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Items: 1 to 50 of 92

1.

Glutathione S-transferase theta genotypes and environmental exposures in the risk of canine transitional cell carcinoma.

Luethcke KR, Ekena J, Chun R, Trepanier LA.

J Vet Intern Med. 2019 May;33(3):1414-1422. doi: 10.1111/jvim.15504. Epub 2019 Apr 22.

2.

Prospective crossover clinical trial comparing transdermal with oral phenobarbital administration in epileptic cats.

Barnes Heller HL, Trepanier LA, Robertson M, Mei C.

J Feline Med Surg. 2019 Dec;21(12):1181-1187. doi: 10.1177/1098612X18823577. Epub 2019 Jan 28.

PMID:
30688552
3.

Glutathione-S-transferase-theta genotypes and the risk of cyclophosphamide toxicity in dogs.

Ekena J, Wood E, Manchester A, Chun R, Trepanier LA.

Vet Comp Oncol. 2018 Dec;16(4):529-534. doi: 10.1111/vco.12411. Epub 2018 Jul 8.

PMID:
29984447
4.

RNA expression profiling in sulfamethoxazole-treated patients with a range of in vitro lymphocyte cytotoxicity phenotypes.

Reinhart JM, Rose W, Panyard DJ, Newton MA, Liebenstein TK, Yee J, Trepanier LA.

Pharmacol Res Perspect. 2018 Mar 2;6(2):e00388. doi: 10.1002/prp2.388. eCollection 2018 Apr.

5.

Evaluation of potential serum biomarkers of hepatic fibrosis and necroinflammatory activity in dogs with liver disease.

Raghu C, Ekena J, Cullen JM, Webb CB, Trepanier LA.

J Vet Intern Med. 2018 May;32(3):1009-1018. doi: 10.1111/jvim.15064. Epub 2018 Feb 27.

6.

A single-nucleotide polymorphism in the canine cytochrome b5 reductase (CYB5R3) gene is associated with sulfonamide hypersensitivity and is overrepresented in Doberman Pinschers.

Reinhart JM, Ekena J, Cioffi AC, Trepanier LA.

J Vet Pharmacol Ther. 2018 Jun;41(3):402-408. doi: 10.1111/jvp.12478. Epub 2018 Jan 15.

7.

Characterization of a low expression haplotype in canine glutathione S-transferase (GSTT1) and its prevalence in golden retrievers.

Craft S, Ekena J, Mayer B, Thamm DH, Saba C, Chun R, Trepanier LA.

Vet Comp Oncol. 2018 Mar;16(1):E61-E67. doi: 10.1111/vco.12333. Epub 2017 Aug 25.

PMID:
28840668
8.

Plasma l-citrulline concentrations in l-arginine-supplemented healthy dogs.

Flynn KM, Kellihan HB, Trepanier LA.

J Vet Cardiol. 2017 Aug;19(4):376-383. doi: 10.1016/j.jvc.2017.04.005. Epub 2017 Jul 3.

PMID:
28684243
9.

Hepatic expression profiles in retroviral infection: relevance to drug hypersensitivity risk.

Wong YY, Johnson B, Friedrich TC, Trepanier LA.

Pharmacol Res Perspect. 2017 Apr 26;5(3):e00312. doi: 10.1002/prp2.312. eCollection 2017 Jun.

10.

Urinary F2 -Isoprostanes in Cats with International Renal Interest Society Stage 1-4 Chronic Kidney Disease.

Whitehouse W, Quimby J, Wan S, Monaghan K, Robbins R, Trepanier LA.

J Vet Intern Med. 2017 Mar;31(2):449-456. doi: 10.1111/jvim.14634. Epub 2017 Feb 4.

11.

Immunogenicity of trimethoprim/sulfamethoxazole in a macaque model of HIV infection.

Wong YY, Rakasz EG, Gasper DJ, Friedrich TC, Trepanier LA.

Toxicology. 2016 Aug 10;368-369:10-18. doi: 10.1016/j.tox.2016.08.010. Epub 2016 Aug 23.

12.

Genome-Wide Association Study in Immunocompetent Patients with Delayed Hypersensitivity to Sulfonamide Antimicrobials.

