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Un-JAMming atherosclerotic arteries: JAM-L as a target to attenuate plaque development.

Sokeechand BSH, Trigatti BL.

Clin Sci (Lond). 2019 Jul 22;133(14):1581-1585. doi: 10.1042/CS20190541. Print 2019 Jul 31.


Treatment with apolipoprotein A1 protects mice against doxorubicin-induced cardiotoxicity in a scavenger receptor class B, type I-dependent manner.

Durham KK, Kluck G, Mak KC, Deng YD, Trigatti BL.

Am J Physiol Heart Circ Physiol. 2019 Jun 1;316(6):H1447-H1457. doi: 10.1152/ajpheart.00432.2018. Epub 2019 Apr 19.


Hyperglycemia Aggravates Diet-Induced Coronary Artery Disease and Myocardial Infarction in SR-B1-Knockout/ApoE-Hypomorphic Mice.

Gonzalez L, MacDonald ME, Deng YD, Trigatti BL.

Front Physiol. 2018 Oct 9;9:1398. doi: 10.3389/fphys.2018.01398. eCollection 2018.


Sialidase down-regulation reduces non-HDL cholesterol, inhibits leukocyte transmigration, and attenuates atherosclerosis in ApoE knockout mice.

White EJ, Gyulay G, Lhoták Š, Szewczyk MM, Chong T, Fuller MT, Dadoo O, Fox-Robichaud AE, Austin RC, Trigatti BL, Igdoura SA.

J Biol Chem. 2018 Sep 21;293(38):14689-14706. doi: 10.1074/jbc.RA118.004589. Epub 2018 Aug 10.


Low-density lipoprotein (LDL)-dependent uptake of Gram-positive lipoteichoic acid and Gram-negative lipopolysaccharide occurs through LDL receptor.

Grin PM, Dwivedi DJ, Chathely KM, Trigatti BL, Prat A, Seidah NG, Liaw PC, Fox-Robichaud AE.

Sci Rep. 2018 Jul 12;8(1):10496. doi: 10.1038/s41598-018-28777-0.


PDZK1 in leukocytes protects against cellular apoptosis and necrotic core development in atherosclerotic plaques in high fat diet fed ldl receptor deficient mice.

Yu P, Qian AS, Chathely KM, Trigatti BL.

Atherosclerosis. 2018 Sep;276:171-181. doi: 10.1016/j.atherosclerosis.2018.05.009. Epub 2018 May 16.


Loss-of-function PCSK9 mutants evade the unfolded protein response sensor GRP78 and fail to induce endoplasmic reticulum stress when retained.

Lebeau P, Platko K, Al-Hashimi AA, Byun JH, Lhoták Š, Holzapfel N, Gyulay G, Igdoura SA, Cool DR, Trigatti B, Seidah NG, Austin RC.

J Biol Chem. 2018 May 11;293(19):7329-7343. doi: 10.1074/jbc.RA117.001049. Epub 2018 Mar 28.


Sphingosine-1-Phosphate Receptor 1, Expressed in Myeloid Cells, Slows Diet-Induced Atherosclerosis and Protects against Macrophage Apoptosis in Ldlr KO Mice.

Gonzalez L, Qian AS, Tahir U, Yu P, Trigatti BL.

Int J Mol Sci. 2017 Dec 15;18(12). pii: E2721. doi: 10.3390/ijms18122721.


Rosuvastatin Reduces Aortic Sinus and Coronary Artery Atherosclerosis in SR-B1 (Scavenger Receptor Class B Type 1)/ApoE (Apolipoprotein E) Double Knockout Mice Independently of Plasma Cholesterol Lowering.

Yu P, Xiong T, Tenedero CB, Lebeau P, Ni R, MacDonald ME, Gross PL, Austin RC, Trigatti BL.

Arterioscler Thromb Vasc Biol. 2018 Jan;38(1):26-39. doi: 10.1161/ATVBAHA.117.305140. Epub 2017 Nov 21.


HDL protects against doxorubicin-induced cardiotoxicity in a scavenger receptor class B type 1-, PI3K-, and Akt-dependent manner.

Durham KK, Chathely KM, Mak KC, Momen A, Thomas CT, Zhao YY, MacDonald ME, Curtis JM, Husain M, Trigatti BL.

Am J Physiol Heart Circ Physiol. 2018 Jan 1;314(1):H31-H44. doi: 10.1152/ajpheart.00521.2016. Epub 2017 Oct 6.


