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Using affinity purification coupled with stable isotope labeling by amino acids in cell culture quantitative mass spectrometry to identify novel interactors/substrates of protein arginine methyltransferases.

Morettin A, Bourassa J, Mahadevan K, Trinkle-Mulcahy L, Cote J.

Methods. 2019 Nov 30. pii: S1046-2023(19)30189-6. doi: 10.1016/j.ymeth.2019.11.015. [Epub ahead of print]


Recent advances in proximity-based labeling methods for interactome mapping.

Trinkle-Mulcahy L.

F1000Res. 2019 Jan 31;8. pii: F1000 Faculty Rev-135. doi: 10.12688/f1000research.16903.1. eCollection 2019. Review.


PRMT7 methylates eukaryotic translation initiation factor 2α and regulates its role in stress granule formation.

Haghandish N, Baldwin RM, Morettin A, Dawit HT, Adhikary H, Masson JY, Mazroui R, Trinkle-Mulcahy L, Côté J.

Mol Biol Cell. 2019 Mar 15;30(6):778-793. doi: 10.1091/mbc.E18-05-0330. Epub 2019 Jan 30. Erratum in: Mol Biol Cell. 2019 Dec 1;30(25):3073.


Regulation of ATR activity via the RNA polymerase II associated factors CDC73 and PNUTS-PP1.

Landsverk HB, Sandquist LE, Sridhara SC, Rødland GE, Sabino JC, de Almeida SF, Grallert B, Trinkle-Mulcahy L, Syljuåsen RG.

Nucleic Acids Res. 2019 Feb 28;47(4):1797-1813. doi: 10.1093/nar/gky1233.


Autophagy and Adult Neurogenesis: Discoveries Made Half a Century Ago Yet in their Infancy of being Connected.

Dhaliwal J, Trinkle-Mulcahy L, Lagace DC.

Brain Plast. 2017 Nov 9;3(1):99-110. doi: 10.3233/BPL-170047. Review.


Regulation of myeloid cell phagocytosis by LRRK2 via WAVE2 complex stabilization is altered in Parkinson's disease.

Kim KS, Marcogliese PC, Yang J, Callaghan SM, Resende V, Abdel-Messih E, Marras C, Visanji NP, Huang J, Schlossmacher MG, Trinkle-Mulcahy L, Slack RS, Lang AE; Canadian Lrrk2 in Inflammation Team (CLINT), Park DS.

Proc Natl Acad Sci U S A. 2018 May 29;115(22):E5164-E5173. doi: 10.1073/pnas.1718946115. Epub 2018 May 14.


Actin-dependent regulation of cilia length by the inverted formin FHDC1.

Copeland SJ, McRae A, Guarguaglini G, Trinkle-Mulcahy L, Copeland JW.

Mol Biol Cell. 2018 Jul 1;29(13):1611-1627. doi: 10.1091/mbc.E18-02-0088. Epub 2018 May 9.


Identification of Cdk1-LATS-Pin1 as a Novel Signaling Axis in Anti-tubulin Drug Response of Cancer Cells.

Yeung B, Khanal P, Mehta V, Trinkle-Mulcahy L, Yang X.

Mol Cancer Res. 2018 Jun;16(6):1035-1045. doi: 10.1158/1541-7786.MCR-17-0684. Epub 2018 Mar 9.


Mapping New Residents of the Mitochondrial Nucleoid.

Trinkle-Mulcahy L.

Cell Chem Biol. 2017 Mar 16;24(3):250-251. doi: 10.1016/j.chembiol.2017.03.006.


Recruitment of PP1 to the centrosomal scaffold protein CEP192.

Nasa I, Trinkle-Mulcahy L, Douglas P, Chaudhuri S, Lees-Miller SP, Lee KS, Moorhead GB.

Biochem Biophys Res Commun. 2017 Mar 18;484(4):864-870. doi: 10.1016/j.bbrc.2017.02.004. Epub 2017 Feb 8.


Cdx2 Regulates Gene Expression through Recruitment of Brg1-associated Switch-Sucrose Non-fermentable (SWI-SNF) Chromatin Remodeling Activity.

Nguyen TT, Savory JG, Brooke-Bisschop T, Ringuette R, Foley T, Hess BL, Mulatz KJ, Trinkle-Mulcahy L, Lohnes D.

J Biol Chem. 2017 Feb 24;292(8):3389-3399. doi: 10.1074/jbc.M116.752774. Epub 2017 Jan 12.


