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A Single-Stranded Oligonucleotide Inhibits Toll-Like Receptor 3 Activation and Reduces Influenza A (H1N1) Infection.

Poux C, Dondalska A, Bergenstråhle J, Pålsson S, Contreras V, Arasa C, Järver P, Albert J, Busse DC, LeGrand R, Lundeberg J, Tregoning JS, Spetz AL.

Front Immunol. 2019 Sep 12;10:2161. doi: 10.3389/fimmu.2019.02161. eCollection 2019.


Effect of a Russian-backbone live-attenuated influenza vaccine with an updated pandemic H1N1 strain on shedding and immunogenicity among children in The Gambia: an open-label, observational, phase 4 study.

Lindsey BB, Jagne YJ, Armitage EP, Singanayagam A, Sallah HJ, Drammeh S, Senghore E, Mohammed NI, Jeffries D, Höschler K, Tregoning JS, Meijer A, Clarke E, Dong T, Barclay W, Kampmann B, de Silva TI.

Lancet Respir Med. 2019 Aug;7(8):665-676. doi: 10.1016/S2213-2600(19)30086-4. Epub 2019 Jun 21.


The switch between acute and persistent paramyxovirus infection caused by single amino acid substitutions in the RNA polymerase P subunit.

Young DF, Wignall-Fleming EB, Busse DC, Pickin MJ, Hankinson J, Randall EM, Tavendale A, Davison AJ, Lamont D, Tregoning JS, Goodbourn S, Randall RE.

PLoS Pathog. 2019 Feb 11;15(2):e1007561. doi: 10.1371/journal.ppat.1007561. eCollection 2019 Feb.


Comparative Metabolomic Sampling of Upper and Lower Airways by Four Different Methods to Identify Biochemicals That May Support Bacterial Growth.

Farne H, Groves HT, Gill SK, Stokes I, McCulloch S, Karoly E, Trujillo-Torralbo MB, Johnston SL, Mallia P, Tregoning JS.

Front Cell Infect Microbiol. 2018 Dec 18;8:432. doi: 10.3389/fcimb.2018.00432. eCollection 2018.


Modulating airway glucose to reduce respiratory infections.

Tregoning JS, Mallia P.

Expert Rev Respir Med. 2019 Feb;13(2):121-124. doi: 10.1080/17476348.2019.1563487. Epub 2019 Jan 7. No abstract available.


Interferon-Induced Transmembrane Protein 1 Restricts Replication of Viruses That Enter Cells via the Plasma Membrane.

Smith SE, Busse DC, Binter S, Weston S, Diaz Soria C, Laksono BM, Clare S, Van Nieuwkoop S, Van den Hoogen BG, Clement M, Marsden M, Humphreys IR, Marsh M, de Swart RL, Wash RS, Tregoning JS, Kellam P.

J Virol. 2019 Mar 5;93(6). pii: e02003-18. doi: 10.1128/JVI.02003-18. Print 2019 Mar 15.


The impact of timing of maternal influenza immunization on infant antibody levels at birth.

Zhong Z, Haltalli M, Holder B, Rice T, Donaldson B, O'Driscoll M, Le-Doare K, Kampmann B, Tregoning JS.

Clin Exp Immunol. 2019 Feb;195(2):139-152. doi: 10.1111/cei.13234. Epub 2018 Dec 2.


Combined HDAC and BET Inhibition Enhances Melanoma Vaccine Immunogenicity and Efficacy.

Badamchi-Zadeh A, Moynihan KD, Larocca RA, Aid M, Provine NM, Iampietro MJ, Kinnear E, Penaloza-MacMaster P, Abbink P, Blass E, Tregoning JS, Irvine DJ, Barouch DH.

J Immunol. 2018 Nov 1;201(9):2744-2752. doi: 10.4049/jimmunol.1800885. Epub 2018 Sep 24.


Respiratory Disease following Viral Lung Infection Alters the Murine Gut Microbiota.

Groves HT, Cuthbertson L, James P, Moffatt MF, Cox MJ, Tregoning JS.

Front Immunol. 2018 Feb 12;9:182. doi: 10.3389/fimmu.2018.00182. eCollection 2018.