Suppression of NK and CD8+ T cells reduces astrogliosis but accelerates cerebellar dysfunction and shortens life span in a mouse model of Sandhoff disease.

White EJ, Trigatti BL, Igdoura SA.

J Neuroimmunol. 2017 May 15;306:55-67. doi: 10.1016/j.jneuroim.2017.03.004. Epub 2017 Mar 6.


Macrophage Apoptosis and Necrotic Core Development in Atherosclerosis: A Rapidly Advancing Field with Clinical Relevance to Imaging and Therapy.

Gonzalez L, Trigatti BL.

Can J Cardiol. 2017 Mar;33(3):303-312. doi: 10.1016/j.cjca.2016.12.010. Epub 2016 Dec 21. Review.


SR-B1 and PDZK1: partners in HDL regulation.

Trigatti BL.

Curr Opin Lipidol. 2017 Apr;28(2):201-208. doi: 10.1097/MOL.0000000000000396. Review.


Endoplasmic Reticulum Stress and Ca2+ Depletion Differentially Modulate the Sterol Regulatory Protein PCSK9 to Control Lipid Metabolism.

Lebeau P, Al-Hashimi A, Sood S, Lhoták Š, Yu P, Gyulay G, Paré G, Chen SR, Trigatti B, Prat A, Seidah NG, Austin RC.

J Biol Chem. 2017 Jan 27;292(4):1510-1523. doi: 10.1074/jbc.M116.744235. Epub 2016 Dec 1.


Characterization of Proliferating Lesion-Resident Cells During All Stages of Atherosclerotic Growth.

Lhoták Š, Gyulay G, Cutz JC, Al-Hashimi A, Trigatti BL, Richards CD, Igdoura SA, Steinberg GR, Bramson J, Ask K, Austin RC.

J Am Heart Assoc. 2016 Aug 15;5(8). pii: e003945. doi: 10.1161/JAHA.116.003945.


Rare Genetic Variants and High-Density Lipoprotein: Marching to a Different Drum.

Trigatti BL, Hegele RA.

Arterioscler Thromb Vasc Biol. 2016 Jun;36(6):e53-5. doi: 10.1161/ATVBAHA.116.307688. Epub 2016 Apr 28. No abstract available.


HDL signaling and protection against coronary artery atherosclerosis in mice.

Trigatti BL, Fuller M.

J Biomed Res. 2016 Mar;30(2):94-100. doi: 10.7555/JBR.30.20150079. Epub 2015 Aug 20. Review.


Intestinal scavenger receptor class B type I as a novel regulator of chylomicron production in healthy and diet-induced obese states.

Lino M, Farr S, Baker C, Fuller M, Trigatti B, Adeli K.

Am J Physiol Gastrointest Liver Physiol. 2015 Sep 1;309(5):G350-9. doi: 10.1152/ajpgi.00086.2015. Epub 2015 Jul 2.


Characterization of mice harboring a variant of EPCR with impaired ability to bind protein C: novel role of EPCR in hematopoiesis.

Pepler L, Yu P, Dwivedi DJ, Trigatti BL, Liaw PC.

Blood. 2015 Jul 30;126(5):673-82. doi: 10.1182/blood-2014-02-558940. Epub 2015 Jun 4.


Interleukin-15 modulates adipose tissue by altering mitochondrial mass and activity.

Barra NG, Palanivel R, Denou E, Chew MV, Gillgrass A, Walker TD, Kong J, Richards CD, Jordana M, Collins SM, Trigatti BL, Holloway AC, Raha S, Steinberg GR, Ashkar AA.

PLoS One. 2014 Dec 17;9(12):e114799. doi: 10.1371/journal.pone.0114799. eCollection 2014.


The effects of diet on occlusive coronary artery atherosclerosis and myocardial infarction in scavenger receptor class B, type 1/low-density lipoprotein receptor double knockout mice.

Fuller M, Dadoo O, Serkis V, Abutouk D, MacDonald M, Dhingani N, Macri J, Igdoura SA, Trigatti BL.

Arterioscler Thromb Vasc Biol. 2014 Nov;34(11):2394-403. doi: 10.1161/ATVBAHA.114.304200. Epub 2014 Sep 11.


Oncostatin M and TLR-4 ligand synergize to induce MCP-1, IL-6, and VEGF in human aortic adventitial fibroblasts and smooth muscle cells.

Schnittker D, Kwofie K, Ashkar A, Trigatti B, Richards CD.

