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GPCRs in Cancer: Protease-Activated Receptors, Endocytic Adaptors and Signaling.

Arakaki AKS, Pan WA, Trejo J.

Int J Mol Sci. 2018 Jun 27;19(7). pii: E1886. doi: 10.3390/ijms19071886. Review.


Rac1 in podocytes promotes glomerular repair and limits the formation of sclerosis.

Asao R, Seki T, Takagi M, Yamada H, Kodama F, Hosoe-Nagai Y, Tanaka E, Trejo JAO, Yamamoto-Nonaka K, Sasaki Y, Hidaka T, Ueno T, Yanagita M, Suzuki Y, Tomino Y, Asanuma K.

Sci Rep. 2018 Mar 22;8(1):5061. doi: 10.1038/s41598-018-23278-6.


The unfolded protein response regulator ATF6 promotes mesodermal differentiation.

Kroeger H, Grimsey N, Paxman R, Chiang WC, Plate L, Jones Y, Shaw PX, Trejo J, Tsang SH, Powers E, Kelly JW, Wiseman RL, Lin JH.

Sci Signal. 2018 Feb 13;11(517). pii: eaan5785. doi: 10.1126/scisignal.aan5785.


The α-arrestin ARRDC3 suppresses breast carcinoma invasion by regulating G protein-coupled receptor lysosomal sorting and signaling.

Arakaki AKS, Pan WA, Lin H, Trejo J.

J Biol Chem. 2018 Mar 2;293(9):3350-3362. doi: 10.1074/jbc.RA117.001516. Epub 2018 Jan 18.


A reflection on faculty diversity in the 21st century.

Trejo J.

Mol Biol Cell. 2017 Nov 1;28(22):2911-2914. doi: 10.1091/mbc.E17-08-0505.


Re-expression of Sall1 in podocytes protects against adriamycin-induced nephrosis.

Hosoe-Nagai Y, Hidaka T, Sonoda A, Sasaki Y, Yamamoto-Nonaka K, Seki T, Asao R, Tanaka E, Trejo JAO, Kodama F, Takagi M, Tada N, Ueno T, Nishinakamura R, Tomino Y, Asanuma K.

Lab Invest. 2017 Nov;97(11):1306-1320. doi: 10.1038/labinvest.2017.69. Epub 2017 Jul 31.


Protease-activated receptor-4 and purinergic receptor P2Y12 dimerize, co-internalize, and activate Akt signaling via endosomal recruitment of β-arrestin.

Smith TH, Li JG, Dores MR, Trejo J.

J Biol Chem. 2017 Aug 18;292(33):13867-13878. doi: 10.1074/jbc.M117.782359. Epub 2017 Jun 26.


Neuronal tetraploidization in the cerebral cortex correlates with reduced cognition in mice and precedes and recapitulates Alzheimer's-associated neuropathology.

López-Sánchez N, Fontán-Lozano Á, Pallé A, González-Álvarez V, Rábano A, Trejo JL, Frade JM.

Neurobiol Aging. 2017 Aug;56:50-66. doi: 10.1016/j.neurobiolaging.2017.04.008. Epub 2017 Apr 18.


The GSK-3-inhibitor VP2.51 produces antidepressant effects associated with adult hippocampal neurogenesis.

Pérez-Domper P, Palomo V, Gradari S, Gil C, de Ceballos ML, Martínez A, Trejo JL.

Neuropharmacology. 2017 Apr;116:174-187. doi: 10.1016/j.neuropharm.2016.12.019. Epub 2016 Dec 22.


Interventions for age-related diseases: Shifting the paradigm.

Figueira I, Fernandes A, Mladenovic Djordjevic A, Lopez-Contreras A, Henriques CM, Selman C, Ferreiro E, Gonos ES, Trejo JL, Misra J, Rasmussen LJ, Xapelli S, Ellam T, Bellantuono I.

Mech Ageing Dev. 2016 Dec;160:69-92. doi: 10.1016/j.mad.2016.09.009. Epub 2016 Sep 29. Review.


Challenges and Opportunities in Protease-Activated Receptor Drug Development.

Hamilton JR, Trejo J.

Annu Rev Pharmacol Toxicol. 2017 Jan 6;57:349-373. doi: 10.1146/annurev-pharmtox-011613-140016. Epub 2016 Sep 9. Review.


