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Items: 21

1.

Long-Lived Folding Intermediates Predominate the Targeting-Competent Secretome.

Tsirigotaki A, Chatzi KE, Koukaki M, De Geyter J, Portaliou AG, Orfanoudaki G, Sardis MF, Trelle MB, Jørgensen TJD, Karamanou S, Economou A.

Structure. 2018 May 1;26(5):695-707.e5. doi: 10.1016/j.str.2018.03.006. Epub 2018 Apr 5.

2.

Conformational preludes to the latency transition in PAI-1 as determined by atomistic computer simulations and hydrogen/deuterium-exchange mass spectrometry.

Petersen M, Madsen JB, Jørgensen TJD, Trelle MB.

Sci Rep. 2017 Jul 26;7(1):6636. doi: 10.1038/s41598-017-06290-0.

3.

Removal of N-Linked Glycosylations at Acidic pH by PNGase A Facilitates Hydrogen/Deuterium Exchange Mass Spectrometry Analysis of N-Linked Glycoproteins.

Jensen PF, Comamala G, Trelle MB, Madsen JB, Jørgensen TJ, Rand KD.

Anal Chem. 2016 Dec 20;88(24):12479-12488. doi: 10.1021/acs.analchem.6b03951. Epub 2016 Nov 28.

PMID:
28193043
4.

Analysis of Translocation-Competent Secretory Proteins by HDX-MS.

Tsirigotaki A, Papanastasiou M, Trelle MB, Jørgensen TJ, Economou A.

Methods Enzymol. 2017;586:57-83. doi: 10.1016/bs.mie.2016.09.028. Epub 2016 Nov 8.

PMID:
28137577
5.

An Asymmetric Runaway Domain Swap Antithrombin Dimer as a Key Intermediate for Polymerization Revealed by Hydrogen/Deuterium-Exchange Mass Spectrometry.

Trelle MB, Pedersen S, Østerlund EC, Madsen JB, Kristensen SR, Jørgensen TJ.

Anal Chem. 2017 Jan 3;89(1):616-624. doi: 10.1021/acs.analchem.6b02518. Epub 2016 Dec 15.

PMID:
27783482
6.

Copper(II) Ions Increase Plasminogen Activator Inhibitor Type 1 Dynamics in Key Structural Regions That Govern Stability.

Bucci JC, Trelle MB, McClintock CS, Qureshi T, Jørgensen TJ, Peterson CB.

Biochemistry. 2016 Aug 9;55(31):4386-98. doi: 10.1021/acs.biochem.6b00256. Epub 2016 Jul 27.

PMID:
27416303
7.

An RNA Aptamer Inhibits a Mutation-Induced Inactivating Misfolding of a Serpin.

Madsen JB, Andersen LM, Dupont DM, Trelle MB, Johansen JS, Jensen JK, Jørgensen TJ, Andreasen PA.

Cell Chem Biol. 2016 Jun 23;23(6):700-8. doi: 10.1016/j.chembiol.2016.04.013. Epub 2016 Jun 2.

8.

Binding of NFκB Appears to Twist the Ankyrin Repeat Domain of IκBα.

Trelle MB, Ramsey KM, Lee TC, Zheng W, Lamboy J, Wolynes PG, Deniz A, Komives EA.

Biophys J. 2016 Feb 23;110(4):887-95. doi: 10.1016/j.bpj.2016.01.001.

9.

Local transient unfolding of native state PAI-1 associated with serpin metastability.

Trelle MB, Madsen JB, Andreasen PA, Jørgensen TJ.

Angew Chem Int Ed Engl. 2014 Sep 8;53(37):9751-4. doi: 10.1002/anie.201402796. Epub 2014 Jul 22.

PMID:
25049220
10.

Dissecting the effect of RNA aptamer binding on the dynamics of plasminogen activator inhibitor 1 using hydrogen/deuterium exchange mass spectrometry.

Trelle MB, Dupont DM, Madsen JB, Andreasen PA, Jørgensen TJ.

ACS Chem Biol. 2014 Jan 17;9(1):174-82. doi: 10.1021/cb400619v. Epub 2013 Nov 14.