Mediators Inflamm. 2013;2013:317503. doi: 10.1155/2013/317503. Epub 2013 Nov 6.


SR-BI in bone marrow derived cells protects mice from diet induced coronary artery atherosclerosis and myocardial infarction.

Pei Y, Chen X, Aboutouk D, Fuller MT, Dadoo O, Yu P, White EJ, Igdoura SA, Trigatti BL.

PLoS One. 2013 Aug 13;8(8):e72492. doi: 10.1371/journal.pone.0072492. eCollection 2013.


Deletion of tumor necrosis factor-α ameliorates neurodegeneration in Sandhoff disease mice.

Abo-Ouf H, Hooper AW, White EJ, Janse van Rensburg HJ, Trigatti BL, Igdoura SA.

Hum Mol Genet. 2013 Oct 1;22(19):3960-75. doi: 10.1093/hmg/ddt250. Epub 2013 May 31.


Deficiency of TDAG51 protects against atherosclerosis by modulating apoptosis, cholesterol efflux, and peroxiredoxin-1 expression.

Hossain GS, Lynn EG, Maclean KN, Zhou J, Dickhout JG, Lhoták S, Trigatti B, Capone J, Rho J, Tang D, McCulloch CA, Al-Bondokji I, Malloy MJ, Pullinger CR, Kane JP, Li Y, Shiffman D, Austin RC.

J Am Heart Assoc. 2013 May 17;2(3):e000134. doi: 10.1161/JAHA.113.000134.


The effect of pomegranate extract on coronary artery atherosclerosis in SR-BI/APOE double knockout mice.

Al-Jarallah A, Igdoura F, Zhang Y, Tenedero CB, White EJ, MacDonald ME, Igdoura SA, Trigatti BL.

Atherosclerosis. 2013 May;228(1):80-9. doi: 10.1016/j.atherosclerosis.2013.02.025. Epub 2013 Mar 7.


Hypomorphic sialidase expression decreases serum cholesterol by downregulation of VLDL production in mice.

Yang A, Gyulay G, Mitchell M, White E, Trigatti BL, Igdoura SA.

J Lipid Res. 2012 Dec;53(12):2573-85. doi: 10.1194/jlr.M027300. Epub 2012 Sep 14.


Modifications in perfringolysin O domain 4 alter the cholesterol concentration threshold required for binding.

Johnson BB, Moe PC, Wang D, Rossi K, Trigatti BL, Heuck AP.

Biochemistry. 2012 Apr 24;51(16):3373-82. doi: 10.1021/bi3003132. Epub 2012 Apr 13.


Intestinal SR-BI is upregulated in insulin-resistant states and is associated with overproduction of intestinal apoB48-containing lipoproteins.

Hayashi AA, Webb J, Choi J, Baker C, Lino M, Trigatti B, Trajcevski KE, Hawke TJ, Adeli K.

Am J Physiol Gastrointest Liver Physiol. 2011 Aug;301(2):G326-37. doi: 10.1152/ajpgi.00425.2010. Epub 2011 May 5.


Modulators of Protein Kinase C Affect SR-BI-Dependent HDL Lipid Uptake in Transfected HepG2 Cells.

Brunet R, How M, Trigatti BL.

Cholesterol. 2011;2011:687939. doi: 10.1155/2011/687939. Epub 2011 Jan 5.


Lipoprotein enrichment in orange insoluble particulate matter reproducibly appearing in cryoprecipitate.

Sheffield WP, Bhakta V, Trigatti B, Jenkins C.

Vox Sang. 2011 May;100(4):422-5. doi: 10.1111/j.1423-0410.2010.01443.x. Epub 2010 Nov 23.


A role for the scavenger receptor, class B type I in high density lipoprotein dependent activation of cellular signaling pathways.

Al-Jarallah A, Trigatti BL.

Biochim Biophys Acta. 2010 Dec;1801(12):1239-48. doi: 10.1016/j.bbalip.2010.08.006. Epub 2010 Aug 21. Review.


Interleukin-15 contributes to the regulation of murine adipose tissue and human adipocytes.

Barra NG, Reid S, MacKenzie R, Werstuck G, Trigatti BL, Richards C, Holloway AC, Ashkar AA.

Obesity (Silver Spring). 2010 Aug;18(8):1601-7. doi: 10.1038/oby.2009.445. Epub 2009 Dec 17.


Hepatic uptake and metabolism of phosphatidylcholine associated with high density lipoproteins.

Robichaud JC, van der Veen JN, Yao Z, Trigatti B, Vance DE.

