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Items: 34


Use of VHH antibodies for the development of antigen detection test for visceral leishmaniasis.

Abeijon C, Dilo J, Tremblay JM, Viana AG, Bueno LL, Carvalho SFG, Fujiwara RT, Shoemaker CB, Campos-Neto A.

Parasite Immunol. 2018 Nov;40(11):e12584. doi: 10.1111/pim.12584. Epub 2018 Sep 11.


High-Resolution Epitope Positioning of a Large Collection of Neutralizing and Nonneutralizing Single-Domain Antibodies on the Enzymatic and Binding Subunits of Ricin Toxin.

Vance DJ, Tremblay JM, Rong Y, Angalakurthi SK, Volkin DB, Middaugh CR, Weis DD, Shoemaker CB, Mantis NJ.

Clin Vaccine Immunol. 2017 Dec 5;24(12). pii: e00236-17. doi: 10.1128/CVI.00236-17. Print 2017 Dec.


Daily Opioid Use Fluctuates as a Function of Pain, Catastrophizing, and Affect in Patients With Sickle Cell Disease: An Electronic Daily Diary Analysis.

Finan PH, Carroll CP, Moscou-Jackson G, Martel MO, Campbell CM, Pressman A, Smyth JM, Tremblay JM, Lanzkron SM, Haythornthwaite JA.

J Pain. 2018 Jan;19(1):46-56. doi: 10.1016/j.jpain.2017.08.010. Epub 2017 Sep 21.


Single-domain antibodies pinpoint potential targets within Shigella invasion plasmid antigen D of the needle tip complex for inhibition of type III secretion.

Barta ML, Shearer JP, Arizmendi O, Tremblay JM, Mehzabeen N, Zheng Q, Battaile KP, Lovell S, Tzipori S, Picking WD, Shoemaker CB, Picking WL.

J Biol Chem. 2017 Oct 6;292(40):16677-16687. doi: 10.1074/jbc.M117.802231. Epub 2017 Aug 25.


Schistosoma mansoni Infection of Mice, Rats and Humans Elicits a Strong Antibody Response to a Limited Number of Reduction-Sensitive Epitopes on Five Major Tegumental Membrane Proteins.

Krautz-Peterson G, Debatis M, Tremblay JM, Oliveira SC, Da'dara AA, Skelly PJ, Shoemaker CB.

PLoS Negl Trop Dis. 2017 Jan 17;11(1):e0005306. doi: 10.1371/journal.pntd.0005306. eCollection 2017 Jan.


A Tetraspecific VHH-Based Neutralizing Antibody Modifies Disease Outcome in Three Animal Models of Clostridium difficile Infection.

Schmidt DJ, Beamer G, Tremblay JM, Steele JA, Kim HB, Wang Y, Debatis M, Sun X, Kashentseva EA, Dmitriev IP, Curiel DT, Shoemaker CB, Tzipori S.

Clin Vaccine Immunol. 2016 Sep 6;23(9):774-84. doi: 10.1128/CVI.00730-15. Print 2016 Sep.


Adenoviral Expression of a Bispecific VHH-Based Neutralizing Agent That Targets Protective Antigen Provides Prophylactic Protection from Anthrax in Mice.

Moayeri M, Tremblay JM, Debatis M, Dmitriev IP, Kashentseva EA, Yeh AJ, Cheung GY, Curiel DT, Leppla S, Shoemaker CB.

Clin Vaccine Immunol. 2016 Jan 6;23(3):213-8. doi: 10.1128/CVI.00611-15.


Mechanisms of Ricin Toxin Neutralization Revealed through Engineered Homodimeric and Heterodimeric Camelid Antibodies.

Herrera C, Tremblay JM, Shoemaker CB, Mantis NJ.

J Biol Chem. 2015 Nov 13;290(46):27880-9. doi: 10.1074/jbc.M115.658070. Epub 2015 Sep 22.


A heterodimer of a VHH (variable domains of camelid heavy chain-only) antibody that inhibits anthrax toxin cell binding linked to a VHH antibody that blocks oligomer formation is highly protective in an anthrax spore challenge model.

