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High Levels of β-Amyloid, Tau, and Phospho-Tau in Red Blood Cells as Biomarkers of Neuropathology in Senescence-Accelerated Mouse.

Piccarducci R, Pietrobono D, Pellegrini C, Daniele S, Fornai M, Antonioli L, Trincavelli ML, Blandizzi C, Martini C.

Oxid Med Cell Longev. 2019 Jun 9;2019:5030475. doi: 10.1155/2019/5030475. eCollection 2019.


Potential Diagnostic Value of Red Blood Cells α-Synuclein Heteroaggregates in Alzheimer's Disease.

Baldacci F, Daniele S, Piccarducci R, Giampietri L, Pietrobono D, Giorgi FS, Nicoletti V, Frosini D, Libertini P, Lo Gerfo A, Petrozzi L, Donadio E, Betti L, Trincavelli ML, Siciliano G, Ceravolo R, Tognoni G, Bonuccelli U, Martini C.

Mol Neurobiol. 2019 Sep;56(9):6451-6459. doi: 10.1007/s12035-019-1531-4. Epub 2019 Mar 2.


Long lasting inhibition of Mdm2-p53 interaction potentiates mesenchymal stem cell differentiation into osteoblasts.

Daniele S, Giacomelli C, Pietrobono D, Barresi E, Piccarducci R, La Pietra V, Taliani S, Da Settimo F, Marinelli L, Novellino E, Martini C, Trincavelli ML.

Biochim Biophys Acta Mol Cell Res. 2019 May;1866(5):737-749. doi: 10.1016/j.bbamcr.2019.01.012. Epub 2019 Jan 28.


Novel fluorescent triazinobenzimidazole derivatives as probes for labelling human A1 and A2B adenosine receptor subtypes.

Barresi E, Giacomelli C, Daniele S, Tonazzini I, Robello M, Salerno S, Piano I, Cosimelli B, Greco G, Da Settimo F, Martini C, Trincavelli ML, Taliani S.

Bioorg Med Chem. 2018 Dec 1;26(22):5885-5895. doi: 10.1016/j.bmc.2018.10.039. Epub 2018 Nov 1.


Studies on enantioselectivity of chiral 4-acetylamino-6-alkyloxy-2-alkylthiopyrimidines acting as antagonists of the human A3 adenosine receptor.

Cosimelli B, Greco G, Laneri S, Novellino E, Sacchi A, Collina S, Rossi D, Cosconati S, Barresi E, Taliani S, Trincavelli ML, Martini C.

Medchemcomm. 2017 Nov 9;9(1):81-86. doi: 10.1039/c7md00375g. eCollection 2018 Jan 1.


Epigenetic Modifications of the α-Synuclein Gene and Relative Protein Content Are Affected by Ageing and Physical Exercise in Blood from Healthy Subjects.

Daniele S, Costa B, Pietrobono D, Giacomelli C, Iofrida C, Trincavelli ML, Fusi J, Franzoni F, Martini C.

Oxid Med Cell Longev. 2018 Apr 15;2018:3740345. doi: 10.1155/2018/3740345. eCollection 2018.


Negative effects of a high tumour necrosis factor-α concentration on human gingival mesenchymal stem cell trophism: the use of natural compounds as modulatory agents.

Giacomelli C, Natali L, Nisi M, De Leo M, Daniele S, Costa B, Graziani F, Gabriele M, Braca A, Trincavelli ML, Martini C.

Stem Cell Res Ther. 2018 May 11;9(1):135. doi: 10.1186/s13287-018-0880-7.


α-Synuclein Heterocomplexes with β-Amyloid Are Increased in Red Blood Cells of Parkinson's Disease Patients and Correlate with Disease Severity.

Daniele S, Frosini D, Pietrobono D, Petrozzi L, Lo Gerfo A, Baldacci F, Fusi J, Giacomelli C, Siciliano G, Trincavelli ML, Franzoni F, Ceravolo R, Martini C, Bonuccelli U.

Front Mol Neurosci. 2018 Feb 22;11:53. doi: 10.3389/fnmol.2018.00053. eCollection 2018.


The A2B Adenosine Receptor Modulates the Epithelial- Mesenchymal Transition through the Balance of cAMP/PKA and MAPK/ERK Pathway Activation in Human Epithelial Lung Cells.

Giacomelli C, Daniele S, Romei C, Tavanti L, Neri T, Piano I, Celi A, Martini C, Trincavelli ML.

Front Pharmacol. 2018 Jan 31;9:54. doi: 10.3389/fphar.2018.00054. eCollection 2018.


