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Items: 1 to 50 of 131

1.

Translational Framework Predicting Tumour Response in Gemcitabine-Treated Patients with Advanced Pancreatic and Ovarian Cancer from Xenograft Studies.

Garcia-Cremades M, Pitou C, Iversen PW, Troconiz IF.

AAPS J. 2019 Jan 31;21(2):23. doi: 10.1208/s12248-018-0291-9.

PMID:
30706160
2.

Iberoamerican Pharmacometrics Network Congress 2018 Report: fostering M&S approaches for drug development, regulatory and clinical applications in Latin America.

Ibarra M, Costa TD, Schaiquevich P, Cristofoletti R, González IH, Fajardo-Robledo NS, Novoa MA, Pecchio M, Cortinez I, Trocóniz IF, Romero-Tejeda EM.

CPT Pharmacometrics Syst Pharmacol. 2019 Jan 25. doi: 10.1002/psp4.12387. [Epub ahead of print]

3.

A new immune-nanoplatform for promoting adaptive antitumor immune response.

Merino M, Contreras A, Casares N, Troconiz IF, Ten Hagen TL, Berraondo P, Zalba S, Garrido MJ.

Nanomedicine. 2019 Jan 14;17:13-25. doi: 10.1016/j.nano.2018.12.016. [Epub ahead of print]

PMID:
30654186
4.

Computational disease model of phenobarbital-induced acute attacks in an acute intermittent porphyria mouse model.

Vera-Yunca D, Serrano-Mendioroz I, Sampedro A, Jericó D, Trocóniz IF, Fontanellas A, Parra-Guillén ZP.

Mol Genet Metab. 2018 Dec 21. pii: S1096-7192(18)30574-2. doi: 10.1016/j.ymgme.2018.12.009. [Epub ahead of print]

PMID:
30639045
5.

Colo-Pro: a pilot randomised controlled trial to compare standard bolus-dosed cefuroxime prophylaxis to bolus-continuous infusion-dosed cefuroxime prophylaxis for the prevention of infections after colorectal surgery.

Kirby A, Asín-Prieto E, Burns FA, Ewin D, Fatania K, Kailavasan M, Nisar S, Pericleous A, Trocóniz IF, Burke D.

Eur J Clin Microbiol Infect Dis. 2019 Feb;38(2):357-363. doi: 10.1007/s10096-018-3435-z. Epub 2018 Dec 5.

6.

Physiologically-Based Pharmacokinetic model for Ciprofloxacin in children with complicated Urinary Tract Infection.

Balbas-Martinez V, Michelet R, Edginton AN, Meesters K, Trocóniz IF, Vermeulen A.

Eur J Pharm Sci. 2019 Feb 1;128:171-179. doi: 10.1016/j.ejps.2018.11.033. Epub 2018 Nov 29.

PMID:
30503378
7.

Population-Pharmacokinetic and Covariate Analysis of Lurbinectedin (PM01183), a New RNA Polymerase II Inhibitor, in Pooled Phase I/II Trials in Patients with Cancer.

Fernandez-Teruel C, Gonzalez I, Trocóniz IF, Lubomirov R, Soto A, Fudio S.

Clin Pharmacokinet. 2019 Mar;58(3):363-374. doi: 10.1007/s40262-018-0701-2.

PMID:
30090974
8.

Semi-mechanistic Pharmacokinetic/Pharmacodynamic model of three pegylated rHuEPO and ior®EPOCIM in New Zealand rabbits.

Reynaldo-Fernández G, Solozábal J, Amaro D, Fernández-Sánchez EM, Rodríguez-Vera L, Bermejo M, Mangas-Sanjuan V, Troconiz IF.

Eur J Pharm Sci. 2018 Jul 30;120:123-132. doi: 10.1016/j.ejps.2018.04.047. Epub 2018 May 2.

PMID:
29729414
9.

