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Items: 1 to 50 of 210

1.

Value for money in self-regulated procedural simulation.

Lafleur A, Demchuk G, Tremblay ML, Simard C, Rivière É.

Clin Teach. 2019 Feb 13. doi: 10.1111/tct.13001. [Epub ahead of print]

PMID:
30761751
2.

Magnesium-sensitive upstream ORF controls PRL phosphatase expression to mediate energy metabolism.

Hardy S, Kostantin E, Wang SJ, Hristova T, Galicia-Vázquez G, Baranov PV, Pelletier J, Tremblay ML.

Proc Natl Acad Sci U S A. 2019 Feb 19;116(8):2925-2934. doi: 10.1073/pnas.1815361116. Epub 2019 Feb 4.

3.

Reduced expression of phosphatase PTPN2 promotes pathogenic conversion of Tregs in autoimmunity.

Svensson MN, Doody KM, Schmiedel BJ, Bhattacharyya S, Panwar B, Wiede F, Yang S, Santelli E, Wu DJ, Sacchetti C, Gujar R, Seumois G, Kiosses WB, Aubry I, Kim G, Mydel P, Sakaguchi S, Kronenberg M, Tiganis T, Tremblay ML, Ay F, Vijayanand P, Bottini N.

J Clin Invest. 2019 Mar 1;129(3):1193-1210. doi: 10.1172/JCI123267. Epub 2019 Feb 11.

4.

Simulation-based education for novices: complex learning tasks promote reflective practice.

Tremblay ML, Leppink J, Leclerc G, Rethans JJ, Dolmans DHJM.

Med Educ. 2019 Apr;53(4):380-389. doi: 10.1111/medu.13748. Epub 2018 Nov 15.

PMID:
30443970
5.

Protein Tyrosine Phosphatases: Regulators of CD4 T Cells in Inflammatory Bowel Disease.

Pike KA, Tremblay ML.

Front Immunol. 2018 Oct 31;9:2504. doi: 10.3389/fimmu.2018.02504. eCollection 2018. Review.

6.

Simulation-based Crisis Resource Management in Pharmacy Education.

Tremblay ML.

Am J Pharm Educ. 2018 Aug;82(6):6531. doi: 10.5688/ajpe6531.

7.

Physiological and oncogenic roles of the PRL phosphatases.

Hardy S, Kostantin E, Hatzihristidis T, Zolotarov Y, Uetani N, Tremblay ML.

FEBS J. 2018 Nov;285(21):3886-3908. doi: 10.1111/febs.14503. Epub 2018 May 27. Review.

PMID:
29770564
8.

Using MRI cell tracking to monitor immune cell recruitment in response to a peptide-based cancer vaccine.

Tremblay ML, Davis C, Bowen CV, Stanley O, Parsons C, Weir G, Karkada M, Stanford MM, Brewer KD.

Magn Reson Med. 2018 Jul;80(1):304-316. doi: 10.1002/mrm.27018. Epub 2017 Nov 29.

PMID:
29193231
9.

TC-PTP regulates the IL-7 transcriptional response during murine early T cell development.

Pike KA, Hatzihristidis T, Bussières-Marmen S, Robert F, Desai N, Miranda-Saavedra D, Pelletier J, Tremblay ML.

Sci Rep. 2017 Oct 16;7(1):13275. doi: 10.1038/s41598-017-13673-w.

10.

Mining the Complex Family of Protein Tyrosine Phosphatases for Checkpoint Regulators in Immunity.

Penafuerte C, Perez-Quintero LA, Vinette V, Hatzihristidis T, Tremblay ML.

Curr Top Microbiol Immunol. 2017;410:191-214. doi: 10.1007/82_2017_68. Review.

PMID:
28929190
11.

Downregulation of PTP1B and TC-PTP phosphatases potentiate dendritic cell-based immunotherapy through IL-12/IFNγ signaling.

Penafuerte C, Feldhammer M, Mills JR, Vinette V, Pike KA, Hall A, Migon E, Karsenty G, Pelletier J, Zogopoulos G, Tremblay ML.

Oncoimmunology. 2017 Apr 28;6(6):e1321185. doi: 10.1080/2162402X.2017.1321185. eCollection 2017.