Editorial: 50th Anniversary of Adult Neurogenesis: Olfaction, Hippocampus, and Beyond.

Martinez-Marcos A, Trejo JL, López-Mascaraque L.

Front Neurosci. 2016 Jun 30;10:319. doi: 10.3389/fnins.2016.00319. eCollection 2016. No abstract available.


Protease-activated Receptor-4 Signaling and Trafficking Is Regulated by the Clathrin Adaptor Protein Complex-2 Independent of β-Arrestins.

Smith TH, Coronel LJ, Li JG, Dores MR, Nieman MT, Trejo J.

J Biol Chem. 2016 Aug 26;291(35):18453-64. doi: 10.1074/jbc.M116.729285. Epub 2016 Jul 11.


ALIX Regulates the Ubiquitin-Independent Lysosomal Sorting of the P2Y1 Purinergic Receptor via a YPX3L Motif.

Dores MR, Grimsey NJ, Mendez F, Trejo J.

PLoS One. 2016 Jun 14;11(6):e0157587. doi: 10.1371/journal.pone.0157587. eCollection 2016.


Can Exercise Make You Smarter, Happier, and Have More Neurons? A Hormetic Perspective.

Gradari S, Pallé A, McGreevy KR, Fontán-Lozano Á, Trejo JL.

Front Neurosci. 2016 Mar 14;10:93. doi: 10.3389/fnins.2016.00093. eCollection 2016.


Integration of endothelial protease-activated receptor-1 inflammatory signaling by ubiquitin.

Grimsey NJ, Trejo J.

Curr Opin Hematol. 2016 May;23(3):274-9. doi: 10.1097/MOH.0000000000000232. Review.


The relationship between behavior acquisition and persistence abilities: Involvement of adult hippocampal neurogenesis.

Gradari S, Pérez-Domper P, Butler RG, Martínez-Cué C, de Polavieja GG, Trejo JL.

Hippocampus. 2016 Jul;26(7):857-74. doi: 10.1002/hipo.22568. Epub 2016 Feb 9.


Recycling and Endosomal Sorting of Protease-activated Receptor-1 Is Distinctly Regulated by Rab11A and Rab11B Proteins.

Grimsey NJ, Coronel LJ, Cordova IC, Trejo J.

J Biol Chem. 2016 Jan 29;291(5):2223-36. doi: 10.1074/jbc.M115.702993. Epub 2015 Dec 3.


The α-arrestin ARRDC3 mediates ALIX ubiquitination and G protein-coupled receptor lysosomal sorting.

Dores MR, Lin H, J Grimsey N, Mendez F, Trejo J.

Mol Biol Cell. 2015 Dec 15;26(25):4660-73. doi: 10.1091/mbc.E15-05-0284. Epub 2015 Oct 21.


Ubiquitin plays an atypical role in GPCR-induced p38 MAP kinase activation on endosomes.

Grimsey NJ, Aguilar B, Smith TH, Le P, Soohoo AL, Puthenveedu MA, Nizet V, Trejo J.

J Cell Biol. 2015 Sep 28;210(7):1117-31. doi: 10.1083/jcb.201504007. Epub 2015 Sep 21.


GPCR sorting at multivesicular endosomes.

Dores MR, Trejo J.

Methods Cell Biol. 2015;130:319-32. doi: 10.1016/bs.mcb.2015.05.006. Epub 2015 Jul 7.


N-linked glycosylation of protease-activated receptor-1 at extracellular loop 2 regulates G-protein signaling bias.

Soto AG, Smith TH, Chen B, Bhattacharya S, Cordova IC, Kenakin T, Vaidehi N, Trejo J.

Proc Natl Acad Sci U S A. 2015 Jul 7;112(27):E3600-8. doi: 10.1073/pnas.1508838112. Epub 2015 Jun 22.


Group B streptococcal infection and activation of human astrocytes.

Stoner TD, Weston TA, Trejo J, Doran KS.

PLoS One. 2015 Jun 1;10(6):e0128431. doi: 10.1371/journal.pone.0128431. eCollection 2015.


Polo-like kinase 2 regulates angiogenic sprouting and blood vessel development.

Yang H, Fang L, Zhan R, Hegarty JM, Ren J, Hsiai TK, Gleeson JG, Miller YI, Trejo J, Chi NC.

Dev Biol. 2015 Aug 15;404(2):49-60. doi: 10.1016/j.ydbio.2015.05.011. Epub 2015 May 22.


