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Items: 1 to 50 of 181

1.

Potent and PPARĪ±-independent anti-proliferative action of the hypolipidemic drug fenofibrate in VEGF-dependent angiosarcomas in vitro.

Majeed Y, Upadhyay R, Alhousseiny S, Taha T, Musthak A, Shaheen Y, Jameel M, Triggle CR, Ding H.

Sci Rep. 2019 Apr 19;9(1):6316. doi: 10.1038/s41598-019-42838-y.

2.

Minimizing Hyperglycemia-Induced Vascular Endothelial Dysfunction by Inhibiting Endothelial Sodium-Glucose Cotransporter 2 and Attenuating Oxidative Stress: Implications for Treating Individuals With Type 2 Diabetes.

Pulakazhi Venu VK, El-Daly M, Saifeddine M, Hirota SA, Ding H, Triggle CR, Hollenberg MD.

Can J Diabetes. 2019 Jan 23. pii: S1499-2671(18)30879-7. doi: 10.1016/j.jcjd.2019.01.005. [Epub ahead of print]

PMID:
30930073
3.

Exercise Alleviates Obesity-Induced Metabolic Dysfunction via Enhancing FGF21 Sensitivity in Adipose Tissues.

Geng L, Liao B, Jin L, Huang Z, Triggle CR, Ding H, Zhang J, Huang Y, Lin Z, Xu A.

Cell Rep. 2019 Mar 5;26(10):2738-2752.e4. doi: 10.1016/j.celrep.2019.02.014.

4.

Impact of currently used anti-diabetic drugs on myoendothelial communication.

Ding H, Ye K, Triggle CR.

Curr Opin Pharmacol. 2019 Apr;45:1-7. doi: 10.1016/j.coph.2018.11.002. Epub 2018 Nov 28. Review.

PMID:
30502742
5.

Hyperglycaemic impairment of PAR2-mediated vasodilation: Prevention by inhibition of aortic endothelial sodium-glucose-co-Transporter-2 and minimizing oxidative stress.

El-Daly M, Pulakazhi Venu VK, Saifeddine M, Mihara K, Kang S, Fedak PWM, Alston LA, Hirota SA, Ding H, Triggle CR, Hollenberg MD.

Vascul Pharmacol. 2018 Oct;109:56-71. doi: 10.1016/j.vph.2018.06.006. Epub 2018 Jun 13.

PMID:
29908295
6.

Hyperglycaemia disrupts conducted vasodilation in the resistance vasculature of db/db mice.

Lemmey HAL, Ye X, Ding HC, Triggle CR, Garland CJ, Dora KA.

Vascul Pharmacol. 2018 Apr;103-105:29-35. doi: 10.1016/j.vph.2018.01.002. Epub 2018 Jan 12.

7.

Effects of oxidative and thermal stresses on stress granule formation in human induced pluripotent stem cells.

Palangi F, Samuel SM, Thompson IR, Triggle CR, Emara MM.

PLoS One. 2017 Jul 26;12(7):e0182059. doi: 10.1371/journal.pone.0182059. eCollection 2017.

8.

Metformin represses glucose starvation induced autophagic response in microvascular endothelial cells and promotes cell death.

Samuel SM, Ghosh S, Majeed Y, Arunachalam G, Emara MM, Ding H, Triggle CR.

Biochem Pharmacol. 2017 May 15;132:118-132. doi: 10.1016/j.bcp.2017.03.001. Epub 2017 Mar 6.

PMID:
28274614
9.

From Gutenberg to Open Science: An Unfulfilled Odyssey.

Triggle CR, Triggle DJ.

Drug Dev Res. 2017 Feb;78(1):3-23. doi: 10.1002/ddr.21369. Epub 2016 Oct 21.

10.

Metformin is not just an antihyperglycaemic drug but also has protective effects on the vascular endothelium.

Triggle CR, Ding H.

