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1997 2
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TRIM38 protects H9c2 cells from hypoxia/reoxygenation injury via the TRAF6/TAK1/NF-kappaB signalling pathway.
Lu Z, Deng M, Ma G, Chen L. Lu Z, et al. PeerJ. 2022 Aug 29;10:e13815. doi: 10.7717/peerj.13815. eCollection 2022. PeerJ. 2022. PMID: 36061751 Free PMC article.
Western blotanalysisshowed that TRIM38 expression was significantly decreased after H/R injury. Functionally, TRIM38 expression relieved inflammatory responses and oxidative stress, and inhibited H/R-induced apoptosis in H9c2 cells. ...The opposite results were obse …
Western blotanalysisshowed that TRIM38 expression was significantly decreased after H/R injury. Functionally, TRIM38 expressio …
TRIM38 suppresses migration, invasion, metastasis, and proliferation in non-small cell lung cancer (NSCLC) via regulating the AMPK/NF-kappaB/NLRP3 pathway.
Zhang K, Lin G, Nie Z, Jin S, Bing X, Li Z, Li M. Zhang K, et al. Mol Cell Biochem. 2023 Aug 11. doi: 10.1007/s11010-023-04823-y. Online ahead of print. Mol Cell Biochem. 2023. PMID: 37566200
Accumulating data have revealed the pivotal function of tripartite motif protein 38 (TRIM38) in tumors. In view of this, this investigation aims to explore the function and potential mechanism of TRIM38 in non-small cell lung cancer (NSCLC). ...For exploring the rol …
Accumulating data have revealed the pivotal function of tripartite motif protein 38 (TRIM38) in tumors. In view of this, this investi …
Multifaceted roles of TRIM38 in innate immune and inflammatory responses.
Hu MM, Shu HB. Hu MM, et al. Cell Mol Immunol. 2017 Apr;14(4):331-338. doi: 10.1038/cmi.2016.66. Epub 2017 Feb 13. Cell Mol Immunol. 2017. PMID: 28194022 Free PMC article. Review.
In these processes, TRIM38 acts as an E3 ubiquitin or SUMO ligase, which targets key cellular signaling components, or as an enzymatic activity-independent regulator. This review summarizes recent advances that highlight the critical roles of TRIM38 in the regulatio …
In these processes, TRIM38 acts as an E3 ubiquitin or SUMO ligase, which targets key cellular signaling components, or as an enzymati …
TRIM38 protects chondrocytes from IL-1beta-induced apoptosis and degeneration via negatively modulating nuclear factor (NF)-kappaB signaling.
Hu S, Li Y, Wang B, Peng K. Hu S, et al. Int Immunopharmacol. 2021 Oct;99:108048. doi: 10.1016/j.intimp.2021.108048. Epub 2021 Aug 14. Int Immunopharmacol. 2021. PMID: 34426118
Tripartite motif protein 38 (TRIM38) has been documented as a vital modulator of inflammation. ...Reactivation of NF-kappaB markedly reversed TRIM38-overexpression-mediated effects, while inhibition of NF-kappaB significantly abolished TRIM38-depletion-induce …
Tripartite motif protein 38 (TRIM38) has been documented as a vital modulator of inflammation. ...Reactivation of NF-kappaB markedly …
TRIM38 regulates NF-kappaB activation through TAB2 degradation in osteoclast and osteoblast differentiation.
Kim K, Kim JH, Kim I, Seong S, Kim N. Kim K, et al. Bone. 2018 Aug;113:17-28. doi: 10.1016/j.bone.2018.05.009. Epub 2018 May 16. Bone. 2018. PMID: 29753717
However, the role of TRIM38 in osteoclast and osteoblast differentiation is not yet known. ...Ectopic expression of TRIM38 in osteoblast precursors induced increased osteoblast differentiation and function. ...
However, the role of TRIM38 in osteoclast and osteoblast differentiation is not yet known. ...Ectopic expression of TRIM38 in …
TRIM38 triggers the uniquitination and degradation of glucose transporter type 1 (GLUT1) to restrict tumor progression in bladder cancer.