Reinhart JM, Motsinger-Reif A, Dickey A, Yale S, Trepanier LA.

PLoS One. 2016 Jun 7;11(6):e0156000. doi: 10.1371/journal.pone.0156000. eCollection 2016.

13.

Transient cold agglutinins associated with Mycoplasma cynos pneumonia in a dog.

Pinkos AC, Friedrichs KR, Monaghan KN, Sample SH, Trepanier LA.

Vet Clin Pathol. 2015 Dec;44(4):498-502. doi: 10.1111/vcp.12286. Epub 2015 Sep 10.

PMID:
26356600
14.

Report from the National Institute of Allergy and Infectious Diseases workshop on drug allergy.

Wheatley LM, Plaut M, Schwaninger JM, Banerji A, Castells M, Finkelman FD, Gleich GJ, Guttman-Yassky E, Mallal SA, Naisbitt DJ, Ostrov DA, Phillips EJ, Pichler WJ, Platts-Mills TA, Roujeau JC, Schwartz LB, Trepanier LA.

J Allergy Clin Immunol. 2015 Aug;136(2):262-71.e2. doi: 10.1016/j.jaci.2015.05.027.

15.

Opportunistic fungal infections in dogs treated with ciclosporin and glucocorticoids: eight cases.

Dowling SR, Webb J, Foster JD, Ginn J, Foy DS, Trepanier LA.

J Small Anim Pract. 2016 Feb;57(2):105-109. doi: 10.1111/jsap.12367. Epub 2015 May 18.

PMID:
25988822
16.

Incidence, timing, and risk factors of azathioprine hepatotoxicosis in dogs.

Wallisch K, Trepanier LA.

J Vet Intern Med. 2015 Mar-Apr;29(2):513-8. doi: 10.1111/jvim.12543. Epub 2015 Jan 29.

17.

Polymorphisms in the carcinogen detoxification genes CYB5A and CYB5R3 and breast cancer risk in African American women.

Blanke KL, Sacco JC, Millikan RC, Olshan AF, Luo J, Trepanier LA.

Cancer Causes Control. 2014 Nov;25(11):1513-21. doi: 10.1007/s10552-014-0454-7. Epub 2014 Sep 16.

18.

Congenital methemoglobinemia in a dog with a promoter deletion and a nonsynonymous coding variant in the gene encoding cytochrome b₅.

McKenna JA, Sacco J, Son TT, Trepanier LA, Callan MB, Harvey JW, Arndt JW.

J Vet Intern Med. 2014 Sep-Oct;28(5):1626-31. doi: 10.1111/jvim.12423. Epub 2014 Aug 21. No abstract available.

19.

Therapeutic serum phenobarbital concentrations obtained using chronic transdermal administration of phenobarbital in healthy cats.

Delamaide Gasper JA, Barnes Heller HL, Robertson M, Trepanier LA.

J Feline Med Surg. 2015 Apr;17(4):359-63. doi: 10.1177/1098612X14545141. Epub 2014 Aug 6.

PMID:
25098448
20.

Serum biomarkers of clinical and cytologic response in dogs with idiopathic immune-mediated polyarthropathy.

Foster JD, Sample S, Kohler R, Watson K, Muir P, Trepanier LA.

J Vet Intern Med. 2014 May-Jun;28(3):905-11. doi: 10.1111/jvim.12351. Epub 2014 Apr 3.

21.

Short- and long-term cure rates of short-duration trimethoprim-sulfamethoxazole treatment in female dogs with uncomplicated bacterial cystitis.

Clare S, Hartmann FA, Jooss M, Bachar E, Wong YY, Trepanier LA, Viviano KR.

J Vet Intern Med. 2014 May-Jun;28(3):818-26. doi: 10.1111/jvim.12324. Epub 2014 Mar 27.

22.

Serum and urine Blastomyces antigen concentrations as markers of clinical remission in dogs treated for systemic blastomycosis.

Foy DS, Trepanier LA, Kirsch EJ, Wheat LJ.

J Vet Intern Med. 2014 Mar-Apr;28(2):305-10. doi: 10.1111/jvim.12306. Epub 2014 Feb 3.

23.

Use of linezolid to treat MRSP bacteremia and discospondylitis in a dog.

Foster JD, Trepanier LA, Ginn JA.

