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A stochastic model of ion channel cluster formation in the plasma membrane.

Sato D, Hernández-Hernández G, Matsumoto C, Tajada S, Moreno CM, Dixon RE, O'Dwyer S, Navedo MF, Trimmer JS, Clancy CE, Binder MD, Santana LF.

J Gen Physiol. 2019 Aug 1. pii: jgp.201912327. doi: 10.1085/jgp.201912327. [Epub ahead of print]


Deep Sequencing of Somatosensory Neurons Reveals Molecular Determinants of Intrinsic Physiological Properties.

Zheng Y, Liu P, Bai L, Trimmer JS, Bean BP, Ginty DD.

Neuron. 2019 Jun 18. pii: S0896-6273(19)30492-1. doi: 10.1016/j.neuron.2019.05.039. [Epub ahead of print]


A toolbox of IgG subclass-switched recombinant monoclonal antibodies for enhanced multiplex immunolabeling of brain.

Andrews NP, Boeckman JX, Manning CF, Nguyen JT, Bechtold H, Dumitras C, Gong B, Nguyen K, van der List D, Murray KD, Engebrecht J, Trimmer JS.

Elife. 2019 Jan 22;8. pii: e43322. doi: 10.7554/eLife.43322.


Remodeling neuronal ER-PM junctions is a conserved nonconducting function of Kv2 plasma membrane ion channels.

Kirmiz M, Palacio S, Thapa P, King AN, Sack JT, Trimmer JS.

Mol Biol Cell. 2018 Oct 1;29(20):2410-2432. doi: 10.1091/mbc.E18-05-0337. Epub 2018 Aug 9.


Antibody validation: a view from the mountains.

Taussig MJ, Fonseca C, Trimmer JS.

N Biotechnol. 2018 Oct 25;45:1-8. doi: 10.1016/j.nbt.2018.08.002. Epub 2018 Aug 4. Review.


Gradient-reading and mechano-effector machinery for netrin-1-induced axon guidance.

Baba K, Yoshida W, Toriyama M, Shimada T, Manning CF, Saito M, Kohno K, Trimmer JS, Watanabe R, Inagaki N.

Elife. 2018 Aug 7;7. pii: e34593. doi: 10.7554/eLife.34593.


A Computational Synaptic Antibody Characterization Tool for Array Tomography.

Simhal AK, Gong B, Trimmer JS, Weinberg RJ, Smith SJ, Sapiro G, Micheva KD.

Front Neuroanat. 2018 Jul 17;12:51. doi: 10.3389/fnana.2018.00051. eCollection 2018.


Identification of VAPA and VAPB as Kv2 Channel-Interacting Proteins Defining Endoplasmic Reticulum-Plasma Membrane Junctions in Mammalian Brain Neurons.

Kirmiz M, Vierra NC, Palacio S, Trimmer JS.

J Neurosci. 2018 Aug 29;38(35):7562-7584. doi: 10.1523/JNEUROSCI.0893-18.2018. Epub 2018 Jul 16.


When monoclonal antibodies are not monospecific: Hybridomas frequently express additional functional variable regions.

Bradbury ARM, Trinklein ND, Thie H, Wilkinson IC, Tandon AK, Anderson S, Bladen CL, Jones B, Aldred SF, Bestagno M, Burrone O, Maynard J, Ferrara F, Trimmer JS, Görnemann J, Glanville J, Wolf P, Frenzel A, Wong J, Koh XY, Eng HY, Lane D, Lefranc MP, Clark M, Dübel S.

MAbs. 2018 May/Jun;10(4):539-546. doi: 10.1080/19420862.2018.1445456. Epub 2018 Mar 29.


Subcellular Localization and Activity of TRPM4 in Medial Prefrontal Cortex Layer 2/3.

Riquelme D, Silva I, Philp AM, Huidobro-Toro JP, Cerda O, Trimmer JS, Leiva-Salcedo E.

Front Cell Neurosci. 2018 Jan 30;12:12. doi: 10.3389/fncel.2018.00012. eCollection 2018.


Kv2 Ion Channels Determine the Expression and Localization of the Associated AMIGO-1 Cell Adhesion Molecule in Adult Brain Neurons.

Bishop HI, Cobb MM, Kirmiz M, Parajuli LK, Mandikian D, Philp AM, Melnik M, Kuja-Panula J, Rauvala H, Shigemoto R, Murray KD, Trimmer JS.