α-Synuclein Aggregated with Tau and β-Amyloid in Human Platelets from Healthy Subjects: Correlation with Physical Exercise.

Daniele S, Pietrobono D, Fusi J, Lo Gerfo A, Cerri E, Chico L, Iofrida C, Petrozzi L, Baldacci F, Giacomelli C, Galetta F, Siciliano G, Bonuccelli U, Trincavelli ML, Franzoni F, Martini C.

Front Aging Neurosci. 2018 Jan 30;10:17. doi: 10.3389/fnagi.2018.00017. eCollection 2018.


Carnosol controls the human glioblastoma stemness features through the epithelial-mesenchymal transition modulation and the induction of cancer stem cell apoptosis.

Giacomelli C, Daniele S, Natali L, Iofrida C, Flamini G, Braca A, Trincavelli ML, Martini C.

Sci Rep. 2017 Nov 9;7(1):15174. doi: 10.1038/s41598-017-15360-2.


Dual MET and SMO Negative Modulators Overcome Resistance to EGFR Inhibitors in Human Nonsmall Cell Lung Cancer.

Morgillo F, Amendola G, Della Corte CM, Giacomelli C, Botta L, Di Maro S, Messere A, Ciaramella V, Taliani S, Marinelli L, Trincavelli ML, Martini C, Novellino E, Ciardiello F, Cosconati S.

J Med Chem. 2017 Sep 14;60(17):7447-7458. doi: 10.1021/acs.jmedchem.7b00794. Epub 2017 Aug 22.


Influence of physical exercise on β-amyloid, α-synuclein and tau accumulation: an in vitro model of oxidative stress in human red blood cells.

Iofrida C, Daniele S, Pietrobono D, Fusi J, Galetta F, Trincavelli ML, Bonuccelli U, Franzoni F, Martini C.

Arch Ital Biol. 2017 Jul 1;155(1-2):33-42. doi: 10.12871/000398292017124.


α-Synuclein Aggregates with β-Amyloid or Tau in Human Red Blood Cells: Correlation with Antioxidant Capability and Physical Exercise in Human Healthy Subjects.

Daniele S, Pietrobono D, Fusi J, Iofrida C, Chico L, Petrozzi L, Gerfo AL, Baldacci F, Galetta F, Siciliano G, Bonuccelli U, Santoro G, Trincavelli ML, Franzoni F, Martini C.

Mol Neurobiol. 2018 Mar;55(3):2653-2675. doi: 10.1007/s12035-017-0523-5. Epub 2017 Apr 18.


Bax Activation Blocks Self-Renewal and Induces Apoptosis of Human Glioblastoma Stem Cells.

Daniele S, Pietrobono D, Costa B, Giustiniano M, La Pietra V, Giacomelli C, La Regina G, Silvestri R, Taliani S, Trincavelli ML, Da Settimo F, Novellino E, Martini C, Marinelli L.

ACS Chem Neurosci. 2018 Jan 17;9(1):85-99. doi: 10.1021/acschemneuro.7b00023. Epub 2017 Apr 11.


Osteogenesis Is Improved by Low Tumor Necrosis Factor Alpha Concentration through the Modulation of Gs-Coupled Receptor Signals.

Daniele S, Natali L, Giacomelli C, Campiglia P, Novellino E, Martini C, Trincavelli ML.

Mol Cell Biol. 2017 Mar 31;37(8). pii: e00442-16. doi: 10.1128/MCB.00442-16. Print 2017 Apr 15.


4-amino-6-alkyloxy-2-alkylthiopyrimidine derivatives as novel non-nucleoside agonists for the adenosine A1 receptor.

Cosimelli B, Greco G, Laneri S, Novellino E, Sacchi A, Trincavelli ML, Giacomelli C, Taliani S, Da Settimo F, Martini C.

Chem Biol Drug Des. 2016 Nov;88(5):724-729. doi: 10.1111/cbdd.12801. Epub 2016 Jul 11.


Toward PET imaging of A2B adenosine receptors: a carbon-11 labeled triazinobenzimidazole tracer: Synthesis and imaging of a new A2B PET tracer.

Petroni D, Giacomelli C, Taliani S, Barresi E, Robello M, Daniele S, Bartoli A, Burchielli S, Pardini S, Salvadori PA, Da Settimo F, Martini C, Trincavelli ML, Menichetti L.

Nucl Med Biol. 2016 May;43(5):309-17. doi: 10.1016/j.nucmedbio.2016.02.005. Epub 2016 Feb 27.


