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Mutagenesis Screens for Prostate Cancer Using Replication-Incompetent Lentiviral Vectors.

Trobridge GD.

Methods Mol Biol. 2019;1907:103-114. doi: 10.1007/978-1-4939-8967-6_8.


Efficacy and safety of a clinically relevant foamy vector design in human hematopoietic repopulating cells.

Everson EM, Hocum JD, Trobridge GD.

J Gene Med. 2018 Jul;20(7-8):e3028. doi: 10.1002/jgm.3028. Epub 2018 Jul 19.


Rapid immune reconstitution of SCID-X1 canines after G-CSF/AMD3100 mobilization and in vivo gene therapy.

Humbert O, Chan F, Rajawat YS, Torgerson TR, Burtner CR, Hubbard NW, Humphrys D, Norgaard ZK, O'Donnell P, Adair JE, Trobridge GD, Scharenberg AM, Felsburg PJ, Rawlings DJ, Kiem HP.

Blood Adv. 2018 May 8;2(9):987-999. doi: 10.1182/bloodadvances.2018016451.


Replication-incompetent gammaretroviral and lentiviral vector-based insertional mutagenesis screens identify prostate cancer progression genes.

Bii VM, Collins CP, Hocum JD, Trobridge GD.

Oncotarget. 2018 Feb 15;9(21):15451-15463. doi: 10.18632/oncotarget.24503. eCollection 2018 Mar 20.


Insulators to Improve the Safety of Retroviral Vectors for HIV Gene Therapy.

Browning DL, Trobridge GD.

Biomedicines. 2016 Mar;4(1). pii: 4. doi: 10.3390/biomedicines4010004. Epub 2016 Feb 2.


Evidence for the in vivo safety of insulated foamy viral vectors.

Browning DL, Everson EM, Leap DJ, Hocum JD, Wang H, Stamatoyannopoulos G, Trobridge GD.

Gene Ther. 2017 Mar;24(3):187-198. doi: 10.1038/gt.2016.88. Epub 2016 Dec 26.


Retargeted Foamy Virus Vectors Integrate Less Frequently Near Proto-oncogenes.

Hocum JD, Linde I, Rae DT, Collins CP, Matern LK, Trobridge GD.

Sci Rep. 2016 Nov 4;6:36610. doi: 10.1038/srep36610.


Identifying Cancer Driver Genes Using Replication-Incompetent Retroviral Vectors.

Bii VM, Trobridge GD.

Cancers (Basel). 2016 Oct 25;8(11). pii: E99. Review.


Semi-automated closed system manufacturing of lentivirus gene-modified haematopoietic stem cells for gene therapy.

Adair JE, Waters T, Haworth KG, Kubek SP, Trobridge GD, Hocum JD, Heimfeld S, Kiem HP.

Nat Commun. 2016 Oct 20;7:13173. doi: 10.1038/ncomms13173.


A comparison of foamy and lentiviral vector genotoxicity in SCID-repopulating cells shows foamy vectors are less prone to clonal dominance.

Everson EM, Olzsko ME, Leap DJ, Hocum JD, Trobridge GD.

Mol Ther Methods Clin Dev. 2016 Aug 17;3:16048. doi: 10.1038/mtm.2016.48. eCollection 2016.


Retroviral vector interactions with hematopoietic cells.

Everson EM, Trobridge GD.

Curr Opin Virol. 2016 Dec;21:41-46. doi: 10.1016/j.coviro.2016.07.010. Epub 2016 Aug 10. Review.


Development of Third-generation Cocal Envelope Producer Cell Lines for Robust Lentiviral Gene Transfer into Hematopoietic Stem Cells and T-cells.

Humbert O, Gisch DW, Wohlfahrt ME, Adams AB, Greenberg PD, Schmitt TM, Trobridge GD, Kiem HP.

Mol Ther. 2016 Aug;24(7):1237-46. doi: 10.1038/mt.2016.70. Epub 2016 Apr 8.


Prospects for Foamy Viral Vector Anti-HIV Gene Therapy.

Nalla AK, Trobridge GD.

Biomedicines. 2016 Mar 29;4(2). pii: E8. doi: 10.3390/biomedicines4020008. Review.