Front Mol Neurosci. 2018 Jan 19;11:1. doi: 10.3389/fnmol.2018.00001. eCollection 2018.


Trafficking of Kv2.1 Channels to the Axon Initial Segment by a Novel Nonconventional Secretory Pathway.

Jensen CS, Watanabe S, Stas JI, Klaphaak J, Yamane A, Schmitt N, Olesen SP, Trimmer JS, Rasmussen HB, Misonou H.

J Neurosci. 2017 Nov 29;37(48):11523-11536. doi: 10.1523/JNEUROSCI.3510-16.2017. Epub 2017 Oct 17.


Whole exome sequencing reveals a functional mutation in the GAIN domain of the Bai2 receptor underlying a forward mutagenesis hyperactivity QTL.

Speca DJ, Trimmer JS, Peterson AS, Díaz E.

Mamm Genome. 2017 Dec;28(11-12):465-475. doi: 10.1007/s00335-017-9716-5. Epub 2017 Sep 12.


Heterogeneity in Kv2 Channel Expression Shapes Action Potential Characteristics and Firing Patterns in CA1 versus CA2 Hippocampal Pyramidal Neurons.

Palacio S, Chevaleyre V, Brann DH, Murray KD, Piskorowski RA, Trimmer JS.

eNeuro. 2017 Aug 24;4(4). pii: ENEURO.0267-17.2017. doi: 10.1523/ENEURO.0267-17.2017. eCollection 2017 Jul-Aug.


Cell cycle-dependent changes in localization and phosphorylation of the plasma membrane Kv2.1 K+ channel impact endoplasmic reticulum membrane contact sites in COS-1 cells.

Cobb MM, Austin DC, Sack JT, Trimmer JS.

J Biol Chem. 2016 Mar 11;291(11):5527. doi: 10.1074/jbc.A115.690198. No abstract available.


Distribution of the SynDIG4/proline-rich transmembrane protein 1 in rat brain.

Kirk LM, Ti SW, Bishop HI, Orozco-Llamas M, Pham M, Trimmer JS, Díaz E.

J Comp Neurol. 2016 Aug 1;524(11):2266-80. doi: 10.1002/cne.23945. Epub 2015 Dec 29.


Developing high-quality mouse monoclonal antibodies for neuroscience research - approaches, perspectives and opportunities.

Gong B, Murray KD, Trimmer JS.

N Biotechnol. 2016 Sep 25;33(5 Pt A):551-64. doi: 10.1016/j.nbt.2015.11.007. Epub 2015 Nov 28.


Distinct Cell- and Layer-Specific Expression Patterns and Independent Regulation of Kv2 Channel Subtypes in Cortical Pyramidal Neurons.

Bishop HI, Guan D, Bocksteins E, Parajuli LK, Murray KD, Cobb MM, Misonou H, Zito K, Foehring RC, Trimmer JS.

J Neurosci. 2015 Nov 4;35(44):14922-42. doi: 10.1523/JNEUROSCI.1897-15.2015.


A novel epileptic encephalopathy mutation in KCNB1 disrupts Kv2.1 ion selectivity, expression, and localization.

Thiffault I, Speca DJ, Austin DC, Cobb MM, Eum KS, Safina NP, Grote L, Farrow EG, Miller N, Soden S, Kingsmore SF, Trimmer JS, Saunders CJ, Sack JT.

J Gen Physiol. 2015 Nov;146(5):399-410. doi: 10.1085/jgp.201511444.


TRPM4 Is a Novel Component of the Adhesome Required for Focal Adhesion Disassembly, Migration and Contractility.

Cáceres M, Ortiz L, Recabarren T, Romero A, Colombo A, Leiva-Salcedo E, Varela D, Rivas J, Silva I, Morales D, Campusano C, Almarza O, Simon F, Toledo H, Park KS, Trimmer JS, Cerda O.

PLoS One. 2015 Jun 25;10(6):e0130540. doi: 10.1371/journal.pone.0130540. eCollection 2015.


BK Channels Localize to the Paranodal Junction and Regulate Action Potentials in Myelinated Axons of Cerebellar Purkinje Cells.

Hirono M, Ogawa Y, Misono K, Zollinger DR, Trimmer JS, Rasband MN, Misonou H.

