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Items: 1 to 50 of 192

1.

Phosphorylation of the HCN channel auxiliary subunit TRIP8b is altered in an animal model of temporal lobe epilepsy and modulates channel function.

Foote KM, Lyman KA, Han Y, Michailidis IE, Heuermann RJ, Mandikian D, Trimmer JS, Swanson GT, Chetkovich DM.

J Biol Chem. 2019 Sep 5. pii: jbc.RA119.010027. doi: 10.1074/jbc.RA119.010027. [Epub ahead of print]

2.

A stochastic model of ion channel cluster formation in the plasma membrane.

Sato D, Hernández-Hernández G, Matsumoto C, Tajada S, Moreno CM, Dixon RE, O'Dwyer S, Navedo MF, Trimmer JS, Clancy CE, Binder MD, Santana LF.

J Gen Physiol. 2019 Sep 2;151(9):1116-1134. doi: 10.1085/jgp.201912327. Epub 2019 Aug 1.

PMID:
31371391
3.

Deep Sequencing of Somatosensory Neurons Reveals Molecular Determinants of Intrinsic Physiological Properties.

Zheng Y, Liu P, Bai L, Trimmer JS, Bean BP, Ginty DD.

Neuron. 2019 Aug 21;103(4):598-616.e7. doi: 10.1016/j.neuron.2019.05.039. Epub 2019 Jun 24.

PMID:
31248728
4.

Aligning Product Chemistry and Soil Context for Agronomic Reuse of Human-Derived Resources.

Trimmer JT, Margenot AJ, Cusick RD, Guest JS.

Environ Sci Technol. 2019 Jun 4;53(11):6501-6510. doi: 10.1021/acs.est.9b00504. Epub 2019 May 2.

PMID:
31017776
5.

Targeting ferroptosis: A novel therapeutic strategy for the treatment of mitochondrial disease-related epilepsy.

Kahn-Kirby AH, Amagata A, Maeder CI, Mei JJ, Sideris S, Kosaka Y, Hinman A, Malone SA, Bruegger JJ, Wang L, Kim V, Shrader WD, Hoff KG, Latham JC, Ashley EA, Wheeler MT, Bertini E, Carrozzo R, Martinelli D, Dionisi-Vici C, Chapman KA, Enns GM, Gahl W, Wolfe L, Saneto RP, Johnson SC, Trimmer JK, Klein MB, Holst CR.

PLoS One. 2019 Mar 28;14(3):e0214250. doi: 10.1371/journal.pone.0214250. eCollection 2019.

6.

A toolbox of IgG subclass-switched recombinant monoclonal antibodies for enhanced multiplex immunolabeling of brain.

Andrews NP, Boeckman JX, Manning CF, Nguyen JT, Bechtold H, Dumitras C, Gong B, Nguyen K, van der List D, Murray KD, Engebrecht J, Trimmer JS.

Elife. 2019 Jan 22;8. pii: e43322. doi: 10.7554/eLife.43322.

7.

Vitamin E hydroquinone is an endogenous regulator of ferroptosis via redox control of 15-lipoxygenase.

Hinman A, Holst CR, Latham JC, Bruegger JJ, Ulas G, McCusker KP, Amagata A, Davis D, Hoff KG, Kahn-Kirby AH, Kim V, Kosaka Y, Lee E, Malone SA, Mei JJ, Richards SJ, Rivera V, Miller G, Trimmer JK, Shrader WD.

PLoS One. 2018 Aug 15;13(8):e0201369. doi: 10.1371/journal.pone.0201369. eCollection 2018.

8.

Remodeling neuronal ER-PM junctions is a conserved nonconducting function of Kv2 plasma membrane ion channels.

Kirmiz M, Palacio S, Thapa P, King AN, Sack JT, Trimmer JS.

Mol Biol Cell. 2018 Oct 1;29(20):2410-2432. doi: 10.1091/mbc.E18-05-0337. Epub 2018 Aug 9.