Insulated Foamy Viral Vectors.

Browning DL, Collins CP, Hocum JD, Leap DJ, Rae DT, Trobridge GD.

Hum Gene Ther. 2016 Mar;27(3):255-66. doi: 10.1089/hum.2015.110. Epub 2016 Mar 15.


Lentiviral vector-mediated insertional mutagenesis screen identifies genes that influence androgen independent prostate cancer progression and predict clinical outcome.

Nalla AK, Williams TF, Collins CP, Rae DT, Trobridge GD.

Mol Carcinog. 2016 Nov;55(11):1761-1771. doi: 10.1002/mc.22425. Epub 2015 Oct 29.


Modified Genomic Sequencing PCR Using the MiSeq Platform to Identify Retroviral Integration Sites.

Rae DT, Collins CP, Hocum JD, Browning DL, Trobridge GD.

Hum Gene Ther Methods. 2015 Dec;26(6):221-7. doi: 10.1089/hgtb.2015.060. Epub 2015 Oct 20.


A novel retroviral mutagenesis screen identifies prognostic genes in RUNX1 mediated myeloid leukemogenesis.

Rae DT, Hocum JD, Bii V, Deeg HJ, Trobridge GD.

Oncotarget. 2015 Oct 13;6(31):30664-74. doi: 10.18632/oncotarget.5133.


VISA--Vector Integration Site Analysis server: a web-based server to rapidly identify retroviral integration sites from next-generation sequencing.

Hocum JD, Battrell LR, Maynard R, Adair JE, Beard BC, Rawlings DJ, Kiem HP, Miller DG, Trobridge GD.

BMC Bioinformatics. 2015 Jul 7;16:212. doi: 10.1186/s12859-015-0653-6.


Foamy viral vector integration sites in SCID-repopulating cells after MGMTP140K-mediated in vivo selection.

Olszko ME, Adair JE, Linde I, Rae DT, Trobridge P, Hocum JD, Rawlings DJ, Kiem HP, Trobridge GD.

Gene Ther. 2015 Jul;22(7):591-5. doi: 10.1038/gt.2015.20. Epub 2015 Mar 19.


High-throughput genomic mapping of vector integration sites in gene therapy studies.

Beard BC, Adair JE, Trobridge GD, Kiem HP.

Methods Mol Biol. 2014;1185:321-44. doi: 10.1007/978-1-4939-1133-2_22.


A novel approach to identify driver genes involved in androgen-independent prostate cancer.

Schinke EN, Bii V, Nalla A, Rae DT, Tedrick L, Meadows GG, Trobridge GD.

Mol Cancer. 2014 May 23;13:120. doi: 10.1186/1476-4598-13-120.


No evidence of clonal dominance after transplant of HOXB4-expanded cord blood cells in a nonhuman primate model.

Watts KL, Beard BC, Wood BL, Trobridge GD, Humphries RK, Adams AB, Nelson V, Kiem HP.

Exp Hematol. 2014 Jul;42(7):497-504. doi: 10.1016/j.exphem.2014.03.007. Epub 2014 Apr 2.


Intravenous injection of a foamy virus vector to correct canine SCID-X1.

Burtner CR, Beard BC, Kennedy DR, Wohlfahrt ME, Adair JE, Trobridge GD, Scharenberg AM, Torgerson TR, Rawlings DJ, Felsburg PJ, Kiem HP.

Blood. 2014 Jun 5;123(23):3578-84. doi: 10.1182/blood-2013-11-538926. Epub 2014 Mar 18.


Identification of Hematopoietic Stem Cell Engraftment Genes in Gene Therapy Studies.

Powers JM, Trobridge GD.

J Stem Cell Res Ther. 2013 Sep 1;2013(Suppl 3). doi: 10.4172/2157-7633.S3-004.


Foamy virus vectors for HIV gene therapy.

Olszko ME, Trobridge GD.

Viruses. 2013 Oct 22;5(10):2585-600. doi: 10.3390/v5102585. Review.


Effect of fetal bovine serum on foamy and lentiviral vector production.

Powers JM, Trobridge GD.

Hum Gene Ther Methods. 2013 Oct;24(5):307-9. doi: 10.1089/hgtb.2013.097. Epub 2013 Aug 28. No abstract available.


