analysis of clock gene-miRNA correlation networks reveals candidate drivers in colorectal cancer.

Mazzoccoli G, Colangelo T, Panza A, Rubino R, Tiberio C, Palumbo O, Carella M, Trombetta D, Gentile A, Tavano F, Valvano MR, Storlazzi CT, Macchia G, De Cata A, Bisceglia G, Capocefalo D, Colantuoni V, Sabatino L, Piepoli A, Mazza T.

Oncotarget. 2016 Jul 19;7(29):45444-45461. doi: 10.18632/oncotarget.9989.


Liquid biopsy and NSCLC.

Trombetta D, Sparaneo A, Fabrizio FP, Muscarella LA.

Lung Cancer Manag. 2016 Jun;5(2):91-104. doi: 10.2217/lmt-2016-0006. Epub 2016 Jul 8. Review.


Chemistry, Pharmacology and Health Benefits of Anthocyanins.

Smeriglio A, Barreca D, Bellocco E, Trombetta D.

Phytother Res. 2016 Aug;30(8):1265-86. doi: 10.1002/ptr.5642. Epub 2016 May 25. Review.


Protective activity of an anthocyanin-rich extract from bilberries and blackcurrants on acute acetaminophen-induced hepatotoxicity in rats.

Cristani M, Speciale A, Mancari F, Arcoraci T, Ferrari D, Fratantonio D, Saija A, Cimino F, Trombetta D.

Nat Prod Res. 2016 Mar 21:1-5. [Epub ahead of print]


Deregulated expression of cryptochrome genes in human colorectal cancer.

Mazzoccoli G, Colangelo T, Panza A, Rubino R, De Cata A, Tiberio C, Valvano MR, Pazienza V, Merla G, Augello B, Trombetta D, Storlazzi CT, Macchia G, Gentile A, Tavano F, Vinciguerra M, Bisceglia G, Rosato V, Colantuoni V, Sabatino L, Piepoli A.

Mol Cancer. 2016 Jan 15;15:6. doi: 10.1186/s12943-016-0492-8.


Evaluation of the nutraceutical, antioxidant and cytoprotective properties of ripe pistachio (Pistacia vera L., variety Bronte) hulls.

Barreca D, Laganà G, Leuzzi U, Smeriglio A, Trombetta D, Bellocco E.

Food Chem. 2016 Apr 1;196:493-502. doi: 10.1016/j.foodchem.2015.09.077. Epub 2015 Sep 25.


Exposure of sea bream (Sparus aurata) to toxic concentrations of benzo[a]pyrene: possible human health effect.

Zena R, Speciale A, Calabrò C, Calò M, Palombieri D, Saija A, Cimino F, Trombetta D, Lo Cascio P.

Ecotoxicol Environ Saf. 2015 Dec;122:116-25. doi: 10.1016/j.ecoenv.2015.07.001. Epub 2015 Jul 28.


Wild Sicilian rosemary: phytochemical and morphological screening and antioxidant activity evaluation of extracts and essential oils.

Napoli EM, Siracusa L, Saija A, Speciale A, Trombetta D, Tuttolomondo T, La Bella S, Licata M, Virga G, Leone R, Leto C, Rubino L, Ruberto G.

Chem Biodivers. 2015 Jul;12(7):1075-94. doi: 10.1002/cbdv.201400274.


Human neural stem cell transplantation in ALS: initial results from a phase I trial.

Mazzini L, Gelati M, Profico DC, Sgaravizzi G, Projetti Pensi M, Muzi G, Ricciolini C, Rota Nodari L, Carletti S, Giorgi C, Spera C, Domenico F, Bersano E, Petruzzelli F, Cisari C, Maglione A, Sarnelli MF, Stecco A, Querin G, Masiero S, Cantello R, Ferrari D, Zalfa C, Binda E, Visioli A, Trombetta D, Novelli A, Torres B, Bernardini L, Carriero A, Prandi P, Servo S, Cerino A, Cima V, Gaiani A, Nasuelli N, Massara M, Glass J, Sorarù G, Boulis NM, Vescovi AL.