Acta Physiol (Oxf). 2017 Jan;219(1):138-151. doi: 10.1111/apha.12644. Epub 2016 Jan 13. Review.

PMID:
26680745
11.

Molecular Interplay between microRNA-34a and Sirtuin1 in Hyperglycemia-Mediated Impaired Angiogenesis in Endothelial Cells: Effects of Metformin.

Arunachalam G, Lakshmanan AP, Samuel SM, Triggle CR, Ding H.

J Pharmacol Exp Ther. 2016 Feb;356(2):314-23. doi: 10.1124/jpet.115.226894. Epub 2015 Nov 18.

PMID:
26582729
12.

Metformin improves endothelial function in aortic tissue and microvascular endothelial cells subjected to diabetic hyperglycaemic conditions.

Ghosh S, Lakshmanan AP, Hwang MJ, Kubba H, Mushannen A, Triggle CR, Ding H.

Biochem Pharmacol. 2015 Dec 1;98(3):412-21. doi: 10.1016/j.bcp.2015.10.008. Epub 2015 Oct 20.

PMID:
26467186
13.

Challenges in the Biomedical Research Enterprise in the 21st century: Antecedents in the writings of David Triggle.

Triggle CR, Williams M.

Biochem Pharmacol. 2015 Nov 15;98(2):342-59. doi: 10.1016/j.bcp.2015.08.089. Epub 2015 Aug 14. Review.

PMID:
26278976
14.

The answer is not 42.

Triggle CR.

Biochem Pharmacol. 2015 Nov 15;98(2):327-34. doi: 10.1016/j.bcp.2015.06.029. Epub 2015 Jul 23. Review.

PMID:
26212546
15.

Metformin: An Old Drug for the Treatment of Diabetes but a New Drug for the Protection of the Endothelium.

Kinaan M, Ding H, Triggle CR.

Med Princ Pract. 2015;24(5):401-15. doi: 10.1159/000381643. Epub 2015 May 28. Review.

16.

MicroRNA Signature and Cardiovascular Dysfunction.

Arunachalam G, Upadhyay R, Ding H, Triggle CR.

J Cardiovasc Pharmacol. 2015 May;65(5):419-29. doi: 10.1097/FJC.0000000000000178. Review.

PMID:
25384197
17.

Cardiovascular impact of drugs used in the treatment of diabetes.

Triggle CR, Ding H.

Ther Adv Chronic Dis. 2014 Nov;5(6):245-68. doi: 10.1177/2040622314546125. Review.

18.

FGF21 maintains glucose homeostasis by mediating the cross talk between liver and brain during prolonged fasting.

Liang Q, Zhong L, Zhang J, Wang Y, Bornstein SR, Triggle CR, Ding H, Lam KS, Xu A.

Diabetes. 2014 Dec;63(12):4064-75. doi: 10.2337/db14-0541. Epub 2014 Jul 14.

19.

Proteinase-activated receptors 1 and 2 and the regulation of porcine coronary artery contractility: a role for distinct tyrosine kinase pathways.

El-Daly M, Saifeddine M, Mihara K, Ramachandran R, Triggle CR, Hollenberg MD.

Br J Pharmacol. 2014 May;171(9):2413-25. doi: 10.1111/bph.12593.

20.

Metformin modulates hyperglycaemia-induced endothelial senescence and apoptosis through SIRT1.

Arunachalam G, Samuel SM, Marei I, Ding H, Triggle CR.

Br J Pharmacol. 2014 Jan;171(2):523-35. doi: 10.1111/bph.12496.

21.

The endothelium: influencing vascular smooth muscle in many ways.

Triggle CR, Samuel SM, Ravishankar S, Marei I, Arunachalam G, Ding H.

Can J Physiol Pharmacol. 2012 Jun;90(6):713-38. doi: 10.1139/y2012-073. Epub 2012 May 24. Review.

22.