9.

Antibody validation: a view from the mountains.

Taussig MJ, Fonseca C, Trimmer JS.

N Biotechnol. 2018 Oct 25;45:1-8. doi: 10.1016/j.nbt.2018.08.002. Epub 2018 Aug 4. Review.

PMID:
30086383
10.

Gradient-reading and mechano-effector machinery for netrin-1-induced axon guidance.

Baba K, Yoshida W, Toriyama M, Shimada T, Manning CF, Saito M, Kohno K, Trimmer JS, Watanabe R, Inagaki N.

Elife. 2018 Aug 7;7. pii: e34593. doi: 10.7554/eLife.34593.

11.

A Computational Synaptic Antibody Characterization Tool for Array Tomography.

Simhal AK, Gong B, Trimmer JS, Weinberg RJ, Smith SJ, Sapiro G, Micheva KD.

Front Neuroanat. 2018 Jul 17;12:51. doi: 10.3389/fnana.2018.00051. eCollection 2018.

12.

Identification of VAPA and VAPB as Kv2 Channel-Interacting Proteins Defining Endoplasmic Reticulum-Plasma Membrane Junctions in Mammalian Brain Neurons.

Kirmiz M, Vierra NC, Palacio S, Trimmer JS.

J Neurosci. 2018 Aug 29;38(35):7562-7584. doi: 10.1523/JNEUROSCI.0893-18.2018. Epub 2018 Jul 16.

13.

Child soil ingestion in rural Ghana - frequency, caregiver perceptions, relationship with household floor material and associations with child diarrhoea.

Bauza V, Byrne DM, Trimmer JT, Lardizabal A, Atiim P, Asigbee MAK, Guest JS.

Trop Med Int Health. 2018 May;23(5):558-569. doi: 10.1111/tmi.13050. Epub 2018 Apr 10.

14.

When monoclonal antibodies are not monospecific: Hybridomas frequently express additional functional variable regions.

Bradbury ARM, Trinklein ND, Thie H, Wilkinson IC, Tandon AK, Anderson S, Bladen CL, Jones B, Aldred SF, Bestagno M, Burrone O, Maynard J, Ferrara F, Trimmer JS, Görnemann J, Glanville J, Wolf P, Frenzel A, Wong J, Koh XY, Eng HY, Lane D, Lefranc MP, Clark M, Dübel S.

MAbs. 2018 May/Jun;10(4):539-546. doi: 10.1080/19420862.2018.1445456. Epub 2018 Mar 29.

15.

Subcellular Localization and Activity of TRPM4 in Medial Prefrontal Cortex Layer 2/3.

Riquelme D, Silva I, Philp AM, Huidobro-Toro JP, Cerda O, Trimmer JS, Leiva-Salcedo E.

Front Cell Neurosci. 2018 Jan 30;12:12. doi: 10.3389/fncel.2018.00012. eCollection 2018.

16.

Kv2 Ion Channels Determine the Expression and Localization of the Associated AMIGO-1 Cell Adhesion Molecule in Adult Brain Neurons.

Bishop HI, Cobb MM, Kirmiz M, Parajuli LK, Mandikian D, Philp AM, Melnik M, Kuja-Panula J, Rauvala H, Shigemoto R, Murray KD, Trimmer JS.

Front Mol Neurosci. 2018 Jan 19;11:1. doi: 10.3389/fnmol.2018.00001. eCollection 2018.

17.

Trafficking of Kv2.1 Channels to the Axon Initial Segment by a Novel Nonconventional Secretory Pathway.

Jensen CS, Watanabe S, Stas JI, Klaphaak J, Yamane A, Schmitt N, Olesen SP, Trimmer JS, Rasmussen HB, Misonou H.

J Neurosci. 2017 Nov 29;37(48):11523-11536. doi: 10.1523/JNEUROSCI.3510-16.2017. Epub 2017 Oct 17.

18.