A promiscuous recognition mechanism between GPR17 and SDF-1: Molecular insights.

Parravicini C, Daniele S, Palazzolo L, Trincavelli ML, Martini C, Zaratin P, Primi R, Coppolino G, Gianazza E, Abbracchio MP, Eberini I.

Cell Signal. 2016 Jun;28(6):631-42. doi: 10.1016/j.cellsig.2016.03.001. Epub 2016 Mar 10.


New insights into the anticancer activity of carnosol: p53 reactivation in the U87MG human glioblastoma cell line.

Giacomelli C, Natali L, Trincavelli ML, Daniele S, Bertoli A, Flamini G, Braca A, Martini C.

Int J Biochem Cell Biol. 2016 May;74:95-108. doi: 10.1016/j.biocel.2016.02.019. Epub 2016 Mar 3.


Long lasting MDM2/Translocator protein modulator: a new strategy for irreversible apoptosis of human glioblastoma cells.

Daniele S, Barresi E, Zappelli E, Marinelli L, Novellino E, Da Settimo F, Taliani S, Trincavelli ML, Martini C.

Oncotarget. 2016 Feb 16;7(7):7866-84. doi: 10.18632/oncotarget.6872.


Copper binding to naturally occurring, lactam form of angiogenin differs from that to recombinant protein, affecting their activity.

La Mendola D, Arnesano F, Hansson Ö, Giacomelli C, Calò V, Mangini V, Magrì A, Bellia F, Trincavelli ML, Martini C, Natile G, Rizzarelli E.

Metallomics. 2016 Jan;8(1):118-24. doi: 10.1039/c5mt00216h.


Lactate dehydrogenase-A inhibition induces human glioblastoma multiforme stem cell differentiation and death.

Daniele S, Giacomelli C, Zappelli E, Granchi C, Trincavelli ML, Minutolo F, Martini C.

Sci Rep. 2015 Oct 23;5:15556. doi: 10.1038/srep15556.


The ubiquitin ligase Mdm2 controls oligodendrocyte maturation by intertwining mTOR with G protein-coupled receptor kinase 2 in the regulation of GPR17 receptor desensitization.

Fumagalli M, Bonfanti E, Daniele S, Zappelli E, Lecca D, Martini C, Trincavelli ML, Abbracchio MP.

Glia. 2015 Dec;63(12):2327-39. doi: 10.1002/glia.22896. Epub 2015 Jul 31.


♦Copper (II) ions modulate Angiogenin activity in human endothelial cells.

Giacomelli C, Trincavelli ML, Satriano C, Hansson Ö, La Mendola D, Rizzarelli E, Martini C.

Int J Biochem Cell Biol. 2015 Mar;60:185-96. doi: 10.1016/j.biocel.2015.01.005. Epub 2015 Jan 14.


Further studies on pyrazolo[1',5':1,6]pyrimido[4,5-d]pyridazin-4(3H)-ones as potent and selective human A1 adenosine receptor antagonists.

Giovannoni MP, Ciciani G, Cilibrizzi A, Crocetti L, Daniele S, Di Cesare Mannelli L, Ghelardini C, Giacomelli C, Guerrini G, Martini C, Trincavelli ML, Vergelli C.

Eur J Med Chem. 2015 Jan 7;89:32-41. doi: 10.1016/j.ejmech.2014.10.020. Epub 2014 Oct 12.


Modulation of A1 and A2B adenosine receptor activity: a new strategy to sensitise glioblastoma stem cells to chemotherapy.

Daniele S, Zappelli E, Natali L, Martini C, Trincavelli ML.

Cell Death Dis. 2014 Nov 27;5:e1539. doi: 10.1038/cddis.2014.487.


Osteoblast differentiation and survival: A role for A2B adenosine receptor allosteric modulators.

Trincavelli ML, Daniele S, Giacomelli C, Taliani S, Da Settimo F, Cosimelli B, Greco G, Novellino E, Martini C.

Biochim Biophys Acta. 2014 Dec;1843(12):2957-66. doi: 10.1016/j.bbamcr.2014.09.013. Epub 2014 Sep 18.


Oxysterols act as promiscuous ligands of class-A GPCRs: in silico molecular modeling and in vitro validation.

Sensi C, Daniele S, Parravicini C, Zappelli E, Russo V, Trincavelli ML, Martini C, Abbracchio MP, Eberini I.

Cell Signal. 2014 Dec;26(12):2614-20. doi: 10.1016/j.cellsig.2014.08.003. Epub 2014 Aug 22.