Adaptation to Stressors by Systemic Protein Amyloidogenesis.

Audas TE, Audas DE, Jacob MD, Ho JJ, Khacho M, Wang M, Perera JK, Gardiner C, Bennett CA, Head T, Kryvenko ON, Jorda M, Daunert S, Malhotra A, Trinkle-Mulcahy L, Gonzalgo ML, Lee S.

Dev Cell. 2016 Oct 24;39(2):155-168. doi: 10.1016/j.devcel.2016.09.002. Epub 2016 Oct 6.


The Cajal body and the nucleolus: "In a relationship" or "It's complicated"?

Trinkle-Mulcahy L, Sleeman JE.

RNA Biol. 2017 Jun 3;14(6):739-751. doi: 10.1080/15476286.2016.1236169. Epub 2016 Sep 23. Review.


Recent advances in large-scale protein interactome mapping.

Mehta V, Trinkle-Mulcahy L.

F1000Res. 2016 Apr 29;5. pii: F1000 Faculty Rev-782. doi: 10.12688/f1000research.7629.1. eCollection 2016. Review.


Regulation of Macropinocytosis by Diacylglycerol Kinase ζ.

Ard R, Mulatz K, Pomoransky JL, Parks RJ, Trinkle-Mulcahy L, Bell JC, Gee SH.

PLoS One. 2015 Dec 23;10(12):e0144942. doi: 10.1371/journal.pone.0144942. eCollection 2015.


Prion-like domains in RNA binding proteins are essential for building subnuclear paraspeckles.

Hennig S, Kong G, Mannen T, Sadowska A, Kobelke S, Blythe A, Knott GJ, Iyer KS, Ho D, Newcombe EA, Hosoki K, Goshima N, Kawaguchi T, Hatters D, Trinkle-Mulcahy L, Hirose T, Bond CS, Fox AH.

J Cell Biol. 2015 Aug 17;210(4):529-39. doi: 10.1083/jcb.201504117.


Mio depletion links mTOR regulation to Aurora A and Plk1 activation at mitotic centrosomes.

Platani M, Trinkle-Mulcahy L, Porter M, Jeyaprakash AA, Earnshaw WC.

J Cell Biol. 2015 Jul 6;210(1):45-62. doi: 10.1083/jcb.201410001. Epub 2015 Jun 29.


New insights into nucleolar structure and function.

Lam YW, Trinkle-Mulcahy L.

F1000Prime Rep. 2015 Apr 2;7:48. doi: 10.12703/P7-48. eCollection 2015. Review.


Phosphorylation of SAF-A/hnRNP-U Serine 59 by Polo-Like Kinase 1 Is Required for Mitosis.

Douglas P, Ye R, Morrice N, Britton S, Trinkle-Mulcahy L, Lees-Miller SP.

Mol Cell Biol. 2015 Aug;35(15):2699-713. doi: 10.1128/MCB.01312-14. Epub 2015 May 18.


Identification of the PRMT1v1 and PRMT1v2 specific interactomes by quantitative mass spectrometry in breast cancer cells.

Baldwin RM, Bejide M, Trinkle-Mulcahy L, Côté J.

Proteomics. 2015 Jul;15(13):2187-97. doi: 10.1002/pmic.201400209. Epub 2015 Mar 19.


Extracting, enriching, and identifying nuclear body sub-complexes using label-based quantitative mass spectrometry.

Fox A, Mehta V, Boulon S, Trinkle-Mulcahy L.

Methods Mol Biol. 2015;1262:215-38. doi: 10.1007/978-1-4939-2253-6_13.


OPA1-dependent cristae modulation is essential for cellular adaptation to metabolic demand.

Patten DA, Wong J, Khacho M, Soubannier V, Mailloux RJ, Pilon-Larose K, MacLaurin JG, Park DS, McBride HM, Trinkle-Mulcahy L, Harper ME, Germain M, Slack RS.

EMBO J. 2014 Nov 18;33(22):2676-91. doi: 10.15252/embj.201488349. Epub 2014 Oct 8.


The human mitotic kinesin KIF18A binds protein phosphatase 1 (PP1) through a highly conserved docking motif.

De Wever V, Nasa I, Chamousset D, Lloyd D, Nimick M, Xu H, Trinkle-Mulcahy L, Moorhead GB.

Biochem Biophys Res Commun. 2014 Oct 24;453(3):432-7. doi: 10.1016/j.bbrc.2014.09.105. Epub 2014 Oct 1.