12.

PRL2 links magnesium flux and sex-dependent circadian metabolic rhythms.

Uetani N, Hardy S, Gravel SP, Kiessling S, Pietrobon A, Wong NN, Chénard V, Cermakian N, St-Pierre J, Tremblay ML.

JCI Insight. 2017 Jul 6;2(13). pii: 91722. doi: 10.1172/jci.insight.91722. eCollection 2017 Jul 6.

13.

Protein tyrosine phosphatase σ regulates autoimmune encephalomyelitis development.

Ohtake Y, Kong W, Hussain R, Horiuchi M, Tremblay ML, Ganea D, Li S.

Brain Behav Immun. 2017 Oct;65:111-124. doi: 10.1016/j.bbi.2017.05.018. Epub 2017 May 27.

14.

Identification of function-regulating antibodies targeting the receptor protein tyrosine phosphatase sigma ectodomain.

Wu CL, Hardy S, Aubry I, Landry M, Haggarty A, Saragovi HU, Tremblay ML.

PLoS One. 2017 May 30;12(5):e0178489. doi: 10.1371/journal.pone.0178489. eCollection 2017.

15.

Loss of T-cell protein tyrosine phosphatase in the intestinal epithelium promotes local inflammation by increasing colonic stem cell proliferation.

Bussières-Marmen S, Vinette V, Gungabeesoon J, Aubry I, Pérez-Quintero LA, Tremblay ML.

Cell Mol Immunol. 2018 Apr;15(4):367-376. doi: 10.1038/cmi.2016.72. Epub 2017 Mar 13.

16.

Structural Basis of the Oncogenic Interaction of Phosphatase PRL-1 with the Magnesium Transporter CNNM2.

Giménez-Mascarell P, Oyenarte I, Hardy S, Breiderhoff T, Stuiver M, Kostantin E, Diercks T, Pey AL, Ereño-Orbea J, Martínez-Chantar ML, Khalaf-Nazzal R, Claverie-Martin F, Müller D, Tremblay ML, Martínez-Cruz LA.

J Biol Chem. 2017 Jan 20;292(3):786-801. doi: 10.1074/jbc.M116.759944. Epub 2016 Nov 29.

17.

New genetic signatures associated with cancer cachexia as defined by low skeletal muscle index and weight loss.

Johns N, Stretch C, Tan BH, Solheim TS, Sørhaug S, Stephens NA, Gioulbasanis I, Skipworth RJ, Deans DA, Vigano A, Ross JA, Bathe OF, Tremblay ML, Kaasa S, Strasser F, Gagnon B, Baracos VE, Damaraju S, Fearon KC.

J Cachexia Sarcopenia Muscle. 2017 Feb;8(1):122-130. doi: 10.1002/jcsm.12138. Epub 2016 Aug 5.

18.

The simulated clinical environment: Cognitive and emotional impact among undergraduates.

Tremblay ML, Lafleur A, Leppink J, Dolmans DH.

Med Teach. 2017 Feb;39(2):181-187. doi: 10.1080/0142159X.2016.1246710. Epub 2016 Nov 10.

PMID:
27832706
19.

Characterizing Aciniform Silk Repetitive Domain Backbone Dynamics and Hydrodynamic Modularity.

Tremblay ML, Xu L, Sarker M, Liu XQ, Rainey JK.

Int J Mol Sci. 2016 Aug 10;17(8). pii: E1305. doi: 10.3390/ijms17081305.

20.

ERRα mediates metabolic adaptations driving lapatinib resistance in breast cancer.

Deblois G, Smith HW, Tam IS, Gravel SP, Caron M, Savage P, Labbé DP, Bégin LR, Tremblay ML, Park M, Bourque G, St-Pierre J, Muller WJ, Giguère V.

Nat Commun. 2016 Jul 12;7:12156. doi: 10.1038/ncomms12156.

21.

Protein tyrosine phosphatase 1B (PTP1B) is dispensable for IgE-mediated cutaneous reaction in vivo.

Yang T, Xie Z, Li H, Yue L, Pang Z, MacNeil AJ, Tremblay ML, Tang JT, Lin TJ.