Apoptosis therapy in cancer: the first single-molecule co-activating p53 and the translocator protein in glioblastoma.

Daniele S, Taliani S, Da Pozzo E, Giacomelli C, Costa B, Trincavelli ML, Rossi L, La Pietra V, Barresi E, Carotenuto A, Limatola A, Lamberti A, Marinelli L, Novellino E, Da Settimo F, Martini C.

Sci Rep. 2014 Apr 23;4:4749. doi: 10.1038/srep04749.


A rapid and efficient immunoenzymatic assay to detect receptor protein interactions: G protein-coupled receptors.

Zappelli E, Daniele S, Abbracchio MP, Martini C, Trincavelli ML.

Int J Mol Sci. 2014 Apr 11;15(4):6252-64. doi: 10.3390/ijms15046252.


Does GRK-β arrestin machinery work as a "switch on" for GPR17-mediated activation of intracellular signaling pathways?

Daniele S, Trincavelli ML, Fumagalli M, Zappelli E, Lecca D, Bonfanti E, Campiglia P, Abbracchio MP, Martini C.

Cell Signal. 2014 Jun;26(6):1310-25. doi: 10.1016/j.cellsig.2014.02.016. Epub 2014 Mar 5.


Allosteric modulators of human A2B adenosine receptor.

Trincavelli ML, Giacomelli C, Daniele S, Taliani S, Cosimelli B, Laneri S, Severi E, Barresi E, Pugliesi I, Greco G, Novellino E, Da Settimo F, Martini C.

Biochim Biophys Acta. 2014 Mar;1840(3):1194-203. doi: 10.1016/j.bbagen.2013.12.021. Epub 2013 Dec 19.


Modulation of A2B adenosine receptor by 1-Benzyl-3-ketoindole derivatives.

Taliani S, Trincavelli ML, Cosimelli B, Laneri S, Severi E, Barresi E, Pugliesi I, Daniele S, Giacomelli C, Greco G, Novellino E, Martini C, Da Settimo F.

Eur J Med Chem. 2013 Nov;69:331-7. doi: 10.1016/j.ejmech.2013.09.001. Epub 2013 Sep 8.


New Pyrazolo[1',5':1,6]pyrimido[4,5-d]pyridazin-4(3H)-ones Fluoroderivatives as Human A1 Adenosine Receptor Ligands.

Graziano A, Giovannoni MP, Cilibrizzi A, Crocetti L, Piaz VD, Vergelli C, Trincavelli ML, Martini C, Giacomelli C.

Acta Chim Slov. 2012 Sep;59(3):648-55.


The oxysterol-CXCR2 axis plays a key role in the recruitment of tumor-promoting neutrophils.

Raccosta L, Fontana R, Maggioni D, Lanterna C, Villablanca EJ, Paniccia A, Musumeci A, Chiricozzi E, Trincavelli ML, Daniele S, Martini C, Gustafsson JA, Doglioni C, Feo SG, Leiva A, Ciampa MG, Mauri L, Sensi C, Prinetti A, Eberini I, Mora JR, Bordignon C, Steffensen KR, Sonnino S, Sozzani S, Traversari C, Russo V.

J Exp Med. 2013 Aug 26;210(9):1711-28. doi: 10.1084/jem.20130440. Epub 2013 Jul 29.


Protective effect of high-dose montelukast on salbutamol-induced homologous desensitisation in airway smooth muscle.

Fogli S, Stefanelli F, Martelli A, Daniele S, Testai L, Calderone V, Trincavelli ML, Martini C, Breschi MC.

Pulm Pharmacol Ther. 2013 Dec;26(6):693-9. doi: 10.1016/j.pupt.2013.06.006. Epub 2013 Jun 27.


Regulation of Erythropoietin Receptor Activity in Endothelial Cells by Different Erythropoietin (EPO) Derivatives: An in Vitro Study.

Trincavelli ML, Da Pozzo E, Ciampi O, Cuboni S, Daniele S, Abbracchio MP, Martini C.

Int J Mol Sci. 2013 Jan 24;14(2):2258-81. doi: 10.3390/ijms14022258.


Combining galantamine and memantine in multitargeted, new chemical entities potentially useful in Alzheimer's disease.

Simoni E, Daniele S, Bottegoni G, Pizzirani D, Trincavelli ML, Goldoni L, Tarozzo G, Reggiani A, Martini C, Piomelli D, Melchiorre C, Rosini M, Cavalli A.

J Med Chem. 2012 Nov 26;55(22):9708-21. doi: 10.1021/jm3009458. Epub 2012 Oct 17.


