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Medroxyprogesterone acetate alters the vaginal microbiota and microenvironment in women and increases susceptibility to HIV-1 in humanized mice.

Wessels JM, Lajoie J, Cooper MIJH, Omollo K, Felker AM, Vitali D, Dupont HA, Nguyen PV, Mueller K, Vahedi F, Kimani J, Oyugi J, Cheruiyot J, Mungai JN, Deshiere A, Tremblay MJ, Mazzulli T, Stearns JC, Ashkar AA, Fowke KR, Surette MG, Kaushic C.

Dis Model Mech. 2019 Oct 23;12(10). pii: dmm039669. doi: 10.1242/dmm.039669.


Host mRNA decay proteins influence HIV-1 replication and viral gene expression in primary monocyte-derived macrophages.

Rao S, Amorim R, Niu M, Breton Y, Tremblay MJ, Mouland AJ.

Retrovirology. 2019 Feb 7;16(1):3. doi: 10.1186/s12977-019-0465-2.


Expression of MDM2 in Macrophages Promotes the Early Postentry Steps of HIV-1 Infection through Inhibition of p53.

Breton Y, Desrosiers V, Ouellet M, Deshiere A, Torresilla C, Cohen ÉA, Tremblay MJ.

J Virol. 2019 Mar 21;93(7). pii: e01871-18. doi: 10.1128/JVI.01871-18. Print 2019 Apr 1.


A new tool for detection of extracellular traps.

Proust A, Lévesque JC, Barat C, Sato S, Tremblay MJ.

Methods Appl Fluoresc. 2018 May 29;6(3):037002. doi: 10.1088/2050-6120/aac51b.


SAMHD1 Phosphorylation Coordinates the Anti-HIV-1 Response by Diverse Interferons and Tyrosine Kinase Inhibition.

Szaniawski MA, Spivak AM, Cox JE, Catrow JL, Hanley T, Williams ESCP, Tremblay MJ, Bosque A, Planelles V.

mBio. 2018 May 15;9(3). pii: e00819-18. doi: 10.1128/mBio.00819-18.


Interferon-β induced in female genital epithelium by HIV-1 glycoprotein 120 via Toll-like-receptor 2 pathway acts to protect the mucosal barrier.

Nazli A, Dizzell S, Zahoor MA, Ferreira VH, Kafka J, Woods MW, Ouellet M, Ashkar AA, Tremblay MJ, Bowdish DM, Kaushic C.

Cell Mol Immunol. 2019 Feb;16(2):178-194. doi: 10.1038/cmi.2017.168. Epub 2018 Mar 19.


Astrocytes sustain long-term productive HIV-1 infection without establishment of reactivable viral latency.

Barat C, Proust A, Deshiere A, Leboeuf M, Drouin J, Tremblay MJ.

Glia. 2018 Jul;66(7):1363-1381. doi: 10.1002/glia.23310. Epub 2018 Feb 21.


Contrasting effect of the latency-reversing agents bryostatin-1 and JQ1 on astrocyte-mediated neuroinflammation and brain neutrophil invasion.

Proust A, Barat C, Leboeuf M, Drouin J, Tremblay MJ.

J Neuroinflammation. 2017 Dec 11;14(1):242. doi: 10.1186/s12974-017-1019-y.


Frequency of Human CD45+ Target Cells is a Key Determinant of Intravaginal HIV-1 Infection in Humanized Mice.

Nguyen PV, Wessels JM, Mueller K, Vahedi F, Anipindi V, Verschoor CP, Chew M, Deshiere A, Karniychuk U, Mazzulli T, Tremblay MJ, Ashkar AA, Kaushic C.

Sci Rep. 2017 Nov 10;7(1):15263. doi: 10.1038/s41598-017-15630-z.


Host MicroRNAs-221 and -222 Inhibit HIV-1 Entry in Macrophages by Targeting the CD4 Viral Receptor.

Lodge R, Ferreira Barbosa JA, Lombard-Vadnais F, Gilmore JC, Deshiere A, Gosselin A, Wiche Salinas TR, Bego MG, Power C, Routy JP, Ancuta P, Tremblay MJ, Cohen ÉA.

Cell Rep. 2017 Oct 3;21(1):141-153. doi: 10.1016/j.celrep.2017.09.030.


Global Mapping of the Macrophage-HIV-1 Transcriptome Reveals that Productive Infection Induces Remodeling of Host Cell DNA and Chromatin.

Deshiere A, Joly-Beauparlant C, Breton Y, Ouellet M, Raymond F, Lodge R, Barat C, Roy MA, Corbeil J, Tremblay MJ.

