Format
Sort by
Items per page

Send to

Choose Destination

Search results

Items: 36

1.

Simultaneous Assessment of Transporter-Mediated Drug-Drug Interactions Using a Probe Drug Cocktail in Cynomolgus Monkey.

Kosa RE, Lazzaro S, Bi YA, Tierney B, Gates D, Modi S, Costales C, Rodrigues AD, Tremaine LM, Varma MV.

Drug Metab Dispos. 2018 Aug;46(8):1179-1189. doi: 10.1124/dmd.118.081794. Epub 2018 Jun 7.

PMID:
29880631
2.

Predicting Human Clearance of Organic Anion Transporting Polypeptide Substrates Using Cynomolgus Monkey: In Vitro-In Vivo Scaling of Hepatic Uptake Clearance.

De Bruyn T, Ufuk A, Cantrill C, Kosa RE, Bi YA, Niosi M, Modi S, Rodrigues AD, Tremaine LM, Varma MVS, Galetin A, Houston JB.

Drug Metab Dispos. 2018 Jul;46(7):989-1000. doi: 10.1124/dmd.118.081315. Epub 2018 May 2.

PMID:
29720472
3.

In Vitro-In Vivo Extrapolation of OATP1B-Mediated Drug-Drug Interactions in Cynomolgus Monkey.

Ufuk A, Kosa RE, Gao H, Bi YA, Modi S, Gates D, Rodrigues AD, Tremaine LM, Varma MVS, Houston JB, Galetin A.

J Pharmacol Exp Ther. 2018 Jun;365(3):688-699. doi: 10.1124/jpet.118.247767. Epub 2018 Apr 11.

PMID:
29643253
4.

A Study on Pharmacokinetics of Bosentan with Systems Modeling, Part 2: Prospectively Predicting Systemic and Liver Exposure in Healthy Subjects.

Li R, Kimoto E, Niosi M, Tess DA, Lin J, Tremaine LM, Di L.

Drug Metab Dispos. 2018 Apr;46(4):357-366. doi: 10.1124/dmd.117.078808. Epub 2018 Jan 12. Erratum in: Drug Metab Dispos. 2018 Apr;46(4):484.

PMID:
29330219
5.

A Study on Pharmacokinetics of Bosentan with Systems Modeling, Part 1: Translating Systemic Plasma Concentration to Liver Exposure in Healthy Subjects.

Li R, Niosi M, Johnson N, Tess DA, Kimoto E, Lin J, Yang X, Riccardi KA, Ryu S, El-Kattan AF, Maurer TS, Tremaine LM, Di L.

Drug Metab Dispos. 2018 Apr;46(4):346-356. doi: 10.1124/dmd.117.078790. Epub 2018 Jan 12. Erratum in: Drug Metab Dispos. 2018 Apr;46(4):483.

PMID:
29330218
6.

Estimation of Circulating Drug Metabolite Exposure in Human Using In Vitro Data and Physiologically Based Pharmacokinetic Modeling: Example of a High Metabolite/Parent Drug Ratio.

Obach RS, Lin J, Kimoto E, Duvvuri S, Nicholas T, Kadar EP, Tremaine LM, Sawant-Basak A.

Drug Metab Dispos. 2018 Feb;46(2):89-99. doi: 10.1124/dmd.117.078279. Epub 2017 Nov 17.

PMID:
29150544
7.

Hepatobiliary Clearance Prediction: Species Scaling From Monkey, Dog, and Rat, and In Vitro-In Vivo Extrapolation of Sandwich-Cultured Human Hepatocytes Using 17 Drugs.

Kimoto E, Bi YA, Kosa RE, Tremaine LM, Varma MVS.

J Pharm Sci. 2017 Sep;106(9):2795-2804. doi: 10.1016/j.xphs.2017.04.043. Epub 2017 Apr 27.

PMID:
28456723
8.

Erratum to: Reliable Rate Measurements for Active and Passive Hepatic Uptake Using Plated Human Hepatocytes.

Bi YA, Scialis RJ, Lazzaro S, Mathialagan S, Kimoto E, Keefer J, Zhang H, Vildhede AM, Costales C, Rodrigues AD, Tremaine LM, Varma MVS.

AAPS J. 2017 May;19(3):882. doi: 10.1208/s12248-017-0061-0. No abstract available.

PMID:
28233243
9.