Systematic Modeling and Design Evaluation of Unperturbed Tumor Dynamics in Xenografts.

Parra-Guillen ZP, Mangas-Sanjuan V, Garcia-Cremades M, Troconiz IF, Mo G, Pitou C, Iversen PW, Wallin JE.

J Pharmacol Exp Ther. 2018 Jul;366(1):96-104. doi: 10.1124/jpet.118.248286. Epub 2018 Apr 24.

PMID:
29691287
10.

Recovery time after oral and maxillofacial ambulatory surgery with dexmedetomidine: an observational study.

Hernando B, Martinez-Simon A, Cacho-Asenjo E, Troconiz IF, Honorato-Cia C, Panadero A, Naval LL, Nuñez-Cordoba JM.

Clin Oral Investig. 2019 Jan;23(1):391-397. doi: 10.1007/s00784-018-2447-5. Epub 2018 Apr 20.

PMID:
29679228
11.

Optimal dynamic control approach in a multi-objective therapeutic scenario: Application to drug delivery in the treatment of prostate cancer.

Irurzun-Arana I, Janda A, Ardanza-Trevijano S, Trocóniz IF.

PLoS Comput Biol. 2018 Apr 19;14(4):e1006087. doi: 10.1371/journal.pcbi.1006087. eCollection 2018 Apr.

12.

The Long Neglected Player: Modeling Tumor Uptake to Guide Optimal Dosing.

Ruiz-Cerdá L, Asín-Prieto E, Parra-Guillen ZP, Trocóniz IF.

Clin Cancer Res. 2018 Jul 15;24(14):3236-3238. doi: 10.1158/1078-0432.CCR-18-0580. Epub 2018 Mar 26.

PMID:
29581133
13.

A systems pharmacology model for inflammatory bowel disease.

Balbas-Martinez V, Ruiz-Cerdá L, Irurzun-Arana I, González-García I, Vermeulen A, Gómez-Mantilla JD, Trocóniz IF.

PLoS One. 2018 Mar 7;13(3):e0192949. doi: 10.1371/journal.pone.0192949. eCollection 2018.

14.

Computer simulations for bioequivalence trials: Selection of analyte in BCS class II and IV drugs with first-pass metabolism, two metabolic pathways and intestinal efflux transporter.

Mangas-Sanjuan V, Navarro-Fontestad C, García-Arieta A, Trocóniz IF, Bermejo M.

Eur J Pharm Sci. 2018 May 30;117:193-203. doi: 10.1016/j.ejps.2018.02.014. Epub 2018 Feb 13.

PMID:
29452210
15.

Predicting tumour growth and its impact on survival in gemcitabine-treated patients with advanced pancreatic cancer.

Garcia-Cremades M, Pitou C, Iversen PW, Troconiz IF.

Eur J Pharm Sci. 2018 Mar 30;115:296-303. doi: 10.1016/j.ejps.2018.01.033. Epub 2018 Jan 31.

PMID:
29366960
16.

Model-Based Reverse Translation Between Veterinary and Human Medicine: The One Health Initiative.

Schneider B, Balbas-Martinez V, Jergens AE, Troconiz IF, Allenspach K, Mochel JP.

CPT Pharmacometrics Syst Pharmacol. 2018 Feb;7(2):65-68. doi: 10.1002/psp4.12262. Epub 2017 Nov 27.

17.

Population Pharmacokinetics of Volasertib Administered in Patients with Acute Myeloid Leukaemia as a Single Agent or in Combination with Cytarabine.

P Solans B, Fleury A, Freiwald M, Fritsch H, Haug K, Trocóniz IF.

Clin Pharmacokinet. 2018 Mar;57(3):379-392. doi: 10.1007/s40262-017-0566-9.

PMID:
28631179
18.

Effect of Dexmedetomidine and Propofol on Basal Ganglia Activity in Parkinson Disease: A Controlled Clinical Trial.

