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Items: 36


Crystal structure of the putative cyclase IdmH from the indanomycin nonribosomal peptide synthase/polyketide synthase.

Drulyte I, Obajdin J, Trinh CH, Kalverda AP, van der Kamp MW, Hemsworth GR, Berry A.

IUCrJ. 2019 Oct 24;6(Pt 6):1120-1133. doi: 10.1107/S2052252519012399. eCollection 2019 Nov 1.


Directed Assembly of Homopentameric Cholera Toxin B-Subunit Proteins into Higher-Order Structures Using Coiled-Coil Appendages.

Ross JF, Wildsmith GC, Johnson M, Hurdiss DL, Hollingsworth K, Thompson RF, Mosayebi M, Trinh CH, Paci E, Pearson AR, Webb ME, Turnbull WB.

J Am Chem Soc. 2019 Apr 3;141(13):5211-5219. doi: 10.1021/jacs.8b11480. Epub 2019 Mar 21.


The Structure of the Human Respiratory Syncytial Virus M2-1 Protein Bound to the Interaction Domain of the Phosphoprotein P Defines the Orientation of the Complex.

Selvaraj M, Yegambaram K, Todd EJAA, Richard CA, Dods RL, Pangratiou GM, Trinh CH, Moul SL, Murphy JC, Mankouri J, Éléouët JF, Barr JN, Edwards TA.

mBio. 2018 Nov 13;9(6). pii: e01554-18. doi: 10.1128/mBio.01554-18.


Identification of the site of oxidase substrate binding in Scytalidium thermophilum catalase.

Yuzugullu Karakus Y, Goc G, Balci S, Yorke BA, Trinh CH, McPherson MJ, Pearson AR.

Acta Crystallogr D Struct Biol. 2018 Oct 1;74(Pt 10):979-985. doi: 10.1107/S2059798318010628. Epub 2018 Oct 2.


Oxygen Activation Switch in the Copper Amine Oxidase of Escherichia coli.

Gaule TG, Smith MA, Tych KM, Pirrat P, Trinh CH, Pearson AR, Knowles PF, McPherson MJ.

Biochemistry. 2018 Sep 11;57(36):5301-5314. doi: 10.1021/acs.biochem.8b00633. Epub 2018 Aug 24.


A Single Mutation is Sufficient to Modify the Metal Selectivity and Specificity of a Eukaryotic Manganese Superoxide Dismutase to Encompass Iron.

Hunter T, Bonetta R, Sacco A, Vella M, Sultana PM, Trinh CH, Fadia HBR, Borowski T, Garcia-Fandiño R, Stockner T, Hunter GJ.

Chemistry. 2018 Apr 6;24(20):5303-5308. doi: 10.1002/chem.201704655. Epub 2017 Dec 12.


Generation of specific inhibitors of SUMO-1- and SUMO-2/3-mediated protein-protein interactions using Affimer (Adhiron) technology.

Hughes DJ, Tiede C, Penswick N, Tang AA, Trinh CH, Mandal U, Zajac KZ, Gaule T, Howell G, Edwards TA, Duan J, Feyfant E, McPherson MJ, Tomlinson DC, Whitehouse A.

Sci Signal. 2017 Nov 14;10(505). pii: eaaj2005. doi: 10.1126/scisignal.aaj2005.


Extending enzyme molecular recognition with an expanded amino acid alphabet.

Windle CL, Simmons KJ, Ault JR, Trinh CH, Nelson A, Pearson AR, Berry A.

Proc Natl Acad Sci U S A. 2017 Mar 7;114(10):2610-2615. doi: 10.1073/pnas.1616816114. Epub 2017 Feb 14.


Hypertrophic cardiomyopathy mutations in the calponin-homology domain of ACTN2 affect actin binding and cardiomyocyte Z-disc incorporation.

Haywood NJ, Wolny M, Rogers B, Trinh CH, Shuping Y, Edwards TA, Peckham M.

Biochem J. 2016 Aug 15;473(16):2485-93. doi: 10.1042/BCJ20160421. Epub 2016 Jun 10.


Genetic Analysis of Physcomitrella patens Identifies ABSCISIC ACID NON-RESPONSIVE, a Regulator of ABA Responses Unique to Basal Land Plants and Required for Desiccation Tolerance.

Stevenson SR, Kamisugi Y, Trinh CH, Schmutz J, Jenkins JW, Grimwood J, Muchero W, Tuskan GA, Rensing SA, Lang D, Reski R, Melkonian M, Rothfels CJ, Li FW, Larsson A, Wong GK, Edwards TA, Cuming AC.

Plant Cell. 2016 Jun;28(6):1310-27. doi: 10.1105/tpc.16.00091. Epub 2016 May 18.


The crystal structure of the Hazara virus nucleocapsid protein.