Reliable Rate Measurements for Active and Passive Hepatic Uptake Using Plated Human Hepatocytes.

Bi YA, Scialis RJ, Lazzaro S, Mathialagan S, Kimoto E, Keefer J, Zhang H, Vildhede AM, Costales C, Rodrigues AD, Tremaine LM, Varma MVS.

AAPS J. 2017 May;19(3):787-796. doi: 10.1208/s12248-017-0051-2. Epub 2017 Feb 10. Erratum in: AAPS J. 2017 May;19(3):882.

PMID:
28188574
10.

Extended Clearance Classification System (ECCS) informed approach for evaluating investigational drugs as substrates of drug transporters.

Varma MV, El-Kattan AF, Feng B, Steyn SJ, Maurer TS, Scott DO, Rodrigues AD, Tremaine LM.

Clin Pharmacol Ther. 2016 Dec 16. doi: 10.1002/cpt.595. [Epub ahead of print] No abstract available.

PMID:
27984654
11.

Transporter-Mediated Hepatic Uptake Plays an Important Role in the Pharmacokinetics and Drug-Drug Interactions of Montelukast.

Varma MV, Kimoto E, Scialis R, Bi Y, Lin J, Eng H, Kalgutkar AS, El-Kattan AF, Rodrigues AD, Tremaine LM.

Clin Pharmacol Ther. 2017 Mar;101(3):406-415. doi: 10.1002/cpt.520. Epub 2016 Nov 18.

PMID:
27648490
12.

Assessment of drug metabolism enzyme and transporter pharmacogenetics in drug discovery and early development: perspectives of the I-PWG.

Brian W, Tremaine LM, Arefayene M, de Kanter R, Evers R, Guo Y, Kalabus J, Lin W, Loi CM, Xiao G.

Pharmacogenomics. 2016 Apr;17(6):615-31. doi: 10.2217/pgs.16.9. Epub 2016 Apr 5. Review.

PMID:
27045656
13.

A novel relay method for determining low-clearance values.

Di L, Trapa P, Obach RS, Atkinson K, Bi YA, Wolford AC, Tan B, McDonald TS, Lai Y, Tremaine LM.

Drug Metab Dispos. 2012 Sep;40(9):1860-5. doi: 10.1124/dmd.112.046425. Epub 2012 May 29.

14.

Deuterium isotope effects on drug pharmacokinetics. I. System-dependent effects of specific deuteration with aldehyde oxidase cleared drugs.

Sharma R, Strelevitz TJ, Gao H, Clark AJ, Schildknegt K, Obach RS, Ripp SL, Spracklin DK, Tremaine LM, Vaz AD.

Drug Metab Dispos. 2012 Mar;40(3):625-34. doi: 10.1124/dmd.111.042770. Epub 2011 Dec 21.

15.

Tissue distribution and elimination of [14C]apixaban in rats.

Wang L, He K, Maxwell B, Grossman SJ, Tremaine LM, Humphreys WG, Zhang D.

Drug Metab Dispos. 2011 Feb;39(2):256-64. doi: 10.1124/dmd.110.036442. Epub 2010 Nov 11.

16.

Prediction of drug-drug interactions from in vitro induction data: application of the relative induction score approach using cryopreserved human hepatocytes.

Fahmi OA, Boldt S, Kish M, Obach RS, Tremaine LM.

Drug Metab Dispos. 2008 Sep;36(9):1971-4. doi: 10.1124/dmd.108.021907. Epub 2008 Jun 2.

17.

Application of liquid chromatography-accelerator mass spectrometry (LC-AMS) to evaluate the metabolic profiles of a drug candidate in human urine and plasma.

Prakash C, Shaffer CL, Tremaine LM, Liberman RG, Skipper PL, Flarakos J, Tannenbaum SR.

Drug Metab Lett. 2007 Aug;1(3):226-31.

PMID:
19356047
18.

In vitro cytochrome P450 inhibition data and the prediction of drug-drug interactions: qualitative relationships, quantitative predictions, and the rank-order approach.

Obach RS, Walsky RL, Venkatakrishnan K, Houston JB, Tremaine LM.

Clin Pharmacol Ther. 2005 Dec;78(6):582-92. Review. No abstract available.

PMID:
16338274
19.

The utility of in vitro cytochrome P450 inhibition data in the prediction of drug-drug interactions.

Obach RS, Walsky RL, Venkatakrishnan K, Gaman EA, Houston JB, Tremaine LM.