Endothelial dysfunction in diabetes mellitus: possible involvement of endoplasmic reticulum stress?

Basha B, Samuel SM, Triggle CR, Ding H.

Exp Diabetes Res. 2012;2012:481840. doi: 10.1155/2012/481840. Epub 2012 Feb 28. Review.

23.

The contribution of d-tubocurarine-sensitive and apamin-sensitive K-channels to EDHF-mediated relaxation of mesenteric arteries from eNOS-/- mice.

Chen X, Li Y, Hollenberg M, Triggle CR, Ding H.

J Cardiovasc Pharmacol. 2012 May;59(5):413-25. doi: 10.1097/FJC.0b013e318248acd9.

PMID:
22217882
24.

Perivascular adipose tissue-derived relaxing factors: release by peptide agonists via proteinase-activated receptor-2 (PAR2) and non-PAR2 mechanisms.

Li Y, Mihara K, Saifeddine M, Krawetz A, Lau DC, Li H, Ding H, Triggle CR, Hollenberg MD.

Br J Pharmacol. 2011 Dec;164(8):1990-2002. doi: 10.1111/j.1476-5381.2011.01501.x.

25.

The endothelium in compliance and resistance vessels.

Triggle CR, Ding H.

Front Biosci (Schol Ed). 2011 Jan 1;3:730-44. Review.

PMID:
21196408
26.

A review of endothelial dysfunction in diabetes: a focus on the contribution of a dysfunctional eNOS.

Triggle CR, Ding H.

J Am Soc Hypertens. 2010 May-Jun;4(3):102-15. doi: 10.1016/j.jash.2010.02.004. Review.

PMID:
20470995
27.

Endothelial dysfunction in diabetes: multiple targets for treatment.

Ding H, Triggle CR.

Pflugers Arch. 2010 May;459(6):977-94. doi: 10.1007/s00424-010-0807-3. Epub 2010 Mar 18. Review.

PMID:
20238124
28.

Endothelium-dependent vasodilation in myogenically active mouse skeletal muscle arterioles: role of EDH and K(+) channels.

Potocnik SJ, McSherry I, Ding H, Murphy TV, Kotecha N, Dora KA, Yuill KH, Triggle CR, Hill MA.

Microcirculation. 2009 Jul;16(5):377-90; 1 p following 390. doi: 10.1080/10739680902804042. Epub 2009 May 7.

PMID:
19424929
29.

A role for nitroxyl (HNO) as an endothelium-derived relaxing and hyperpolarizing factor in resistance arteries.

Andrews KL, Irvine JC, Tare M, Apostolopoulos J, Favaloro JL, Triggle CR, Kemp-Harper BK.

Br J Pharmacol. 2009 Jun;157(4):540-50. doi: 10.1111/j.1476-5381.2009.00150.x. Epub 2009 Mar 26.

30.

Effects of a Western diet versus high glucose on endothelium-dependent relaxation in murine micro- and macro-vasculature.

Ellis A, Cheng ZJ, Li Y, Jiang YF, Yang J, Pannirselvam M, Ding H, Hollenberg MD, Triggle CR.

Eur J Pharmacol. 2008 Dec 28;601(1-3):111-7. doi: 10.1016/j.ejphar.2008.10.042. Epub 2008 Oct 29.

PMID:
18996368
31.

Defying the economists: a decrease in heart rate improves not only cardiac but also endothelial function.

Triggle CR.

Br J Pharmacol. 2008 Jun;154(4):727-8. doi: 10.1038/bjp.2008.168. Epub 2008 Apr 28.

32.
33.

Reduced EDHF responses and connexin activity in mesenteric arteries from the insulin-resistant obese Zucker rat.

Young EJ, Hill MA, Wiehler WB, Triggle CR, Reid JJ.

Diabetologia. 2008 May;51(5):872-81. doi: 10.1007/s00125-008-0934-y. Epub 2008 Mar 7.

PMID:
18324386
34.

