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Items: 1 to 50 of 83

1.

De novo and recessive forms of congenital heart disease have distinct genetic and phenotypic landscapes.

Watkins WS, Hernandez EJ, Wesolowski S, Bisgrove BW, Sunderland RT, Lin E, Lemmon G, Demarest BL, Miller TA, Bernstein D, Brueckner M, Chung WK, Gelb BD, Goldmuntz E, Newburger JW, Seidman CE, Shen Y, Yost HJ, Yandell M, Tristani-Firouzi M.

Nat Commun. 2019 Oct 17;10(1):4722. doi: 10.1038/s41467-019-12582-y.

2.

Inhibition of Notch signaling rescues cardiovascular development in Kabuki Syndrome.

Serrano MLA, Demarest BL, Tone-Pah-Hote T, Tristani-Firouzi M, Yost HJ.

PLoS Biol. 2019 Sep 3;17(9):e3000087. doi: 10.1371/journal.pbio.3000087. eCollection 2019 Sep.

3.

DNA methylation reprograms cardiac metabolic gene expression in end-stage human heart failure.

Pepin ME, Drakos S, Ha CM, Tristani-Firouzi M, Selzman CH, Fang JC, Wende AR, Wever-Pinzon O.

Am J Physiol Heart Circ Physiol. 2019 Oct 1;317(4):H674-H684. doi: 10.1152/ajpheart.00016.2019. Epub 2019 Jul 12.

PMID:
31298559
4.

Modeling effects of voltage dependent properties of the cardiac muscarinic receptor on human sinus node function.

Moss R, Sachse FB, Moreno-Galindo EG, Navarro-Polanco RA, Tristani-Firouzi M, Seemann G.

PLoS Comput Biol. 2018 Oct 10;14(10):e1006438. doi: 10.1371/journal.pcbi.1006438. eCollection 2018 Oct.

5.

The voltage-sensitive cardiac M2 muscarinic receptor modulates the inward rectification of the G protein-coupled, ACh-gated K+ current.

Salazar-Fajardo PD, Aréchiga-Figueroa IA, López-Serrano AL, Rodriguez-Elias JC, Alamilla J, Sánchez-Chapula JA, Tristani-Firouzi M, Navarro-Polanco RA, Moreno-Galindo EG.

Pflugers Arch. 2018 Dec;470(12):1765-1776. doi: 10.1007/s00424-018-2196-y. Epub 2018 Aug 28.

PMID:
30155776
6.

Electrocardiograms in Healthy North American Children in the Digital Age.

Saarel EV, Granger S, Kaltman JR, Minich LL, Tristani-Firouzi M, Kim JJ, Ash K, Tsao SS, Berul CI, Stephenson EA, Gamboa DG, Trachtenberg F, Fischbach P, Vetter VL, Czosek RJ, Johnson TR, Salerno JC, Cain NB, Pass RH, Zeltser I, Silver ES, Kovach JR, Alexander ME; Pediatric Heart Network Investigators*.

Circ Arrhythm Electrophysiol. 2018 Jul;11(7):e005808. doi: 10.1161/CIRCEP.117.005808.

7.

Molecular determinants of Kv7.1/KCNE1 channel inhibition by amitriptyline.

Villatoro-Gómez K, Pacheco-Rojas DO, Moreno-Galindo EG, Navarro-Polanco RA, Tristani-Firouzi M, Gazgalis D, Cui M, Sánchez-Chapula JA, Ferrer T.

Biochem Pharmacol. 2018 Jun;152:264-271. doi: 10.1016/j.bcp.2018.03.016. Epub 2018 Apr 3.

PMID:
29621539
8.

Robust identification of deletions in exome and genome sequence data based on clustering of Mendelian errors.

Manheimer KB, Patel N, Richter F, Gorham J, Tai AC, Homsy J, Boskovski MT, Parfenov M, Goldmuntz E, Chung WK, Brueckner M, Tristani-Firouzi M, Srivastava D, Seidman JG, Seidman CE, Gelb BD, Sharp AJ.

Hum Mutat. 2018 Jun;39(6):870-881. doi: 10.1002/humu.23419. Epub 2018 Mar 22.

9.

Atrium-specific ion channels in the zebrafish-A role of IKACh in atrial repolarization.

Skarsfeldt MA, Bomholtz SH, Lundegaard PR, Lopez-Izquierdo A, Tristani-Firouzi M, Bentzen BH.

Acta Physiol (Oxf). 2018 Jul;223(3):e13049. doi: 10.1111/apha.13049. Epub 2018 Feb 27.