Martinez-Simon A, Alegre M, Honorato-Cia C, Nuñez-Cordoba JM, Cacho-Asenjo E, Trocóniz IF, Carmona-Abellán M, Valencia M, Guridi J.

Anesthesiology. 2017 Jun;126(6):1033-1042. doi: 10.1097/ALN.0000000000001620.

PMID:
28492384
19.

CORRIGENDUM: Commentary on Pharmacometrics for Immunotherapy.

Garrido MJ, Berraondo P, Trocóniz IF.

CPT Pharmacometrics Syst Pharmacol. 2017 Apr;6(4):277. doi: 10.1002/psp4.12186. Epub 2017 Apr 6. No abstract available.

20.

Advanced Boolean modeling of biological networks applied to systems pharmacology.

Irurzun-Arana I, Pastor JM, Trocóniz IF, Gómez-Mantilla JD.

Bioinformatics. 2017 Apr 1;33(7):1040-1048. doi: 10.1093/bioinformatics/btw747.

PMID:
28073755
21.

Characterizing Gemcitabine Effects Administered as Single Agent or Combined with Carboplatin in Mice Pancreatic and Ovarian Cancer Xenografts: A Semimechanistic Pharmacokinetic/Pharmacodynamics Tumor Growth-Response Model.

Garcia-Cremades M, Pitou C, Iversen PW, Troconiz IF.

J Pharmacol Exp Ther. 2017 Mar;360(3):445-456. doi: 10.1124/jpet.116.237610. Epub 2016 Dec 27.

PMID:
28028124
22.

Commentary on Pharmacometrics for Immunotherapy.

Garrido MJ, Berraondo P, Trocóniz IF.

CPT Pharmacometrics Syst Pharmacol. 2017 Jan;6(1):8-10. doi: 10.1002/psp4.12162. Epub 2017 Jan 17. Erratum in: CPT Pharmacometrics Syst Pharmacol. 2017 Apr;6(4):277.

23.

Population pharmacokinetic model of lithium and drug compliance assessment.

Pérez-Castelló I, Mangas-Sanjuan V, González-García I, Gonzalez-Alvarez I, Bermejo M, Marco-Garbayo JL, Trocóniz IF.

Eur Neuropsychopharmacol. 2016 Dec;26(12):1868-1876. doi: 10.1016/j.euroneuro.2016.11.005. Epub 2016 Nov 16.

PMID:
27865605
24.

Correlation between anti-PD-L1 tumor concentrations and tumor-specific and nonspecific biomarkers in a melanoma mouse model.

Contreras-Sandoval AM, Merino M, Vasquez M, Trocóniz IF, Berraondo P, Garrido MJ.

Oncotarget. 2016 Nov 22;7(47):76891-76901. doi: 10.18632/oncotarget.12727.

25.

Mechanism-based modeling of the clinical effects of bevacizumab and everolimus on vestibular schwannomas of patients with neurofibromatosis type 2.

Ouerdani A, Goutagny S, Kalamarides M, Trocóniz IF, Ribba B.

Cancer Chemother Pharmacol. 2016 Jun;77(6):1263-73. doi: 10.1007/s00280-016-3046-2. Epub 2016 May 4.

PMID:
27146400
26.

Towards patient stratification and treatment in the autoimmune disease lupus erythematosus using a systems pharmacology approach.

Ruiz-Cerdá ML, Irurzun-Arana I, González-Garcia I, Hu C, Zhou H, Vermeulen A, Trocóniz IF, Gómez-Mantilla JD.

Eur J Pharm Sci. 2016 Oct 30;94:46-58. doi: 10.1016/j.ejps.2016.04.010. Epub 2016 Apr 11. Review.

PMID:
27080094
27.

Population pharmacokinetic/pharmacodynamic modelling of the effects of axomadol and its O-demethyl metabolite on pupil diameter and nociception in healthy subjects.

