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BMJ Case Rep. 2019 Apr 30;12(4). pii: e229135. doi: 10.1136/bcr-2018-229135.

Signet ring cell carcinoma of the rectum: atypical metastatic presentation.

Author information

1
Department of Colorectal Surgery, Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran, Tlalpan, Mexico City, Mexico.
2
Department of Pathology, Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran, Tlalpan, Mexico City, Mexico.
3
Department of General Surgery, Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran, Tlalpan, Mexico City, Mexico.

Abstract

Colorectal cancer is the third most common cancer in the world and the fourth most common cause of death related to cancer. Signet ring cell carcinoma represents an uncommon histological type for rectal cancer with less than 1% of all rectal neoplasms. It usually behaves aggressively and has an inferior prognosis. We present the case of a young man diagnosed with signet ring cell rectal carcinoma. He underwent neoadjuvant therapy with partial response, had surgery with curative intent and showed local recurrence after only 3 months. Disease progression happened only weeks after recurrence with metastasis to vertebrae, extraocular muscles, bone marrow and skin. He is currently receiving palliative chemotherapy.

KEYWORDS:

Colon cancer; Colorectal surgery; Oncologic surgery; Signet-ring cell; Surgery

PMID:
31040144
DOI:
10.1136/bcr-2018-229135

Conflict of interest statement

Competing interests: None declared.

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