Surtees R, Ariza A, Punch EK, Trinh CH, Dowall SD, Hewson R, Hiscox JA, Barr JN, Edwards TA.

BMC Struct Biol. 2015 Dec 29;15:24. doi: 10.1186/s12900-015-0051-3.


Evaluation of fluoropyruvate as nucleophile in reactions catalysed by N-acetyl neuraminic acid lyase variants: scope, limitations and stereoselectivity.

Stockwell J, Daniels AD, Windle CL, Harman TA, Woodhall T, Lebl T, Trinh CH, Mulholland K, Pearson AR, Berry A, Nelson A.

Org Biomol Chem. 2016 Jan 7;14(1):105-12. doi: 10.1039/c5ob02037a. Epub 2015 Nov 5.


The structure of the Caenorhabditis elegans manganese superoxide dismutase MnSOD-3-azide complex.

Hunter GJ, Trinh CH, Bonetta R, Stewart EE, Cabelli DE, Hunter T.

Protein Sci. 2015 Nov;24(11):1777-88. doi: 10.1002/pro.2768. Epub 2015 Aug 27.


Reaction mechanism of N-acetylneuraminic acid lyase revealed by a combination of crystallography, QM/MM simulation, and mutagenesis.

Daniels AD, Campeotto I, van der Kamp MW, Bolt AH, Trinh CH, Phillips SE, Pearson AR, Nelson A, Mulholland AJ, Berry A.

ACS Chem Biol. 2014 Apr 18;9(4):1025-32. doi: 10.1021/cb500067z. Epub 2014 Feb 21.


Crystal structure of the essential transcription antiterminator M2-1 protein of human respiratory syncytial virus and implications of its phosphorylation.

Tanner SJ, Ariza A, Richard CA, Kyle HF, Dods RL, Blondot ML, Wu W, Trincão J, Trinh CH, Hiscox JA, Carroll MW, Silman NJ, Eléouët JF, Edwards TA, Barr JN.

Proc Natl Acad Sci U S A. 2014 Jan 28;111(4):1580-5. doi: 10.1073/pnas.1317262111. Epub 2014 Jan 13.


Investigating the active centre of the Scytalidium thermophilum catalase.

Yuzugullu Y, Trinh CH, Fairhurst L, Ogel ZB, McPherson MJ, Pearson AR.

Acta Crystallogr Sect F Struct Biol Cryst Commun. 2013 Apr 1;69(Pt 4):369-75. doi: 10.1107/S1744309113004211. Epub 2013 Mar 28.


Structure, recombinant expression and mutagenesis studies of the catalase with oxidase activity from Scytalidium thermophilum.

Yuzugullu Y, Trinh CH, Smith MA, Pearson AR, Phillips SE, Sutay Kocabas D, Bakir U, Ogel ZB, McPherson MJ.

Acta Crystallogr D Biol Crystallogr. 2013 Mar;69(Pt 3):398-408. doi: 10.1107/S0907444912049001. Epub 2013 Feb 16.


Structural insights into the recovery of aldolase activity in N-acetylneuraminic acid lyase by replacement of the catalytically active lysine with γ-thialysine by using a chemical mutagenesis strategy.

Timms N, Windle CL, Polyakova A, Ault JR, Trinh CH, Pearson AR, Nelson A, Berry A.

Chembiochem. 2013 Mar 4;14(4):474-81. doi: 10.1002/cbic.201200714. Epub 2013 Feb 18.


X-ray structure of the dimeric cytochrome bc(1) complex from the soil bacterium Paracoccus denitrificans at 2.7-Å resolution.

Kleinschroth T, Castellani M, Trinh CH, Morgner N, Brutschy B, Ludwig B, Hunte C.

Biochim Biophys Acta. 2011 Dec;1807(12):1606-15. doi: 10.1016/j.bbabio.2011.09.017. Epub 2011 Oct 3.


Construction and crystal structure of recombinant STNV capsids.

Lane SW, Dennis CA, Lane CL, Trinh CH, Rizkallah PJ, Stockley PG, Phillips SE.

J Mol Biol. 2011 Oct 14;413(1):41-50. doi: 10.1016/j.jmb.2011.07.062. Epub 2011 Aug 3.


Structural insights into substrate specificity in variants of N-acetylneuraminic Acid lyase produced by directed evolution.

Campeotto I, Bolt AH, Harman TA, Dennis C, Trinh CH, Phillips SE, Nelson A, Pearson AR, Berry A.

J Mol Biol. 2010 Nov 19;404(1):56-69. doi: 10.1016/j.jmb.2010.08.008. Epub 2010 Sep 6.


Novel human pathological mutations. Gene symbol: F13A1. Disease: Factor XIII Deficiency.

Anwar R, Valleley EM, Trinh CH.

Hum Genet. 2010 Jan;127(1):115-6. No abstract available.