Mangas-Sanjuan V, Pastor JM, Rengelshausen J, Bursi R, Troconiz IF.

Br J Clin Pharmacol. 2016 Jul;82(1):92-107. doi: 10.1111/bcp.12921. Epub 2016 Apr 14.

28.

Establishing the Quantitative Relationship Between Lanreotide Autogel®, Chromogranin A, and Progression-Free Survival in Patients with Nonfunctioning Gastroenteropancreatic Neuroendocrine Tumors.

Buil-Bruna N, Dehez M, Manon A, Nguyen TX, Trocóniz IF.

AAPS J. 2016 May;18(3):703-12. doi: 10.1208/s12248-016-9884-3. Epub 2016 Feb 23.

29.

EGF-liposomes promote efficient EGFR targeting in xenograft colocarcinoma model.

Zalba S, Contreras AM, Merino M, Navarro I, de Ilarduya CT, Trocóniz IF, Koning G, Garrido MJ.

Nanomedicine (Lond). 2016;11(5):465-77. doi: 10.2217/nnm.15.208. Epub 2016 Feb 19.

PMID:
26892017
30.

Bringing Model-Based Prediction to Oncology Clinical Practice: A Review of Pharmacometrics Principles and Applications.

Buil-Bruna N, López-Picazo JM, Martín-Algarra S, Trocóniz IF.

Oncologist. 2016 Feb;21(2):220-32. doi: 10.1634/theoncologist.2015-0322. Epub 2015 Dec 14. Review.

31.

Modeling Respiratory Depression Induced by Remifentanil and Propofol during Sedation and Analgesia Using a Continuous Noninvasive Measurement of pCO2.

Hannam JA, Borrat X, Trocóniz IF, Valencia JF, Jensen EW, Pedroso A, Muñoz J, Castellví-Bel S, Castells A, Gambús PL.

J Pharmacol Exp Ther. 2016 Mar;356(3):563-73. doi: 10.1124/jpet.115.226977. Epub 2015 Dec 11.

PMID:
26660440
32.

Population Pharmacokinetic Analysis of Lanreotide Autogel/Depot in the Treatment of Neuroendocrine Tumors: Pooled Analysis of Four Clinical Trials.

Buil-Bruna N, Garrido MJ, Dehez M, Manon A, Nguyen TX, Gomez-Panzani EL, Trocóniz IF.

Clin Pharmacokinet. 2016 Apr;55(4):461-73. doi: 10.1007/s40262-015-0329-4.

PMID:
26416534
33.

Pharmacometrics Markup Language (PharmML): Opening New Perspectives for Model Exchange in Drug Development.

Swat MJ, Moodie S, Wimalaratne SM, Kristensen NR, Lavielle M, Mari A, Magni P, Smith MK, Bizzotto R, Pasotti L, Mezzalana E, Comets E, Sarr C, Terranova N, Blaudez E, Chan P, Chard J, Chatel K, Chenel M, Edwards D, Franklin C, Giorgino T, Glont M, Girard P, Grenon P, Harling K, Hooker AC, Kaye R, Keizer R, Kloft C, Kok JN, Kokash N, Laibe C, Laveille C, Lestini G, Mentré F, Munafo A, Nordgren R, Nyberg HB, Parra-Guillen ZP, Plan E, Ribba B, Smith G, Trocóniz IF, Yvon F, Milligan PA, Harnisch L, Karlsson M, Hermjakob H, Le Novère N.

CPT Pharmacometrics Syst Pharmacol. 2015 Jun;4(6):316-9. doi: 10.1002/psp4.57. Epub 2015 Jun 15.

34.

Relation between acute and long-term cognitive decline after surgery: Influence of metabolic syndrome.

Gambús PL, Trocóniz IF, Feng X, Gimenez-Milá M, Mellado R, Degos V, Vacas S, Maze M.

Brain Behav Immun. 2015 Nov;50:203-208. doi: 10.1016/j.bbi.2015.07.005. Epub 2015 Jul 8.

