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Items: 1 to 50 of 65

1.

Structural and Functional Characterization of Sulfonium Carbon-Oxygen Hydrogen Bonding in the Deoxyamino Sugar Methyltransferase TylM1.

Fick RJ, Horowitz S, McDole BG, Clay MC, Mehl RA, Al-Hashimi HM, Scheiner S, Trievel RC.

Biochemistry. 2019 Apr 23;58(16):2152-2159. doi: 10.1021/acs.biochem.8b01141. Epub 2019 Apr 8.

PMID:
30810306
2.

Crystallographic and Computational Characterization of Methyl Tetrel Bonding in S-Adenosylmethionine-Dependent Methyltransferases.

Trievel RC, Scheiner S.

Molecules. 2018 Nov 13;23(11). pii: E2965. doi: 10.3390/molecules23112965.

3.

Reply to 'Misreading chaperone-substrate complexes from random noise'.

Horowitz S, Salmon L, Koldewey P, Ahlstrom LS, Martin R, Quan S, Afonine PV, van den Bedem H, Wang L, Xu Q, Trievel RC, Brooks CL 3rd, Bardwell JCA.

Nat Struct Mol Biol. 2018 Nov;25(11):990-991. doi: 10.1038/s41594-018-0145-2. No abstract available.

PMID:
30297780
4.

The structure of human Nocturnin reveals a conserved ribonuclease domain that represses target transcript translation and abundance in cells.

Abshire ET, Chasseur J, Bohn JA, Del Rizzo PA, Freddolino PL, Goldstrohm AC, Trievel RC.

Nucleic Acids Res. 2018 Jul 6;46(12):6257-6270. doi: 10.1093/nar/gky412.

5.

Water-Mediated Carbon-Oxygen Hydrogen Bonding Facilitates S-Adenosylmethionine Recognition in the Reactivation Domain of Cobalamin-Dependent Methionine Synthase.

Fick RJ, Clay MC, Vander Lee L, Scheiner S, Al-Hashimi H, Trievel RC.

Biochemistry. 2018 Jul 3;57(26):3733-3740. doi: 10.1021/acs.biochem.8b00375. Epub 2018 May 21.

PMID:
29733595
6.

Structure, mechanism, and regulation of polycomb-repressive complex 2.

Moritz LE, Trievel RC.

J Biol Chem. 2018 Sep 7;293(36):13805-13814. doi: 10.1074/jbc.R117.800367. Epub 2017 Sep 14. Review.

PMID:
28912274
7.

Substrate Specificity Profiling of Histone-Modifying Enzymes by Peptide Microarray.

Cornett EM, Dickson BM, Vaughan RM, Krishnan S, Trievel RC, Strahl BD, Rothbart SB.

Methods Enzymol. 2016;574:31-52. doi: 10.1016/bs.mie.2016.01.008. Epub 2016 Feb 16.

8.

Purification, Biochemical Analysis, and Structure Determination of JmjC Lysine Demethylases.

Krishnan S, Trievel RC.

Methods Enzymol. 2016;573:279-301. doi: 10.1016/bs.mie.2016.01.023. Epub 2016 Mar 2.

PMID:
27372758
9.

Visualizing chaperone-assisted protein folding.

Horowitz S, Salmon L, Koldewey P, Ahlstrom LS, Martin R, Quan S, Afonine PV, van den Bedem H, Wang L, Xu Q, Trievel RC, Brooks CL 3rd, Bardwell JC.

Nat Struct Mol Biol. 2016 Jul;23(7):691-7. doi: 10.1038/nsmb.3237. Epub 2016 May 30.

10.

The HIV-1 Tat Protein Is Monomethylated at Lysine 71 by the Lysine Methyltransferase KMT7.

Ali I, Ramage H, Boehm D, Dirk LM, Sakane N, Hanada K, Pagans S, Kaehlcke K, Aull K, Weinberger L, Trievel R, Schnoelzer M, Kamada M, Houtz R, Ott M.

J Biol Chem. 2016 Jul 29;291(31):16240-8. doi: 10.1074/jbc.M116.735415. Epub 2016 May 27.

11.

Measuring the Kinetics of Molecular Association by Isothermal Titration Calorimetry.

Vander Meulen KA, Horowitz S, Trievel RC, Butcher SE.

Methods Enzymol. 2016;567:181-213. doi: 10.1016/bs.mie.2015.08.012. Epub 2015 Oct 9.