J Pharmacol Exp Ther. 2006 Jan;316(1):336-48. Epub 2005 Sep 28.

20.
21.

Effect of sertraline on protein binding of warfarin.

Apseloff G, Wilner KD, Gerber N, Tremaine LM.

Clin Pharmacokinet. 1997;32 Suppl 1:37-42.

PMID:
9068934
22.

A study of the potential effect of sertraline on the pharmacokinetics and protein binding of tolbutamide.

Tremaine LM, Wilner KD, Preskorn SH.

Clin Pharmacokinet. 1997;32 Suppl 1:31-6.

PMID:
9068933
23.

Pharmacokinetics of sertraline and its N-demethyl metabolite in elderly and young male and female volunteers.

Ronfeld RA, Tremaine LM, Wilner KD.

Clin Pharmacokinet. 1997;32 Suppl 1:22-30.

PMID:
9068932
24.

Sertraline does not alter steady-state concentrations or renal clearance of lithium in healthy volunteers.

Apseloff G, Wilner KD, von Deutsch DA, Henry EB, Tremaine LM, Gerber N, Lazar JD.

J Clin Pharmacol. 1992 Jul;32(7):643-6.

PMID:
1640004
25.

Automated gas chromatographic-electron-capture assay for the selective serotonin uptake blocker sertraline.

Tremaine LM, Joerg EA.

J Chromatogr. 1989 Nov 24;496(2):423-9. No abstract available.

PMID:
2613845
26.

Metabolism and disposition of the 5-hydroxytryptamine uptake blocker sertraline in the rat and dog.

Tremaine LM, Welch WM, Ronfeld RA.

Drug Metab Dispos. 1989 Sep-Oct;17(5):542-50.

PMID:
2573498
27.

Characterization of a carbamic acid ester glucuronide of the secondary amine sertraline.

Tremaine LM, Stroh JG, Ronfeld RA.

Drug Metab Dispos. 1989 Jan-Feb;17(1):58-63.

PMID:
2566471
28.

Renal tubular excretory transport of oxalate in the chicken.

Tremaine LM, Bird JE, Quebbemann AJ.

J Pharmacol Exp Ther. 1985 Apr;233(1):7-11.

PMID:
3981463
29.

Quantitative determination of organ contribution to excretory metabolism.

Tremaine LM, Diamond GL, Quebbemann AJ.

J Pharmacol Methods. 1985 Feb;13(1):9-35.

PMID:
3974258
30.

The renal handling of terephthalic acid.

Tremaine LM, Quebbemann AJ.

Toxicol Appl Pharmacol. 1985 Jan;77(1):165-74.

PMID:
3966238
31.

In vivo quantification of renal glucuronide and sulfate conjugation of 1-naphthol and p-nitrophenol in the rat.

Tremaine LM, Diamond GL, Quebbemann AJ.

Biochem Pharmacol. 1984 Feb 1;33(3):419-27.

PMID:
6704161
32.

Salicylate enhancement of renal glucuronide conjugation and tubular excretory transfer of phenols.

Diamond GL, Anders MW, Tremaine LM, Quebbemann AJ.

Drug Metab Dispos. 1982 Nov-Dec;10(6):573-8.

PMID:
6130902
33.

Hemoglobin Nigeria (alpha-81 Ser replaced by Cys):a new variant associated with alpha-thalassemia.

Honig GR, Shamsuddin M, Mason RG, Vida LN, Tremaine LM, Tarr GE, Shahidi NT.

Blood. 1980 Jan;55(1):131-7.

34.

Sickle cell syndromes. III. Silent-carrier alpha-thalassemia in combination with hemoglobin S and hemoglobin C.

Honig GR, Mason RG, Tremaine LM, Vida LN.

Pediatr Res. 1979 Oct;13(10):1109-11.

PMID:
503635
35.

Unbalanced globin chain synthesis by Hb Lincoln Park (anti-Lepore) reticulocytes.

Honig GR, Mason RG, Tremaine LM, Vida LN.

Am J Hematol. 1978;5(4):335-40.

PMID:
753103
36.

Restoration of a fractured canine tooth in a dog.

Wynne WP, Tremaine LM, Matthews JR Jr.

J Am Vet Med Assoc. 1973 Mar 1;162(5):396-7. No abstract available.

PMID:
4691376

Supplemental Content

Loading ...
Support Center