Whole exome sequencing reveals a functional mutation in the GAIN domain of the Bai2 receptor underlying a forward mutagenesis hyperactivity QTL.

Speca DJ, Trimmer JS, Peterson AS, Díaz E.

Mamm Genome. 2017 Dec;28(11-12):465-475. doi: 10.1007/s00335-017-9716-5. Epub 2017 Sep 12.

19.

Amplifying Progress toward Multiple Development Goals through Resource Recovery from Sanitation.

Trimmer JT, Cusick RD, Guest JS.

Environ Sci Technol. 2017 Sep 19;51(18):10765-10776. doi: 10.1021/acs.est.7b02147. Epub 2017 Sep 6.

PMID:
28875704
20.

Heterogeneity in Kv2 Channel Expression Shapes Action Potential Characteristics and Firing Patterns in CA1 versus CA2 Hippocampal Pyramidal Neurons.

Palacio S, Chevaleyre V, Brann DH, Murray KD, Piskorowski RA, Trimmer JS.

eNeuro. 2017 Aug 24;4(4). pii: ENEURO.0267-17.2017. doi: 10.1523/ENEURO.0267-17.2017. eCollection 2017 Jul-Aug.

21.

Branched-chain amino acid restriction in Zucker-fatty rats improves muscle insulin sensitivity by enhancing efficiency of fatty acid oxidation and acyl-glycine export.

White PJ, Lapworth AL, An J, Wang L, McGarrah RW, Stevens RD, Ilkayeva O, George T, Muehlbauer MJ, Bain JR, Trimmer JK, Brosnan MJ, Rolph TP, Newgard CB.

Mol Metab. 2016 Apr 22;5(7):538-551. doi: 10.1016/j.molmet.2016.04.006. eCollection 2016 Jul.

22.

Cell cycle-dependent changes in localization and phosphorylation of the plasma membrane Kv2.1 K+ channel impact endoplasmic reticulum membrane contact sites in COS-1 cells.

Cobb MM, Austin DC, Sack JT, Trimmer JS.

J Biol Chem. 2016 Mar 11;291(11):5527. doi: 10.1074/jbc.A115.690198. No abstract available.

23.

A Long-Acting FGF21 Molecule, PF-05231023, Decreases Body Weight and Improves Lipid Profile in Non-human Primates and Type 2 Diabetic Subjects.

Talukdar S, Zhou Y, Li D, Rossulek M, Dong J, Somayaji V, Weng Y, Clark R, Lanba A, Owen BM, Brenner MB, Trimmer JK, Gropp KE, Chabot JR, Erion DM, Rolph TP, Goodwin B, Calle RA.

Cell Metab. 2016 Mar 8;23(3):427-40. doi: 10.1016/j.cmet.2016.02.001.

24.

Viability and fate of Cryptosporidium parvum and Giardia lamblia in tubular anaerobic digesters.

Kinyua MN, Trimmer J, Izurieta R, Cunningham J, Ergas SJ.

Sci Total Environ. 2016 Jun 1;554-555:167-77. doi: 10.1016/j.scitotenv.2016.02.170. Epub 2016 Mar 5.

PMID:
26950630
25.

Distribution of the SynDIG4/proline-rich transmembrane protein 1 in rat brain.

Kirk LM, Ti SW, Bishop HI, Orozco-Llamas M, Pham M, Trimmer JS, Díaz E.

J Comp Neurol. 2016 Aug 1;524(11):2266-80. doi: 10.1002/cne.23945. Epub 2015 Dec 29.

26.

Developing high-quality mouse monoclonal antibodies for neuroscience research - approaches, perspectives and opportunities.

Gong B, Murray KD, Trimmer JS.

N Biotechnol. 2016 Sep 25;33(5 Pt A):551-64. doi: 10.1016/j.nbt.2015.11.007. Epub 2015 Nov 28.

27.

Distinct Cell- and Layer-Specific Expression Patterns and Independent Regulation of Kv2 Channel Subtypes in Cortical Pyramidal Neurons.