The early effects of elevated glucose on endothelial function as a target in the treatment of type 2 diabetes.

Triggle CR.

Drugs Today (Barc). 2007 Nov;43(11):815-26. doi: 10.1358/dot.2007.43.11.1120870. Review.

PMID:
18174967
35.

Vascular dysfunction in type 2 diabetic TallyHo mice: role for an increase in the contribution of PGH2/TxA2 receptor activation and cytochrome p450 products.

Cheng ZJ, Jiang YF, Ding H, Severson D, Triggle CR.

Can J Physiol Pharmacol. 2007 Mar-Apr;85(3-4):404-12.

PMID:
17612649
37.

Oxidative stress and increased eNOS and NADPH oxidase expression in mouse microvessel endothelial cells.

Ding H, Aljofan M, Triggle CR.

J Cell Physiol. 2007 Sep;212(3):682-9.

PMID:
17443690
39.

Calcium-activated potassium channel and connexin expression in small mesenteric arteries from eNOS-deficient (eNOS-/-) and eNOS-expressing (eNOS+/+) mice.

Ceroni L, Ellis A, Wiehler WB, Jiang YF, Ding H, Triggle CR.

Eur J Pharmacol. 2007 Apr 10;560(2-3):193-200. Epub 2007 Jan 19.

PMID:
17300779
40.

Nitrosothiol stores in vascular tissue: modulation by ultraviolet light, acetylcholine and ionomycin.

Ng ES, Cheng ZJ, Ellis A, Ding H, Jiang Y, Li Y, Hollenberg MD, Triggle CR.

Eur J Pharmacol. 2007 Apr 10;560(2-3):183-92. Epub 2007 Jan 19.

PMID:
17292350
41.

Pharmacological characteristics of endothelium-derived hyperpolarizing factor-mediated relaxation of small mesenteric arteries from db/db mice.

Pannirselvam M, Ding H, Anderson TJ, Triggle CR.

Eur J Pharmacol. 2006 Dec 3;551(1-3):98-107. Epub 2006 Sep 12.

PMID:
17027963
42.

Novel role for K+-dependent Na+/Ca2+ exchangers in regulation of cytoplasmic free Ca2+ and contractility in arterial smooth muscle.

Dong H, Jiang Y, Triggle CR, Li X, Lytton J.

Am J Physiol Heart Circ Physiol. 2006 Sep;291(3):H1226-35. Epub 2006 Apr 14.

43.
44.

A nonthiazolidinedione peroxisome proliferator-activated receptor gamma agonist reverses endothelial dysfunction in diabetic (db/db-/-) mice.

Howarth AG, Wiehler WB, Pannirselvam M, Jiang Y, Berger JP, Severson D, Anderson TJ, Triggle CR.

J Pharmacol Exp Ther. 2006 Jan;316(1):364-70. Epub 2005 Oct 25.

PMID:
16249369
45.
46.

Endothelial dysfunction in Type 2 diabetes correlates with deregulated expression of the tail-anchored membrane protein SLMAP.

Ding H, Howarth AG, Pannirselvam M, Anderson TJ, Severson DL, Wiehler WB, Triggle CR, Tuana BS.

Am J Physiol Heart Circ Physiol. 2005 Jul;289(1):H206-11. Epub 2005 Mar 11.

47.

The vascular endothelium in diabetes: a practical target for drug treatment?

Andrews KL, Pannirselvam M, Anderson TJ, Jenkins AJ, Triggle CR, Hill MA.

Expert Opin Ther Targets. 2005 Feb;9(1):101-17. Review.

PMID:
15757485
48.
49.

Hyperpolarization of murine small caliber mesenteric arteries by activation of endothelial proteinase-activated receptor 2.

McGuire JJ, Hollenberg MD, Bennett BM, Triggle CR.

Can J Physiol Pharmacol. 2004 Dec;82(12):1103-12.

PMID:
15644953

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