Biochim Biophys Acta. 2009 Jun;1790(6):538-51. doi: 10.1016/j.bbagen.2009.02.010. Epub 2009 Feb 27.


A point mutation in the neu1 promoter recruits an ectopic repressor, Nkx3.2 and results in a mouse model of sialidase deficiency.

Champigny MJ, Mitchell M, Fox-Robichaud A, Trigatti BL, Igdoura SA.

Mol Genet Metab. 2009 May;97(1):43-52. doi: 10.1016/j.ymgme.2009.01.004. Epub 2009 Feb 13.


Enhanced cellular uptake of remnant high-density lipoprotein particles: a mechanism for high-density lipoprotein lowering in insulin resistance and hypertriglyceridemia.

Xiao C, Watanabe T, Zhang Y, Trigatti B, Szeto L, Connelly PW, Marcovina S, Vaisar T, Heinecke JW, Lewis GF.

Circ Res. 2008 Jul 18;103(2):159-66. doi: 10.1161/CIRCRESAHA.108.178756. Epub 2008 Jun 12.


Hyperhomocysteinemia induced by methionine supplementation does not independently cause atherosclerosis in C57BL/6J mice.

Zhou J, Werstuck GH, Lhoták S, Shi YY, Tedesco V, Trigatti B, Dickhout J, Majors AK, DiBello PM, Jacobsen DW, Austin RC.

FASEB J. 2008 Jul;22(7):2569-78. doi: 10.1096/fj.07-105353. Epub 2008 Mar 25.


Myocardial infarction following atherosclerosis in murine models.

Braun A, Rigotti A, Trigatti BL.

Curr Drug Targets. 2008 Mar;9(3):217-23. Review.


Conversion of low density lipoprotein-associated phosphatidylcholine to triacylglycerol by primary hepatocytes.

Minahk C, Kim KW, Nelson R, Trigatti B, Lehner R, Vance DE.

J Biol Chem. 2008 Mar 7;283(10):6449-58. doi: 10.1074/jbc.M706995200. Epub 2008 Jan 5.


The inhibition of endocytosis affects HDL-lipid uptake mediated by the human scavenger receptor class B type I.

Zhang Y, Ahmed AM, Tran TL, Lin J, McFarlane N, Boreham DR, Igdoura SA, Truant R, Trigatti BL.

Mol Membr Biol. 2007 Sep-Dec;24(5-6):442-54.


Liver X receptor stimulates cholesterol efflux and inhibits expression of proinflammatory mediators in human airway smooth muscle cells.

Delvecchio CJ, Bilan P, Radford K, Stephen J, Trigatti BL, Cox G, Parameswaran K, Capone JP.

Mol Endocrinol. 2007 Jun;21(6):1324-34. Epub 2007 Apr 3.


Cholesterol depletion inhibits fatty acid uptake without affecting CD36 or caveolin-1 distribution in adipocytes.

Covey SD, Brunet RH, Gandhi SG, McFarlane N, Boreham DR, Gerber GE, Trigatti BL.

Biochem Biophys Res Commun. 2007 Mar 30;355(1):67-71. Epub 2007 Feb 2.


Regulation of SR-BI-mediated selective lipid uptake in Chinese hamster ovary-derived cells by protein kinase signaling pathways.

Zhang Y, Ahmed AM, McFarlane N, Capone C, Boreham DR, Truant R, Igdoura SA, Trigatti BL.

J Lipid Res. 2007 Feb;48(2):405-16. Epub 2006 Nov 1.


Hepatic lipase deficiency delays atherosclerosis, myocardial infarction, and cardiac dysfunction and extends lifespan in SR-BI/apolipoprotein E double knockout mice.

Karackattu SL, Trigatti B, Krieger M.

Arterioscler Thromb Vasc Biol. 2006 Mar;26(3):548-54. Epub 2006 Jan 5.


Glucosamine-induced endoplasmic reticulum dysfunction is associated with accelerated atherosclerosis in a hyperglycemic mouse model.

Werstuck GH, Khan MI, Femia G, Kim AJ, Tedesco V, Trigatti B, Shi Y.

Diabetes. 2006 Jan;55(1):93-101.


Biochemical demonstration of the involvement of fatty acyl-CoA synthetase in fatty acid translocation across the plasma membrane.

Schmelter T, Trigatti BL, Gerber GE, Mangroo D.

J Biol Chem. 2004 Jun 4;279(23):24163-70. Epub 2004 Apr 2.

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