35.

Semimechanistic cell-cycle type-based pharmacokinetic/pharmacodynamic model of chemotherapy-induced neutropenic effects of diflomotecan under different dosing schedules.

Mangas-Sanjuan V, Buil-Bruna N, Garrido MJ, Soto E, Trocóniz IF.

J Pharmacol Exp Ther. 2015 Jul;354(1):55-64. doi: 10.1124/jpet.115.223776. Epub 2015 May 6.

PMID:
25948593
36.

Early Prediction of Disease Progression in Small Cell Lung Cancer: Toward Model-Based Personalized Medicine in Oncology.

Buil-Bruna N, Sahota T, López-Picazo JM, Moreno-Jiménez M, Martín-Algarra S, Ribba B, Trocóniz IF.

Cancer Res. 2015 Jun 15;75(12):2416-25. doi: 10.1158/0008-5472.CAN-14-2584. Epub 2015 May 4.

37.

Semi-physiologic model validation and bioequivalence trials simulation to select the best analyte for acetylsalicylic acid.

Cuesta-Gragera A, Navarro-Fontestad C, Mangas-Sanjuan V, González-Álvarez I, García-Arieta A, Trocóniz IF, Casabó VG, Bermejo M.

Eur J Pharm Sci. 2015 Jul 10;74:86-94. doi: 10.1016/j.ejps.2015.04.002. Epub 2015 Apr 11.

PMID:
25869458
38.

Population pharmacokinetic analysis of tacrolimus in Mexican paediatric renal transplant patients: role of CYP3A5 genotype and formulation.

Jacobo-Cabral CO, García-Roca P, Romero-Tejeda EM, Reyes H, Medeiros M, Castañeda-Hernández G, Trocóniz IF.

Br J Clin Pharmacol. 2015 Oct;80(4):630-41. doi: 10.1111/bcp.12649. Epub 2015 Jun 22.

39.

Validation of a semi-physiological model for caffeine in healthy subjects and cirrhotic patients.

Cuesta-Gragera A, Navarro-Fontestad C, Mangas-Sanjuan V, González-Álvarez I, García-Arieta A, Trocóniz IF, Casabó VG, Bermejo M.

Eur J Pharm Sci. 2015 Jun 20;73:57-63. doi: 10.1016/j.ejps.2015.03.018. Epub 2015 Apr 2.

PMID:
25843043
40.

Population pharmacokinetic models for cefuroxime and metronidazole used in combination as prophylactic agents in colorectal surgery: Model-based evaluation of standard dosing regimens.

Asín-Prieto E, Soraluce A, Trocóniz IF, Campo Cimarras E, Sáenz de Ugarte Sobrón J, Rodríguez-Gascón A, Isla A.

Int J Antimicrob Agents. 2015 May;45(5):504-11. doi: 10.1016/j.ijantimicag.2015.01.008. Epub 2015 Feb 16.

PMID:
25758019
41.

Optimizing oncology therapeutics through quantitative translational and clinical pharmacology: challenges and opportunities.

Venkatakrishnan K, Friberg LE, Ouellet D, Mettetal JT, Stein A, Trocóniz IF, Bruno R, Mehrotra N, Gobburu J, Mould DR.

Clin Pharmacol Ther. 2015 Jan;97(1):37-54. doi: 10.1002/cpt.7. Epub 2014 Dec 9. Review.

PMID:
25670382
42.

Can pentylenetetrazole and maximal electroshock rodent seizure models quantitatively predict antiepileptic efficacy in humans?

Yuen ES, Trocóniz IF.

Seizure. 2015 Jan;24:21-7. doi: 10.1016/j.seizure.2014.11.006. Epub 2014 Nov 22.

43.

Population pharmacokinetic modelling of irosustat in postmenopausal women with oestrogen-receptor positive breast cancer incorporating non-linear red blood cell uptake.

