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Protein Signatures and Tissue Diagnosis of Pancreatic Cancer.

Underwood PW, Gerber MH, Nguyen K, Delitto D, Han S, Thomas RM, Forsmark CE, Trevino JG, Gooding WE, Hughes SJ.

J Am Coll Surg. 2019 Oct 16. pii: S1072-7515(19)32122-2. doi: 10.1016/j.jamcollsurg.2019.10.002. [Epub ahead of print]


Dual Farnesyl and Geranylgeranyl Transferase Inhibitor Thwarts Mutant KRAS-Driven Patient-Derived Pancreatic Tumors.

Kazi A, Xiang S, Yang H, Chen L, Kennedy P, Ayaz M, Fletcher S, Cummings C, Lawrence HR, Beato F, Kang Y, Kim MP, Delitto A, Underwood PW, Fleming JB, Trevino JG, Hamilton AD, Sebti SM.

Clin Cancer Res. 2019 Oct 1;25(19):5984-5996. doi: 10.1158/1078-0432.CCR-18-3399. Epub 2019 Jun 21.


A deeper understanding of the tumor microenvironment in pancreatic cancer: the key to developing effective immunotherapies.

Underwood PW, Trevino JG.

Ann Transl Med. 2019 Apr;7(8):162. doi: 10.21037/atm.2019.03.14. No abstract available.


Racial and ethnic disparities in a state-wide registry of patients with pancreatic cancer and an exploratory investigation of cancer cachexia as a contributor to observed inequities.

Permuth JB, Clark Daly A, Jeong D, Choi JW, Cameron ME, Chen DT, Teer JK, Barnett TE, Li J, Powers BD, Kumar NB, George TJ, Ali KN, Huynh T, Vyas S, Gwede CK, Simmons VN, Hodul PJ, Carballido EM, Judge AR, Fleming JB, Merchant N, Trevino JG.

Cancer Med. 2019 Jun;8(6):3314-3324. doi: 10.1002/cam4.2180. Epub 2019 May 9.


Skeletal Muscle Fibrosis in Pancreatic Cancer Patients with Respect to Survival.

Judge SM, Nosacka RL, Delitto D, Gerber MH, Cameron ME, Trevino JG, Judge AR.

JNCI Cancer Spectr. 2018 Jul;2(3):pky043. doi: 10.1093/jncics/pky043. Epub 2018 Aug 6.


Glucose and Lactate Transport in Pancreatic Cancer: Glycolytic Metabolism Revisited.

Cameron ME, Yakovenko A, Trevino JG.

J Oncol. 2018 Dec 4;2018:6214838. doi: 10.1155/2018/6214838. eCollection 2018. Review.


Molecular therapeutic strategies targeting pancreatic cancer induced cachexia.

Yakovenko A, Cameron M, Trevino JG.

World J Gastrointest Surg. 2018 Dec 27;10(9):95-106. doi: 10.4240/wjgs.v10.i9.95. Review.


Local and Systemic Cytokine Profiling for Pancreatic Ductal Adenocarcinoma to Study Cancer Cachexia in an Era of Precision Medicine.

Gerber MH, Underwood PW, Judge SM, Delitto D, Delitto AE, Nosacka RL, DiVita BB, Thomas RM, Permuth JB, Hughes SJ, Wallet SM, Judge AR, Trevino JG.

Int J Mol Sci. 2018 Dec 1;19(12). pii: E3836. doi: 10.3390/ijms19123836.


Mas Receptor Activation Slows Tumor Growth and Attenuates Muscle Wasting in Cancer.

Murphy KT, Hossain MI, Swiderski K, Chee A, Naim T, Trieu J, Haynes V, Read SJ, Stapleton DI, Judge SM, Trevino JG, Judge AR, Lynch GS.

Cancer Res. 2019 Feb 15;79(4):706-719. doi: 10.1158/0008-5472.CAN-18-1207. Epub 2018 Nov 12.


Development of apratoxin S10 (Apra S10) as an anti-pancreatic cancer agent and its preliminary evaluation in an orthotopic patient-derived xenograft (PDX) model.