Cell Immunol. 2016 Aug-Sep;306-307:9-16. doi: 10.1016/j.cellimm.2016.05.005. Epub 2016 May 27.

PMID:
27311921
22.

Tracking Transitions in Spider Wrapping Silk Conformation and Dynamics by (19)F Nuclear Magnetic Resonance Spectroscopy.

Sarker M, Orrell KE, Xu L, Tremblay ML, Bak JJ, Liu XQ, Rainey JK.

Biochemistry. 2016 May 31;55(21):3048-59. doi: 10.1021/acs.biochem.6b00429. Epub 2016 May 18.

23.

Protein Tyrosine Phosphatase-1B Negatively Impacts Host Defense against Pseudomonas aeruginosa Infection.

Yue L, Xie Z, Li H, Pang Z, Junkins RD, Tremblay ML, Chen X, Lin TJ.

Am J Pathol. 2016 May;186(5):1234-44. doi: 10.1016/j.ajpath.2016.01.005.

PMID:
27105736
24.

PTP1B Deficiency Enables the Ability of a High-Fat Diet to Drive the Invasive Character of PTEN-Deficient Prostate Cancers.

Labbé DP, Uetani N, Vinette V, Lessard L, Aubry I, Migon E, Sirois J, Haigh JJ, Bégin LR, Trotman LC, Paquet M, Tremblay ML.

Cancer Res. 2016 Jun 1;76(11):3130-5. doi: 10.1158/0008-5472.CAN-15-1501. Epub 2016 Mar 28.

25.

Localizing PRL-2 expression and determining the effects of dietary Mg(2+) on expression levels.

Gungabeesoon J, Tremblay ML, Uetani N.

Histochem Cell Biol. 2016 Jul;146(1):99-111. doi: 10.1007/s00418-016-1427-6. Epub 2016 Mar 25.

PMID:
27015884
26.

Inhibition of PRL-2·CNNM3 Protein Complex Formation Decreases Breast Cancer Proliferation and Tumor Growth.

Kostantin E, Hardy S, Valinsky WC, Kompatscher A, de Baaij JH, Zolotarov Y, Landry M, Uetani N, Martínez-Cruz LA, Hoenderop JG, Shrier A, Tremblay ML.

J Biol Chem. 2016 May 13;291(20):10716-25. doi: 10.1074/jbc.M115.705863. Epub 2016 Mar 11.

27.

Identification of neutrophil-derived proteases and angiotensin II as biomarkers of cancer cachexia.

Penafuerte CA, Gagnon B, Sirois J, Murphy J, MacDonald N, Tremblay ML.

Br J Cancer. 2016 Mar 15;114(6):680-7. doi: 10.1038/bjc.2016.3. Epub 2016 Mar 8.

28.

TC-PTP and PTP1B: Regulating JAK-STAT signaling, controlling lymphoid malignancies.

Pike KA, Tremblay ML.

Cytokine. 2016 Jun;82:52-7. doi: 10.1016/j.cyto.2015.12.025. Epub 2016 Jan 23. Review.

PMID:
26817397
29.

PTP-PEST controls EphA3 activation and ephrin-induced cytoskeletal remodelling.

Mansour M, Nievergall E, Gegenbauer K, Llerena C, Atapattu L, Hallé M, Tremblay ML, Janes PW, Lackmann M.

J Cell Sci. 2016 Jan 15;129(2):277-89. doi: 10.1242/jcs.174490. Epub 2015 Dec 7.

30.

Identification of Bidentate Salicylic Acid Inhibitors of PTP1B.

Haftchenary S, Jouk AO, Aubry I, Lewis AM, Landry M, Ball DP, Shouksmith AE, Collins CV, Tremblay ML, Gunning PT.

ACS Med Chem Lett. 2015 Jul 22;6(9):982-6. doi: 10.1021/acsmedchemlett.5b00171. eCollection 2015 Sep 10.

31.

Protein Tyrosine Phosphatase PTPRS Is an Inhibitory Receptor on Human and Murine Plasmacytoid Dendritic Cells.