J Neurosci. 2015 May 6;35(18):7082-94. doi: 10.1523/JNEUROSCI.3778-14.2015.


Androgen receptor and chemokine receptors 4 and 7 form a signaling axis to regulate CXCL12-dependent cellular motility.

Hsiao JJ, Ng BH, Smits MM, Wang J, Jasavala RJ, Martinez HD, Lee J, Alston JJ, Misonou H, Trimmer JS, Wright ME.

BMC Cancer. 2015 Mar 31;15:204. doi: 10.1186/s12885-015-1201-5.


Casein kinase-mediated phosphorylation of serine 839 is necessary for basolateral localization of the Ca²⁺-activated non-selective cation channel TRPM4.

Cerda O, Cáceres M, Park KS, Leiva-Salcedo E, Romero A, Varela D, Trimmer JS, Stutzin A.

Pflugers Arch. 2015 Aug;467(8):1723-1732. doi: 10.1007/s00424-014-1610-3. Epub 2014 Sep 18.


Clarification of previously published perspective.

Trimmer JS.

Epilepsia. 2014 Sep;55(9):1469. doi: 10.1111/epi.12727. No abstract available.


Cell type-specific spatial and functional coupling between mammalian brain Kv2.1 K+ channels and ryanodine receptors.

Mandikian D, Bocksteins E, Parajuli LK, Bishop HI, Cerda O, Shigemoto R, Trimmer JS.

J Comp Neurol. 2014 Oct 15;522(15):3555-74. doi: 10.1002/cne.23641. Epub 2014 Jul 14.


Reciprocal changes in phosphorylation and methylation of mammalian brain sodium channels in response to seizures.

Baek JH, Rubinstein M, Scheuer T, Trimmer JS.

J Biol Chem. 2014 May 30;289(22):15363-73. doi: 10.1074/jbc.M114.562785. Epub 2014 Apr 15.


Ion channels and pain: important steps towards validating a new therapeutic target for neuropathic pain.

Trimmer JS.

Exp Neurol. 2014 Apr;254:190-4. doi: 10.1016/j.expneurol.2014.01.019. Epub 2014 Feb 5. No abstract available.


Deletion of the Kv2.1 delayed rectifier potassium channel leads to neuronal and behavioral hyperexcitability.

Speca DJ, Ogata G, Mandikian D, Bishop HI, Wiler SW, Eum K, Wenzel HJ, Doisy ET, Matt L, Campi KL, Golub MS, Nerbonne JM, Hell JW, Trainor BC, Sack JT, Schwartzkroin PA, Trimmer JS.

Genes Brain Behav. 2014 Apr;13(4):394-408. doi: 10.1111/gbb.12120. Epub 2014 Mar 7.


A unique ion channel clustering domain on the axon initial segment of mammalian neurons.

King AN, Manning CF, Trimmer JS.

J Comp Neurol. 2014 Aug 1;522(11):2594-608. doi: 10.1002/cne.23551.


Antibody-guided photoablation of voltage-gated potassium currents.

Sack JT, Stephanopoulos N, Austin DC, Francis MB, Trimmer JS.

J Gen Physiol. 2013 Sep;142(3):315-24. doi: 10.1085/jgp.201311023. Epub 2013 Aug 12.


Trafficking mechanisms underlying neuronal voltage-gated ion channel localization at the axon initial segment.

Vacher H, Trimmer JS.

Epilepsia. 2012 Dec;53 Suppl 9:21-31. doi: 10.1111/epi.12032. Review.


Benefits and pitfalls of secondary antibodies: why choosing the right secondary is of primary importance.

Manning CF, Bundros AM, Trimmer JS.

PLoS One. 2012;7(6):e38313. doi: 10.1371/journal.pone.0038313. Epub 2012 Jun 1.


The importance of immunohistochemical analyses in evaluating the phenotype of Kv channel knockout mice.

Menegola M, Clark E, Trimmer JS.

Epilepsia. 2012 Jun;53 Suppl 1:142-9. doi: 10.1111/j.1528-1167.2012.03485.x.


Diverse roles for auxiliary subunits in phosphorylation-dependent regulation of mammalian brain voltage-gated potassium channels.

Vacher H, Trimmer JS.

Pflugers Arch. 2011 Nov;462(5):631-43. doi: 10.1007/s00424-011-1004-8. Epub 2011 Aug 6. Review.


Activity-dependent phosphorylation of neuronal Kv2.1 potassium channels by CDK5.

