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Items: 29


Space-like 56Fe irradiation manifests mild, early sex-specific behavioral and neuropathological changes in wildtype and Alzheimer's-like transgenic mice.

Liu B, Hinshaw RG, Le KX, Park MA, Wang S, Belanger AP, Dubey S, Frost JL, Shi Q, Holton P, Trojanczyk L, Reiser V, Jones PA, Trigg W, Di Carli MF, Lorello P, Caldarone BJ, Williams JP, O'Banion MK, Lemere CA.

Sci Rep. 2019 Aug 20;9(1):12118. doi: 10.1038/s41598-019-48615-1.


Radiosynthesis of (R,S)-[18 F]GE387: A Potential PET Radiotracer for Imaging Translocator Protein 18 kDa (TSPO) with Low Binding Sensitivity to the Human Gene Polymorphism rs6971.

Qiao L, Fisher E, McMurray L, Milicevic Sephton S, Hird M, Kuzhuppilly-Ramakrishnan N, Williamson DJ, Zhou X, Werry E, Kassiou M, Luthra S, Trigg W, Aigbirhio FI.

ChemMedChem. 2019 May 6;14(9):982-993. doi: 10.1002/cmdc.201900023. Epub 2019 Apr 8.


Comment on " In Vivo [18F]GE-179 Brain Signal Does Not Show NMDA-Specific Modulation with Drug Challenges in Rodents and Nonhuman Primates".

McGinnity CJ, Årstad E, Beck K, Brooks DJ, Coles JP, Duncan JS, Galovic M, Hinz R, Hirani E, Howes OD, Jones PA, Koepp MJ, Luo F, Riaño Barros DA, Singh N, Trigg W, Hammers A.

ACS Chem Neurosci. 2019 Jan 16;10(1):768-772. doi: 10.1021/acschemneuro.8b00246. Epub 2018 Oct 11.


Dynamic TSPO-PET for assessing early effects of cerebral hypoxia and resuscitation in new born pigs.

de Lange C, Solberg R, Holtedahl JE, Tulipan A, Barlinn J, Trigg W, Wickstrøm T, Saugstad OD, Malinen E, Revheim ME.

Nucl Med Biol. 2018 Nov;66:49-57. doi: 10.1016/j.nucmedbio.2018.08.004. Epub 2018 Aug 24.


Positron Emission Tomography Imaging of Macrophages in Atherosclerosis with 18F-GE-180, a Radiotracer for Translocator Protein (TSPO).

Hellberg S, Liljenbäck H, Eskola O, Morisson-Iveson V, Morrison M, Trigg W, Saukko P, Ylä-Herttuala S, Knuuti J, Saraste A, Roivainen A.

Contrast Media Mol Imaging. 2018 May 22;2018:9186902. doi: 10.1155/2018/9186902. eCollection 2018.


Simplifying [18F]GE-179 PET: are both arterial blood sampling and 90-min acquisitions essential?

McGinnity CJ, Riaño Barros DA, Trigg W, Brooks DJ, Hinz R, Duncan JS, Koepp MJ, Hammers A.

EJNMMI Res. 2018 Jun 11;8(1):46. doi: 10.1186/s13550-018-0396-2.


[18F]GE-180 PET Detects Reduced Microglia Activation After LM11A-31 Therapy in a Mouse Model of Alzheimer's Disease.

James ML, Belichenko NP, Shuhendler AJ, Hoehne A, Andrews LE, Condon C, Nguyen TV, Reiser V, Jones P, Trigg W, Rao J, Gambhir SS, Longo FM.

Theranostics. 2017 Mar 24;7(6):1422-1436. doi: 10.7150/thno.17666. eCollection 2017.


Flutriciclamide (18F-GE180) PET: First-in-Human PET Study of Novel Third-Generation In Vivo Marker of Human Translocator Protein.

Fan Z, Calsolaro V, Atkinson RA, Femminella GD, Waldman A, Buckley C, Trigg W, Brooks DJ, Hinz R, Edison P.

J Nucl Med. 2016 Nov;57(11):1753-1759. Epub 2016 Jun 3.


Comparative Evaluation of Three TSPO PET Radiotracers in a LPS-Induced Model of Mild Neuroinflammation in Rats.

Sridharan S, Lepelletier FX, Trigg W, Banister S, Reekie T, Kassiou M, Gerhard A, Hinz R, Boutin H.

Mol Imaging Biol. 2017 Feb;19(1):77-89. doi: 10.1007/s11307-016-0984-3.


Kinetic analysis of the translocator protein positron emission tomography ligand [18F]GE-180 in the human brain.

Feeney C, Scott G, Raffel J, Roberts S, Coello C, Jolly A, Searle G, Goldstone AP, Brooks DJ, Nicholas RS, Trigg W, Gunn RN, Sharp DJ.