Characterization of thrombin-bound dabigatran effects on protease-activated receptor-1 expression and signaling in vitro.

Chen B, Soto AG, Coronel LJ, Goss A, van Ryn J, Trejo J.

Mol Pharmacol. 2015 Jul;88(1):95-105. doi: 10.1124/mol.114.096446. Epub 2015 May 1.


[Intima-media thickness in a middle-old age sample of the Spanish general population].

Calmarza P, Trejo JM, Lapresta C, López P.

Clin Investig Arterioscler. 2015 May-Jun;27(3):111-7. doi: 10.1016/j.arteri.2014.09.005. Epub 2014 Dec 23. Spanish.


The postnatal origin of adult neural stem cells and the effects of glucocorticoids on their genesis.

Ortega-Martínez S, Trejo JL.

Behav Brain Res. 2015 Feb 15;279:166-76. doi: 10.1016/j.bbr.2014.11.013. Epub 2014 Nov 12.


Atypical regulation of G protein-coupled receptor intracellular trafficking by ubiquitination.

Dores MR, Trejo J.

Curr Opin Cell Biol. 2014 Apr;27:44-50. doi: 10.1016/ Epub 2013 Dec 7. Review.


A general method for site specific fluorescent labeling of recombinant chemokines.

Kawamura T, Stephens B, Qin L, Yin X, Dores MR, Smith TH, Grimsey N, Abagyan R, Trejo J, Kufareva I, Fuster MM, Salanga CL, Handel TM.

PLoS One. 2014 Jan 28;9(1):e81454. doi: 10.1371/journal.pone.0081454. eCollection 2014.


Endosomal signaling by protease-activated receptors.

Grimsey N, Lin H, Trejo J.

Methods Enzymol. 2014;535:389-401. doi: 10.1016/B978-0-12-397925-4.00022-5. Review.


Regulation of protease-activated receptor 1 signaling by the adaptor protein complex 2 and R4 subfamily of regulator of G protein signaling proteins.

Chen B, Siderovski DP, Neubig RR, Lawson MA, Trejo J.

J Biol Chem. 2014 Jan 17;289(3):1580-91. doi: 10.1074/jbc.M113.528273. Epub 2013 Dec 2.


Cofactoring and dimerization of proteinase-activated receptors.

Lin H, Liu AP, Smith TH, Trejo J.

Pharmacol Rev. 2013 Sep 24;65(4):1198-213. doi: 10.1124/pr.111.004747. Print 2013. Review.


The chemokine receptor CCR1 is constitutively active, which leads to G protein-independent, β-arrestin-mediated internalization.

Gilliland CT, Salanga CL, Kawamura T, Trejo J, Handel TM.

J Biol Chem. 2013 Nov 8;288(45):32194-210. doi: 10.1074/jbc.M113.503797. Epub 2013 Sep 20.


From the nose to the brain: olfaction and neuroscience.

López-Mascaraque L, Trejo JL.

Anat Rec (Hoboken). 2013 Sep;296(9):1285-6. doi: 10.1002/ar.22743. Epub 2013 Jul 31. No abstract available.


The Anatomical Record is smell-bound.

Albertine KH, Trejo JL.

Anat Rec (Hoboken). 2013 Sep;296(9):1283-4. doi: 10.1002/ar.22742. Epub 2013 Jul 31. No abstract available.


The growth factors cascade and the dendrito-/synapto-genesis versus cell survival in adult hippocampal neurogenesis: the chicken or the egg.

Pérez-Domper P, Gradari S, Trejo JL.

Ageing Res Rev. 2013 Jun;12(3):777-85. doi: 10.1016/j.arr.2013.06.001. Epub 2013 Jun 15. Review.


LDL oxidation and its association with carotid artery intima-media thickness and other cardiovascular risk factors in a sample of Spanish general population.

Calmarza P, Trejo JM, Lapresta C, López P.

Angiology. 2014 Apr;65(4):357-62. doi: 10.1177/0003319713488639. Epub 2013 May 9.


Advanced primary care in San Antonio: linking practice and community strategies to improve health.

Ferrer RL, Gonzalez Schlenker C, Lozano Romero R, Poursani R, Bazaldua O, Davidson D, Ann Gonzales M, Dehoyos J, Castilla M, Corona BA, Tysinger J, Alsip B, Trejo J, Jaén CR.