Bishop HI, Guan D, Bocksteins E, Parajuli LK, Murray KD, Cobb MM, Misonou H, Zito K, Foehring RC, Trimmer JS.

J Neurosci. 2015 Nov 4;35(44):14922-42. doi: 10.1523/JNEUROSCI.1897-15.2015.

28.

A novel epileptic encephalopathy mutation in KCNB1 disrupts Kv2.1 ion selectivity, expression, and localization.

Thiffault I, Speca DJ, Austin DC, Cobb MM, Eum KS, Safina NP, Grote L, Farrow EG, Miller N, Soden S, Kingsmore SF, Trimmer JS, Saunders CJ, Sack JT.

J Gen Physiol. 2015 Nov;146(5):399-410. doi: 10.1085/jgp.201511444.

29.
30.

Isocitrate-to-SENP1 signaling amplifies insulin secretion and rescues dysfunctional β cells.

Ferdaoussi M, Dai X, Jensen MV, Wang R, Peterson BS, Huang C, Ilkayeva O, Smith N, Miller N, Hajmrle C, Spigelman AF, Wright RC, Plummer G, Suzuki K, Mackay JP, van de Bunt M, Gloyn AL, Ryan TE, Norquay LD, Brosnan MJ, Trimmer JK, Rolph TP, Kibbey RG, Manning Fox JE, Colmers WF, Shirihai OS, Neufer PD, Yeh ET, Newgard CB, MacDonald PE.

J Clin Invest. 2015 Oct 1;125(10):3847-60. doi: 10.1172/JCI82498. Epub 2015 Sep 21.

31.

Impact of combined resistance and aerobic exercise training on branched-chain amino acid turnover, glycine metabolism and insulin sensitivity in overweight humans.

Glynn EL, Piner LW, Huffman KM, Slentz CA, Elliot-Penry L, AbouAssi H, White PJ, Bain JR, Muehlbauer MJ, Ilkayeva OR, Stevens RD, Porter Starr KN, Bales CW, Volpi E, Brosnan MJ, Trimmer JK, Rolph TP, Newgard CB, Kraus WE.

Diabetologia. 2015 Oct;58(10):2324-35. doi: 10.1007/s00125-015-3705-6. Epub 2015 Aug 9.

32.

TRPM4 Is a Novel Component of the Adhesome Required for Focal Adhesion Disassembly, Migration and Contractility.

Cáceres M, Ortiz L, Recabarren T, Romero A, Colombo A, Leiva-Salcedo E, Varela D, Rivas J, Silva I, Morales D, Campusano C, Almarza O, Simon F, Toledo H, Park KS, Trimmer JS, Cerda O.

PLoS One. 2015 Jun 25;10(6):e0130540. doi: 10.1371/journal.pone.0130540. eCollection 2015.

33.

Metabolomic identification of a novel pathway of blood pressure regulation involving hexadecanedioate.

Menni C, Graham D, Kastenmüller G, Alharbi NH, Alsanosi SM, McBride M, Mangino M, Titcombe P, Shin SY, Psatha M, Geisendorfer T, Huber A, Peters A, Wang-Sattler R, Xu T, Brosnan MJ, Trimmer J, Reichel C, Mohney RP, Soranzo N, Edwards MH, Cooper C, Church AC, Suhre K, Gieger C, Dominiczak AF, Spector TD, Padmanabhan S, Valdes AM.

Hypertension. 2015 Aug;66(2):422-9. doi: 10.1161/HYPERTENSIONAHA.115.05544. Epub 2015 Jun 1.

34.

BK Channels Localize to the Paranodal Junction and Regulate Action Potentials in Myelinated Axons of Cerebellar Purkinje Cells.

Hirono M, Ogawa Y, Misono K, Zollinger DR, Trimmer JS, Rasband MN, Misonou H.

J Neurosci. 2015 May 6;35(18):7082-94. doi: 10.1523/JNEUROSCI.3778-14.2015.