Eur J Nucl Med Mol Imaging. 2016 Nov;43(12):2201-2210. Epub 2016 Jun 28.


Ex Vivo Tracing of NMDA and GABA-A Receptors in Rat Brain After Traumatic Brain Injury Using 18F-GE-179 and 18F-GE-194 Autoradiography.

López-Picón F, Snellman A, Shatillo O, Lehtiniemi P, Grönroos TJ, Marjamäki P, Trigg W, Jones PA, Solin O, Pitkänen A, Haaparanta-Solin M.

J Nucl Med. 2016 Sep;57(9):1442-7. doi: 10.2967/jnumed.115.167403. Epub 2016 May 19.


In vivo PET imaging of the neuroinflammatory response in rat spinal cord injury using the TSPO tracer [(18)F]GE-180 and effect of docosahexaenoic acid.

Tremoleda JL, Thau-Zuchman O, Davies M, Foster J, Khan I, Vadivelu KC, Yip PK, Sosabowski J, Trigg W, Michael-Titus AT.

Eur J Nucl Med Mol Imaging. 2016 Aug;43(9):1710-22. doi: 10.1007/s00259-016-3391-8. Epub 2016 May 7.


In Vivo Detection of Age- and Disease-Related Increases in Neuroinflammation by 18F-GE180 TSPO MicroPET Imaging in Wild-Type and Alzheimer's Transgenic Mice.

Liu B, Le KX, Park MA, Wang S, Belanger AP, Dubey S, Frost JL, Holton P, Reiser V, Jones PA, Trigg W, Di Carli MF, Lemere CA.

J Neurosci. 2015 Nov 25;35(47):15716-30. doi: 10.1523/JNEUROSCI.0996-15.2015.


Exploration of the impact of stereochemistry on the identification of the novel translocator protein PET imaging agent [(18)F]GE-180.

Chau WF, Black AM, Clarke A, Durrant C, Gausemel I, Khan I, Mantzilas D, Oulie I, Rogstad A, Trigg W, Jones PA.

Nucl Med Biol. 2015 Sep;42(9):711-9. doi: 10.1016/j.nucmedbio.2015.05.004. Epub 2015 May 27.


NMDA receptor binding in focal epilepsies.

McGinnity CJ, Koepp MJ, Hammers A, Riaño Barros DA, Pressler RM, Luthra S, Jones PA, Trigg W, Micallef C, Symms MR, Brooks DJ, Duncan JS.

J Neurol Neurosurg Psychiatry. 2015 Oct;86(10):1150-7. doi: 10.1136/jnnp-2014-309897. Epub 2015 May 19.


(99m)Tc SPECT imaging agent based on cFLFLFK for the detection of FPR1 in inflammation.

Stasiuk GJ, Holloway PM, Rivas C, Trigg W, Luthra SK, Morisson Iveson V, Gavins FN, Long NJ.

Dalton Trans. 2015 Mar 21;44(11):4986-93. doi: 10.1039/c4dt02980a.


In vivo PET imaging demonstrates diminished microglial activation after fingolimod treatment in an animal model of multiple sclerosis.

Airas L, Dickens AM, Elo P, Marjamäki P, Johansson J, Eskola O, Jones PA, Trigg W, Solin O, Haaparanta-Solin M, Anthony DC, Rinne J.

J Nucl Med. 2015 Feb;56(2):305-10. doi: 10.2967/jnumed.114.149955. Epub 2015 Jan 8. Erratum in: J Nucl Med. 2015 Mar;56(3):495. J Nucl Med. 2019 Apr;60(4):529.


18F-GE-180: a novel TSPO radiotracer compared to 11C-R-PK11195 in a preclinical model of stroke.

Boutin H, Murray K, Pradillo J, Maroy R, Smigova A, Gerhard A, Jones PA, Trigg W.

Eur J Nucl Med Mol Imaging. 2015 Mar;42(3):503-11. doi: 10.1007/s00259-014-2939-8. Epub 2014 Oct 29.


Initial evaluation of 18F-GE-179, a putative PET Tracer for activated N-methyl D-aspartate receptors.

McGinnity CJ, Hammers A, Riaño Barros DA, Luthra SK, Jones PA, Trigg W, Micallef C, Symms MR, Brooks DJ, Koepp MJ, Duncan JS.

J Nucl Med. 2014 Mar;55(3):423-30. doi: 10.2967/jnumed.113.130641. Epub 2014 Feb 13.


Detection of microglial activation in an acute model of neuroinflammation using PET and radiotracers 11C-(R)-PK11195 and 18F-GE-180.

Dickens AM, Vainio S, Marjamäki P, Johansson J, Lehtiniemi P, Rokka J, Rinne J, Solin O, Haaparanta-Solin M, Jones PA, Trigg W, Anthony DC, Airas L.