PMID:
29412518
10.

Contribution of rare inherited and de novo variants in 2,871 congenital heart disease probands.

Jin SC, Homsy J, Zaidi S, Lu Q, Morton S, DePalma SR, Zeng X, Qi H, Chang W, Sierant MC, Hung WC, Haider S, Zhang J, Knight J, Bjornson RD, Castaldi C, Tikhonoa IR, Bilguvar K, Mane SM, Sanders SJ, Mital S, Russell MW, Gaynor JW, Deanfield J, Giardini A, Porter GA Jr, Srivastava D, Lo CW, Shen Y, Watkins WS, Yandell M, Yost HJ, Tristani-Firouzi M, Newburger JW, Roberts AE, Kim R, Zhao H, Kaltman JR, Goldmuntz E, Chung WK, Seidman JG, Gelb BD, Seidman CE, Lifton RP, Brueckner M.

Nat Genet. 2017 Nov;49(11):1593-1601. doi: 10.1038/ng.3970. Epub 2017 Oct 9.

11.

A Functional Assay for Sick Sinus Syndrome Genetic Variants.

Jou CJ, Arrington CB, Barnett S, Shen J, Cho S, Sheng X, McCullagh PC, Bowles NE, Pribble CM, Saarel EV, Pilcher TA, Etheridge SP, Tristani-Firouzi M.

Cell Physiol Biochem. 2017;42(5):2021-2029. doi: 10.1159/000479897. Epub 2017 Aug 11.

12.

Adrenergic receptor genotypes influence postoperative outcomes in infants in the Single-Ventricle Reconstruction Trial.

Ramroop R, Manase G, Lu D, Manase D, Chen S, Kim R, Lee T, Mahle WT, McHugh K, Mitchell M, Tristani-Firouzi M, Wechsler SB, Wilder NS, Zak V, Lafreniere-Roula M, Newburger JW, Gaynor JW, Russell MW, Mital S.

J Thorac Cardiovasc Surg. 2017 Nov;154(5):1703-1710.e3. doi: 10.1016/j.jtcvs.2017.06.041. Epub 2017 Jun 24.

13.

CRISPR/Cas9-Directed Gene Editing for the Generation of Loss-of-Function Mutants in High-Throughput Zebrafish F0 Screens.

Shankaran SS, Dahlem TJ, Bisgrove BW, Yost HJ, Tristani-Firouzi M.

Curr Protoc Mol Biol. 2017 Jul 5;119:31.9.1-31.9.22. doi: 10.1002/cpmb.42.

PMID:
28678442
14.

Efficient Precision Genome Editing in iPSCs via Genetic Co-targeting with Selection.

Mitzelfelt KA, McDermott-Roe C, Grzybowski MN, Marquez M, Kuo CT, Riedel M, Lai S, Choi MJ, Kolander KD, Helbling D, Dimmock DP, Battle MA, Jou CJ, Tristani-Firouzi M, Verbsky JW, Benjamin IJ, Geurts AM.

Stem Cell Reports. 2017 Mar 14;8(3):491-499. doi: 10.1016/j.stemcr.2017.01.021. Epub 2017 Feb 24.

15.

Sheet-Like Remodeling of the Transverse Tubular System in Human Heart Failure Impairs Excitation-Contraction Coupling and Functional Recovery by Mechanical Unloading.

Seidel T, Navankasattusas S, Ahmad A, Diakos NA, Xu WD, Tristani-Firouzi M, Bonios MJ, Taleb I, Li DY, Selzman CH, Drakos SG, Sachse FB.

Circulation. 2017 Apr 25;135(17):1632-1645. doi: 10.1161/CIRCULATIONAHA.116.024470. Epub 2017 Jan 10.

16.

Pharmacological Conversion of a Cardiac Inward Rectifier into an Outward Rectifier Potassium Channel.

Moreno-Galindo EG, Sanchez-Chapula JA, Tristani-Firouzi M, Navarro-Polanco RA.

Mol Pharmacol. 2016 Sep;90(3):334-40. doi: 10.1124/mol.116.104950. Epub 2016 May 31. Review.

PMID:
27247338
17.

The agonist-specific voltage dependence of M2 muscarinic receptors modulates the deactivation of the acetylcholine-gated K(+) current (I KACh).

Moreno-Galindo EG, Alamilla J, Sanchez-Chapula JA, Tristani-Firouzi M, Navarro-Polanco RA.

Pflugers Arch. 2016 Jul;468(7):1207-1214. doi: 10.1007/s00424-016-1812-y. Epub 2016 Mar 29.