PMID:
26794355
12.

Sulfur-Oxygen Chalcogen Bonding Mediates AdoMet Recognition in the Lysine Methyltransferase SET7/9.

Fick RJ, Kroner GM, Nepal B, Magnani R, Horowitz S, Houtz RL, Scheiner S, Trievel RC.

ACS Chem Biol. 2016 Mar 18;11(3):748-54. doi: 10.1021/acschembio.5b00852. Epub 2016 Jan 12.

PMID:
26713889
13.

The LSD1 inhibitor RN-1 induces fetal hemoglobin synthesis and reduces disease pathology in sickle cell mice.

Cui S, Lim KC, Shi L, Lee M, Jearawiriyapaisarn N, Myers G, Campbell A, Harro D, Iwase S, Trievel RC, Rivers A, DeSimone J, Lavelle D, Saunthararajah Y, Engel JD.

Blood. 2015 Jul 16;126(3):386-96. doi: 10.1182/blood-2015-02-626259. Epub 2015 Jun 1.

14.

Frequent side chain methyl carbon-oxygen hydrogen bonding in proteins revealed by computational and stereochemical analysis of neutron structures.

Yesselman JD, Horowitz S, Brooks CL 3rd, Trievel RC.

Proteins. 2015 Mar;83(3):403-410. doi: 10.1002/prot.24724. Epub 2015 Jan 21.

15.

Molecular basis for substrate recognition by lysine methyltransferases and demethylases.

Del Rizzo PA, Trievel RC.

Biochim Biophys Acta. 2014 Dec;1839(12):1404-15. doi: 10.1016/j.bbagrm.2014.06.008. Epub 2014 Jun 17. Review.

PMID:
24946978
16.

Manipulating unconventional CH-based hydrogen bonding in a methyltransferase via noncanonical amino acid mutagenesis.

Horowitz S, Adhikari U, Dirk LM, Del Rizzo PA, Mehl RA, Houtz RL, Al-Hashimi HM, Scheiner S, Trievel RC.

ACS Chem Biol. 2014 Aug 15;9(8):1692-7. doi: 10.1021/cb5001185. Epub 2014 Jul 3.

PMID:
24914947
17.

Conservation and functional importance of carbon-oxygen hydrogen bonding in AdoMet-dependent methyltransferases.

Horowitz S, Dirk LM, Yesselman JD, Nimtz JS, Adhikari U, Mehl RA, Scheiner S, Houtz RL, Al-Hashimi HM, Trievel RC.

J Am Chem Soc. 2013 Oct 16;135(41):15536-48. doi: 10.1021/ja407140k. Epub 2013 Oct 7.

PMID:
24093804
18.

Crystal structure of Saccharomyces cerevisiae Aro8, a putative α-aminoadipate aminotransferase.

Bulfer SL, Brunzelle JS, Trievel RC.

Protein Sci. 2013 Oct;22(10):1417-24. doi: 10.1002/pro.2315. Epub 2013 Aug 28.

19.

Structural and functional analysis of JMJD2D reveals molecular basis for site-specific demethylation among JMJD2 demethylases.

Krishnan S, Trievel RC.

Structure. 2013 Jan 8;21(1):98-108. doi: 10.1016/j.str.2012.10.018. Epub 2012 Dec 6.

20.

An overview of chromatin modifications.

Fick RJ, Trievel RC.

Biopolymers. 2013 Feb;99(2):95-7. doi: 10.1002/bip.22158.

21.

Carbon-oxygen hydrogen bonding in biological structure and function.

Horowitz S, Trievel RC.

J Biol Chem. 2012 Dec 7;287(50):41576-82. doi: 10.1074/jbc.R112.418574. Epub 2012 Oct 9. Review.

22.

Crystal structure and functional analysis of JMJD5 indicate an alternate specificity and function.

Del Rizzo PA, Krishnan S, Trievel RC.

Mol Cell Biol. 2012 Oct;32(19):4044-52. doi: 10.1128/MCB.00513-12. Epub 2012 Jul 30.

23.

Structural analysis of the core COMPASS family of histone H3K4 methylases from yeast to human.

Takahashi YH, Westfield GH, Oleskie AN, Trievel RC, Shilatifard A, Skiniotis G.