35.

Androgen receptor and chemokine receptors 4 and 7 form a signaling axis to regulate CXCL12-dependent cellular motility.

Hsiao JJ, Ng BH, Smits MM, Wang J, Jasavala RJ, Martinez HD, Lee J, Alston JJ, Misonou H, Trimmer JS, Wright ME.

BMC Cancer. 2015 Mar 31;15:204. doi: 10.1186/s12885-015-1201-5.

36.
37.

Metabolomic study of carotid-femoral pulse-wave velocity in women.

Menni C, Mangino M, Cecelja M, Psatha M, Brosnan MJ, Trimmer J, Mohney RP, Chowienczyk P, Padmanabhan S, Spector TD, Valdes AM.

J Hypertens. 2015 Apr;33(4):791-6; discussion 796. doi: 10.1097/HJH.0000000000000467.

38.

Casein kinase-mediated phosphorylation of serine 839 is necessary for basolateral localization of the Ca²⁺-activated non-selective cation channel TRPM4.

Cerda O, Cáceres M, Park KS, Leiva-Salcedo E, Romero A, Varela D, Trimmer JS, Stutzin A.

Pflugers Arch. 2015 Aug;467(8):1723-1732. doi: 10.1007/s00424-014-1610-3. Epub 2014 Sep 18.

39.

Clarification of previously published perspective.

Trimmer JS.

Epilepsia. 2014 Sep;55(9):1469. doi: 10.1111/epi.12727. No abstract available.

40.

When to say no and walk away.

Trimmer J.

MGMA Connex. 2014 Apr;14(4):29-30. No abstract available.

PMID:
25167652
41.

Cell type-specific spatial and functional coupling between mammalian brain Kv2.1 K+ channels and ryanodine receptors.

Mandikian D, Bocksteins E, Parajuli LK, Bishop HI, Cerda O, Shigemoto R, Trimmer JS.

J Comp Neurol. 2014 Oct 15;522(15):3555-74. doi: 10.1002/cne.23641. Epub 2014 Jul 14.

42.

The hepatoselective glucokinase activator PF-04991532 ameliorates hyperglycemia without causing hepatic steatosis in diabetic rats.

Erion DM, Lapworth A, Amor PA, Bai G, Vera NB, Clark RW, Yan Q, Zhu Y, Ross TT, Purkal J, Gorgoglione M, Zhang G, Bonato V, Baker L, Barucci N, D'Aquila T, Robertson A, Aiello RJ, Yan J, Trimmer J, Rolph TP, Pfefferkorn JA.

PLoS One. 2014 May 23;9(5):e97139. doi: 10.1371/journal.pone.0097139. eCollection 2014.

43.

An atlas of genetic influences on human blood metabolites.

Shin SY, Fauman EB, Petersen AK, Krumsiek J, Santos R, Huang J, Arnold M, Erte I, Forgetta V, Yang TP, Walter K, Menni C, Chen L, Vasquez L, Valdes AM, Hyde CL, Wang V, Ziemek D, Roberts P, Xi L, Grundberg E; Multiple Tissue Human Expression Resource (MuTHER) Consortium, Waldenberger M, Richards JB, Mohney RP, Milburn MV, John SL, Trimmer J, Theis FJ, Overington JP, Suhre K, Brosnan MJ, Gieger C, Kastenmüller G, Spector TD, Soranzo N.

Nat Genet. 2014 Jun;46(6):543-550. doi: 10.1038/ng.2982. Epub 2014 May 11.

44.

Reciprocal changes in phosphorylation and methylation of mammalian brain sodium channels in response to seizures.

Baek JH, Rubinstein M, Scheuer T, Trimmer JS.

J Biol Chem. 2014 May 30;289(22):15363-73. doi: 10.1074/jbc.M114.562785. Epub 2014 Apr 15.

45.

Loss-of-function mutations in SLC30A8 protect against type 2 diabetes.