PMID:
27023349
18.

Revisiting the challenges of universal screening for long QT syndrome.

Tristani-Firouzi M.

J Electrocardiol. 2015 Nov-Dec;48(6):1053-7. doi: 10.1016/j.jelectrocard.2015.08.024. Epub 2015 Aug 12. Review.

PMID:
26355713
19.

Exome analysis of a family with Wolff-Parkinson-White syndrome identifies a novel disease locus.

Bowles NE, Jou CJ, Arrington CB, Kennedy BJ, Earl A, Matsunami N, Meyers LL, Etheridge SP, Saarel EV, Bleyl SB, Yost HJ, Yandell M, Leppert MF, Tristani-Firouzi M, Gruber PJ; Baylor Hopkins Centers for Mendelian Genomics.

Am J Med Genet A. 2015 Dec;167A(12):2975-84. doi: 10.1002/ajmg.a.37297. Epub 2015 Aug 18.

20.

A near-infrared fluorescent voltage-sensitive dye allows for moderate-throughput electrophysiological analyses of human induced pluripotent stem cell-derived cardiomyocytes.

Lopez-Izquierdo A, Warren M, Riedel M, Cho S, Lai S, Lux RL, Spitzer KW, Benjamin IJ, Tristani-Firouzi M, Jou CJ.

Am J Physiol Heart Circ Physiol. 2014 Nov 1;307(9):H1370-7. doi: 10.1152/ajpheart.00344.2014. Epub 2014 Aug 29.

21.

Functional and pharmacological analysis of cardiomyocytes differentiated from human peripheral blood mononuclear-derived pluripotent stem cells.

Riedel M, Jou CJ, Lai S, Lux RL, Moreno AP, Spitzer KW, Christians E, Tristani-Firouzi M, Benjamin IJ.

Stem Cell Reports. 2014 May 29;3(1):131-41. doi: 10.1016/j.stemcr.2014.04.017. eCollection 2014 Jul 8.

22.

The pharmacokinetics of methadone and its metabolites in neonates, infants, and children.

Ward RM, Drover DR, Hammer GB, Stemland CJ, Kern S, Tristani-Firouzi M, Lugo RA, Satterfield K, Anderson BJ.

Paediatr Anaesth. 2014 Jun;24(6):591-601. doi: 10.1111/pan.12385. Epub 2014 Mar 26.

23.

The application of root mean square electrocardiography (RMS ECG) for the detection of acquired and congenital long QT syndrome.

Lux RL, Sower CT, Allen N, Etheridge SP, Tristani-Firouzi M, Saarel EV.

PLoS One. 2014 Jan 15;9(1):e85689. doi: 10.1371/journal.pone.0085689. eCollection 2014.

24.

The absence of insulin signaling in the heart induces changes in potassium channel expression and ventricular repolarization.

Lopez-Izquierdo A, Pereira RO, Wende AR, Punske BB, Abel ED, Tristani-Firouzi M.

Am J Physiol Heart Circ Physiol. 2014 Mar 1;306(5):H747-54. doi: 10.1152/ajpheart.00849.2013. Epub 2013 Dec 27.

25.

The Long and Short of It: Insights Into the Short QT Syndrome.

Tristani-Firouzi M.

J Am Coll Cardiol. 2014 Apr 8;63(13):1309-1310. doi: 10.1016/j.jacc.2013.11.021. Epub 2013 Dec 11. No abstract available.

26.

3-OST-7 regulates BMP-dependent cardiac contraction.

Samson SC, Ferrer T, Jou CJ, Sachse FB, Shankaran SS, Shaw RM, Chi NC, Tristani-Firouzi M, Yost HJ.

PLoS Biol. 2013 Dec;11(12):e1001727. doi: 10.1371/journal.pbio.1001727. Epub 2013 Dec 3.

27.

Tamoxifen inhibition of kv7.2/kv7.3 channels.

Ferrer T, Aréchiga-Figueroa IA, Shapiro MS, Tristani-Firouzi M, Sanchez-Chapula JA.

PLoS One. 2013 Sep 24;8(9):e76085. doi: 10.1371/journal.pone.0076085. eCollection 2013.

28.

Adaptation of the Voltage Dependent Muscarinic M2 Receptor on Cardiac Ik,Ach to Different Ligands.

Moss R, Seemann G, Dössel O, Sachse FB, Tristani-Firouzi M.

Biomed Tech (Berl). 2013 Aug;58 Suppl 1. pii: /j/bmte.2013.58.issue-s1-N/bmt-2013-4332/bmt-2013-4332.xml. doi: 10.1515/bmt-2013-4332. Epub 2013 Sep 7. No abstract available.