Bunin A, Sisirak V, Ghosh HS, Grajkowska LT, Hou ZE, Miron M, Yang C, Ceribelli M, Uetani N, Chaperot L, Plumas J, Hendriks W, Tremblay ML, Häcker H, Staudt LM, Green PH, Bhagat G, Reizis B.

Immunity. 2015 Aug 18;43(2):277-88. doi: 10.1016/j.immuni.2015.07.009. Epub 2015 Jul 28.

32.

Spider wrapping silk fibre architecture arising from its modular soluble protein precursor.

Tremblay ML, Xu L, Lefèvre T, Sarker M, Orrell KE, Leclerc J, Meng Q, Pézolet M, Auger M, Liu XQ, Rainey JK.

Sci Rep. 2015 Jun 26;5:11502. doi: 10.1038/srep11502.

33.

Targeting phosphatase-dependent proteoglycan switch for rheumatoid arthritis therapy.

Doody KM, Stanford SM, Sacchetti C, Svensson MN, Coles CH, Mitakidis N, Kiosses WB, Bartok B, Fos C, Cory E, Sah RL, Liu-Bryan R, Boyle DL, Arnett HA, Mustelin T, Corr M, Esko JD, Tremblay ML, Firestein GS, Aricescu AR, Bottini N.

Sci Transl Med. 2015 May 20;7(288):288ra76. doi: 10.1126/scitranslmed.aaa4616.

34.

Deletion of Protein Tyrosine Phosphatase 1B (PTP1B) Enhances Endothelial Cyclooxygenase 2 Expression and Protects Mice from Type 1 Diabetes-Induced Endothelial Dysfunction.

Herren DJ, Norman JB, Anderson R, Tremblay ML, Huby AC, Belin de Chantemèle EJ.

PLoS One. 2015 May 14;10(5):e0126866. doi: 10.1371/journal.pone.0126866. eCollection 2015. Erratum in: PLoS One. 2015;10(6):e0130781. Herre, David J [corrected to Herren, David J].

35.

A Drosophila-centric view of protein tyrosine phosphatases.

Hatzihristidis T, Desai N, Hutchins AP, Meng TC, Tremblay ML, Miranda-Saavedra D.

FEBS Lett. 2015 Apr 13;589(9):951-66. doi: 10.1016/j.febslet.2015.03.005. Epub 2015 Mar 13. Review.

36.

UBC9-dependent association between calnexin and protein tyrosine phosphatase 1B (PTP1B) at the endoplasmic reticulum.

Lee D, Kraus A, Prins D, Groenendyk J, Aubry I, Liu WX, Li HD, Julien O, Touret N, Sykes BD, Tremblay ML, Michalak M.

J Biol Chem. 2015 Feb 27;290(9):5725-38. doi: 10.1074/jbc.M114.635474. Epub 2015 Jan 13.

37.

Deletion of the gene encoding G0/G 1 switch protein 2 (G0s2) alleviates high-fat-diet-induced weight gain and insulin resistance, and promotes browning of white adipose tissue in mice.

El-Assaad W, El-Kouhen K, Mohammad AH, Yang J, Morita M, Gamache I, Mamer O, Avizonis D, Hermance N, Kersten S, Tremblay ML, Kelliher MA, Teodoro JG.

Diabetologia. 2015 Jan;58(1):149-57. doi: 10.1007/s00125-014-3429-z. Epub 2014 Nov 9.

38.

Complement-mediated glomerular injury is reduced by inhibition of protein-tyrosine phosphatase 1B.

Nezvitsky L, Tremblay ML, Takano T, Papillon J, Cybulsky AV.

Am J Physiol Renal Physiol. 2014 Sep 1;307(5):F634-47. doi: 10.1152/ajprenal.00191.2014. Epub 2014 Jul 23.

39.

The Mmachc gene is required for pre-implantation embryogenesis in the mouse.

Moreno-Garcia MA, Pupavac M, Rosenblatt DS, Tremblay ML, Jerome-Majewska LA.

Mol Genet Metab. 2014 Jul;112(3):198-204. doi: 10.1016/j.ymgme.2014.05.002. Epub 2014 May 14. Erratum in: Mol Genet Metab. 2014 Nov;113(3):236.