Cai W, Ratnayake R, Gerber MH, Chen QY, Yu Y, Derendorf H, Trevino JG, Luesch H.

Invest New Drugs. 2019 Apr;37(2):364-374. doi: 10.1007/s10637-018-0647-0. Epub 2018 Aug 3.


Linc-ing Circulating Long Non-coding RNAs to the Diagnosis and Malignant Prediction of Intraductal Papillary Mucinous Neoplasms of the Pancreas.

Permuth JB, Chen DT, Yoder SJ, Li J, Smith AT, Choi JW, Kim J, Balagurunathan Y, Jiang K, Coppola D, Centeno BA, Klapman J, Hodul P, Karreth FA, Trevino JG, Merchant N, Magliocco A, Malafa MP, Gillies R.

Sci Rep. 2017 Sep 5;7(1):10484. doi: 10.1038/s41598-017-09754-5.


A Prospective Randomized Multicenter Trial of Distal Pancreatectomy With and Without Routine Intraperitoneal Drainage.

Van Buren G 2nd, Bloomston M, Schmidt CR, Behrman SW, Zyromski NJ, Ball CG, Morgan KA, Hughes SJ, Karanicolas PJ, Allendorf JD, Vollmer CM Jr, Ly Q, Brown KM, Velanovich V, Winter JM, McElhany AL, Muscarella P 2nd, Schmidt CM, House MG, Dixon E, Dillhoff ME, Trevino JG, Hallet J, Coburn NSG, Nakeeb A, Behrns KE, Sasson AR, Ceppa EP, Abdel-Misih SRZ, Riall TS, Silberfein EJ, Ellison EC, Adams DB, Hsu C, Tran Cao HS, Mohammed S, Villafañe-Ferriol N, Barakat O, Massarweh NN, Chai C, Mendez-Reyes JE, Fang A, Jo E, Mo Q, Fisher WE.

Ann Surg. 2017 Sep;266(3):421-431. doi: 10.1097/SLA.0000000000002375.


Orthotopic Patient-Derived Pancreatic Cancer Xenografts Engraft Into the Pancreatic Parenchyma, Metastasize, and Induce Muscle Wasting to Recapitulate the Human Disease.

Go KL, Delitto D, Judge SM, Gerber MH, George TJ Jr, Behrns KE, Hughes SJ, Judge AR, Trevino JG.

Pancreas. 2017 Jul;46(6):813-819. doi: 10.1097/MPA.0000000000000843.


Analysis of the Cost Effectiveness of Laparoscopic Pancreatoduodenectomy.

Gerber MH, Delitto D, Crippen CJ, George TJ Jr, Behrns KE, Trevino JG, Cioffi JL, Hughes SJ.

J Gastrointest Surg. 2017 Sep;21(9):1404-1410. doi: 10.1007/s11605-017-3466-2. Epub 2017 May 31.


A pilot study of radiologic measures of abdominal adiposity: weighty contributors to early pancreatic carcinogenesis worth evaluating?

Permuth JB, Choi JW, Chen DT, Jiang K, DeNicola G, Li JN, Coppola D, Centeno BA, Magliocco A, Balagurunathan Y, Merchant N, Trevino JG, Jeong D.

Cancer Biol Med. 2017 Feb;14(1):66-73. doi: 10.20892/j.issn.2095-3941.2017.0006.


A clinically applicable muscular index predicts long-term survival in resectable pancreatic cancer.

Delitto D, Judge SM, George TJ Jr, Sarosi GA, Thomas RM, Behrns KE, Hughes SJ, Judge AR, Trevino JG.

Surgery. 2017 Apr;161(4):930-938. doi: 10.1016/j.surg.2016.09.038. Epub 2016 Dec 5.


Human pancreatic cancer xenografts recapitulate key aspects of cancer cachexia.

Delitto D, Judge SM, Delitto AE, Nosacka RL, Rocha FG, DiVita BB, Gerber MH, George TJ Jr, Behrns KE, Hughes SJ, Wallet SM, Judge AR, Trevino JG.

Oncotarget. 2017 Jan 3;8(1):1177-1189. doi: 10.18632/oncotarget.13593.