PMID:
24043063
29.

Voltage sensitivity of M2 muscarinic receptors underlies the delayed rectifier-like activation of ACh-gated K(+) current by choline in feline atrial myocytes.

Navarro-Polanco RA, Aréchiga-Figueroa IA, Salazar-Fajardo PD, Benavides-Haro DE, Rodríguez-Elías JC, Sachse FB, Tristani-Firouzi M, Sánchez-Chapula JA, Moreno-Galindo EG.

J Physiol. 2013 Sep 1;591(17):4273-86. doi: 10.1113/jphysiol.2013.255166. Epub 2013 May 7.

30.

An in vivo cardiac assay to determine the functional consequences of putative long QT syndrome mutations.

Jou CJ, Barnett SM, Bian JT, Weng HC, Sheng X, Tristani-Firouzi M.

Circ Res. 2013 Mar 1;112(5):826-30. doi: 10.1161/CIRCRESAHA.112.300664. Epub 2013 Jan 9.

31.

Congenital long QT 3 in the pediatric population.

Blaufox AD, Tristani-Firouzi M, Seslar S, Sanatani S, Trivedi B, Fischbach P, Paul T, Young ML, Tisma-Dupanovic S, Silva J, Cuneo B, Fournier A, Singh H, Tanel RE, Etheridge SP.

Am J Cardiol. 2012 May 15;109(10):1459-65. doi: 10.1016/j.amjcard.2012.01.361. Epub 2012 Feb 21.

PMID:
22360817
32.

Lethal arrhythmias in Tbx3-deficient mice reveal extreme dosage sensitivity of cardiac conduction system function and homeostasis.

Frank DU, Carter KL, Thomas KR, Burr RM, Bakker ML, Coetzee WA, Tristani-Firouzi M, Bamshad MJ, Christoffels VM, Moon AM.

Proc Natl Acad Sci U S A. 2012 Jan 17;109(3):E154-63. doi: 10.1073/pnas.1115165109. Epub 2011 Dec 27.

33.

Somatic mosaicism contributes to phenotypic variation in Timothy syndrome.

Etheridge SP, Bowles NE, Arrington CB, Pilcher T, Rope A, Wilde AA, Alders M, Saarel EV, Tavernier R, Timothy KW, Tristani-Firouzi M.

Am J Med Genet A. 2011 Oct;155A(10):2578-83. doi: 10.1002/ajmg.a.34223. Epub 2011 Sep 9.

PMID:
21910241
34.

Molecular coupling in the human ether-a-go-go-related gene-1 (hERG1) K+ channel inactivation pathway.

Ferrer T, Cordero-Morales JF, Arias M, Ficker E, Medovoy D, Perozo E, Tristani-Firouzi M.

J Biol Chem. 2011 Nov 11;286(45):39091-9. doi: 10.1074/jbc.M111.292060. Epub 2011 Sep 9.

35.

Conformational changes in the M2 muscarinic receptor induced by membrane voltage and agonist binding.

Navarro-Polanco RA, Moreno Galindo EG, Ferrer-Villada T, Arias M, Rigby JR, Sánchez-Chapula JA, Tristani-Firouzi M.

J Physiol. 2011 Apr 1;589(Pt 7):1741-53. doi: 10.1113/jphysiol.2010.204107. Epub 2011 Jan 31.

36.

Relaxation gating of the acetylcholine-activated inward rectifier K+ current is mediated by intrinsic voltage sensitivity of the muscarinic receptor.

Moreno-Galindo EG, Sánchez-Chapula JA, Sachse FB, Rodríguez-Paredes JA, Tristani-Firouzi M, Navarro-Polanco RA.

J Physiol. 2011 Apr 1;589(Pt 7):1755-67. doi: 10.1113/jphysiol.2010.204115. Epub 2011 Jan 31.

37.

Modification of hERG1 channel gating by Cd2+.

Abbruzzese J, Sachse FB, Tristani-Firouzi M, Sanguinetti MC.

J Gen Physiol. 2010 Aug;136(2):203-24. doi: 10.1085/jgp.201010450.

38.

Blebbistatin effectively uncouples the excitation-contraction process in zebrafish embryonic heart.

Jou CJ, Spitzer KW, Tristani-Firouzi M.

Cell Physiol Biochem. 2010;25(4-5):419-24. doi: 10.1159/000303046. Epub 2010 Mar 23.

39.