Wang X, He H, Rui W, Zhang N, Zhu Y, Xie X. Wang X, et al. J Transl Med. 2021 Dec 14;19(1):508. doi: 10.1186/s12967-021-03173-x. J Transl Med. 2021. PMID: 34906161 Free PMC article.
Colony formation assay, Transwell assay, sphere formation assays were used to assess functional roles of TRIM38. TAP/MS assay was used to identify downstream substrates of TRIM38. ...Targeting TRIM38 reinforced BLCA cells proliferation, migration and stemness …
Colony formation assay, Transwell assay, sphere formation assays were used to assess functional roles of TRIM38. TAP/MS assay was use …
Tripartite motif 38 alleviates the pathological process of NAFLD-NASH by promoting TAB2 degradation.
Yao X, Dong R, Hu S, Liu Z, Cui J, Hu F, Cheng X, Wang X, Ma T, Tian S, Zhang XJ, Hu Y, Bai L, Li H, Zhang P. Yao X, et al. J Lipid Res. 2023 Jul;64(7):100382. doi: 10.1016/j.jlr.2023.100382. Epub 2023 Apr 26. J Lipid Res. 2023. PMID: 37116711 Free PMC article.
However, the functional roles of TRIM38 in NAFLD remain largely unknown. Here, the expression of TRIM38 was first detected in liver samples of both NAFLD mice model and patients diagnosed with NAFLD. ...TRIM38 could be a potential target for NAFLD treatment.. …
However, the functional roles of TRIM38 in NAFLD remain largely unknown. Here, the expression of TRIM38 was first detected in …
Investigation into the role of the MITA-TRIM38 interaction in regulating pyroptosis and maintaining immune tolerance at the maternal-fetal interface.
Liu J, Deng Y, Wang A, Liu B, Zhou X, Yin T, Wang Y, Tang T, Qiu Y, Chen J, Yang J. Liu J, et al. Cell Death Dis. 2023 Nov 28;14(11):780. doi: 10.1038/s41419-023-06314-w. Cell Death Dis. 2023. PMID: 38012139 Free PMC article.
Our findings show that the interaction between MITA and TRIM38 plays a crucial role in maintaining the immunosuppressed state of the maternal-fetal interface. Specifically, we observed that TRIM38-mediated K48 ubiquitination of MITA was higher in M2 macrophages, lea …
Our findings show that the interaction between MITA and TRIM38 plays a crucial role in maintaining the immunosuppressed state of the …
TRIM38 inhibits TNFalpha- and IL-1beta-triggered NF-kappaB activation by mediating lysosome-dependent degradation of TAB2/3.
Hu MM, Yang Q, Zhang J, Liu SM, Zhang Y, Lin H, Huang ZF, Wang YY, Zhang XD, Zhong B, Shu HB. Hu MM, et al. Proc Natl Acad Sci U S A. 2014 Jan 28;111(4):1509-14. doi: 10.1073/pnas.1318227111. Epub 2014 Jan 13. Proc Natl Acad Sci U S A. 2014. PMID: 24434549 Free PMC article.
Overexpression of TRIM38 inhibited activation of NF-kappaB and induction of downstream cytokines following TNFalpha and IL-1beta stimulation, whereas knockdown or knockout of TRIM38 had the opposite effects. ...Consistently, deficiency of TRIM38 resulted in a …
Overexpression of TRIM38 inhibited activation of NF-kappaB and induction of downstream cytokines following TNFalpha and IL-1beta stim …
TRIM38 negatively regulates TLR3-mediated IFN-beta signaling by targeting TRIF for degradation.
Xue Q, Zhou Z, Lei X, Liu X, He B, Wang J, Hung T. Xue Q, et al. PLoS One. 2012;7(10):e46825. doi: 10.1371/journal.pone.0046825. Epub 2012 Oct 8. PLoS One. 2012. PMID: 23056470 Free PMC article.
We found that overexpression of TRIM38 inhibits TLR3-mediated type I interferon signaling, whereas knockdown of TRIM38 has the reverse effects. ...TRIF is co-immunoprecipitated with TRIM38, and domain mapping experiments show that PRYSPRY of TRIM38 int …
We found that overexpression of TRIM38 inhibits TLR3-mediated type I interferon signaling, whereas knockdown of TRIM38 has the …
42 results