Cerda O, Trimmer JS.

J Biol Chem. 2011 Aug 19;286(33):28738-48. doi: 10.1074/jbc.M111.251942. Epub 2011 Jun 28.


A SUMO-Phospho tag team for wrestling with potassium channel gating.

Mandikian D, Cerda O, Sack JT, Trimmer JS.

J Gen Physiol. 2011 May;137(5):435-9. doi: 10.1085/jgp.201110648. No abstract available.


Cdk-mediated phosphorylation of the Kvβ2 auxiliary subunit regulates Kv1 channel axonal targeting.

Vacher H, Yang JW, Cerda O, Autillo-Touati A, Dargent B, Trimmer JS.

J Cell Biol. 2011 Mar 7;192(5):813-24. doi: 10.1083/jcb.201007113. Epub 2011 Feb 28.


Mining recent brain proteomic databases for ion channel phosphosite nuggets.

Cerda O, Baek JH, Trimmer JS.

J Gen Physiol. 2011 Jan;137(1):3-16. doi: 10.1085/jgp.201010555. Epub 2010 Dec 13. Review.


How native cells regulate their ion channels.

Trimmer JS.

Semin Cell Dev Biol. 2011 Apr;22(2):131. doi: 10.1016/j.semcdb.2010.09.012. Epub 2010 Oct 24. No abstract available.


Mass spectrometry-based phosphoproteomics reveals multisite phosphorylation on mammalian brain voltage-gated sodium and potassium channels.

Baek JH, Cerda O, Trimmer JS.

Semin Cell Dev Biol. 2011 Apr;22(2):153-9. doi: 10.1016/j.semcdb.2010.09.009. Epub 2010 Oct 12. Review.


Analysis and functional implications of phosphorylation of neuronal voltage-gated potassium channels.

Cerda O, Trimmer JS.

Neurosci Lett. 2010 Dec 10;486(2):60-7. doi: 10.1016/j.neulet.2010.06.064. Epub 2010 Jun 30. Review.


SynDIG1: an activity-regulated, AMPA- receptor-interacting transmembrane protein that regulates excitatory synapse development.

Kalashnikova E, Lorca RA, Kaur I, Barisone GA, Li B, Ishimaru T, Trimmer JS, Mohapatra DP, Díaz E.

Neuron. 2010 Jan 14;65(1):80-93. doi: 10.1016/j.neuron.2009.12.021.


Multisite phosphorylation of voltage-gated sodium channel alpha subunits from rat brain.

Berendt FJ, Park KS, Trimmer JS.

J Proteome Res. 2010 Apr 5;9(4):1976-84. doi: 10.1021/pr901171q.


ADAM22, a Kv1 channel-interacting protein, recruits membrane-associated guanylate kinases to juxtaparanodes of myelinated axons.

Ogawa Y, Oses-Prieto J, Kim MY, Horresh I, Peles E, Burlingame AL, Trimmer JS, Meijer D, Rasband MN.

J Neurosci. 2010 Jan 20;30(3):1038-48. doi: 10.1523/JNEUROSCI.4661-09.2010.


A novel cyclic nucleotide-gated ion channel enriched in synaptic terminals of isotocin neurons in zebrafish brain and pituitary.

Khan S, Perry C, Tetreault ML, Henry D, Trimmer JS, Zimmerman AL, Matthews G.

Neuroscience. 2010 Jan 13;165(1):79-89. doi: 10.1016/j.neuroscience.2009.09.040. Epub 2009 Sep 22.


Convergent modulation of Kv4.2 channel alpha subunits by structurally distinct DPPX and KChIP auxiliary subunits.

Seikel E, Trimmer JS.

Biochemistry. 2009 Jun 23;48(24):5721-30. doi: 10.1021/bi802316m.


Complete 3D visualization of primate striosomes by KChIP1 immunostaining.

Mikula S, Parrish SK, Trimmer JS, Jones EG.

J Comp Neurol. 2009 Jun 10;514(5):507-17. doi: 10.1002/cne.22051.


Regulation of intrinsic excitability in hippocampal neurons by activity-dependent modulation of the KV2.1 potassium channel.

Mohapatra DP, Misonou H, Pan SJ, Held JE, Surmeier DJ, Trimmer JS.

Channels (Austin). 2009 Jan-Feb;3(1):46-56.

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