Dissection of a novel autocrine signaling pathway via quantitative secretome and interactome mapping.

Larivière N, Law J, Trinkle-Mulcahy L.

J Proteome Res. 2014 Jul 3;13(7):3432-43. doi: 10.1021/pr500392m. Epub 2014 Jun 23.


Polo-like kinase 1 (PLK1) and protein phosphatase 6 (PP6) regulate DNA-dependent protein kinase catalytic subunit (DNA-PKcs) phosphorylation in mitosis.

Douglas P, Ye R, Trinkle-Mulcahy L, Neal JA, De Wever V, Morrice NA, Meek K, Lees-Miller SP.

Biosci Rep. 2014 Jun 25;34(3). pii: e00113. doi: 10.1042/BSR20140051.


Nuclear bodies: new insights into assembly/dynamics and disease relevance.

Sleeman JE, Trinkle-Mulcahy L.

Curr Opin Cell Biol. 2014 Jun;28:76-83. doi: 10.1016/ Epub 2014 Apr 3. Review.


Time-resolved quantitative proteomics implicates the core snRNP protein SmB together with SMN in neural trafficking.

Prescott AR, Bales A, James J, Trinkle-Mulcahy L, Sleeman JE.

J Cell Sci. 2014 Feb 15;127(Pt 4):812-27. doi: 10.1242/jcs.137703. Epub 2013 Dec 19.


Novel methods for studying multiprotein complexes in vivo.

Mehta V, Trinkle-Mulcahy L.

F1000Prime Rep. 2013 Aug 1;5:30. doi: 10.12703/P5-30. eCollection 2013.


Environmental cues induce a long noncoding RNA-dependent remodeling of the nucleolus.

Jacob MD, Audas TE, Uniacke J, Trinkle-Mulcahy L, Lee S.

Mol Biol Cell. 2013 Sep;24(18):2943-53. doi: 10.1091/mbc.E13-04-0223. Epub 2013 Jul 31.


Quantitative fragmentome mapping reveals novel, domain-specific partners for the modular protein RepoMan (recruits PP1 onto mitotic chromatin at anaphase).

Prévost M, Chamousset D, Nasa I, Freele E, Morrice N, Moorhead G, Trinkle-Mulcahy L.

Mol Cell Proteomics. 2013 May;12(5):1468-86. doi: 10.1074/mcp.M112.023291. Epub 2013 Jan 29.


Taperin (c9orf75), a mutated gene in nonsyndromic deafness, encodes a vertebrate specific, nuclear localized protein phosphatase one alpha (PP1α) docking protein.

Ferrar T, Chamousset D, De Wever V, Nimick M, Andersen J, Trinkle-Mulcahy L, Moorhead GB.

Biol Open. 2012 Feb 15;1(2):128-39. doi: 10.1242/bio.2011049. Epub 2011 Nov 24.


Molecular mechanisms underlying the interaction of protein phosphatase-1c with ASPP proteins.

Skene-Arnold TD, Luu HA, Uhrig RG, De Wever V, Nimick M, Maynes J, Fong A, James MN, Trinkle-Mulcahy L, Moorhead GB, Holmes CF.

Biochem J. 2013 Feb 1;449(3):649-59. doi: 10.1042/BJ20120506.


Isolation of human mitotic protein phosphatase complexes: identification of a complex between protein phosphatase 1 and the RNA helicase Ddx21.

De Wever V, Lloyd DC, Nasa I, Nimick M, Trinkle-Mulcahy L, Gourlay R, Morrice N, Moorhead GB.

PLoS One. 2012;7(6):e39510. doi: 10.1371/journal.pone.0039510. Epub 2012 Jun 28.


Resolving protein interactions and complexes by affinity purification followed by label-based quantitative mass spectrometry.

Trinkle-Mulcahy L.

Proteomics. 2012 May;12(10):1623-38. doi: 10.1002/pmic.201100438. Review.


RRP1B targets PP1 to mammalian cell nucleoli and is associated with Pre-60S ribosomal subunits.

Chamousset D, De Wever V, Moorhead GB, Chen Y, Boisvert FM, Lamond AI, Trinkle-Mulcahy L.

Mol Biol Cell. 2010 Dec;21(23):4212-26. doi: 10.1091/mbc.E10-04-0287. Epub 2010 Oct 6.


Live-cell imaging RNAi screen identifies PP2A-B55alpha and importin-beta1 as key mitotic exit regulators in human cells.