Mouse Models of Influenza Infection with Circulating Strains to Test Seasonal Vaccine Efficacy.

Groves HT, McDonald JU, Langat P, Kinnear E, Kellam P, McCauley J, Ellis J, Thompson C, Elderfield R, Parker L, Barclay W, Tregoning JS.

Front Immunol. 2018 Jan 31;9:126. doi: 10.3389/fimmu.2018.00126. eCollection 2018.


Role of airway glucose in bacterial infections in patients with chronic obstructive pulmonary disease.

Mallia P, Webber J, Gill SK, Trujillo-Torralbo MB, Calderazzo MA, Finney L, Bakhsoliani E, Farne H, Singanayagam A, Footitt J, Hewitt R, Kebadze T, Aniscenko J, Padmanaban V, Molyneaux PL, Adcock IM, Barnes PJ, Ito K, Elkin SL, Kon OM, Cookson WO, Moffat MF, Johnston SL, Tregoning JS.

J Allergy Clin Immunol. 2018 Sep;142(3):815-823.e6. doi: 10.1016/j.jaci.2017.10.017. Epub 2018 Jan 5.


Self-Amplifying RNA Vaccines Give Equivalent Protection against Influenza to mRNA Vaccines but at Much Lower Doses.

Vogel AB, Lambert L, Kinnear E, Busse D, Erbar S, Reuter KC, Wicke L, Perkovic M, Beissert T, Haas H, Reece ST, Sahin U, Tregoning JS.

Mol Ther. 2018 Feb 7;26(2):446-455. doi: 10.1016/j.ymthe.2017.11.017. Epub 2017 Dec 5.


Adjuvanted influenza vaccines.

Tregoning JS, Russell RF, Kinnear E.

Hum Vaccin Immunother. 2018 Mar 4;14(3):550-564. doi: 10.1080/21645515.2017.1415684. Epub 2018 Jan 25. Review.


Airway T cells protect against RSV infection in the absence of antibody.

Kinnear E, Lambert L, McDonald JU, Cheeseman HM, Caproni LJ, Tregoning JS.

Mucosal Immunol. 2018 Jan;11(1):290. doi: 10.1038/mi.2017.79. Epub 2017 Aug 30.


The synergistic effects of combining TLR ligand based adjuvants on the cytokine response are dependent upon p38/JNK signalling.

Fischetti L, Zhong Z, Pinder CL, Tregoning JS, Shattock RJ.

Cytokine. 2017 Nov;99:287-296. doi: 10.1016/j.cyto.2017.08.009. Epub 2017 Aug 18.


Comparison of mucosal lining fluid sampling methods and influenza-specific IgA detection assays for use in human studies of influenza immunity.

de Silva TI, Gould V, Mohammed NI, Cope A, Meijer A, Zutt I, Reimerink J, Kampmann B, Hoschler K, Zambon M, Tregoning JS.

J Immunol Methods. 2017 Oct;449:1-6. doi: 10.1016/j.jim.2017.06.008. Epub 2017 Jun 21.


Nasal IgA Provides Protection against Human Influenza Challenge in Volunteers with Low Serum Influenza Antibody Titre.

Gould VMW, Francis JN, Anderson KJ, Georges B, Cope AV, Tregoning JS.

Front Microbiol. 2017 May 17;8:900. doi: 10.3389/fmicb.2017.00900. eCollection 2017.


Airway T cells protect against RSV infection in the absence of antibody.

Kinnear E, Lambert L, McDonald JU, Cheeseman HM, Caproni LJ, Tregoning JS.

Mucosal Immunol. 2018 Jan;11(1):249-256. doi: 10.1038/mi.2017.46. Epub 2017 May 24. Erratum in: Mucosal Immunol. 2017 Aug 30;:.


Inflammatory responses to influenza vaccination at the extremes of age.

McDonald JU, Zhong Z, Groves HT, Tregoning JS.

Immunology. 2017 Aug;151(4):451-463. doi: 10.1111/imm.12742. Epub 2017 May 16.


Dapagliflozin-lowered blood glucose reduces respiratory Pseudomonas aeruginosa infection in diabetic mice.