Sci Rep. 2017 Jul 12;7(1):5238. doi: 10.1038/s41598-017-05566-9.


Epigenetic Metabolite Acetate Inhibits Class I/II Histone Deacetylases, Promotes Histone Acetylation, and Increases HIV-1 Integration in CD4+ T Cells.

Bolduc JF, Hany L, Barat C, Ouellet M, Tremblay MJ.

J Virol. 2017 Jul 27;91(16). pii: e01943-16. doi: 10.1128/JVI.01943-16. Print 2017 Aug 15.


HIV-1 Latency-Reversing Agents Prostratin and Bryostatin-1 Induce Blood-Brain Barrier Disruption/Inflammation and Modulate Leukocyte Adhesion/Transmigration.

Dental C, Proust A, Ouellet M, Barat C, Tremblay MJ.

J Immunol. 2017 Feb 1;198(3):1229-1241. doi: 10.4049/jimmunol.1600742. Epub 2016 Dec 19.


Toll-Like Receptor 2 Ligation Enhances HIV-1 Replication in Activated CCR6+ CD4+ T Cells by Increasing Virus Entry and Establishing a More Permissive Environment to Infection.

Bolduc JF, Ouellet M, Hany L, Tremblay MJ.

J Virol. 2017 Jan 31;91(4). pii: e01402-16. doi: 10.1128/JVI.01402-16. Print 2017 Feb 15.


HIV-1-Mediated BAFF Secretion in Macrophages Does Not Require Endosomal TLRs, Type-I IFN, and Nef, but Depends on the Cellular Phenotype Status.

Gomez AM, Ouellet M, Deshiere A, Breton Y, Tremblay MJ.

J Immunol. 2016 May 1;196(9):3806-17. doi: 10.4049/jimmunol.1501249. Epub 2016 Mar 28.


TOE1 is an inhibitor of HIV-1 replication with cell-penetrating capability.

Sperandio S, Barat C, Cabrita MA, Gargaun A, Berezovski MV, Tremblay MJ, de Belle I.

Proc Natl Acad Sci U S A. 2015 Jun 30;112(26):E3392-401. doi: 10.1073/pnas.1500857112. Epub 2015 Jun 8.


Leishmania infantum amastigotes trigger a subpopulation of human B cells with an immunoregulatory phenotype.

Andreani G, Ouellet M, Menasria R, Gomez AM, Barat C, Tremblay MJ.

PLoS Negl Trop Dis. 2015 Feb 24;9(2):e0003543. doi: 10.1371/journal.pntd.0003543. eCollection 2015 Feb.


HIV-1-triggered release of type I IFN by plasmacytoid dendritic cells induces BAFF production in monocytes.

Gomez AM, Ouellet M, Tremblay MJ.

J Immunol. 2015 Mar 1;194(5):2300-8. doi: 10.4049/jimmunol.1402147. Epub 2015 Jan 30.


Medroxyprogesterone Acetate Regulates HIV-1 Uptake and Transcytosis but Not Replication in Primary Genital Epithelial Cells, Resulting in Enhanced T-Cell Infection.

Ferreira VH, Dizzell S, Nazli A, Kafka JK, Mueller K, Nguyen PV, Tremblay MJ, Cochrane A, Kaushic C.

J Infect Dis. 2015 Jun 1;211(11):1745-56. doi: 10.1093/infdis/jiu832. Epub 2014 Dec 23.


Selective acquisition of host-derived ICAM-1 by HIV-1 is a matrix-dependent process.

Jalaguier P, Cantin R, Maaroufi H, Tremblay MJ.

J Virol. 2015 Jan;89(1):323-36. doi: 10.1128/JVI.02701-14. Epub 2014 Oct 15.


Effect of galectins on viral transmission.

Ouellet M, St-Pierre C, Tremblay MJ, Sato S.

Methods Mol Biol. 2015;1207:397-420. doi: 10.1007/978-1-4939-1396-1_26.


Exposure of human astrocytes to leukotriene C4 promotes a CX3CL1/fractalkine-mediated transmigration of HIV-1-infected CD4⁺ T cells across an in vitro blood-brain barrier model.

Bertin J, Jalaguier P, Barat C, Roy MA, Tremblay MJ.

Virology. 2014 Apr;454-455:128-38. doi: 10.1016/j.virol.2014.02.007. Epub 2014 Feb 28.


Functional evidence for the involvement of microtubules and dynein motor complexes in TRIM5α-mediated restriction of retroviruses.

Pawlica P, Le Sage V, Poccardi N, Tremblay MJ, Mouland AJ, Berthoux L.

