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Items: 1 to 50 of 114


RPEL-family rhoGAPs link Rac/Cdc42 GTP loading to G-actin availability.

Diring J, Mouilleron S, McDonald NQ, Treisman R.

Nat Cell Biol. 2019 Jul;21(7):845-855. doi: 10.1038/s41556-019-0337-y. Epub 2019 Jun 17.


ERK Signaling Controls Innate-like CD8+ T Cell Differentiation via the ELK4 (SAP-1) and ELK1 Transcription Factors.

Maurice D, Costello P, Sargent M, Treisman R.

J Immunol. 2018 Sep 15;201(6):1681-1691. doi: 10.4049/jimmunol.1800704. Epub 2018 Aug 1.


A Novel Approach to Data Collection for Difficult Structures: Data Management for Large Numbers of Crystals with the BLEND Software.

Mylona A, Carr S, Aller P, Moraes I, Treisman R, Evans G, Foadi J.

Crystals (Basel). 2017 Aug 4;7(8):242. doi: 10.3390/cryst7080242.


Mutual dependence of the MRTF-SRF and YAP-TEAD pathways in cancer-associated fibroblasts is indirect and mediated by cytoskeletal dynamics.

Foster CT, Gualdrini F, Treisman R.

Genes Dev. 2017 Dec 1;31(23-24):2361-2375. doi: 10.1101/gad.304501.117. Epub 2018 Jan 9.


Local delivery of novel MRTF/SRF inhibitors prevents scar tissue formation in a preclinical model of fibrosis.

Yu-Wai-Man C, Spencer-Dene B, Lee RMH, Hutchings K, Lisabeth EM, Treisman R, Bailly M, Larsen SD, Neubig RR, Khaw PT.

Sci Rep. 2017 Mar 31;7(1):518. doi: 10.1038/s41598-017-00212-w.


ERK-Induced Activation of TCF Family of SRF Cofactors Initiates a Chromatin Modification Cascade Associated with Transcription.

Esnault C, Gualdrini F, Horswell S, Kelly G, Stewart A, East P, Matthews N, Treisman R.

Mol Cell. 2017 Mar 16;65(6):1081-1095.e5. doi: 10.1016/j.molcel.2017.02.005. Epub 2017 Mar 9.


SRF Co-factors Control the Balance between Cell Proliferation and Contractility.

Gualdrini F, Esnault C, Horswell S, Stewart A, Matthews N, Treisman R.

Mol Cell. 2016 Dec 15;64(6):1048-1061. doi: 10.1016/j.molcel.2016.10.016. Epub 2016 Nov 17.


Opposing effects of Elk-1 multisite phosphorylation shape its response to ERK activation.

Mylona A, Theillet FX, Foster C, Cheng TM, Miralles F, Bates PA, Selenko P, Treisman R.

Science. 2016 Oct 14;354(6309):233-237.


Phosphorylation acts positively and negatively to regulate MRTF-A subcellular localisation and activity.

Panayiotou R, Miralles F, Pawlowski R, Diring J, Flynn HR, Skehel M, Treisman R.

Elife. 2016 Jun 15;5. pii: e15460. doi: 10.7554/eLife.15460.


Repression of SRF target genes is critical for Myc-dependent apoptosis of epithelial cells.

Wiese KE, Haikala HM, von Eyss B, Wolf E, Esnault C, Rosenwald A, Treisman R, Klefström J, Eilers M.

EMBO J. 2015 Jun 3;34(11):1554-71. doi: 10.15252/embj.201490467. Epub 2015 Apr 20.


RNA export factor Ddx19 is required for nuclear import of the SRF coactivator MKL1.

Rajakylä EK, Viita T, Kyheröinen S, Huet G, Treisman R, Vartiainen MK.

Nat Commun. 2015 Jan 14;6:5978. doi: 10.1038/ncomms6978.


MRTF-SRF signaling is required for seeding of HSC/Ps in bone marrow during development.

Costello P, Sargent M, Maurice D, Esnault C, Foster K, Anjos-Afonso F, Treisman R.

Blood. 2015 Feb 19;125(8):1244-55. doi: 10.1182/blood-2014-08-595603. Epub 2015 Jan 8.


Exploring future nurses' attitudes and beliefs related to childhood overweight.

Snethen JA, Treisman RA, Buseh AG, Kelber ST.

J Nurs Educ. 2014 Sep;53(9 Suppl):S101-5.


The role of the MRTF-A/SRF pathway in ocular fibrosis.

