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Items: 46

1.

CLPP deficiency protects against metabolic syndrome but hinders adaptive thermogenesis.

Becker C, Kukat A, Szczepanowska K, Hermans S, Senft K, Brandscheid CP, Maiti P, Trifunovic A.

EMBO Rep. 2018 May;19(5). pii: e45126. doi: 10.15252/embr.201745126. Epub 2018 Mar 27.

PMID:
29588285
2.

DARS2 protects against neuroinflammation and apoptotic neuronal loss, but is dispensable for myelin producing cells.

Aradjanski M, Dogan SA, Lotter S, Wang S, Hermans S, Wibom R, Rugarli E, Trifunovic A.

Hum Mol Genet. 2017 Nov 1;26(21):4181-4189. doi: 10.1093/hmg/ddx307.

PMID:
28985337
3.

Origins of mtDNA mutations in ageing.

Szczepanowska K, Trifunovic A.

Essays Biochem. 2017 Jul 11;61(3):325-337. doi: 10.1042/EBC20160090. Print 2017 Jul 15. Review.

PMID:
28698307
4.

Deficiency of WARS2, encoding mitochondrial tryptophanyl tRNA synthetase, causes severe infantile onset leukoencephalopathy.

Theisen BE, Rumyantseva A, Cohen JS, Alcaraz WA, Shinde DN, Tang S, Srivastava S, Pevsner J, Trifunovic A, Fatemi A.

Am J Med Genet A. 2017 Sep;173(9):2505-2510. doi: 10.1002/ajmg.a.38339. Epub 2017 Jun 26.

PMID:
28650581
5.

The importance of spatial orientation and knowledge of traffic signs for children's traffic safety.

Trifunović A, Pešić D, Čičević S, Antić B.

Accid Anal Prev. 2017 May;102:81-92. doi: 10.1016/j.aap.2017.02.019. Epub 2017 Mar 6.

PMID:
28273551
6.

CLPP coordinates mitoribosomal assembly through the regulation of ERAL1 levels.

Szczepanowska K, Maiti P, Kukat A, Hofsetz E, Nolte H, Senft K, Becker C, Ruzzenente B, Hornig-Do HT, Wibom R, Wiesner RJ, Krüger M, Trifunovic A.

EMBO J. 2016 Dec 1;35(23):2566-2583. Epub 2016 Oct 20.

7.

Human R1441C LRRK2 regulates the synaptic vesicle proteome and phosphoproteome in a Drosophila model of Parkinson's disease.

Islam MS, Nolte H, Jacob W, Ziegler AB, Pütz S, Grosjean Y, Szczepanowska K, Trifunovic A, Braun T, Heumann H, Heumann R, Hovemann B, Moore DJ, Krüger M.

Hum Mol Genet. 2016 Dec 15;25(24):5365-5382. doi: 10.1093/hmg/ddw352.

8.

Loss of CLPP alleviates mitochondrial cardiomyopathy without affecting the mammalian UPRmt.

Seiferling D, Szczepanowska K, Becker C, Senft K, Hermans S, Maiti P, König T, Kukat A, Trifunovic A.

EMBO Rep. 2016 Jul;17(7):953-64. doi: 10.15252/embr.201642077. Epub 2016 May 6.

9.

The CoQH2/CoQ Ratio Serves as a Sensor of Respiratory Chain Efficiency.

Guarás A, Perales-Clemente E, Calvo E, Acín-Pérez R, Loureiro-Lopez M, Pujol C, Martínez-Carrascoso I, Nuñez E, García-Marqués F, Rodríguez-Hernández MA, Cortés A, Diaz F, Pérez-Martos A, Moraes CT, Fernández-Silva P, Trifunovic A, Navas P, Vazquez J, Enríquez JA.

Cell Rep. 2016 Apr 5;15(1):197-209. doi: 10.1016/j.celrep.2016.03.009. Epub 2016 Mar 24.

10.

Is mitochondrial free radical theory of aging getting old?

Rugarli E, Trifunovic A.

Biochim Biophys Acta. 2015 Nov;1847(11):1345-6. doi: 10.1016/j.bbabio.2015.08.004. Epub 2015 Aug 15. No abstract available.

11.