J Virol. 2014 May;88(10):5661-76. doi: 10.1128/JVI.03717-13. Epub 2014 Mar 5.


Keratin 8 is required for the maintenance of architectural structure in thymus epithelium.

Odaka C, Loranger A, Takizawa K, Ouellet M, Tremblay MJ, Murata S, Inoko A, Inagaki M, Marceau N.

PLoS One. 2013 Sep 24;8(9):e75101. doi: 10.1371/journal.pone.0075101. eCollection 2013.


HIV-1 gp120 induces TLR2- and TLR4-mediated innate immune activation in human female genital epithelium.

Nazli A, Kafka JK, Ferreira VH, Anipindi V, Mueller K, Osborne BJ, Dizzell S, Chauvin S, Mian MF, Ouellet M, Tremblay MJ, Mossman KL, Ashkar AA, Kovacs C, Bowdish DM, Snider DP, Kaul R, Kaushic C.

J Immunol. 2013 Oct 15;191(8):4246-58. doi: 10.4049/jimmunol.1301482. Epub 2013 Sep 16.


Dendritic cell immunoreceptor is a new target for anti-AIDS drug development: identification of DCIR/HIV-1 inhibitors.

Lambert AA, Azzi A, Lin SX, Allaire G, St-Gelais KP, Tremblay MJ, Gilbert C.

PLoS One. 2013 Jul 9;8(7):e67873. doi: 10.1371/journal.pone.0067873. Print 2013.


Dectin-1/TLR2 and NOD2 agonists render dendritic cells susceptible to infection by X4-using HIV-1 and promote cis-infection of CD4(+) T cells.

Côté SC, Plante A, Tardif MR, Tremblay MJ.

PLoS One. 2013 Jul 2;8(7):e67735. doi: 10.1371/journal.pone.0067735. Print 2013.


Gene expression modulation and the molecular mechanisms involved in Nelfinavir resistance in Leishmania donovani axenic amastigotes.

Kumar P, Lodge R, Raymond F, Ritt JF, Jalaguier P, Corbeil J, Ouellette M, Tremblay MJ.

Mol Microbiol. 2013 Aug;89(3):565-82. doi: 10.1111/mmi.12298. Epub 2013 Jul 5.


Macropinocytosis-like HIV-1 internalization in macrophages is CCR5 dependent and leads to efficient but delayed degradation in endosomal compartments.

Gobeil LA, Lodge R, Tremblay MJ.

J Virol. 2013 Jan;87(2):735-45. doi: 10.1128/JVI.01802-12. Epub 2012 Oct 31.


An in vitro co-infection model to study Plasmodium falciparum-HIV-1 interactions in human primary monocyte-derived immune cells.

Andreani G, Gagnon D, Lodge R, Tremblay MJ, Richard D.

J Vis Exp. 2012 Aug 15;(66):e4166. doi: 10.3791/4166.


Exon level transcriptomic profiling of HIV-1-infected CD4(+) T cells reveals virus-induced genes and host environment favorable for viral replication.

Imbeault M, Giguère K, Ouellet M, Tremblay MJ.

PLoS Pathog. 2012;8(8):e1002861. doi: 10.1371/journal.ppat.1002861. Epub 2012 Aug 2.


Differential HIV-1 endocytosis and susceptibility to virus infection in human macrophages correlate with cell activation status.

Gobeil LA, Lodge R, Tremblay MJ.

J Virol. 2012 Oct;86(19):10399-407. doi: 10.1128/JVI.01051-12. Epub 2012 Jul 11.


Miltefosine represses HIV-1 replication in human dendritic cell/T-cell cocultures partially by inducing secretion of type-I interferon.

Garg R, Tremblay MJ.

Virology. 2012 Oct 25;432(2):271-6. doi: 10.1016/j.virol.2012.05.032. Epub 2012 Jun 15.


Glycans, galectins, and HIV-1 infection.

Sato S, Ouellet M, St-Pierre C, Tremblay MJ.

Ann N Y Acad Sci. 2012 Apr;1253:133-48. doi: 10.1111/j.1749-6632.2012.06475.x. Review.


Leukotrienes inhibit early stages of HIV-1 infection in monocyte-derived microglia-like cells.

Bertin J, Barat C, Bélanger D, Tremblay MJ.

J Neuroinflammation. 2012 Mar 16;9:55. doi: 10.1186/1742-2094-9-55.


Mechanisms of interaction between protozoan parasites and HIV.

Andreani G, Lodge R, Richard D, Tremblay MJ.

Curr Opin HIV AIDS. 2012 May;7(3):276-82. doi: 10.1097/COH.0b013e32835211e9. Review.