Positive selection of mC46-expressing CD4+ T cells and maintenance of virus specific immunity in a primate AIDS model.

Younan PM, Polacino P, Kowalski JP, Peterson CW, Maurice NJ, Williams NP, Ho O, Trobridge GD, Von Laer D, Prlic M, Beard BC, DeRosa S, Hu SL, Kiem HP.

Blood. 2013 Jul 11;122(2):179-87. doi: 10.1182/blood-2013-01-482224. Epub 2013 May 29.


Allogeneic transplantation, Fas signaling, and dysregulation of hepcidin.

Li X, Xu F, Karoopongse E, Marcondes AM, Lee K, Kowdley KV, Miao CH, Trobridge GD, Campbell JS, Deeg HJ.

Biol Blood Marrow Transplant. 2013 Aug;19(8):1210-9. doi: 10.1016/j.bbmt.2013.05.012. Epub 2013 May 22.


CD34(+) expansion with Delta-1 and HOXB4 promotes rapid engraftment and transfusion independence in a Macaca nemestrina cord blood transplant model.

Watts KL, Delaney C, Nelson V, Trobridge GD, Beard BC, Humphries RK, Kiem HP.

Mol Ther. 2013 Jun;21(6):1270-8. doi: 10.1038/mt.2013.40. Epub 2013 Apr 16.


Large animal models for foamy virus vector gene therapy.

Trobridge GD, Horn PA, Beard BC, Kiem HP.

Viruses. 2012 Dec 7;4(12):3572-88. doi: 10.3390/v4123572. Review.


Genetic manipulation of myoblasts and a novel primary myosatellite cell culture system: comparing and optimizing approaches.

Jackson MF, Hoversten KE, Powers JM, Trobridge GD, Rodgers BD.

FEBS J. 2013 Feb;280(3):827-39. doi: 10.1111/febs.12072. Epub 2013 Jan 2.


Establishment of an immunodeficient alcohol mouse model to study the effects of alcohol on human cells in vivo.

Powers J, Zhang H, Battrell L, Meadows GG, Trobridge GD.

J Stud Alcohol Drugs. 2012 Nov;73(6):933-7.


Stem cell selection in vivo using foamy vectors cures canine pyruvate kinase deficiency.

Trobridge GD, Beard BC, Wu RA, Ironside C, Malik P, Kiem HP.

PLoS One. 2012;7(9):e45173. doi: 10.1371/journal.pone.0045173. Epub 2012 Sep 13. Erratum in: PLoS One. 2013;8(10). doi:10.1371/annotation/90f278b2-f474-42ec-8645-435f7006018c.


AMP-activated protein kinase stimulates myostatin expression in C2C12 cells.

Das AK, Yang QY, Fu X, Liang JF, Duarte MS, Zhu MJ, Trobridge GD, Du M.

Biochem Biophys Res Commun. 2012 Oct 12;427(1):36-40. doi: 10.1016/j.bbrc.2012.08.138. Epub 2012 Sep 6.


Cyclophosphamide promotes engraftment of gene-modified cells in a mouse model of Fanconi anemia without causing cytogenetic abnormalities.

Adair JE, Zhao X, Chien S, Fang M, Wohlfahrt ME, Trobridge GD, Taylor JA, Beard BC, Kiem HP, Becker PS.

J Mol Med (Berl). 2012 Nov;90(11):1283-94. doi: 10.1007/s00109-012-0905-0. Epub 2012 Jun 3.


Extended survival of glioblastoma patients after chemoprotective HSC gene therapy.

Adair JE, Beard BC, Trobridge GD, Neff T, Rockhill JK, Silbergeld DL, Mrugala MM, Kiem HP.

Sci Transl Med. 2012 May 9;4(133):133ra57. doi: 10.1126/scitranslmed.3003425.


Hematopoietic stem cell expansion facilitates multilineage engraftment in a nonhuman primate cord blood transplantation model.

Watts KL, Nelson V, Wood BL, Trobridge GD, Beard BC, Humphries RK, Kiem HP.

Exp Hematol. 2012 Mar;40(3):187-96. doi: 10.1016/j.exphem.2011.11.009. Epub 2011 Dec 8.