PMID:
24138169
11.

Hydrogen/deuterium exchange mass spectrometry reveals specific changes in the local flexibility of plasminogen activator inhibitor 1 upon binding to the somatomedin B domain of vitronectin.

Trelle MB, Hirschberg D, Jansson A, Ploug M, Roepstorff P, Andreasen PA, Jørgensen TJ.

Biochemistry. 2012 Oct 16;51(41):8256-66. doi: 10.1021/bi3008998. Epub 2012 Oct 4.

PMID:
22957734
12.

Spatially resolved protein hydrogen exchange measured by subzero-cooled chip-based nanoelectrospray ionization tandem mass spectrometry.

Amon S, Trelle MB, Jensen ON, Jørgensen TJ.

Anal Chem. 2012 May 15;84(10):4467-73. doi: 10.1021/ac300268r. Epub 2012 Apr 26.

PMID:
22536891
13.

SET8 is degraded via PCNA-coupled CRL4(CDT2) ubiquitylation in S phase and after UV irradiation.

Jørgensen S, Eskildsen M, Fugger K, Hansen L, Larsen MS, Kousholt AN, Syljuåsen RG, Trelle MB, Jensen ON, Helin K, Sørensen CS.

J Cell Biol. 2011 Jan 10;192(1):43-54. doi: 10.1083/jcb.201009076.

14.

Dynamic histone H3 epigenome marking during the intraerythrocytic cycle of Plasmodium falciparum.

Salcedo-Amaya AM, van Driel MA, Alako BT, Trelle MB, van den Elzen AM, Cohen AM, Janssen-Megens EM, van de Vegte-Bolmer M, Selzer RR, Iniguez AL, Green RD, Sauerwein RW, Jensen ON, Stunnenberg HG.

Proc Natl Acad Sci U S A. 2009 Jun 16;106(24):9655-60. doi: 10.1073/pnas.0902515106. Epub 2009 Jun 2.

15.

Global histone analysis by mass spectrometry reveals a high content of acetylated lysine residues in the malaria parasite Plasmodium falciparum.

Trelle MB, Salcedo-Amaya AM, Cohen AM, Stunnenberg HG, Jensen ON.

J Proteome Res. 2009 Jul;8(7):3439-50. doi: 10.1021/pr9000898.

PMID:
19351122
16.

Automated 2D peptide separation on a 1D nano-LC-MS system.

Taylor P, Nielsen PA, Trelle MB, Hørning OB, Andersen MB, Vorm O, Moran MF, Kislinger T.

J Proteome Res. 2009 Mar;8(3):1610-6. doi: 10.1021/pr800986c.

PMID:
19178303
17.

Utility of immonium ions for assignment of epsilon-N-acetyllysine-containing peptides by tandem mass spectrometry.

Trelle MB, Jensen ON.

Anal Chem. 2008 May 1;80(9):3422-30. doi: 10.1021/ac800005n. Epub 2008 Mar 14.

PMID:
18338905
18.

The histone methyltransferase SET8 is required for S-phase progression.

Jørgensen S, Elvers I, Trelle MB, Menzel T, Eskildsen M, Jensen ON, Helleday T, Helin K, Sørensen CS.

J Cell Biol. 2007 Dec 31;179(7):1337-45. doi: 10.1083/jcb.200706150.

19.

Functional proteomics in histone research and epigenetics.

Trelle MB, Jensen ON.

Expert Rev Proteomics. 2007 Aug;4(4):491-503. Review.

PMID:
17705707
20.

Analysis of posttranslational modifications of proteins by tandem mass spectrometry.

Larsen MR, Trelle MB, Thingholm TE, Jensen ON.

Biotechniques. 2006 Jun;40(6):790-8. Review.

21.

VEMS 3.0: algorithms and computational tools for tandem mass spectrometry based identification of post-translational modifications in proteins.

Matthiesen R, Trelle MB, Højrup P, Bunkenborg J, Jensen ON.

J Proteome Res. 2005 Nov-Dec;4(6):2338-47.

PMID:
16335983

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