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Items: 11

1.

β-Cardiac myosin hypertrophic cardiomyopathy mutations release sequestered heads and increase enzymatic activity.

Adhikari AS, Trivedi DV, Sarkar SS, Song D, Kooiker KB, Bernstein D, Spudich JA, Ruppel KM.

Nat Commun. 2019 Jun 18;10(1):2685. doi: 10.1038/s41467-019-10555-9.

2.

SETD3 is an actin histidine methyltransferase that prevents primary dystocia.

Wilkinson AW, Diep J, Dai S, Liu S, Ooi YS, Song D, Li TM, Horton JR, Zhang X, Liu C, Trivedi DV, Ruppel KM, Vilches-Moure JG, Casey KM, Mak J, Cowan T, Elias JE, Nagamine CM, Spudich JA, Cheng X, Carette JE, Gozani O.

Nature. 2019 Jan;565(7739):372-376. doi: 10.1038/s41586-018-0821-8. Epub 2018 Dec 10.

3.

Converter domain mutations in myosin alter structural kinetics and motor function.

Gunther LK, Rohde JA, Tang W, Walton SD, Unrath WC, Trivedi DV, Muretta JM, Thomas DD, Yengo CM.

J Biol Chem. 2019 Feb 1;294(5):1554-1567. doi: 10.1074/jbc.RA118.006128. Epub 2018 Dec 5.

PMID:
30518549
4.

Deciphering the super relaxed state of human β-cardiac myosin and the mode of action of mavacamten from myosin molecules to muscle fibers.

Anderson RL, Trivedi DV, Sarkar SS, Henze M, Ma W, Gong H, Rogers CS, Gorham JM, Wong FL, Morck MM, Seidman JG, Ruppel KM, Irving TC, Cooke R, Green EM, Spudich JA.

Proc Natl Acad Sci U S A. 2018 Aug 28;115(35):E8143-E8152. doi: 10.1073/pnas.1809540115. Epub 2018 Aug 13.

5.

Hypertrophic cardiomyopathy and the myosin mesa: viewing an old disease in a new light.

Trivedi DV, Adhikari AS, Sarkar SS, Ruppel KM, Spudich JA.

Biophys Rev. 2018 Feb;10(1):27-48. doi: 10.1007/s12551-017-0274-6. Epub 2017 Jul 17. Review.

6.

The myosin mesa and the basis of hypercontractility caused by hypertrophic cardiomyopathy mutations.

Nag S, Trivedi DV, Sarkar SS, Adhikari AS, Sunitha MS, Sutton S, Ruppel KM, Spudich JA.

Nat Struct Mol Biol. 2017 Jun;24(6):525-533. doi: 10.1038/nsmb.3408. Epub 2017 May 8.

7.

Direct measurements of the coordination of lever arm swing and the catalytic cycle in myosin V.

Trivedi DV, Muretta JM, Swenson AM, Davis JP, Thomas DD, Yengo CM.

Proc Natl Acad Sci U S A. 2015 Nov 24;112(47):14593-8. doi: 10.1073/pnas.1517566112. Epub 2015 Nov 9.

8.

Magnesium modulates actin binding and ADP release in myosin motors.

Swenson AM, Trivedi DV, Rauscher AA, Wang Y, Takagi Y, Palmer BM, Málnási-Csizmadia A, Debold EP, Yengo CM.

J Biol Chem. 2014 Aug 22;289(34):23977-91. doi: 10.1074/jbc.M114.562231. Epub 2014 Jul 8.

9.

Magnesium impacts myosin V motor activity by altering key conformational changes in the mechanochemical cycle.

Trivedi DV, Muretta JM, Swenson AM, Thomas DD, Yengo CM.

Biochemistry. 2013 Jul 9;52(27):4710-22. doi: 10.1021/bi4004364. Epub 2013 Jun 25.

10.

Switch II mutants reveal coupling between the nucleotide- and actin-binding regions in myosin V.

Trivedi DV, David C, Jacobs DJ, Yengo CM.

Biophys J. 2012 Jun 6;102(11):2545-55. doi: 10.1016/j.bpj.2012.04.025. Epub 2012 Jun 5.

11.

Osteopetrosis ('marble bone' disease).

Manusov EG, Douville DR, Page LV, Trivedi DV.

Am Fam Physician. 1993 Jan;47(1):175-80. Review.

PMID:
8418580

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