Human Pancreatic Cancer Cells Induce a MyD88-Dependent Stromal Response to Promote a Tumor-Tolerant Immune Microenvironment.

Delitto D, Delitto AE, DiVita BB, Pham K, Han S, Hartlage ER, Newby BN, Gerber MH, Behrns KE, Moldawer LL, Thomas RM, George TJ Jr, Brusko TM, Mathews CE, Liu C, Trevino JG, Hughes SJ, Wallet SM.

Cancer Res. 2017 Feb 1;77(3):672-683. doi: 10.1158/0008-5472.CAN-16-1765. Epub 2016 Nov 18.


The pancreatic tumor microenvironment drives changes in miRNA expression that promote cytokine production and inhibit migration by the tumor associated stroma.

Han S, Gonzalo DH, Feely M, Delitto D, Behrns KE, Beveridge M, Zhang D, Thomas R, Trevino JG, Schmittgen TD, Hughes SJ.

Oncotarget. 2016 Jul 20;8(33):54054-54067. doi: 10.18632/oncotarget.10722. eCollection 2017 Aug 15.


Atypical presentation of a hepatic artery pseudoaneurysm: A case report and review of the literature.

Luckhurst CM, Perez C, Collinsworth AL, Trevino JG.

World J Hepatol. 2016 Jun 28;8(18):779-84. doi: 10.4254/wjh.v8.i18.779.


Standardization of surgical care in a high-volume center improves survival in resected pancreatic head cancer.

Delitto D, Black BS, Cunningham HB, Sliesoraitis S, Lu X, Liu C, Sarosi GA, Thomas RM, Trevino JG, Hughes SJ, George TJ Jr, Behrns KE.

Am J Surg. 2016 Aug;212(2):195-201.e1. doi: 10.1016/j.amjsurg.2016.03.001. Epub 2016 May 10.


Oncologic and Perioperative Outcomes Following Selective Application of Laparoscopic Pancreaticoduodenectomy for Periampullary Malignancies.

Delitto D, Luckhurst CM, Black BS, Beck JL, George TJ Jr, Sarosi GA, Thomas RM, Trevino JG, Behrns KE, Hughes SJ.

J Gastrointest Surg. 2016 Jul;20(7):1343-9. doi: 10.1007/s11605-016-3136-9. Epub 2016 May 3.


Isolation of Pancreatic Cancer Cells from a Patient-Derived Xenograft Model Allows for Practical Expansion and Preserved Heterogeneity in Culture.

Pham K, Delitto D, Knowlton AE, Hartlage ER, Madhavan R, Gonzalo DH, Thomas RM, Behrns KE, George TJ Jr, Hughes SJ, Wallet SM, Liu C, Trevino JG.

Am J Pathol. 2016 Jun;186(6):1537-46. doi: 10.1016/j.ajpath.2016.02.009. Epub 2016 Apr 18.


Src drives the Warburg effect and therapy resistance by inactivating pyruvate dehydrogenase through tyrosine-289 phosphorylation.

Jin Y, Cai Q, Shenoy AK, Lim S, Zhang Y, Charles S, Tarrash M, Fu X, Kamarajugadda S, Trevino JG, Tan M, Lu J.

Oncotarget. 2016 May 3;7(18):25113-24. doi: 10.18632/oncotarget.7159.


Nicotine Reduces Survival via Augmentation of Paracrine HGF-MET Signaling in the Pancreatic Cancer Microenvironment.

Delitto D, Zhang D, Han S, Black BS, Knowlton AE, Vlada AC, Sarosi GA, Behrns KE, Thomas RM, Lu X, Liu C, George TJ, Hughes SJ, Wallet SM, Trevino JG.

Clin Cancer Res. 2016 Apr 1;22(7):1787-99. doi: 10.1158/1078-0432.CCR-15-1256. Epub 2015 Dec 14.


The inflammatory milieu within the pancreatic cancer microenvironment correlates with clinicopathologic parameters, chemoresistance and survival.

Delitto D, Black BS, Sorenson HL, Knowlton AE, Thomas RM, Sarosi GA, Moldawer LL, Behrns KE, Liu C, George TJ, Trevino JG, Wallet SM, Hughes SJ.