3-(Fur-2-yl)-10-(2-phenylethyl)-[1,2,4]triazino[4,3-a]benzimidazol-4(10H)-one, a novel adenosine receptor antagonist with A(2A)-mediated neuroprotective effects.

Scatena A, Fornai F, Trincavelli ML, Taliani S, Daniele S, Pugliesi I, Cosconati S, Martini C, Da Settimo F.

ACS Chem Neurosci. 2011 Sep 21;2(9):526-35. doi: 10.1021/cn200036s. Epub 2011 Jun 10.


Synthesis, benzodiazepine receptor binding and molecular modelling of isochromeno[4,3-c]pyrazol-5(1H)-one derivatives.

Maggio B, Raffa D, Raimondi MV, Plescia F, Trincavelli ML, Martini C, Meneghetti F, Basile L, Guccione S, Daidone G.

Eur J Med Chem. 2012 Aug;54:709-20. doi: 10.1016/j.ejmech.2012.06.028. Epub 2012 Jun 28.


Modulation of PAR(1) signalling by benzimidazole compounds.

Asteriti S, Daniele S, Porchia F, Dell'Anno MT, Fazzini A, Pugliesi I, Trincavelli ML, Taliani S, Martini C, Mazzoni MR, Gilchrist A.

Br J Pharmacol. 2012 Sep;167(1):80-94. doi: 10.1111/j.1476-5381.2012.01974.x.


3-aryl-[1,2,4]triazino[4,3-a]benzimidazol-4(10H)-one: a novel template for the design of highly selective A₂B adenosine receptor antagonists.

Taliani S, Pugliesi I, Barresi E, Simorini F, Salerno S, La Motta C, Marini AM, Cosimelli B, Cosconati S, Di Maro S, Marinelli L, Daniele S, Trincavelli ML, Greco G, Novellino E, Martini C, Da Settimo F.

J Med Chem. 2012 Feb 23;55(4):1490-9. doi: 10.1021/jm201177b. Epub 2012 Feb 7.


A new D₂ dopamine receptor agonist allosterically modulates A(2A) adenosine receptor signalling by interacting with the A(2A)/D₂ receptor heteromer.

Trincavelli ML, Daniele S, Orlandini E, Navarro G, Casadó V, Giacomelli C, Nencetti S, Nuti E, Macchia M, Huebner H, Gmeiner P, Rossello A, Lluís C, Martini C.

Cell Signal. 2012 Apr;24(4):951-60. doi: 10.1016/j.cellsig.2011.12.018. Epub 2011 Dec 30.


The GABAA-BZR complex as target for the development of anxiolytic drugs.

Trincavelli ML, Da Pozzo E, Daniele S, Martini C.

Curr Top Med Chem. 2012;12(4):254-69. Review.


Derivatives of benzimidazol-2-ylquinoline and benzimidazol-2-ylisoquinoline as selective A1 adenosine receptor antagonists with stimulant activity on human colon motility.

Cosimelli B, Taliani S, Greco G, Novellino E, Sala A, Severi E, Da Settimo F, La Motta C, Pugliesi I, Antonioli L, Fornai M, Colucci R, Blandizzi C, Daniele S, Trincavelli ML, Martini C.

ChemMedChem. 2011 Oct 4;6(10):1909-18. doi: 10.1002/cmdc.201100284. Epub 2011 Jul 27.


In silico identification of new ligands for GPR17: a promising therapeutic target for neurodegenerative diseases.

Eberini I, Daniele S, Parravicini C, Sensi C, Trincavelli ML, Martini C, Abbracchio MP.

J Comput Aided Mol Des. 2011 Aug;25(8):743-52. doi: 10.1007/s10822-011-9455-8. Epub 2011 Jul 9.


Cyclic adenosine monophosphate responsive element binding protein in post-traumatic stress disorder.

Martini C, Da Pozzo E, Carmassi C, Cuboni S, Trincavelli ML, Massimetti G, Marazziti D, Dell'Osso L.

World J Biol Psychiatry. 2013 Jul;14(5):396-402. doi: 10.3109/15622975.2011.577189. Epub 2011 Jun 23.


Agonist-induced desensitization/resensitization of human G protein-coupled receptor 17: a functional cross-talk between purinergic and cysteinyl-leukotriene ligands.

Daniele S, Trincavelli ML, Gabelloni P, Lecca D, Rosa P, Abbracchio MP, Martini C.

J Pharmacol Exp Ther. 2011 Aug;338(2):559-67. doi: 10.1124/jpet.110.178715. Epub 2011 Apr 29.


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