Oxygen reactivity of mammalian sulfite oxidase provides a concept for the treatment of sulfite oxidase deficiency.

Belaidi AA, Röper J, Arjune S, Krizowski S, Trifunovic A, Schwarz G.

Biochem J. 2015 Jul 15;469(2):211-21. doi: 10.1042/BJ20140768.

PMID:
26171830
12.

Different faces of mitochondrial DNA mutators.

Szczepanowska K, Trifunovic A.

Biochim Biophys Acta. 2015 Nov;1847(11):1362-72. doi: 10.1016/j.bbabio.2015.05.016. Epub 2015 May 23. Review.

13.

Spastin binds to lipid droplets and affects lipid metabolism.

Papadopoulos C, Orso G, Mancuso G, Herholz M, Gumeni S, Tadepalle N, Jüngst C, Tzschichholz A, Schauss A, Höning S, Trifunovic A, Daga A, Rugarli EI.

PLoS Genet. 2015 Apr 13;11(4):e1005149. doi: 10.1371/journal.pgen.1005149. eCollection 2015 Apr.

14.

Obesity-induced CerS6-dependent C16:0 ceramide production promotes weight gain and glucose intolerance.

Turpin SM, Nicholls HT, Willmes DM, Mourier A, Brodesser S, Wunderlich CM, Mauer J, Xu E, Hammerschmidt P, Brönneke HS, Trifunovic A, LoSasso G, Wunderlich FT, Kornfeld JW, Blüher M, Krönke M, Brüning JC.

Cell Metab. 2014 Oct 7;20(4):678-86. doi: 10.1016/j.cmet.2014.08.002.

15.

Defects in β-cell Ca2+ dynamics in age-induced diabetes.

Li L, Trifunovic A, Köhler M, Wang Y, Petrovic Berglund J, Illies C, Juntti-Berggren L, Larsson NG, Berggren PO.

Diabetes. 2014 Dec;63(12):4100-14. doi: 10.2337/db13-1855. Epub 2014 Jul 1.

16.

Loss of UCP2 attenuates mitochondrial dysfunction without altering ROS production and uncoupling activity.

Kukat A, Dogan SA, Edgar D, Mourier A, Jacoby C, Maiti P, Mauer J, Becker C, Senft K, Wibom R, Kudin AP, Hultenby K, Flögel U, Rosenkranz S, Ricquier D, Kunz WS, Trifunovic A.

PLoS Genet. 2014 Jun 19;10(6):e1004385. doi: 10.1371/journal.pgen.1004385. eCollection 2014 Jun.

17.

Mitochondria and metabolic control of the aging process.

Trifunovic A, Ventura N.

Exp Gerontol. 2014 Aug;56:1-2. doi: 10.1016/j.exger.2014.05.009. No abstract available. Erratum in: Exp Gerontol. 2014 Sep;57:272.

PMID:
24906804
18.

Embelin inhibits endothelial mitochondrial respiration and impairs neoangiogenesis during tumor growth and wound healing.

Coutelle O, Hornig-Do HT, Witt A, Andree M, Schiffmann LM, Piekarek M, Brinkmann K, Seeger JM, Liwschitz M, Miwa S, Hallek M, Krönke M, Trifunovic A, Eming SA, Wiesner RJ, Hacker UT, Kashkar H.

EMBO Mol Med. 2014 May;6(5):624-39. doi: 10.1002/emmm.201303016.

19.

Tissue-specific loss of DARS2 activates stress responses independently of respiratory chain deficiency in the heart.

Dogan SA, Pujol C, Maiti P, Kukat A, Wang S, Hermans S, Senft K, Wibom R, Rugarli EI, Trifunovic A.

Cell Metab. 2014 Mar 4;19(3):458-69. doi: 10.1016/j.cmet.2014.02.004.

20.

Succinate dehydrogenase upregulation destabilize complex I and limits the lifespan of gas-1 mutant.

Pujol C, Bratic-Hench I, Sumakovic M, Hench J, Mourier A, Baumann L, Pavlenko V, Trifunovic A.

PLoS One. 2013;8(3):e59493. doi: 10.1371/journal.pone.0059493. Epub 2013 Mar 28.

21.