Yu-Wai-Man C, Treisman R, Bailly M, Khaw PT.

Invest Ophthalmol Vis Sci. 2014 Jul 23;55(7):4560-7. doi: 10.1167/iovs.14-14692. Review.


Rho-actin signaling to the MRTF coactivators dominates the immediate transcriptional response to serum in fibroblasts.

Esnault C, Stewart A, Gualdrini F, East P, Horswell S, Matthews N, Treisman R.

Genes Dev. 2014 May 1;28(9):943-58. doi: 10.1101/gad.239327.114. Epub 2014 Apr 14.


Building better institutions.

Nurse P, Treisman R, Smith J.

Science. 2013 Jul 5;341(6141):10. doi: 10.1126/science.1242307. No abstract available.


Shedding light on nuclear actin dynamics and function.

Treisman R.

Trends Biochem Sci. 2013 Aug;38(8):376-7. doi: 10.1016/j.tibs.2013.06.004. Epub 2013 Jun 27.


Blood-borne circadian signal stimulates daily oscillations in actin dynamics and SRF activity.

Gerber A, Esnault C, Aubert G, Treisman R, Pralong F, Schibler U.

Cell. 2013 Jan 31;152(3):492-503. doi: 10.1016/j.cell.2012.12.027.


Structures of the Phactr1 RPEL domain and RPEL motif complexes with G-actin reveal the molecular basis for actin binding cooperativity.

Mouilleron S, Wiezlak M, O'Reilly N, Treisman R, McDonald NQ.

Structure. 2012 Nov 7;20(11):1960-70. doi: 10.1016/j.str.2012.08.031. Epub 2012 Oct 4.


G-actin regulates the shuttling and PP1 binding of the RPEL protein Phactr1 to control actomyosin assembly.

Wiezlak M, Diring J, Abella J, Mouilleron S, Way M, McDonald NQ, Treisman R.

J Cell Sci. 2012 Dec 1;125(Pt 23):5860-72. doi: 10.1242/jcs.112078. Epub 2012 Sep 12.


Nuclear transport of the serum response factor coactivator MRTF-A is downregulated at tensional homeostasis.

McGee KM, Vartiainen MK, Khaw PT, Treisman R, Bailly M.

EMBO Rep. 2011 Sep 1;12(9):963-70. doi: 10.1038/embor.2011.141.


Structure of a pentavalent G-actin*MRTF-A complex reveals how G-actin controls nucleocytoplasmic shuttling of a transcriptional coactivator.

Mouilleron S, Langer CA, Guettler S, McDonald NQ, Treisman R.

Sci Signal. 2011 Jun 14;4(177):ra40. doi: 10.1126/scisignal.2001750.


The essential function for serum response factor in T-cell development reflects its specific coupling to extracellular signal-regulated kinase signaling.

Mylona A, Nicolas R, Maurice D, Sargent M, Tuil D, Daegelen D, Treisman R, Costello P.

Mol Cell Biol. 2011 Jan;31(2):267-76. doi: 10.1128/MCB.01058-10. Epub 2010 Nov 22.


An actin-regulated importin α/β-dependent extended bipartite NLS directs nuclear import of MRTF-A.

Pawłowski R, Rajakylä EK, Vartiainen MK, Treisman R.

EMBO J. 2010 Oct 20;29(20):3448-58. doi: 10.1038/emboj.2010.216. Epub 2010 Sep 3.


Ternary complex factors SAP-1 and Elk-1, but not net, are functionally equivalent in thymocyte development.

Costello P, Nicolas R, Willoughby J, Wasylyk B, Nordheim A, Treisman R.

J Immunol. 2010 Jul 15;185(2):1082-92. doi: 10.4049/jimmunol.1000472. Epub 2010 Jun 16.


Myocardin-related transcription factors and SRF are required for cytoskeletal dynamics and experimental metastasis.

Medjkane S, Perez-Sanchez C, Gaggioli C, Sahai E, Treisman R.

Nat Cell Biol. 2009 Mar;11(3):257-68. doi: 10.1038/ncb1833. Epub 2009 Feb 8.


Molecular basis for G-actin binding to RPEL motifs from the serum response factor coactivator MAL.

Mouilleron S, Guettler S, Langer CA, Treisman R, McDonald NQ.

EMBO J. 2008 Dec 3;27(23):3198-208. doi: 10.1038/emboj.2008.235. Epub 2008 Nov 13.