J Am Board Fam Med. 2013 May-Jun;26(3):288-98. doi: 10.3122/jabfm.2013.03.120238.


Palmitoylation of protease-activated receptor-1 regulates adaptor protein complex-2 and -3 interaction with tyrosine-based motifs and endocytic sorting.

Canto I, Trejo J.

J Biol Chem. 2013 May 31;288(22):15900-12. doi: 10.1074/jbc.M113.469866. Epub 2013 Apr 11.


Transactivation of the PAR1-PAR2 heterodimer by thrombin elicits β-arrestin-mediated endosomal signaling.

Lin H, Trejo J.

J Biol Chem. 2013 Apr 19;288(16):11203-15. doi: 10.1074/jbc.M112.439950. Epub 2013 Mar 8.


Lack of association between carotid intima-media thickness and apolipoprotein (a) isoforms in a sample of Spanish general population.

Calmarza P, Trejo JM, Lapresta C, Lopez P.

J Cardiol. 2013 May;61(5):372-7. doi: 10.1016/j.jjcc.2013.01.006. Epub 2013 Mar 6.


Reducing GABAA α5 receptor-mediated inhibition rescues functional and neuromorphological deficits in a mouse model of down syndrome.

Martínez-Cué C, Martínez P, Rueda N, Vidal R, García S, Vidal V, Corrales A, Montero JA, Pazos Á, Flórez J, Gasser R, Thomas AW, Honer M, Knoflach F, Trejo JL, Wettstein JG, Hernández MC.

J Neurosci. 2013 Feb 27;33(9):3953-66. doi: 10.1523/JNEUROSCI.1203-12.2013.


Cessation of voluntary wheel running increases anxiety-like behavior and impairs adult hippocampal neurogenesis in mice.

Nishijima T, Llorens-Martín M, Tejeda GS, Inoue K, Yamamura Y, Soya H, Trejo JL, Torres-Alemán I.

Behav Brain Res. 2013 May 15;245:34-41. doi: 10.1016/j.bbr.2013.02.009. Epub 2013 Feb 18.


PAR-1 contributes to the innate immune response during viral infection.

Antoniak S, Owens AP 3rd, Baunacke M, Williams JC, Lee RD, Weithäuser A, Sheridan PA, Malz R, Luyendyk JP, Esserman DA, Trejo J, Kirchhofer D, Blaxall BC, Pawlinski R, Beck MA, Rauch U, Mackman N.

J Clin Invest. 2013 Mar;123(3):1310-22. doi: 10.1172/JCI66125. Epub 2013 Feb 8.


Association of tic disorders with poor academic performance in central Spain: a population-based study.

Cubo E, Trejo J, Ausín V, Sáez S, Delgado V, Macarrón J, Cordero J, Louis ED, Kompoliti K, Benito-León J.

J Pediatr. 2013 Jul;163(1):217-23.e1-3. doi: 10.1016/j.jpeds.2012.12.030. Epub 2013 Jan 23.


Ubiquitin-dependent regulation of G protein-coupled receptor trafficking and signaling.

Marchese A, Trejo J.

Cell Signal. 2013 Mar;25(3):707-16. doi: 10.1016/j.cellsig.2012.11.024. Epub 2012 Nov 29. Review.


AP-3 regulates PAR1 ubiquitin-independent MVB/lysosomal sorting via an ALIX-mediated pathway.

Dores MR, Paing MM, Lin H, Montagne WA, Marchese A, Trejo J.

Mol Biol Cell. 2012 Sep;23(18):3612-23. doi: 10.1091/mbc.E12-03-0251. Epub 2012 Jul 25.


Ubiquitination of G protein-coupled receptors: functional implications and drug discovery.

Dores MR, Trejo J.

Mol Pharmacol. 2012 Oct;82(4):563-70. Epub 2012 Jun 14. Review.


Allosteric modulation of protease-activated receptor signaling.

Canto I, Soh UJ, Trejo J.

Mini Rev Med Chem. 2012 Aug;12(9):804-11. Review.


ALIX binds a YPX(3)L motif of the GPCR PAR1 and mediates ubiquitin-independent ESCRT-III/MVB sorting.

Dores MR, Chen B, Lin H, Soh UJ, Paing MM, Montagne WA, Meerloo T, Trejo J.

J Cell Biol. 2012 Apr 30;197(3):407-19. doi: 10.1083/jcb.201110031.

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