J Nucl Med. 2014 Mar;55(3):466-72. doi: 10.2967/jnumed.113.125625. Epub 2014 Feb 10.


Evaluation of a novel series of fluorine-18-labeled imidazobenzodiazepines as potential new positron emission tomography radioligands for the GABAA receptor.

Jackson A, Battle MR, O'Shea DM, Chau WF, Gaeta A, Brown SL, Ewan AL, Jones CL, Jones PA, Woodcraft JL, Bouvet DR, Guilbert BB, Trigg W.

Nucl Med Biol. 2014 Feb;41(2):196-202. doi: 10.1016/j.nucmedbio.2013.11.010. Epub 2013 Dec 7.


The development of an automated and GMP compliant FASTlab™ Synthesis of [(18) F]GE-180; a radiotracer for imaging translocator protein (TSPO).

Wickstrøm T, Clarke A, Gausemel I, Horn E, Jørgensen K, Khan I, Mantzilas D, Rajanayagam T, in 't Veld DJ, Trigg W.

J Labelled Comp Radiopharm. 2014 Jan;57(1):42-8. doi: 10.1002/jlcr.3112. Epub 2013 Sep 23.


Novel fluorine-18 PET radiotracers based on flumazenil for GABAA imaging in the brain.

Rodnick ME, Hockley BG, Sherman P, Quesada C, Battle MR, Jackson A, Linder KE, Macholl S, Trigg WJ, Kilbourn MR, Scott PJ.

Nucl Med Biol. 2013 Oct;40(7):901-5. doi: 10.1016/j.nucmedbio.2013.06.004. Epub 2013 Jul 23.


Exploration of the structure-activity relationship of a novel tetracyclic class of TSPO ligands-potential novel positron emitting tomography imaging agents.

O'Shea D, Ahmad R, Årstad E, Avory M, Chau WF, Durrant C, Hirani E, Jones PA, Khan I, Luthra SK, Mantzilas D, Morisson-Iveson V, Passmore J, Robins EG, Shan B, Wadsworth H, Walton S, Zhao Y, Trigg W.

Bioorg Med Chem Lett. 2013 Apr 15;23(8):2368-72. doi: 10.1016/j.bmcl.2013.02.057. Epub 2013 Feb 24.


The development of potential new fluorine-18 labelled radiotracers for imaging the GABA(A) receptor.

Jackson A, Guilbert BB, Plant SD, Goggi J, Battle MR, Woodcraft JL, Gaeta A, Jones CL, Bouvet DR, Jones PA, O'Shea DM, Zheng PH, Brown SL, Ewan AL, Trigg W.

Bioorg Med Chem Lett. 2013 Feb 1;23(3):821-6. doi: 10.1016/j.bmcl.2012.11.066. Epub 2012 Nov 28.


Gd3+ cFLFLFK conjugate for MRI: a targeted contrast agent for FPR1 in inflammation.

Stasiuk GJ, Smith H, Wylezinska-Arridge M, Tremoleda JL, Trigg W, Luthra SK, Morisson Iveson V, Gavins FN, Long NJ.

Chem Commun (Camb). 2013 Jan 21;49(6):564-6. doi: 10.1039/c2cc37460a. Epub 2012 Dec 4.


Exploration of the structure-activity relationship of the diaryl anilide class of ligands for translocator protein--potential novel positron emitting tomography imaging agents.

Wadsworth H, Jones PA, Chau WF, Durrant C, Morisson-Iveson V, Passmore J, O'Shea D, Wynn D, Khan I, Black A, Avory M, Trigg W.

Bioorg Med Chem Lett. 2012 Sep 15;22(18):5795-800. doi: 10.1016/j.bmcl.2012.07.093. Epub 2012 Aug 3.


[¹⁸F]GE-180: a novel fluorine-18 labelled PET tracer for imaging Translocator protein 18 kDa (TSPO).

Wadsworth H, Jones PA, Chau WF, Durrant C, Fouladi N, Passmore J, O'Shea D, Wynn D, Morisson-Iveson V, Ewan A, Thaning M, Mantzilas D, Gausemel I, Khan I, Black A, Avory M, Trigg W.

Bioorg Med Chem Lett. 2012 Feb 1;22(3):1308-13. doi: 10.1016/j.bmcl.2011.12.084. Epub 2011 Dec 27.


Use of 2-[(18)F]fluoroethylazide for the Staudinger ligation - Preparation and characterisation of GABA(A) receptor binding 4-quinolones.

Gaeta A, Woodcraft J, Plant S, Goggi J, Jones P, Battle M, Trigg W, Luthra SK, Glaser M.

Bioorg Med Chem Lett. 2010 Aug 1;20(15):4649-52. doi: 10.1016/j.bmcl.2010.05.106. Epub 2010 Jun 8.


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