OTT-MAL is a deregulated activator of serum response factor-dependent gene expression.

Descot A, Rex-Haffner M, Courtois G, Bluteau D, Menssen A, Mercher T, Bernard OA, Treisman R, Posern G.

Mol Cell Biol. 2008 Oct;28(20):6171-81. doi: 10.1128/MCB.00303-08. Epub 2008 Aug 18.


RPEL motifs link the serum response factor cofactor MAL but not myocardin to Rho signaling via actin binding.

Guettler S, Vartiainen MK, Miralles F, Larijani B, Treisman R.

Mol Cell Biol. 2008 Jan;28(2):732-42. Epub 2007 Nov 19.


Raf signaling but not the ERK effector SAP-1 is required for regulatory T cell development.

Willoughby JE, Costello PS, Nicolas RH, Robinson NJ, Stamp G, Powrie F, Treisman R.

J Immunol. 2007 Nov 15;179(10):6836-44.


Nuclear actin regulates dynamic subcellular localization and activity of the SRF cofactor MAL.

Vartiainen MK, Guettler S, Larijani B, Treisman R.

Science. 2007 Jun 22;316(5832):1749-52.


Expression and function of microRNAs in viruses great and small.

Sullivan CS, Grundhoff A, Tevethia S, Treisman R, Pipas JM, Ganem D.

Cold Spring Harb Symp Quant Biol. 2006;71:351-6. Review.


Actin' together: serum response factor, its cofactors and the link to signal transduction.

Posern G, Treisman R.

Trends Cell Biol. 2006 Nov;16(11):588-96. Epub 2006 Oct 10. Review.


Mutant actins that stabilise F-actin use distinct mechanisms to activate the SRF coactivator MAL.

Posern G, Miralles F, Guettler S, Treisman R.

EMBO J. 2004 Oct 13;23(20):3973-83. Epub 2004 Sep 23.


Homo-oligomerization is essential for F-actin assembly by the formin family FH2 domain.

Copeland JW, Copeland SJ, Treisman R.

J Biol Chem. 2004 Nov 26;279(48):50250-6. Epub 2004 Sep 14.


Ternary complex factor SAP-1 is required for Erk-mediated thymocyte positive selection.

Costello PS, Nicolas RH, Watanabe Y, Rosewell I, Treisman R.

Nat Immunol. 2004 Mar;5(3):289-98. Epub 2004 Feb 8.


A role for VASP in RhoA-Diaphanous signalling to actin dynamics and SRF activity.

Grosse R, Copeland JW, Newsome TP, Way M, Treisman R.

EMBO J. 2003 Jun 16;22(12):3050-61.


Actin dynamics control SRF activity by regulation of its coactivator MAL.

Miralles F, Posern G, Zaromytidou AI, Treisman R.

Cell. 2003 May 2;113(3):329-42.


LIM kinase and Diaphanous cooperate to regulate serum response factor and actin dynamics.

Geneste O, Copeland JW, Treisman R.

J Cell Biol. 2002 May 27;157(5):831-8. Epub 2002 May 28.


Growth factors and gene expression: fresh insights from arrays.

Hill CS, Treisman R.

Sci STKE. 1999 Oct 12;1999(3):PE1. Review.


Differential usage of signal transduction pathways defines two types of serum response factor target gene.

Gineitis D, Treisman R.

J Biol Chem. 2001 Jul 6;276(27):24531-9. Epub 2001 May 7.


Ezrin function is required for ROCK-mediated fibroblast transformation by the Net and Dbl oncogenes.

Tran Quang C, Gautreau A, Arpin M, Treisman R.

EMBO J. 2000 Sep 1;19(17):4565-76.


ERK activation induces phosphorylation of Elk-1 at multiple S/T-P motifs to high stoichiometry.

Cruzalegui FH, Cano E, Treisman R.

Oncogene. 1999 Dec 23;18(56):7948-57.


Signal-regulated activation of serum response factor is mediated by changes in actin dynamics.

Sotiropoulos A, Gineitis D, Copeland J, Treisman R.

Cell. 1999 Jul 23;98(2):159-69.


Regulation of SRF activity by Rho family GTPases.

Treisman R, Alberts AS, Sahai E.

Cold Spring Harb Symp Quant Biol. 1998;63:643-51. Review. No abstract available.


Transformation mediated by RhoA requires activity of ROCK kinases.

Sahai E, Ishizaki T, Narumiya S, Treisman R.

Curr Biol. 1999 Feb 11;9(3):136-45.

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