Somatic progenitor cell vulnerability to mitochondrial DNA mutagenesis underlies progeroid phenotypes in Polg mutator mice.

Ahlqvist KJ, Hämäläinen RH, Yatsuga S, Uutela M, Terzioglu M, Götz A, Forsström S, Salven P, Angers-Loustau A, Kopra OH, Tyynismaa H, Larsson NG, Wartiovaara K, Prolla T, Trifunovic A, Suomalainen A.

Cell Metab. 2012 Jan 4;15(1):100-9. doi: 10.1016/j.cmet.2011.11.012.

22.

A tissue-specific approach to the analysis of metabolic changes in Caenorhabditis elegans.

Hench J, Bratić Hench I, Pujol C, Ipsen S, Brodesser S, Mourier A, Tolnay M, Frank S, Trifunović A.

PLoS One. 2011;6(12):e28417. doi: 10.1371/journal.pone.0028417. Epub 2011 Dec 5.

23.

Modelling mitochondrial dysfunction in mice.

Dogan SA, Trifunovic A.

Physiol Res. 2011;60 Suppl 1:S61-70. Epub 2011 Jul 19. Review.

24.

Random mtDNA mutations modulate proliferation capacity in mouse embryonic fibroblasts.

Kukat A, Edgar D, Bratic I, Maiti P, Trifunovic A.

Biochem Biophys Res Commun. 2011 Jun 10;409(3):394-9. doi: 10.1016/j.bbrc.2011.04.145. Epub 2011 May 7.

PMID:
21575603
25.

High brain lactate is a hallmark of aging and caused by a shift in the lactate dehydrogenase A/B ratio.

Ross JM, Öberg J, Brené S, Coppotelli G, Terzioglu M, Pernold K, Goiny M, Sitnikov R, Kehr J, Trifunovic A, Larsson NG, Hoffer BJ, Olson L.

Proc Natl Acad Sci U S A. 2010 Nov 16;107(46):20087-92. doi: 10.1073/pnas.1008189107. Epub 2010 Nov 1.

26.

Highlight: The biology of aging: mechanisms and intervention.

Brüning J, Langer T, Trifunovic A.

Biol Chem. 2010 Oct;391(10):1113. doi: 10.1515/BC.2010.127. No abstract available.

PMID:
21028967
27.

Caenorhabditis elegans as a model system for mtDNA replication defects.

Bratic I, Hench J, Trifunovic A.

Methods. 2010 Aug;51(4):437-43. doi: 10.1016/j.ymeth.2010.03.003. Epub 2010 Mar 15.

PMID:
20230897
28.

The mtDNA mutator mouse: Dissecting mitochondrial involvement in aging.

Edgar D, Trifunovic A.

Aging (Albany NY). 2009 Dec 11;1(12):1028-32.

29.

Response: Point Mutations Are Causing Progeroid Phenotypes in the mtDNA Mutator Mouse.

Edgar D, Larsson NG, Trifunovic A.

Cell Metab. 2010 Jan 6;11(1):93. No abstract available.

30.

Mitochondrial energy metabolism and ageing.

Bratic I, Trifunovic A.

Biochim Biophys Acta. 2010 Jun-Jul;1797(6-7):961-7. doi: 10.1016/j.bbabio.2010.01.004. Epub 2010 Jan 11. Review.

31.

Point mutations are causing progeroid phenotypes in the mtDNA mutator mouse.

Edgar D, Larsson NG, Trifunovic A.

Cell Metab. 2010 Jan;11(1):1. doi: 10.1016/j.cmet.2009.12.001. No abstract available.

32.

Random point mutations with major effects on protein-coding genes are the driving force behind premature aging in mtDNA mutator mice.

Edgar D, Shabalina I, Camara Y, Wredenberg A, Calvaruso MA, Nijtmans L, Nedergaard J, Cannon B, Larsson NG, Trifunovic A.

Cell Metab. 2009 Aug;10(2):131-8. doi: 10.1016/j.cmet.2009.06.010.

33.

Mitochondrial DNA level, but not active replicase, is essential for Caenorhabditis elegans development.

Bratic I, Hench J, Henriksson J, Antebi A, Bürglin TR, Trifunovic A.