Schmitz MH, Held M, Janssens V, Hutchins JR, Hudecz O, Ivanova E, Goris J, Trinkle-Mulcahy L, Lamond AI, Poser I, Hyman AA, Mechtler K, Peters JM, Gerlich DW.

Nat Cell Biol. 2010 Sep;12(9):886-93. doi: 10.1038/ncb2092. Epub 2010 Aug 15.


Efficient extraction of nucleolar proteins for interactome analyses.

Chamousset D, Mamane S, Boisvert FM, Trinkle-Mulcahy L.

Proteomics. 2010 Aug;10(16):3045-50. doi: 10.1002/pmic.201000162.


Establishment of a protein frequency library and its application in the reliable identification of specific protein interaction partners.

Boulon S, Ahmad Y, Trinkle-Mulcahy L, Verheggen C, Cobley A, Gregor P, Bertrand E, Whitehorn M, Lamond AI.

Mol Cell Proteomics. 2010 May;9(5):861-79. doi: 10.1074/mcp.M900517-MCP200. Epub 2009 Dec 20.


Aberrant mRNA transcripts and nonsense-mediated decay.

Trinkle-Mulcahy L.

F1000 Biol Rep. 2009 Dec 9;1:93. doi: 10.3410/B1-93.


Displacement affinity chromatography of protein phosphatase one (PP1) complexes.

Moorhead GB, Trinkle-Mulcahy L, Nimick M, De Wever V, Campbell DG, Gourlay R, Lam YW, Lamond AI.

BMC Biochem. 2008 Nov 10;9:28. doi: 10.1186/1471-2091-9-28.


Identifying specific protein interaction partners using quantitative mass spectrometry and bead proteomes.

Trinkle-Mulcahy L, Boulon S, Lam YW, Urcia R, Boisvert FM, Vandermoere F, Morrice NA, Swift S, Rothbauer U, Leonhardt H, Lamond A.

J Cell Biol. 2008 Oct 20;183(2):223-39. doi: 10.1083/jcb.200805092.


Nuclear functions in space and time: gene expression in a dynamic, constrained environment.

Trinkle-Mulcahy L, Lamond AI.

FEBS Lett. 2008 Jun 18;582(14):1960-70. doi: 10.1016/j.febslet.2008.04.029. Epub 2008 Apr 28. Review.


Toward a high-resolution view of nuclear dynamics.

Trinkle-Mulcahy L, Lamond AI.

Science. 2007 Nov 30;318(5855):1402-7. Review.


The nuclear PP1 interacting protein ZAP3 (ZAP) is a putative nucleoside kinase that complexes with SAM68, CIA, NF110/45, and HNRNP-G.

Ulke-Lemée A, Trinkle-Mulcahy L, Chaulk S, Bernstein NK, Morrice N, Glover M, Lamond AI, Moorhead GB.

Biochim Biophys Acta. 2007 Oct;1774(10):1339-50. Epub 2007 Aug 15.


Emerging roles of nuclear protein phosphatases.

Moorhead GB, Trinkle-Mulcahy L, Ulke-Lemée A.

Nat Rev Mol Cell Biol. 2007 Mar;8(3):234-44. Review.


Visualization of intracellular PP1 targeting through transiently and stably expressed fluorescent protein fusions.

Trinkle-Mulcahy L, Chusainow J, Lam YW, Swift S, Lamond A.

Methods Mol Biol. 2007;365:133-54.


Mitotic phosphatases: no longer silent partners.

Trinkle-Mulcahy L, Lamond AI.

Curr Opin Cell Biol. 2006 Dec;18(6):623-31. Epub 2006 Oct 9. Review.


Condensin and Repo-Man-PP1 co-operate in the regulation of chromosome architecture during mitosis.

Vagnarelli P, Hudson DF, Ribeiro SA, Trinkle-Mulcahy L, Spence JM, Lai F, Farr CJ, Lamond AI, Earnshaw WC.

Nat Cell Biol. 2006 Oct;8(10):1133-42. Epub 2006 Sep 24.


Repo-Man recruits PP1 gamma to chromatin and is essential for cell viability.

Trinkle-Mulcahy L, Andersen J, Lam YW, Moorhead G, Mann M, Lamond AI.

J Cell Biol. 2006 Feb 27;172(5):679-92. Epub 2006 Feb 21.


NOPdb: Nucleolar Proteome Database.

Leung AK, Trinkle-Mulcahy L, Lam YW, Andersen JS, Mann M, Lamond AI.

Nucleic Acids Res. 2006 Jan 1;34(Database issue):D218-20.

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