Proc Natl Acad Sci U S A. 2011 Dec 20;108(51):20526-31. doi: 10.1073/pnas.1109360108. Epub 2011 Dec 7.

24.

Crystal structure of homoisocitrate dehydrogenase from Schizosaccharomyces pombe.

Bulfer SL, Hendershot JM, Trievel RC.

Proteins. 2012 Feb;80(2):661-6. doi: 10.1002/prot.23231. Epub 2011 Nov 22.

25.

Purification and assay protocols for obtaining highly active Jumonji C demethylases.

Krishnan S, Collazo E, Ortiz-Tello PA, Trievel RC.

Anal Biochem. 2012 Jan 1;420(1):48-53. doi: 10.1016/j.ab.2011.08.034. Epub 2011 Aug 26.

PMID:
21925481
26.

Substrate and product specificities of SET domain methyltransferases.

Del Rizzo PA, Trievel RC.

Epigenetics. 2011 Sep 1;6(9):1059-67. doi: 10.4161/epi.6.9.16069. Epub 2011 Sep 1. Review.

27.

Direct evidence for methyl group coordination by carbon-oxygen hydrogen bonds in the lysine methyltransferase SET7/9.

Horowitz S, Yesselman JD, Al-Hashimi HM, Trievel RC.

J Biol Chem. 2011 May 27;286(21):18658-63. doi: 10.1074/jbc.M111.232876. Epub 2011 Mar 18.

28.

Structure and function of histone H3 lysine 9 methyltransferases and demethylases.

Krishnan S, Horowitz S, Trievel RC.

Chembiochem. 2011 Jan 24;12(2):254-63. doi: 10.1002/cbic.201000545. Epub 2011 Jan 5. Review.

29.

Application of a high-throughput fluorescent acetyltransferase assay to identify inhibitors of homocitrate synthase.

Bulfer SL, McQuade TJ, Larsen MJ, Trievel RC.

Anal Biochem. 2011 Mar 1;410(1):133-40. doi: 10.1016/j.ab.2010.11.004. Epub 2010 Nov 10.

30.

Calmodulin methyltransferase is an evolutionarily conserved enzyme that trimethylates Lys-115 in calmodulin.

Magnani R, Dirk LM, Trievel RC, Houtz RL.

Nat Commun. 2010 Jul 27;1:43. doi: 10.1038/ncomms1044.

PMID:
20975703
31.

SET7/9 catalytic mutants reveal the role of active site water molecules in lysine multiple methylation.

Del Rizzo PA, Couture JF, Dirk LM, Strunk BS, Roiko MS, Brunzelle JS, Houtz RL, Trievel RC.

J Biol Chem. 2010 Oct 8;285(41):31849-58. doi: 10.1074/jbc.M110.114587. Epub 2010 Aug 1.

32.

The Cellular lysine methyltransferase Set7/9-KMT7 binds HIV-1 TAR RNA, monomethylates the viral transactivator Tat, and enhances HIV transcription.

Pagans S, Kauder SE, Kaehlcke K, Sakane N, Schroeder S, Dormeyer W, Trievel RC, Verdin E, Schnolzer M, Ott M.

Cell Host Microbe. 2010 Mar 18;7(3):234-44. doi: 10.1016/j.chom.2010.02.005.

33.

Structural basis for L-lysine feedback inhibition of homocitrate synthase.

Bulfer SL, Scott EM, Pillus L, Trievel RC.

J Biol Chem. 2010 Apr 2;285(14):10446-53. doi: 10.1074/jbc.M109.094383. Epub 2010 Jan 19.

34.

Coxibs interfere with the action of aspirin by binding tightly to one monomer of cyclooxygenase-1.

Rimon G, Sidhu RS, Lauver DA, Lee JY, Sharma NP, Yuan C, Frieler RA, Trievel RC, Lucchesi BR, Smith WL.

Proc Natl Acad Sci U S A. 2010 Jan 5;107(1):28-33. doi: 10.1073/pnas.0909765106. Epub 2009 Dec 1.

35.

Crystal structure and functional analysis of homocitrate synthase, an essential enzyme in lysine biosynthesis.

Bulfer SL, Scott EM, Couture JF, Pillus L, Trievel RC.

J Biol Chem. 2009 Dec 18;284(51):35769-80. doi: 10.1074/jbc.M109.046821.

36.

WDR5, a complexed protein.

Trievel RC, Shilatifard A.