Moayeri M, Leysath CE, Tremblay JM, Vrentas C, Crown D, Leppla SH, Shoemaker CB.

J Biol Chem. 2015 Mar 6;290(10):6584-95. doi: 10.1074/jbc.M114.627943. Epub 2015 Jan 6.


Adenovirus vector expressing Stx1/Stx2-neutralizing agent protects piglets infected with Escherichia coli O157:H7 against fatal systemic intoxication.

Sheoran AS, Dmitriev IP, Kashentseva EA, Cohen O, Mukherjee J, Debatis M, Shearer J, Tremblay JM, Beamer G, Curiel DT, Shoemaker CB, Tzipori S.

Infect Immun. 2015 Jan;83(1):286-91. doi: 10.1128/IAI.02360-14. Epub 2014 Nov 3.


Prolonged prophylactic protection from botulism with a single adenovirus treatment promoting serum expression of a VHH-based antitoxin protein.

Mukherjee J, Dmitriev I, Debatis M, Tremblay JM, Beamer G, Kashentseva EA, Curiel DT, Shoemaker CB.

PLoS One. 2014 Aug 29;9(8):e106422. doi: 10.1371/journal.pone.0106422. eCollection 2014.


Adenoviral targeting using genetically incorporated camelid single variable domains.

Kaliberov SA, Kaliberova LN, Buggio M, Tremblay JM, Shoemaker CB, Curiel DT.

Lab Invest. 2014 Aug;94(8):893-905. doi: 10.1038/labinvest.2014.82. Epub 2014 Jun 16.


A novel multivalent, single-domain antibody targeting TcdA and TcdB prevents fulminant Clostridium difficile infection in mice.

Yang Z, Schmidt D, Liu W, Li S, Shi L, Sheng J, Chen K, Yu H, Tremblay JM, Chen X, Piepenbrink KH, Sundberg EJ, Kelly CP, Bai G, Shoemaker CB, Feng H.

J Infect Dis. 2014 Sep 15;210(6):964-72. doi: 10.1093/infdis/jiu196. Epub 2014 Mar 27.


Stepwise engineering of heterodimeric single domain camelid VHH antibodies that passively protect mice from ricin toxin.

Vance DJ, Tremblay JM, Mantis NJ, Shoemaker CB.

J Biol Chem. 2013 Dec 20;288(51):36538-47. doi: 10.1074/jbc.M113.519207. Epub 2013 Nov 7.


A single VHH-based toxin-neutralizing agent and an effector antibody protect mice against challenge with Shiga toxins 1 and 2.

Tremblay JM, Mukherjee J, Leysath CE, Debatis M, Ofori K, Baldwin K, Boucher C, Peters R, Beamer G, Sheoran A, Bedenice D, Tzipori S, Shoemaker CB.

Infect Immun. 2013 Dec;81(12):4592-603. doi: 10.1128/IAI.01033-13. Epub 2013 Sep 30.


Generation of a phage-display library of single-domain camelid VH H antibodies directed against Chlamydomonas reinhardtii antigens, and characterization of VH Hs binding cell-surface antigens.

Jiang W, Rosenberg JN, Wauchope AD, Tremblay JM, Shoemaker CB, Weeks DP, Oyler GA.

Plant J. 2013 Nov;76(4):709-17. doi: 10.1111/tpj.12316. Epub 2013 Oct 17.


A novel strategy for development of recombinant antitoxin therapeutics tested in a mouse botulism model.

Mukherjee J, Tremblay JM, Leysath CE, Ofori K, Baldwin K, Feng X, Bedenice D, Webb RP, Wright PM, Smith LA, Tzipori S, Shoemaker CB.

PLoS One. 2012;7(1):e29941. doi: 10.1371/journal.pone.0029941. Epub 2012 Jan 6.


Camelid single domain antibodies (VHHs) as neuronal cell intrabody binding agents and inhibitors of Clostridium botulinum neurotoxin (BoNT) proteases.

Tremblay JM, Kuo CL, Abeijon C, Sepulveda J, Oyler G, Hu X, Jin MM, Shoemaker CB.