Kir 2.1 channelopathies: the Andersen-Tawil syndrome.

Tristani-Firouzi M, Etheridge SP.

Pflugers Arch. 2010 Jul;460(2):289-94. doi: 10.1007/s00424-010-0820-6. Epub 2010 Mar 21. Review.

PMID:
20306271
40.

Molecular basis for a high-potency open-channel block of Kv1.5 channel by the endocannabinoid anandamide.

Moreno-Galindo EG, Barrio-Echavarría GF, Vásquez JC, Decher N, Sachse FB, Tristani-Firouzi M, Sánchez-Chapula JA, Navarro-Polanco RA.

Mol Pharmacol. 2010 May;77(5):751-8. doi: 10.1124/mol.109.063008. Epub 2010 Feb 4.

PMID:
20133392
41.

Resuscitated sudden cardiac death in Andersen-Tawil syndrome.

Airey KJ, Etheridge SP, Tawil R, Tristani-Firouzi M.

Heart Rhythm. 2009 Dec;6(12):1814-7. doi: 10.1016/j.hrthm.2009.08.032. Epub 2009 Aug 29. No abstract available.

42.

Chloroquine blocks a mutant Kir2.1 channel responsible for short QT syndrome and normalizes repolarization properties in silico.

Lopez-Izquierdo A, Ponce-Balbuena D, Ferrer T, Sachse FB, Tristani-Firouzi M, Sanchez-Chapula JA.

Cell Physiol Biochem. 2009;24(3-4):153-60. doi: 10.1159/000233241. Epub 2009 Aug 3.

43.

Kv1.5 open channel block by the antiarrhythmic drug disopyramide: molecular determinants of block.

Aréchiga IA, Barrio-Echavarria GF, Rodríguez-Menchaca AA, Moreno-Galindo EG, Decher N, Tristani-Firouzi M, Sánchez-Chapula JA, Navarro-Polanco RA.

J Pharmacol Sci. 2008 Sep;108(1):49-55.

44.

Congenital long QT syndrome in children identified by family screening.

Petko C, Bradley DJ, Tristani-Firouzi M, Cohen MI, Sanatani S, Saarel EV, Albaro CA, Etheridge SP.

Am J Cardiol. 2008 Jun 15;101(12):1756-8. doi: 10.1016/j.amjcard.2008.02.068. Epub 2008 Apr 9.

PMID:
18549854
45.

Genetic and physiologic dissection of the vertebrate cardiac conduction system.

Chi NC, Shaw RM, Jungblut B, Huisken J, Ferrer T, Arnaout R, Scott I, Beis D, Xiao T, Baier H, Jan LY, Tristani-Firouzi M, Stainier DY.

PLoS Biol. 2008 May 13;6(5):e109. doi: 10.1371/journal.pbio.0060109.

46.

The molecular basis of chloroquine block of the inward rectifier Kir2.1 channel.

Rodríguez-Menchaca AA, Navarro-Polanco RA, Ferrer-Villada T, Rupp J, Sachse FB, Tristani-Firouzi M, Sánchez-Chapula JA.

Proc Natl Acad Sci U S A. 2008 Jan 29;105(4):1364-8. doi: 10.1073/pnas.0708153105. Epub 2008 Jan 23.

47.

Cooperative interactions between R531 and acidic residues in the voltage sensing module of hERG1 channels.

Piper DR, Rupp J, Sachse FB, Sanguinetti MC, Tristani-Firouzi M.

Cell Physiol Biochem. 2008;21(1-3):37-46. doi: 10.1159/000113745. Epub 2008 Jan 16.

48.

Flecainide suppresses bidirectional ventricular tachycardia and reverses tachycardia-induced cardiomyopathy in Andersen-Tawil syndrome.

Pellizzón OA, Kalaizich L, Ptácek LJ, Tristani-Firouzi M, Gonzalez MD.

J Cardiovasc Electrophysiol. 2008 Jan;19(1):95-7. Epub 2007 Jul 27.

PMID:
17655675
49.

Zebrafish model for human long QT syndrome.

Arnaout R, Ferrer T, Huisken J, Spitzer K, Stainier DY, Tristani-Firouzi M, Chi NC.

Proc Natl Acad Sci U S A. 2007 Jul 3;104(27):11316-21. Epub 2007 Jun 25.

50.

Sudden cardiac death in Andersen-Tawil syndrome.

Peters S, Schulze-Bahr E, Etheridge SP, Tristani-Firouzi M.

Europace. 2007 Mar;9(3):162-6. Epub 2007 Feb 1.

PMID:
17272325

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