BMC Cancer. 2015 Oct 24;15:783. doi: 10.1186/s12885-015-1820-x.


Downstream mediators of the intratumoral interferon response suppress antitumor immunity, induce gemcitabine resistance and associate with poor survival in human pancreatic cancer.

Delitto D, Perez C, Han S, Gonzalo DH, Pham K, Knowlton AE, Graves CL, Behrns KE, Moldawer LL, Thomas RM, Liu C, George TJ Jr, Trevino JG, Wallet SM, Hughes SJ.

Cancer Immunol Immunother. 2015 Dec;64(12):1553-63. doi: 10.1007/s00262-015-1760-y. Epub 2015 Sep 30.


Hepatocyte Growth Factor from a Clinical Perspective: A Pancreatic Cancer Challenge.

Rizwani W, Allen AE, Trevino JG.

Cancers (Basel). 2015 Sep 3;7(3):1785-805. doi: 10.3390/cancers7030861. Review.


Primary outgrowth cultures are a reliable source of human pancreatic stellate cells.

Han S, Delitto D, Zhang D, Sorenson HL, Sarosi GA, Thomas RM, Behrns KE, Wallet SM, Trevino JG, Hughes SJ.

Lab Invest. 2015 Nov;95(11):1331-40. doi: 10.1038/labinvest.2015.117. Epub 2015 Aug 31.


Local pancreatic head resection: the search for optimal indications through quality of life assessments.

Fischer TD, Gutman DS, Warner EA, Trevino JG, Hughes SJ, Behrns KE.

Am J Surg. 2015 Sep;210(3):417-23. doi: 10.1016/j.amjsurg.2014.12.049. Epub 2015 May 1.


Patient-derived xenograft models for pancreatic adenocarcinoma demonstrate retention of tumor morphology through incorporation of murine stromal elements.

Delitto D, Pham K, Vlada AC, Sarosi GA, Thomas RM, Behrns KE, Liu C, Hughes SJ, Wallet SM, Trevino JG.

Am J Pathol. 2015 May;185(5):1297-303. doi: 10.1016/j.ajpath.2015.01.016. Epub 2015 Mar 12.


Multidisciplinary neoadjuvant management for potentially curable pancreatic cancer.

Desai NV, Sliesoraitis S, Hughes SJ, Trevino JG, Zlotecki RA, Ivey AM, George TJ Jr.

Cancer Med. 2015 Aug;4(8):1224-39. doi: 10.1002/cam4.444. Epub 2015 Mar 13. Review.


Disconnected pancreatic duct syndrome: disease classification and management strategies.

Fischer TD, Gutman DS, Hughes SJ, Trevino JG, Behrns KE.

J Am Coll Surg. 2014 Oct;219(4):704-12. doi: 10.1016/j.jamcollsurg.2014.03.055. Epub 2014 May 22.


c-Met signaling in the development of tumorigenesis and chemoresistance: potential applications in pancreatic cancer.

Delitto D, Vertes-George E, Hughes SJ, Behrns KE, Trevino JG.

World J Gastroenterol. 2014 Jul 14;20(26):8458-70. doi: 10.3748/wjg.v20.i26.8458. Review.


IgG4-related cholecystitis presenting as biliary malignancy: report of three cases.

Feely MM, Gonzalo DH, Corbera M, Hughes SJ, Trevino JG.

J Gastrointest Surg. 2014 Sep;18(9):1710-5. doi: 10.1007/s11605-014-2568-3. Epub 2014 Jun 19.


Src inhibition is still a relevant target in pancreatic cancer.

George TJ Jr, Trevino JG, Liu C.

Oncologist. 2014 Feb;19(2):211. doi: 10.1634/theoncologist.2013-0410. Epub 2014 Jan 23. No abstract available.


Autocrine extra-pancreatic trypsin 3 secretion promotes cell proliferation and survival in esophageal adenocarcinoma.

Han S, Lee CW, Trevino JG, Hughes SJ, Sarosi GA Jr.

PLoS One. 2013 Oct 11;8(10):e76667. doi: 10.1371/journal.pone.0076667. eCollection 2013.