Flannick J, Thorleifsson G, Beer NL, Jacobs SB, Grarup N, Burtt NP, Mahajan A, Fuchsberger C, Atzmon G, Benediktsson R, Blangero J, Bowden DW, Brandslund I, Brosnan J, Burslem F, Chambers J, Cho YS, Christensen C, Douglas DA, Duggirala R, Dymek Z, Farjoun Y, Fennell T, Fontanillas P, Forsén T, Gabriel S, Glaser B, Gudbjartsson DF, Hanis C, Hansen T, Hreidarsson AB, Hveem K, Ingelsson E, Isomaa B, Johansson S, Jørgensen T, Jørgensen ME, Kathiresan S, Kong A, Kooner J, Kravic J, Laakso M, Lee JY, Lind L, Lindgren CM, Linneberg A, Masson G, Meitinger T, Mohlke KL, Molven A, Morris AP, Potluri S, Rauramaa R, Ribel-Madsen R, Richard AM, Rolph T, Salomaa V, Segrè AV, Skärstrand H, Steinthorsdottir V, Stringham HM, Sulem P, Tai ES, Teo YY, Teslovich T, Thorsteinsdottir U, Trimmer JK, Tuomi T, Tuomilehto J, Vaziri-Sani F, Voight BF, Wilson JG, Boehnke M, McCarthy MI, Njølstad PR, Pedersen O; Go-T2D Consortium; T2D-GENES Consortium, Groop L, Cox DR, Stefansson K, Altshuler D.

Nat Genet. 2014 Apr;46(4):357-63. doi: 10.1038/ng.2915. Epub 2014 Mar 2.

46.

Ion channels and pain: important steps towards validating a new therapeutic target for neuropathic pain.

Trimmer JS.

Exp Neurol. 2014 Apr;254:190-4. doi: 10.1016/j.expneurol.2014.01.019. Epub 2014 Feb 5. No abstract available.

47.

Deletion of the Kv2.1 delayed rectifier potassium channel leads to neuronal and behavioral hyperexcitability.

Speca DJ, Ogata G, Mandikian D, Bishop HI, Wiler SW, Eum K, Wenzel HJ, Doisy ET, Matt L, Campi KL, Golub MS, Nerbonne JM, Hell JW, Trainor BC, Sack JT, Schwartzkroin PA, Trimmer JS.

Genes Brain Behav. 2014 Apr;13(4):394-408. doi: 10.1111/gbb.12120. Epub 2014 Mar 7.

48.

A unique ion channel clustering domain on the axon initial segment of mammalian neurons.

King AN, Manning CF, Trimmer JS.

J Comp Neurol. 2014 Aug 1;522(11):2594-608. doi: 10.1002/cne.23551.

49.

Direct assessment of hepatic mitochondrial oxidative and anaplerotic fluxes in humans using dynamic 13C magnetic resonance spectroscopy.

Befroy DE, Perry RJ, Jain N, Dufour S, Cline GW, Trimmer JK, Brosnan J, Rothman DL, Petersen KF, Shulman GI.

Nat Med. 2014 Jan;20(1):98-102. doi: 10.1038/nm.3415. Epub 2013 Dec 8.

50.

Assessing the phenotypic effects in the general population of rare variants in genes for a dominant Mendelian form of diabetes.

Flannick J, Beer NL, Bick AG, Agarwala V, Molnes J, Gupta N, Burtt NP, Florez JC, Meigs JB, Taylor H, Lyssenko V, Irgens H, Fox E, Burslem F, Johansson S, Brosnan MJ, Trimmer JK, Newton-Cheh C, Tuomi T, Molven A, Wilson JG, O'Donnell CJ, Kathiresan S, Hirschhorn JN, Njølstad PR, Rolph T, Seidman JG, Gabriel S, Cox DR, Seidman CE, Groop L, Altshuler D.

Nat Genet. 2013 Nov;45(11):1380-5. doi: 10.1038/ng.2794. Epub 2013 Oct 6.

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