Åstrand A, Wingren C, Benjamin A, Tregoning JS, Garnett JP, Groves H, Gill S, Orogo-Wenn M, Lundqvist AJ, Walters D, Smith DM, Taylor JD, Baker EH, Baines DL.

Br J Pharmacol. 2017 May;174(9):836-847. doi: 10.1111/bph.13741. Epub 2017 Mar 9.


A Simple Screening Approach To Prioritize Genes for Functional Analysis Identifies a Role for Interferon Regulatory Factor 7 in the Control of Respiratory Syncytial Virus Disease.

McDonald JU, Kaforou M, Clare S, Hale C, Ivanova M, Huntley D, Dorner M, Wright VJ, Levin M, Martinon-Torres F, Herberg JA, Tregoning JS.

mSystems. 2016 Jun 28;1(3). pii: e00051-16. eCollection 2016 May-Jun.


DNA Vaccines Encoding Antigen Targeted to MHC Class II Induce Influenza-Specific CD8(+) T Cell Responses, Enabling Faster Resolution of Influenza Disease.

Lambert L, Kinnear E, McDonald JU, Grodeland G, Bogen B, Stubsrud E, Lindeberg MM, Fredriksen AB, Tregoning JS.

Front Immunol. 2016 Aug 23;7:321. doi: 10.3389/fimmu.2016.00321. eCollection 2016.


Increased airway glucose increases airway bacterial load in hyperglycaemia.

Gill SK, Hui K, Farne H, Garnett JP, Baines DL, Moore LS, Holmes AH, Filloux A, Tregoning JS.

Sci Rep. 2016 Jun 8;6:27636. doi: 10.1038/srep27636.


A Multi-Component Prime-Boost Vaccination Regimen with a Consensus MOMP Antigen Enhances Chlamydia trachomatis Clearance.

Badamchi-Zadeh A, McKay PF, Korber BT, Barinaga G, Walters AA, Nunes A, Gomes JP, Follmann F, Tregoning JS, Shattock RJ.

Front Immunol. 2016 Apr 28;7:162. doi: 10.3389/fimmu.2016.00162. eCollection 2016.


CD71 targeting boosts immunogenicity of sublingually delivered influenza haemagglutinin antigen and protects against viral challenge in mice.

Mann JF, Tregoning JS, Aldon Y, Shattock RJ, McKay PF.

J Control Release. 2016 Jun 28;232:75-82. doi: 10.1016/j.jconrel.2016.04.022. Epub 2016 Apr 16.


Development of a custom pentaplex sandwich immunoassay using Protein-G coupled beads for the Luminex® xMAP® platform.

McDonald JU, Ekeruche-Makinde J, Ho MM, Tregoning JS, Ashiru O.

J Immunol Methods. 2016 Jun;433:6-16. doi: 10.1016/j.jim.2016.02.018. Epub 2016 Feb 24.


Use of the Microparticle Nanoscale Silicon Dioxide as an Adjuvant To Boost Vaccine Immune Responses against Influenza Virus in Neonatal Mice.

Russell RF, McDonald JU, Lambert L, Tregoning JS.

J Virol. 2016 Apr 14;90(9):4735-4744. doi: 10.1128/JVI.03159-15. Print 2016 May.


Evaluation of mucosal adjuvants and immunization routes for the induction of systemic and mucosal humoral immune responses in macaques.

Veazey RS, Siddiqui A, Klein K, Buffa V, Fischetti L, Doyle-Meyers L, King DF, Tregoning JS, Shattock RJ.

Hum Vaccin Immunother. 2015;11(12):2913-22. doi: 10.1080/21645515.2015.1070998.


Intramuscular Immunisation with Chlamydial Proteins Induces Chlamydia trachomatis Specific Ocular Antibodies.

Badamchi-Zadeh A, McKay PF, Holland MJ, Paes W, Brzozowski A, Lacey C, Follmann F, Tregoning JS, Shattock RJ.

PLoS One. 2015 Oct 26;10(10):e0141209. doi: 10.1371/journal.pone.0141209. eCollection 2015.