PMID:
24889031
40.

Protein tyrosine phosphatase 1B is a regulator of the interleukin-10-induced transcriptional program in macrophages.

Pike KA, Hutchins AP, Vinette V, Théberge JF, Sabbagh L, Tremblay ML, Miranda-Saavedra D.

Sci Signal. 2014 May 6;7(324):ra43. doi: 10.1126/scisignal.2005020.

PMID:
24803538
41.

The protein tyrosine phosphatase PRL-2 interacts with the magnesium transporter CNNM3 to promote oncogenesis.

Hardy S, Uetani N, Wong N, Kostantin E, Labbé DP, Bégin LR, Mes-Masson A, Miranda-Saavedra D, Tremblay ML.

Oncogene. 2015 Feb 19;34(8):986-95. doi: 10.1038/onc.2014.33. Epub 2014 Mar 17.

PMID:
24632616
42.

Allosteric noncompetitive small molecule selective inhibitors of CD45 tyrosine phosphatase suppress T-cell receptor signals and inflammation in vivo.

Perron MD, Chowdhury S, Aubry I, Purisima E, Tremblay ML, Saragovi HU.

Mol Pharmacol. 2014 Apr;85(4):553-63. doi: 10.1124/mol.113.089847. Epub 2014 Jan 28.

PMID:
24473749
43.

Prostate cancer genetic-susceptibility locus on chromosome 20q13 is amplified and coupled to androgen receptor-regulation in metastatic tumors.

Labbé DP, Nowak DG, Deblois G, Lessard L, Giguère V, Trotman LC, Tremblay ML.

Mol Cancer Res. 2014 Feb;12(2):184-9. doi: 10.1158/1541-7786.MCR-13-0477. Epub 2013 Dec 30.

44.

Nanoparticle self-assembly by a highly stable recombinant spider wrapping silk protein subunit.

Xu L, Tremblay ML, Orrell KE, Leclerc J, Meng Q, Liu XQ, Rainey JK.

FEBS Lett. 2013 Oct 1;587(19):3273-80. doi: 10.1016/j.febslet.2013.08.024. Epub 2013 Aug 28.

45.

Characterization of PTPN2 and its use as a biomarker.

Bussières-Marmen S, Hutchins AP, Schirbel A, Rebert N, Tiganis T, Fiocchi C, Miranda-Saavedra D, Tremblay ML.

Methods. 2014 Jan 15;65(2):239-46. doi: 10.1016/j.ymeth.2013.08.020. Epub 2013 Aug 30.

PMID:
23994241
46.

PTP-central: a comprehensive resource of protein tyrosine phosphatases in eukaryotic genomes.

Hatzihristidis T, Liu S, Pryszcz L, Hutchins AP, Gabaldón T, Tremblay ML, Miranda-Saavedra D.

Methods. 2014 Jan 15;65(2):156-64. doi: 10.1016/j.ymeth.2013.07.031. Epub 2013 Jul 31.

PMID:
23911837
47.
48.

Regulation of the Src kinase-associated phosphoprotein 55 homologue by the protein tyrosine phosphatase PTP-PEST in the control of cell motility.

Ayoub E, Hall A, Scott AM, Chagnon MJ, Miquel G, Hallé M, Noda M, Bikfalvi A, Tremblay ML.

J Biol Chem. 2013 Sep 6;288(36):25739-48. doi: 10.1074/jbc.M113.501007. Epub 2013 Jul 29.

49.

PTP1B: a simple enzyme for a complex world.

Feldhammer M, Uetani N, Miranda-Saavedra D, Tremblay ML.

Crit Rev Biochem Mol Biol. 2013 Sep-Oct;48(5):430-45. doi: 10.3109/10409238.2013.819830. Epub 2013 Jul 23. Review.

PMID:
23879520
50.

Inactivation of LAR family phosphatase genes Ptprs and Ptprf causes craniofacial malformations resembling Pierre-Robin sequence.

Stewart K, Uetani N, Hendriks W, Tremblay ML, Bouchard M.

Development. 2013 Aug;140(16):3413-22. doi: 10.1242/dev.094532. Epub 2013 Jul 17.

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