Selective disruption of rb-raf-1 kinase interaction inhibits pancreatic adenocarcinoma growth irrespective of gemcitabine sensitivity.

Treviño JG, Verma M, Singh S, Pillai S, Zhang D, Pernazza D, Sebti SM, Lawrence NJ, Centeno BA, Chellappan SP.

Mol Cancer Ther. 2013 Dec;12(12):2722-34. doi: 10.1158/1535-7163.MCT-12-0719. Epub 2013 Oct 9.


Failure to follow evidence-based best practice guidelines in the treatment of severe acute pancreatitis.

Vlada AC, Schmit B, Perry A, Trevino JG, Behrns KE, Hughes SJ.

HPB (Oxford). 2013 Oct;15(10):822-7. doi: 10.1111/hpb.12140.


Characteristics and outcomes of adenosquamous carcinoma of the pancreas.

Simone CG, Zuluaga Toro T, Chan E, Feely MM, Trevino JG, George TJ Jr.

Gastrointest Cancer Res. 2013 May;6(3):75-9.


Nicotine induces inhibitor of differentiation-1 in a Src-dependent pathway promoting metastasis and chemoresistance in pancreatic adenocarcinoma.

Treviño JG, Pillai S, Kunigal S, Singh S, Fulp WJ, Centeno BA, Chellappan SP.

Neoplasia. 2012 Dec;14(12):1102-14.


Traumatic intraperitoneal rupture of an urachal leiomyosarcoma: unique presentation as hemorrhagic shock.

Saied A, Salzman S, Hochwald SN, Trevino JG.

Am Surg. 2012 Sep;78(9):E409-11. No abstract available.


Gastrointestinal stromal tumors: a paradigm for therapeutic options in solid organ tumors.

Novak C, Trevino JG.

Mini Rev Med Chem. 2010 Jun;10(7):624-34. Review.


Current adjuvant and targeted therapies for pancreatic adenocarcinoma.

Sanchez SE, Trevino JG.

Curr Med Chem. 2008;15(17):1674-83. Review.


Antiangiogenic and antitumor effects of SRC inhibition in ovarian carcinoma.

Han LY, Landen CN, Trevino JG, Halder J, Lin YG, Kamat AA, Kim TJ, Merritt WM, Coleman RL, Gershenson DM, Shakespeare WC, Wang Y, Sundaramoorth R, Metcalf CA 3rd, Dalgarno DC, Sawyer TK, Gallick GE, Sood AK.

Cancer Res. 2006 Sep 1;66(17):8633-9.


Intraductal papillary mucinous neoplasms of the pancreas.

Trevino JG, Espat NJ, Helton WS.

Curr Treat Options Gastroenterol. 2006 Sep;9(5):385-90.


Src activation of Stat3 is an independent requirement from NF-kappaB activation for constitutive IL-8 expression in human pancreatic adenocarcinoma cells.

Trevino JG, Gray MJ, Nawrocki ST, Summy JM, Lesslie DP, Evans DB, Sawyer TK, Shakespeare WC, Watowich SS, Chiao PJ, McConkey DJ, Gallick GE.

Angiogenesis. 2006;9(2):101-10. Epub 2006 Jul 27.


SRC inhibitors as potential therapeutic agents for human cancers.

Trevino JG, Summy JM, Gallick GE.

Mini Rev Med Chem. 2006 Jun;6(6):681-7. Review.


Inhibition of PDGFR phosphorylation and Src and Akt activity by GN963 leads to therapy of human pancreatic cancer growing orthotopically in nude mice.

Baker CH, Trevino JG, Summy JM, Zhang F, Caron A, Nesbit M, Gallick GE, Fidler IJ.

Int J Oncol. 2006 Jul;29(1):125-38.


Vascular endothelial growth factor receptor-1 mediates migration of human colorectal carcinoma cells by activation of Src family kinases.

Lesslie DP, Summy JM, Parikh NU, Fan F, Trevino JG, Sawyer TK, Metcalf CA, Shakespeare WC, Hicklin DJ, Ellis LM, Gallick GE.

Br J Cancer. 2006 Jun 5;94(11):1710-7.

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