PHiD-CV induces anti-Protein D antibodies but does not augment pulmonary clearance of nontypeable Haemophilus influenzae in mice.

Siggins MK, Gill SK, Langford PR, Li Y, Ladhani SN, Tregoning JS.

Vaccine. 2015 Sep 11;33(38):4954-61. doi: 10.1016/j.vaccine.2015.07.034. Epub 2015 Jul 26.


Using Plasmids as DNA Vaccines for Infectious Diseases.

Tregoning JS, Kinnear E.

Microbiol Spectr. 2014 Dec;2(6). doi: 10.1128/microbiolspec.PLAS-0028-2014. Review.


A Comparison of Red Fluorescent Proteins to Model DNA Vaccine Expression by Whole Animal In Vivo Imaging.

Kinnear E, Caproni LJ, Tregoning JS.

PLoS One. 2015 Jun 19;10(6):e0130375. doi: 10.1371/journal.pone.0130375. eCollection 2015.


Partial Attenuation of Respiratory Syncytial Virus with a Deletion of a Small Hydrophobic Gene Is Associated with Elevated Interleukin-1β Responses.

Russell RF, McDonald JU, Ivanova M, Zhong Z, Bukreyev A, Tregoning JS.

J Virol. 2015 Sep;89(17):8974-81. doi: 10.1128/JVI.01070-15. Epub 2015 Jun 17.


MF59 Mediates Its B Cell Adjuvanticity by Promoting T Follicular Helper Cells and Thus Germinal Center Responses in Adult and Early Life.

Mastelic Gavillet B, Eberhardt CS, Auderset F, Castellino F, Seubert A, Tregoning JS, Lambert PH, de Gregorio E, Del Giudice G, Siegrist CA.

J Immunol. 2015 May 15;194(10):4836-45. doi: 10.4049/jimmunol.1402071. Epub 2015 Apr 13.


Comparative analysis of enzymatically produced novel linear DNA constructs with plasmids for use as DNA vaccines.

Walters AA, Kinnear E, Shattock RJ, McDonald JU, Caproni LJ, Porter N, Tregoning JS.

Gene Ther. 2014 Jul;21(7):645-52. doi: 10.1038/gt.2014.37. Epub 2014 May 15.


Defining the range of pathogens susceptible to Ifitm3 restriction using a knockout mouse model.

Everitt AR, Clare S, McDonald JU, Kane L, Harcourt K, Ahras M, Lall A, Hale C, Rodgers A, Young DB, Haque A, Billker O, Tregoning JS, Dougan G, Kellam P.

PLoS One. 2013 Nov 21;8(11):e80723. doi: 10.1371/journal.pone.0080723. eCollection 2013.


A "prime-pull" vaccine strategy has a modest effect on local and systemic antibody responses to HIV gp140 in mice.

Tregoning JS, Buffa V, Oszmiana A, Klein K, Walters AA, Shattock RJ.

PLoS One. 2013 Nov 19;8(11):e80559. doi: 10.1371/journal.pone.0080559. eCollection 2013.


Delayed sequelae of neonatal respiratory syncytial virus infection are dependent on cells of the innate immune system.

Harker JA, Yamaguchi Y, Culley FJ, Tregoning JS, Openshaw PJ.

J Virol. 2014 Jan;88(1):604-11. doi: 10.1128/JVI.02620-13. Epub 2013 Oct 30.


Mucosal application of gp140 encoding DNA polyplexes to different tissues results in altered immunological outcomes in mice.

Mann JF, McKay PF, Arokiasamy S, Patel RK, Tregoning JS, Shattock RJ.

PLoS One. 2013 Jun 24;8(6):e67412. doi: 10.1371/journal.pone.0067412. Print 2013.


Metformin reduces airway glucose permeability and hyperglycaemia-induced Staphylococcus aureus load independently of effects on blood glucose.

Garnett JP, Baker EH, Naik S, Lindsay JA, Knight GM, Gill S, Tregoning JS, Baines DL.

Thorax. 2013 Sep;68(9):835-45. doi: 10.1136/thoraxjnl-2012-203178. Epub 2013 May 24.


Neonatal antibody responses are attenuated by interferon-γ produced by NK and T cells during RSV infection.