Novel reporter systems for facile evaluation of I-SceI-mediated genome editing.

Muñoz NM, Beard BC, Ryu BY, Luche RM, Trobridge GD, Rawlings DJ, Scharenberg AM, Kiem HP.

Nucleic Acids Res. 2012 Jan;40(2):e14. doi: 10.1093/nar/gkr897. Epub 2011 Nov 21.


Differential effects of HOXB4 and NUP98-HOXA10hd on hematopoietic repopulating cells in a nonhuman primate model.

Watts KL, Zhang X, Beard BC, Chiu SY, Trobridge GD, Humphries RK, Kiem HP.

Hum Gene Ther. 2011 Dec;22(12):1475-82. doi: 10.1089/hum.2011.100. Epub 2011 Sep 6.


Genotoxicity of retroviral hematopoietic stem cell gene therapy.

Trobridge GD.

Expert Opin Biol Ther. 2011 May;11(5):581-93. doi: 10.1517/14712598.2011.562496. Epub 2011 Mar 7. Review.


Efficient generation of nonhuman primate induced pluripotent stem cells.

Zhong B, Trobridge GD, Zhang X, Watts KL, Ramakrishnan A, Wohlfahrt M, Adair JE, Kiem HP.

Stem Cells Dev. 2011 May;20(5):795-807. doi: 10.1089/scd.2010.0343. Epub 2011 Feb 1.


Efficient and stable MGMT-mediated selection of long-term repopulating stem cells in nonhuman primates.

Beard BC, Trobridge GD, Ironside C, McCune JS, Adair JE, Kiem HP.

J Clin Invest. 2010 Jul;120(7):2345-54. doi: 10.1172/JCI40767. Epub 2010 Jun 14.


Preclinical correction of human Fanconi anemia complementation group A bone marrow cells using a safety-modified lentiviral vector.

Becker PS, Taylor JA, Trobridge GD, Zhao X, Beard BC, Chien S, Adair J, Kohn DB, Wagner JE, Shimamura A, Kiem HP.

Gene Ther. 2010 Oct;17(10):1244-52. doi: 10.1038/gt.2010.62. Epub 2010 May 20.


A retroviral vector common integration site between leupaxin and zinc finger protein 91 (ZFP91) observed in baboon hematopoietic repopulating cells.

Kiem HP, Ironside C, Beard BC, Trobridge GD.

Exp Hematol. 2010 Sep;38(9):819-22, 822.e1-3. doi: 10.1016/j.exphem.2010.04.014. Epub 2010 Apr 29.


Large animal models of hematopoietic stem cell gene therapy.

Trobridge GD, Kiem HP.

Gene Ther. 2010 Aug;17(8):939-48. doi: 10.1038/gt.2010.47. Epub 2010 Apr 29. Review.


Cocal-pseudotyped lentiviral vectors resist inactivation by human serum and efficiently transduce primate hematopoietic repopulating cells.

Trobridge GD, Wu RA, Hansen M, Ironside C, Watts KL, Olsen P, Beard BC, Kiem HP.

Mol Ther. 2010 Apr;18(4):725-33. doi: 10.1038/mt.2009.282. Epub 2009 Dec 8.


Stable marking and transgene expression without progression to monoclonality in canine long-term hematopoietic repopulating cells transduced with lentiviral vectors.

Enssle J, Trobridge GD, Keyser KA, Ironside C, Beard BC, Kiem HP.

Hum Gene Ther. 2010 Apr;21(4):397-403. doi: 10.1089/hum.2009.076.


Protection of stem cell-derived lymphocytes in a primate AIDS gene therapy model after in vivo selection.

Trobridge GD, Wu RA, Beard BC, Chiu SY, Muñoz NM, von Laer D, Rossi JJ, Kiem HP.

PLoS One. 2009 Nov 2;4(11):e7693. doi: 10.1371/journal.pone.0007693.


Ex vivo expansion and lentiviral transduction of Macaca nemestrina CD4+ T cells.

Muñoz NM, Trobridge GD, Kiem HP.

J Med Primatol. 2009 Dec;38(6):438-43. doi: 10.1111/j.1600-0684.2009.00383.x. Epub 2009 Sep 28.

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