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Items: 10

1.

Can inhibitor-resistant substitutions in the Mycobacterium tuberculosis β-Lactamase BlaC lead to clavulanate resistance?: a biochemical rationale for the use of β-lactam-β-lactamase inhibitor combinations.

Kurz SG, Wolff KA, Hazra S, Bethel CR, Hujer AM, Smith KM, Xu Y, Tremblay LW, Blanchard JS, Nguyen L, Bonomo RA.

Antimicrob Agents Chemother. 2013 Dec;57(12):6085-96. doi: 10.1128/AAC.01253-13. Epub 2013 Sep 23.

3.

Biochemical and structural characterization of Mycobacterium tuberculosis beta-lactamase with the carbapenems ertapenem and doripenem.

Tremblay LW, Fan F, Blanchard JS.

Biochemistry. 2010 May 4;49(17):3766-73. doi: 10.1021/bi100232q.

4.

The 1.9 A structure of the branched-chain amino-acid transaminase (IlvE) from Mycobacterium tuberculosis.

Tremblay LW, Blanchard JS.

Acta Crystallogr Sect F Struct Biol Cryst Commun. 2009 Nov 1;65(Pt 11):1071-7. doi: 10.1107/S1744309109036690. Epub 2009 Oct 13.

5.

Meropenem-clavulanate is effective against extensively drug-resistant Mycobacterium tuberculosis.

Hugonnet JE, Tremblay LW, Boshoff HI, Barry CE 3rd, Blanchard JS.

Science. 2009 Feb 27;323(5918):1215-8. doi: 10.1126/science.1167498.

6.

The 1.6 A crystal structure of Mycobacterium smegmatis MshC: the penultimate enzyme in the mycothiol biosynthetic pathway.

Tremblay LW, Fan F, Vetting MW, Blanchard JS.

Biochemistry. 2008 Dec 16;47(50):13326-35. doi: 10.1021/bi801708f.

7.

Structure of the covalent adduct formed between Mycobacterium tuberculosis beta-lactamase and clavulanate.

Tremblay LW, Hugonnet JE, Blanchard JS.

Biochemistry. 2008 May 13;47(19):5312-6. doi: 10.1021/bi8001055. Epub 2008 Apr 19.

PMID:
18422342
9.

Catalytic cycling in beta-phosphoglucomutase: a kinetic and structural analysis.

Zhang G, Dai J, Wang L, Dunaway-Mariano D, Tremblay LW, Allen KN.

Biochemistry. 2005 Jul 12;44(27):9404-16.

PMID:
15996095
10.

Chemical confirmation of a pentavalent phosphorane in complex with beta-phosphoglucomutase.

Tremblay LW, Zhang G, Dai J, Dunaway-Mariano D, Allen KN.

J Am Chem Soc. 2005 Apr 20;127(15):5298-9.

PMID:
15826149

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