Tregoning JS, Wang BL, McDonald JU, Yamaguchi Y, Harker JA, Goritzka M, Johansson C, Bukreyev A, Collins PL, Openshaw PJ.

Proc Natl Acad Sci U S A. 2013 Apr 2;110(14):5576-81. doi: 10.1073/pnas.1214247110. Epub 2013 Mar 18.


Glucopyranosyl Lipid Adjuvant (GLA), a Synthetic TLR4 agonist, promotes potent systemic and mucosal responses to intranasal immunization with HIVgp140.

Arias MA, Van Roey GA, Tregoning JS, Moutaftsi M, Coler RN, Windish HP, Reed SG, Carter D, Shattock RJ.

PLoS One. 2012;7(7):e41144. doi: 10.1371/journal.pone.0041144. Epub 2012 Jul 19.


Preexposure to CpG protects against the delayed effects of neonatal respiratory syncytial virus infection.

Yamaguchi Y, Harker JA, Wang B, Openshaw PJ, Tregoning JS, Culley FJ.

J Virol. 2012 Oct;86(19):10456-61. doi: 10.1128/JVI.01082-12. Epub 2012 Jul 18.


Thymic stromal lymphopoietin (TSLP) acts as a potent mucosal adjuvant for HIV-1 gp140 vaccination in mice.

Van Roey GA, Arias MA, Tregoning JS, Rowe G, Shattock RJ.

Eur J Immunol. 2012 Feb;42(2):353-63. doi: 10.1002/eji.201141787. Epub 2011 Dec 19.


Intravaginal immunization using the recombinant HIV-1 clade-C trimeric envelope glycoprotein CN54gp140 formulated within lyophilized solid dosage forms.

Donnelly L, Curran RM, Tregoning JS, McKay PF, Cole T, Morrow RJ, Kett VL, Andrews GP, Woolfson AD, Malcolm RK, Shattock RJ.

Vaccine. 2011 Jun 15;29(27):4512-20. doi: 10.1016/j.vaccine.2011.04.023. Epub 2011 Apr 21.


Genetic susceptibility to the delayed sequelae of neonatal respiratory syncytial virus infection is MHC dependent.

Tregoning JS, Yamaguchi Y, Wang B, Mihm D, Harker JA, Bushell ES, Zheng M, Liao G, Peltz G, Openshaw PJ.

J Immunol. 2010 Nov 1;185(9):5384-91. doi: 10.4049/jimmunol.1001594. Epub 2010 Oct 4.


CD25+ natural regulatory T cells are critical in limiting innate and adaptive immunity and resolving disease following respiratory syncytial virus infection.

Lee DC, Harker JA, Tregoning JS, Atabani SF, Johansson C, Schwarze J, Openshaw PJ.

J Virol. 2010 Sep;84(17):8790-8. doi: 10.1128/JVI.00796-10. Epub 2010 Jun 23.


Delivery of cytokines by recombinant virus in early life alters the immune response to adult lung infection.

Harker JA, Lee DC, Yamaguchi Y, Wang B, Bukreyev A, Collins PL, Tregoning JS, Openshaw PJ.

J Virol. 2010 May;84(10):5294-302. doi: 10.1128/JVI.02503-09. Epub 2010 Mar 3.


The chemokine MIP1alpha/CCL3 determines pathology in primary RSV infection by regulating the balance of T cell populations in the murine lung.

Tregoning JS, Pribul PK, Pennycook AM, Hussell T, Wang B, Lukacs N, Schwarze J, Culley FJ, Openshaw PJ.

PLoS One. 2010 Feb 24;5(2):e9381. doi: 10.1371/journal.pone.0009381.


Interleukin 18 coexpression during respiratory syncytial virus infection results in enhanced disease mediated by natural killer cells.

Harker JA, Godlee A, Wahlsten JL, Lee DC, Thorne LG, Sawant D, Tregoning JS, Caspi RR, Bukreyev A, Collins PL, Openshaw PJ.

J Virol. 2010 Apr;84(8):4073-82. doi: 10.1128/JVI.02014-09. Epub 2010 Feb 3.

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