J Am Anim Hosp Assoc. 2014 Jan-Feb;50(1):53-8. doi: 10.5326/JAAHA-MS-5947. Epub 2013 Nov 11.

PMID:
24216492
24.

Idiosyncratic drug toxicity affecting the liver, skin, and bone marrow in dogs and cats.

Trepanier LA.

Vet Clin North Am Small Anim Pract. 2013 Sep;43(5):1055-66. doi: 10.1016/j.cvsm.2013.04.003. Epub 2013 Jun 5.

PMID:
23890238
25.

Applying pharmacokinetics to veterinary clinical practice.

Trepanier LA.

Vet Clin North Am Small Anim Pract. 2013 Sep;43(5):1013-26. doi: 10.1016/j.cvsm.2013.04.002. Epub 2013 Jun 13.

PMID:
23890235
26.

Positive association between a glutathione-S-transferase polymorphism and lymphoma in dogs.

Ginn J, Sacco J, Wong YY, Motsinger-Reif A, Chun R, Trepanier LA.

Vet Comp Oncol. 2014 Sep;12(3):227-36. doi: 10.1111/vco.12000. Epub 2012 Sep 29.

PMID:
23020265
27.

Evaluation of polymorphisms in the sulfonamide detoxification genes NAT2, CYB5A, and CYB5R3 in patients with sulfonamide hypersensitivity.

Sacco JC, Abouraya M, Motsinger-Reif A, Yale SH, McCarty CA, Trepanier LA.

Pharmacogenet Genomics. 2012 Oct;22(10):733-40. doi: 10.1097/FPC.0b013e328357a735.

28.

Evaluation of polymorphisms in the sulfonamide detoxification genes CYB5A and CYB5R3 in dogs with sulfonamide hypersensitivity.

Funk-Keenan J, Sacco J, Wong YY, Rasmussen S, Motsinger-Reif A, Trepanier LA.

J Vet Intern Med. 2012 Sep-Oct;26(5):1126-33. doi: 10.1111/j.1939-1676.2012.00965.x. Epub 2012 Jul 21.

29.

Antioxidant status in hyperthyroid cats before and after radioiodine treatment.

Branter E, Drescher N, Padilla M, Trepanier LA.

J Vet Intern Med. 2012 May-Jun;26(3):582-8. doi: 10.1111/j.1939-1676.2012.00903.x. Epub 2012 Mar 17.

30.

Cholinergic crisis after neostigmine administration in a dog with acquired focal myasthenia gravis.

Foy DS, Trepanier LA, Shelton GD.

J Vet Emerg Crit Care (San Antonio). 2011 Oct;21(5):547-51. doi: 10.1111/j.1476-4431.2011.00672.x. Epub 2011 Aug 24.

PMID:
22316202
31.

Individual variability in the detoxification of carcinogenic arylhydroxylamines in human breast.

Rhoads K, Sacco JC, Drescher N, Wong A, Trepanier LA.

Toxicol Sci. 2011 Jun;121(2):245-56. doi: 10.1093/toxsci/kfr073. Epub 2011 Mar 29.

32.

Dapsone-associated methemoglobinemia in a patient with slow NAT2*5B haplotype and impaired cytochrome b5 reductase activity.

Abouraya M, Sacco JC, Hayes K, Thomas S, Kitchens CS, Trepanier LA.

J Clin Pharmacol. 2012 Feb;52(2):272-8. doi: 10.1177/0091270010393343. No abstract available.

33.

Retrospective comparison of the efficacy of fluconazole or itraconazole for the treatment of systemic blastomycosis in dogs.

Mazepa AS, Trepanier LA, Foy DS.

J Vet Intern Med. 2011 May-Jun;25(3):440-5. doi: 10.1111/j.1939-1676.2011.0710.x. Epub 2011 Mar 21.

34.

Evaluation of sulfonamide detoxification pathways in haematologic malignancy patients prior to intermittent trimethoprim-sulfamethoxazole prophylaxis.

Abouraya M, Sacco JC, Kahl BS, Trepanier LA.

Br J Clin Pharmacol. 2011 Apr;71(4):566-74. doi: 10.1111/j.1365-2125.2010.03889.x.

35.