Nat Struct Mol Biol. 2009 Jul;16(7):678-80. doi: 10.1038/nsmb0709-678. No abstract available.

PMID:
19578375
37.

Regulation of H3K4 trimethylation via Cps40 (Spp1) of COMPASS is monoubiquitination independent: implication for a Phe/Tyr switch by the catalytic domain of Set1.

Takahashi YH, Lee JS, Swanson SK, Saraf A, Florens L, Washburn MP, Trievel RC, Shilatifard A.

Mol Cell Biol. 2009 Jul;29(13):3478-86. doi: 10.1128/MCB.00013-09. Epub 2009 Apr 27.

38.

Rubisco in complex with Rubisco large subunit methyltransferase.

Raunser S, Magnani R, Huang Z, Houtz RL, Trievel RC, Penczek PA, Walz T.

Proc Natl Acad Sci U S A. 2009 Mar 3;106(9):3160-5. doi: 10.1073/pnas.0810563106. Epub 2009 Feb 10.

39.

Structural origins for the product specificity of SET domain protein methyltransferases.

Couture JF, Dirk LM, Brunzelle JS, Houtz RL, Trievel RC.

Proc Natl Acad Sci U S A. 2008 Dec 30;105(52):20659-64. doi: 10.1073/pnas.0806712105. Epub 2008 Dec 16.

40.

Histone modifying enzymes: structures, mechanisms, and specificities.

Marmorstein R, Trievel RC.

Biochim Biophys Acta. 2009 Jan;1789(1):58-68. doi: 10.1016/j.bbagrm.2008.07.009. Epub 2008 Aug 3. Review.

41.

Human SFMBT is a transcriptional repressor protein that selectively binds the N-terminal tail of histone H3.

Wu S, Trievel RC, Rice JC.

FEBS Lett. 2007 Jul 10;581(17):3289-96. Epub 2007 Jun 21.

42.

Specificity and mechanism of JMJD2A, a trimethyllysine-specific histone demethylase.

Couture JF, Collazo E, Ortiz-Tello PA, Brunzelle JS, Trievel RC.

Nat Struct Mol Biol. 2007 Aug;14(8):689-95. Epub 2007 Jun 24.

PMID:
17589523
43.

Kinetic manifestation of processivity during multiple methylations catalyzed by SET domain protein methyltransferases.

Dirk LM, Flynn EM, Dietzel K, Couture JF, Trievel RC, Houtz RL.

Biochemistry. 2007 Mar 27;46(12):3905-15. Epub 2007 Mar 6.

PMID:
17338551
44.

Histone-modifying enzymes: encrypting an enigmatic epigenetic code.

Couture JF, Trievel RC.

Curr Opin Struct Biol. 2006 Dec;16(6):753-60. Epub 2006 Oct 27. Review.

PMID:
17070031
45.

Molecular recognition of histone H3 by the WD40 protein WDR5.

Couture JF, Collazo E, Trievel RC.

Nat Struct Mol Biol. 2006 Aug;13(8):698-703. Epub 2006 Jul 9.

PMID:
16829960
46.

Catalytic roles for carbon-oxygen hydrogen bonding in SET domain lysine methyltransferases.

Couture JF, Hauk G, Thompson MJ, Blackburn GM, Trievel RC.

J Biol Chem. 2006 Jul 14;281(28):19280-7. Epub 2006 May 8.

47.

Structural basis for the methylation site specificity of SET7/9.

Couture JF, Collazo E, Hauk G, Trievel RC.

Nat Struct Mol Biol. 2006 Feb;13(2):140-6. Epub 2006 Jan 15.

PMID:
16415881
48.

7 Non-histone protein lysine methyltransferases: Structure and catalytic roles.

Dirk LM, Trievel RC, Houtz RL.

Enzymes. 2006;24:179-228. doi: 10.1016/S1874-6047(06)80009-0. Epub 2007 Jun 4.

PMID:
26718041
49.

The SET-domain protein superfamily: protein lysine methyltransferases.

Dillon SC, Zhang X, Trievel RC, Cheng X.

Genome Biol. 2005;6(8):227. Epub 2005 Aug 2. Review.

50.

A coupled fluorescent assay for histone methyltransferases.

Collazo E, Couture JF, Bulfer S, Trievel RC.

Anal Biochem. 2005 Jul 1;342(1):86-92.

PMID:
15958184

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