HIV-1 promotes intake of Leishmania parasites by enhancing phosphatidylserine-mediated, CD91/LRP-1-dependent phagocytosis in human macrophages.

Lodge R, Ouellet M, Barat C, Andreani G, Kumar P, Tremblay MJ.

PLoS One. 2012;7(3):e32761. doi: 10.1371/journal.pone.0032761. Epub 2012 Mar 6.


Interactions between prostaglandins, leukotrienes and HIV-1: possible implications for the central nervous system.

Bertin J, Barat C, Méthot S, Tremblay MJ.

Retrovirology. 2012 Jan 11;9:4. doi: 10.1186/1742-4690-9-4. Review.


Efficient production of HIV-1 virus-like particles from a mammalian expression vector requires the N-terminal capsid domain.

Jalaguier P, Turcotte K, Danylo A, Cantin R, Tremblay MJ.

PLoS One. 2011;6(11):e28314. doi: 10.1371/journal.pone.0028314. Epub 2011 Nov 30.


Galectin-1-specific inhibitors as a new class of compounds to treat HIV-1 infection.

St-Pierre C, Ouellet M, Giguère D, Ohtake R, Roy R, Sato S, Tremblay MJ.

Antimicrob Agents Chemother. 2012 Jan;56(1):154-62. doi: 10.1128/AAC.05595-11. Epub 2011 Nov 7.


Genome sequencing of the lizard parasite Leishmania tarentolae reveals loss of genes associated to the intracellular stage of human pathogenic species.

Raymond F, Boisvert S, Roy G, Ritt JF, Légaré D, Isnard A, Stanke M, Olivier M, Tremblay MJ, Papadopoulou B, Ouellette M, Corbeil J.

Nucleic Acids Res. 2012 Feb;40(3):1131-47. doi: 10.1093/nar/gkr834. Epub 2011 Oct 13.


Host-soluble galectin-1 promotes HIV-1 replication through a direct interaction with glycans of viral gp120 and host CD4.

St-Pierre C, Manya H, Ouellet M, Clark GF, Endo T, Tremblay MJ, Sato S.

J Virol. 2011 Nov;85(22):11742-51. doi: 10.1128/JVI.05351-11. Epub 2011 Aug 31.


HIV-1 replication in monocyte-derived dendritic cells is stimulated by melarsoprol, one of the main drugs against human African trypanosomiasis.

Barat C, Pepin J, Tremblay MJ.

J Mol Biol. 2011 Jul 29;410(5):1052-64. doi: 10.1016/j.jmb.2011.03.012.


DCIR-mediated enhancement of HIV-1 infection requires the ITIM-associated signal transduction pathway.

Lambert AA, Barabé F, Gilbert C, Tremblay MJ.

Blood. 2011 Jun 16;117(24):6589-99. doi: 10.1182/blood-2011-01-331363. Epub 2011 May 2.


Acquisition of host-derived CD40L by HIV-1 in vivo and its functional consequences in the B-cell compartment.

Imbeault M, Ouellet M, Giguère K, Bertin J, Bélanger D, Martin G, Tremblay MJ.

J Virol. 2011 Mar;85(5):2189-200. doi: 10.1128/JVI.01993-10. Epub 2010 Dec 22.


Inefficient fusion due to a lack of attachment receptor/co-receptor restricts productive human immunodeficiency virus type 1 infection in human hepatoma Huh7.5 cells.

Fromentin R, Tardif MR, Tremblay MJ.

J Gen Virol. 2011 Mar;92(Pt 3):587-97. doi: 10.1099/vir.0.028746-0. Epub 2010 Dec 1.


HIV-1 induces DCIR expression in CD4+ T cells.

Lambert AA, Imbeault M, Gilbert C, Tremblay MJ.

PLoS Pathog. 2010 Nov 11;6(11):e1001188. doi: 10.1371/journal.ppat.1001188.


Cholera toxin inhibits HIV-1 replication in human colorectal epithelial HT-29 cells through adenylate cyclase activation.

Gauthier S, Tremblay MJ.

Antiviral Res. 2010 Nov;88(2):207-16. doi: 10.1016/j.antiviral.2010.08.015. Epub 2010 Sep 15.


Galectin-1 and HIV-1 Infection.

St-Pierre C, Ouellet M, Tremblay MJ, Sato S.

Methods Enzymol. 2010;480:267-94. doi: 10.1016/S0076-6879(10)80013-8. Review.


HIV-1 and pattern-recognition receptors: a marriage of convenience.

Tremblay MJ.

Nat Immunol. 2010 May;11(5):363-5. doi: 10.1038/ni0510-363. No abstract available.


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