Clinical presentation of 26 anaplasma phagocytophilum-seropositive dogs residing in an endemic area.

Mazepa AW, Kidd LB, Young KM, Trepanier LA.

J Am Anim Hosp Assoc. 2010 Nov-Dec;46(6):405-12.

PMID:
21041333
36.

Antifungal treatment of small animal veterinary patients.

Foy DS, Trepanier LA.

Vet Clin North Am Small Anim Pract. 2010 Nov;40(6):1171-88. doi: 10.1016/j.cvsm.2010.07.006. Review.

PMID:
20933143
37.

Combined ascorbate and glutathione deficiency leads to decreased cytochrome b5 expression and impaired reduction of sulfamethoxazole hydroxylamine.

Bhusari S, Abouraya M, Padilla ML, Pinkerton ME, Drescher NJ, Sacco JC, Trepanier LA.

Arch Toxicol. 2010 Aug;84(8):597-607. doi: 10.1007/s00204-010-0530-z. Epub 2010 Mar 11.

38.

Cytochrome b5 and NADH cytochrome b5 reductase: genotype-phenotype correlations for hydroxylamine reduction.

Sacco JC, Trepanier LA.

Pharmacogenet Genomics. 2010 Jan;20(1):26-37. doi: 10.1097/FPC.0b013e3283343296.

39.

Glutathione, cysteine, and ascorbate concentrations in clinically ill dogs and cats.

Viviano KR, Lavergne SN, Goodman L, Vanderwielen B, Grundahl L, Padilla M, Trepanier LA.

J Vet Intern Med. 2009 Mar-Apr;23(2):250-7. doi: 10.1111/j.1939-1676.2008.0238.x. Epub 2008 Dec 16.

40.

Erythrocyte glutathione and plasma cysteine concentrations in young versus old dogs.

Moyer KL, Trepanier LA.

J Am Vet Med Assoc. 2009 Jan 1;234(1):95-9. doi: 10.2460/javma.234.1.95.

PMID:
19119971
41.

Role of NADPH-cytochrome P450 reductase and cytochrome-b5/NADH-b5 reductase in variability of CYP3A activity in human liver microsomes.

Gan L, von Moltke LL, Trepanier LA, Harmatz JS, Greenblatt DJ, Court MH.

Drug Metab Dispos. 2009 Jan;37(1):90-6. doi: 10.1124/dmd.108.023424. Epub 2008 Oct 6.

42.

Risk of hemolytic anemia with intravenous administration of famotidine to hospitalized cats.

de Brito Galvao JF, Trepanier LA.

J Vet Intern Med. 2008 Mar-Apr;22(2):325-9. doi: 10.1111/j.1939-1676.2008.0077.x.

43.

Anti-platelet antibodies in a natural animal model of sulphonamide-associated thrombocytopaenia.

Lavergne SN, Trepanier LA.

Platelets. 2007 Dec;18(8):595-604.

PMID:
18041651
44.

Anti-myeloperoxidase and anti-cathepsin G antibodies in sulphonamide hypersensitivity.

Lavergne SN, Drescher NJ, Trepanier LA.

Clin Exp Allergy. 2008 Jan;38(1):199-207. Epub 2007 Nov 1.

PMID:
17976219
45.

Discovery and characterization of a cytochrome b5 variant in humans with impaired hydroxylamine reduction capacity.

Kurian JR, Longlais BJ, Trepanier LA.

Pharmacogenet Genomics. 2007 Aug;17(8):597-603.

PMID:
17622936
46.

Pharmacologic management of feline hyperthyroidism.

Trepanier LA.

Vet Clin North Am Small Anim Pract. 2007 Jul;37(4):775-88, vii. Review.

PMID:
17619011
47.
48.

Reductive detoxification of arylhydroxylamine carcinogens by human NADH cytochrome b5 reductase and cytochrome b5.

Kurian JR, Chin NA, Longlais BJ, Hayes KL, Trepanier LA.

Chem Res Toxicol. 2006 Oct;19(10):1366-73.

49.

Cytochrome P450 and its role in veterinary drug interactions.

Trepanier LA.

Vet Clin North Am Small Anim Pract. 2006 Sep;36(5):975-85, v. Review.

PMID:
16984823
50.

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