Exploring the roles of the metal ions in Escherichia coli copper amine oxidase.

Smith MA, Pirrat P, Pearson AR, Kurtis CR, Trinh CH, Gaule TG, Knowles PF, Phillips SE, McPherson MJ.

Biochemistry. 2010 Feb 16;49(6):1268-80. doi: 10.1021/bi901738k.


Structure of an Escherichia coli N-acetyl-D-neuraminic acid lyase mutant, E192N, in complex with pyruvate at 1.45 angstrom resolution.

Campeotto I, Carr SB, Trinh CH, Nelson AS, Berry A, Phillips SE, Pearson AR.

Acta Crystallogr Sect F Struct Biol Cryst Commun. 2009 Nov 1;65(Pt 11):1088-90. doi: 10.1107/S1744309109037403. Epub 2009 Oct 24.


Crystallization and preliminary X-ray analysis of a bifunctional catalase-phenol oxidase from Scytalidium thermophilum.

Sutay Kocabas D, Pearson AR, Phillips SE, Bakir U, Ogel ZB, McPherson MJ, Trinh CH.

Acta Crystallogr Sect F Struct Biol Cryst Commun. 2009 May 1;65(Pt 5):486-8. doi: 10.1107/S1744309109012007. Epub 2009 Apr 24.


Structures of alternatively spliced isoforms of human ketohexokinase.

Trinh CH, Asipu A, Bonthron DT, Phillips SE.

Acta Crystallogr D Biol Crystallogr. 2009 Mar;65(Pt 3):201-11. doi: 10.1107/S0907444908041115. Epub 2009 Feb 20.


Purification, crystallization and X-ray structures of the two manganese superoxide dismutases from Caenorhabditis elegans.

Trinh CH, Hunter T, Stewart EE, Phillips SE, Hunter GJ.

Acta Crystallogr Sect F Struct Biol Cryst Commun. 2008 Dec 1;64(Pt 12):1110-4. doi: 10.1107/S1744309108037056. Epub 2008 Nov 28.


Structure of the wild-type human BCL6 POZ domain.

Stead MA, Rosbrook GO, Hadden JM, Trinh CH, Carr SB, Wright SC.

Acta Crystallogr Sect F Struct Biol Cryst Commun. 2008 Dec 1;64(Pt 12):1101-4. doi: 10.1107/S1744309108036063. Epub 2008 Nov 28.


Molecular analysis of sixteen unrelated factor XIIIA deficient families from south-east of Iran.

Trinh CH, Sh Elsayed W, Eshghi P, Miri-Moghaddam E, Zadeh-Vakili A, Markham AF, Anwar R.

Br J Haematol. 2008 Mar;140(5):581-4. doi: 10.1111/j.1365-2141.2007.06963.x. No abstract available.


A beta-sheet interaction interface directs the tetramerisation of the Miz-1 POZ domain.

Stead MA, Trinh CH, Garnett JA, Carr SB, Baron AJ, Edwards TA, Wright SC.

J Mol Biol. 2007 Nov 2;373(4):820-6. Epub 2007 Aug 21.


Structure of the response regulator VicR DNA-binding domain.

Trinh CH, Liu Y, Phillips SE, Phillips-Jones MK.

Acta Crystallogr D Biol Crystallogr. 2007 Feb;63(Pt 2):266-9. Epub 2007 Jan 16.


[The return of the prodigal child or allergy to ficus].

Pradalier A, Leriche E, Trinh Ch, Molitor JL.

Eur Ann Allergy Clin Immunol. 2004 Nov;36(9):326-9. Review. French.


Thermodynamics of binding of 2-methoxy-3-isopropylpyrazine and 2-methoxy-3-isobutylpyrazine to the major urinary protein.

Bingham RJ, Findlay JB, Hsieh SY, Kalverda AP, Kjellberg A, Perazzolo C, Phillips SE, Seshadri K, Trinh CH, Turnbull WB, Bodenhausen G, Homans SW.

J Am Chem Soc. 2004 Feb 18;126(6):1675-81.


Crystal structure of monomeric human beta-2-microglobulin reveals clues to its amyloidogenic properties.

Trinh CH, Smith DP, Kalverda AP, Phillips SE, Radford SE.

Proc Natl Acad Sci U S A. 2002 Jul 23;99(15):9771-6. Epub 2002 Jul 15.


Delayed umbilical bleeding--a presenting feature for factor XIII deficiency: clinical features, genetics, and management.

Anwar R, Minford A, Gallivan L, Trinh CH, Markham AF.

Pediatrics. 2002 Feb;109(2):E32.


Antibody fragment Fv4155 bound to two closely related steroid hormones: the structural basis of fine specificity.

Trinh CH, Hemmington SD, Verhoeyen ME, Phillips SE.

Structure. 1997 Jul 15;5(7):937-48.

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