Parra-Guillen ZP, Cendrós Carreras JM, Peraire C, Obach R, Prunynosa J, Chetaille E, Trocóniz IF.

Pharm Res. 2015 Apr;32(4):1493-504. doi: 10.1007/s11095-014-1555-4. Epub 2014 Oct 30.

PMID:
25355461
44.

Tramadol and o-desmethyl tramadol clearance maturation and disposition in humans: a pooled pharmacokinetic study.

Allegaert K, Holford N, Anderson BJ, Holford S, Stuber F, Rochette A, Trocóniz IF, Beier H, de Hoon JN, Pedersen RS, Stamer U.

Clin Pharmacokinet. 2015 Feb;54(2):167-78. doi: 10.1007/s40262-014-0191-9.

PMID:
25258277
45.

Review on modeling anti-antibody responses to monoclonal antibodies.

Gómez-Mantilla JD, Trocóniz IF, Parra-Guillén Z, Garrido MJ.

J Pharmacokinet Pharmacodyn. 2014 Oct;41(5):523-36. doi: 10.1007/s10928-014-9367-z. Epub 2014 Jul 16. Review.

PMID:
25027160
46.

A population pharmacodynamic model for lactate dehydrogenase and neuron specific enolase to predict tumor progression in small cell lung cancer patients.

Buil-Bruna N, López-Picazo JM, Moreno-Jiménez M, Martín-Algarra S, Ribba B, Trocóniz IF.

AAPS J. 2014 May;16(3):609-19. doi: 10.1208/s12248-014-9600-0. Epub 2014 Apr 17.

47.

Pharmacological profiles of acute myeloid leukemia treatments in patient samples by automated flow cytometry: a bridge to individualized medicine.

Bennett TA, Montesinos P, Moscardo F, Martinez-Cuadron D, Martinez J, Sierra J, García R, de Oteyza JP, Fernandez P, Serrano J, Fernandez A, Herrera P, Gonzalez A, Bethancourt C, Rodriguez-Macias G, Alonso A, Vera JA, Navas B, Lavilla E, Lopez JA, Jimenez S, Simiele A, Vidriales B, Gonzalez BJ, Burgaleta C, Hernandez Rivas JA, Mascuñano RC, Bautista G, Perez Simon JA, Fuente Ade L, Rayón C, Troconiz IF, Janda A, Bosanquet AG, Hernandez-Campo P, Primo D, Lopez R, Liebana B, Rojas JL, Gorrochategui J, Sanz MA, Ballesteros J.

Clin Lymphoma Myeloma Leuk. 2014 Aug;14(4):305-18. doi: 10.1016/j.clml.2013.11.006. Epub 2013 Nov 15.

48.

Pharmacokinetic-pharmacodynamic modelling in anaesthesia.

Gambús PL, Trocóniz IF.

Br J Clin Pharmacol. 2015 Jan;79(1):72-84. doi: 10.1111/bcp.12286. Review.

49.

Semi-mechanistic modelling of the analgesic effect of gabapentin in the formalin-induced rat model of experimental pain.

Taneja A, Troconiz IF, Danhof M, Della Pasqua O; Neuropathic Pain Project of the PKPD Modelling Platform.

Pharm Res. 2014 Mar;31(3):593-606. doi: 10.1007/s11095-013-1183-4. Epub 2013 Oct 5.

PMID:
24096967
50.

Predicting relapsing-remitting dynamics in multiple sclerosis using discrete distribution models: a population approach.

Velez de Mendizabal N, Hutmacher MM, Troconiz IF, Goñi J, Villoslada P, Bagnato F, Bies RR.

PLoS One. 2013 Sep 5;8(9):e73361. doi: 10.1371/journal.pone.0073361. eCollection 2013. Erratum in: PLoS One. 2014;9(1). doi:10.1371/annotation/40be1d29-5c85-40a8-a379-666ffd18afdc.

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