Nucleic Acids Res. 2009 Apr;37(6):1817-28. doi: 10.1093/nar/gkp018. Epub 2009 Jan 30.

34.

Somatic mtDNA mutations and aging--facts and fancies.

Kukat A, Trifunovic A.

Exp Gerontol. 2009 Jan-Feb;44(1-2):101-5. doi: 10.1016/j.exger.2008.05.006. Epub 2008 May 21. Review.

PMID:
18585880
35.

Strong purifying selection in transmission of mammalian mitochondrial DNA.

Stewart JB, Freyer C, Elson JL, Wredenberg A, Cansu Z, Trifunovic A, Larsson NG.

PLoS Biol. 2008 Jan;6(1):e10. doi: 10.1371/journal.pbio.0060010.

36.

Mitochondrial dysfunction as a cause of ageing.

Trifunovic A, Larsson NG.

J Intern Med. 2008 Feb;263(2):167-78. doi: 10.1111/j.1365-2796.2007.01905.x.

37.

Somatic mtDNA mutations cause progressive hearing loss in the mouse.

Niu X, Trifunovic A, Larsson NG, Canlon B.

Exp Cell Res. 2007 Nov 1;313(18):3924-34. Epub 2007 Jun 29.

PMID:
17662273
38.

Progressive parkinsonism in mice with respiratory-chain-deficient dopamine neurons.

Ekstrand MI, Terzioglu M, Galter D, Zhu S, Hofstetter C, Lindqvist E, Thams S, Bergstrand A, Hansson FS, Trifunovic A, Hoffer B, Cullheim S, Mohammed AH, Olson L, Larsson NG.

Proc Natl Acad Sci U S A. 2007 Jan 23;104(4):1325-30. Epub 2007 Jan 16.

39.

Proteolytic processing of OPA1 links mitochondrial dysfunction to alterations in mitochondrial morphology.

Duvezin-Caubet S, Jagasia R, Wagener J, Hofmann S, Trifunovic A, Hansson A, Chomyn A, Bauer MF, Attardi G, Larsson NG, Neupert W, Reichert AS.

J Biol Chem. 2006 Dec 8;281(49):37972-9. Epub 2006 Sep 26.

40.

Mitochondrial DNA and ageing.

Trifunovic A.

Biochim Biophys Acta. 2006 May-Jun;1757(5-6):611-7. Epub 2006 Mar 31. Review.

41.

Somatic mtDNA mutations cause aging phenotypes without affecting reactive oxygen species production.

Trifunovic A, Hansson A, Wredenberg A, Rovio AT, Dufour E, Khvorostov I, Spelbrink JN, Wibom R, Jacobs HT, Larsson NG.

Proc Natl Acad Sci U S A. 2005 Dec 13;102(50):17993-8. Epub 2005 Dec 6.

42.

Mitochondrial DNA polymerase gamma is essential for mammalian embryogenesis.

Hance N, Ekstrand MI, Trifunovic A.

Hum Mol Genet. 2005 Jul 1;14(13):1775-83. Epub 2005 May 11.

PMID:
15888483
43.

Premature ageing in mice expressing defective mitochondrial DNA polymerase.

Trifunovic A, Wredenberg A, Falkenberg M, Spelbrink JN, Rovio AT, Bruder CE, Bohlooly-Y M, Gidlöf S, Oldfors A, Wibom R, Törnell J, Jacobs HT, Larsson NG.

Nature. 2004 May 27;429(6990):417-23.

PMID:
15164064
44.

Tissue-specific knockout model for study of mitochondrial DNA mutation disorders.

Trifunovic A, Larsson NG.

Methods Enzymol. 2002;353:409-21. No abstract available.

PMID:
12078514
45.

Mitochondrial transcription factors B1 and B2 activate transcription of human mtDNA.

Falkenberg M, Gaspari M, Rantanen A, Trifunovic A, Larsson NG, Gustafsson CM.

Nat Genet. 2002 Jul;31(3):289-94. Epub 2002 Jun 17.

PMID:
12068295
46.

Induced synthesis of albumin-like protein in damaged rat reticulocytes.

Trifunović A, Zarić J, Lusić M, Mijatović M, Glisin V, Popović Z.

Br J Haematol. 2001 Oct;115(1):205-12.

PMID:
11722434

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