Toxicon. 2010 Nov;56(6):990-8. doi: 10.1016/j.toxicon.2010.07.003. Epub 2010 Jul 14.


Schistosoma mansoni host-exposed surface antigens characterized by sera and recombinant antibodies from schistosomiasis-resistant rats.

Sepulveda J, Tremblay JM, DeGnore JP, Skelly PJ, Shoemaker CB.

Int J Parasitol. 2010 Oct;40(12):1407-17. doi: 10.1016/j.ijpara.2010.04.019. Epub 2010 Jun 30.


Mechanism of interaction of PITPalpha with membranes: conformational changes in the C-terminus associated with membrane binding.

Tremblay JM, Unruh JR, Johnson CK, Yarbrough LR.

Arch Biochem Biophys. 2005 Dec 15;444(2):112-20. Epub 2005 Nov 15.


Structure of PITPbeta in complex with phosphatidylcholine: comparison of structure and lipid transfer to other PITP isoforms.

Vordtriede PB, Doan CN, Tremblay JM, Helmkamp GM Jr, Yoder MD.

Biochemistry. 2005 Nov 15;44(45):14760-71.


Both isoforms of mammalian phosphatidylinositol transfer protein are capable of binding and transporting sphingomyelin.

Li H, Tremblay JM, Yarbrough LR, Helmkamp GM Jr.

Biochim Biophys Acta. 2002 Jan 30;1580(1):67-76.


Structure of a multifunctional protein. Mammalian phosphatidylinositol transfer protein complexed with phosphatidylcholine.

Yoder MD, Thomas LM, Tremblay JM, Oliver RL, Yarbrough LR, Helmkamp GM Jr.

J Biol Chem. 2001 Mar 23;276(12):9246-52. Epub 2000 Dec 4.


X-ray analysis of crystals of rat phosphatidylinositol-transfer protein with bound phosphatidylcholine.

Oliver RL, Tremblay JM, Helmkamp GM Jr, Yarbrough LR, Breakfield NW, Yoder MD.

Acta Crystallogr D Biol Crystallogr. 1999 Feb;55(Pt 2):522-4.


The C-terminus of phosphatidylinositol transfer protein modulates membrane interactions and transfer activity but not phospholipid binding.

Tremblay JM, Voziyan PA, Helmkamp GM Jr, Yarbrough LR.

Biochim Biophys Acta. 1998 Jan 15;1389(2):91-100.


Importance of phospholipid in the folding and conformation of phosphatidylinositol transfer protein: comparison of apo and holo species.

Voziyan PA, Tremblay JM, Yarbrough LR, Helmkamp GM Jr.

Biochemistry. 1997 Aug 19;36(33):10082-8.


Truncations of the C-terminus have different effects on the conformation and activity of phosphatidylinositol transfer protein.

Voziyan PA, Tremblay JM, Yarbrough LR, Helmkamp GM Jr.

Biochemistry. 1996 Sep 24;35(38):12526-31.


An impedance method for blood pressure measurement in awake rats without preheating.

Wen SF, Tremblay JM, Qu MH, Webster JG.

Hypertension. 1988 Apr;11(4):371-5.


Tissue and cell type-specific expression of two human c-onc genes.

Müller R, Tremblay JM, Adamson ED, Verma IM.

Nature. 1983 Aug 4-10;304(5925):454-6.


Transcription of c-onc genes c-rasKi and c-fms during mouse development.

Müller R, Slamon DJ, Adamson ED, Tremblay JM, Müller D, Cline MJ, Verma IM.

Mol Cell Biol. 1983 Jun;3(6):1062-9.


Differential expression of cellular oncogenes during pre- and postnatal development of the mouse.

Müller R, Slamon DJ, Tremblay JM, Cline MJ, Verma IM.

Nature. 1982 Oct 14;299(5884):640-4. No abstract available.


Hygiène dans la classe ouvrière.


Bull Sanit. 1948 Jan-Feb;48(1):2-5. Undetermined Language. No abstract available.


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