J Transl Med. 2015 Jan 27;13:17. doi: 10.1186/s12967-014-0371-2.


Evaluation of the radiotherapy treatment planning in the presence of a magnetic valve tissue expander.

Trombetta DM, Cardoso SC, Alves VG, Facure A, Batista DV, da Silva AX.

PLoS One. 2015 Feb 13;10(2):e0117548. doi: 10.1371/journal.pone.0117548. eCollection 2015.


Selective COX-2 inhibitory properties of dihydrostilbenes from liquorice leaves--in vitro assays and structure/activity relationship study.

Trombetta D, Giofrè SV, Tomaino A, Raciti R, Saija A, Cristani M, Romeo R, Siracusa L, Ruberto G.

Nat Prod Commun. 2014 Dec;9(12):1761-4.


Health effects of Vaccinium myrtillus L.: evaluation of efficacy and technological strategies for preservation of active ingredients.

Smeriglio A, Monteleone D, Trombetta D.

Mini Rev Med Chem. 2014;14(7):567-84. Review.


Genomic organization and evolution of double minutes/homogeneously staining regions with MYC amplification in human cancer.

L'Abbate A, Macchia G, D'Addabbo P, Lonoce A, Tolomeo D, Trombetta D, Kok K, Bartenhagen C, Whelan CW, Palumbo O, Severgnini M, Cifola I, Dugas M, Carella M, De Bellis G, Rocchi M, Carbone L, Storlazzi CT.

Nucleic Acids Res. 2014 Aug;42(14):9131-45. doi: 10.1093/nar/gku590. Epub 2014 Jul 17.


Intracellular distribution and biological effects of phytochemicals in a sex steroid- sensitive model of human prostate adenocarcinoma.

Smeriglio A, Trombetta D, Marcoccia D, Narciso L, Mantovani A, Lorenzetti S.

Anticancer Agents Med Chem. 2014;14(10):1386-96.


Protective effect of red orange extract supplementation against UV-induced skin damages: photoaging and solar lentigines.

Puglia C, Offerta A, Saija A, Trombetta D, Venera C.

J Cosmet Dermatol. 2014 Jun;13(2):151-7. doi: 10.1111/jocd.12083.


Herbal products in pregnancy: experimental studies and clinical reports.

Smeriglio A, Tomaino A, Trombetta D.

Phytother Res. 2014 Aug;28(8):1107-16. doi: 10.1002/ptr.5106. Epub 2014 Jan 7. Review.


Establishment and genetic characterization of ANGM-CSS, a novel, immortal cell line derived from a human glioblastoma multiforme.

Notarangelo A, Trombetta D, D'Angelo V, Parrella P, Palumbo O, Storlazzi CT, Impera L, Muscarella LA, La Torre A, Affuso A, Fazio VM, Carella M, Zelante L.

Int J Oncol. 2014 Mar;44(3):717-24. doi: 10.3892/ijo.2013.2224. Epub 2013 Dec 23.


Cytotoxic effects induced in vitro by organic extracts from urban air particulate matter in human leukocytes.

Cimino F, Speciale A, Siracusa L, Naccari C, Saija A, Mancari F, Raciti R, Cristani M, Trombetta D.

Drug Chem Toxicol. 2014 Jan;37(1):32-9. doi: 10.3109/01480545.2013.806529. Epub 2013 Nov 6.


Escitalopram-associated acute urinary retention.

Trombetta D, Garrett K, Harrison M.

Consult Pharm. 2013 Oct;28(10):661-9. doi: 10.4140/TCP.n.2013.661.


Antioxidant and photoprotective effects of blanch water, a byproduct of the almond processing industry.

Mandalari G, Arcoraci T, Martorana M, Bisignano C, Rizza L, Bonina FP, Trombetta D, Tomaino A.

Molecules. 2013 Oct 9;18(10):12426-40. doi: 10.3390/molecules181012426.

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