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Items: 1 to 50 of 195

1.

Minimum active structure of insulin-like peptide 5.

Belgi A, Bathgate RA, Kocan M, Patil N, Zhang S, Tregear GW, Wade JD, Hossain MA.

J Med Chem. 2013 Dec 12;56(23):9509-16. doi: 10.1021/jm400924p. Epub 2013 Nov 21.

PMID:
24188028
2.

Research performance evaluation: the experience of an independent medical research institute.

Schapper CC, Dwyer T, Tregear GW, Aitken M, Clay MA.

Aust Health Rev. 2012 May;36(2):218-23. doi: 10.1071/AH11057.

PMID:
22624645
3.

Structure and function relationship of murine insulin-like peptide 5 (INSL5): free C-terminus is essential for RXFP4 receptor binding and activation.

Belgi A, Hossain MA, Shabanpoor F, Chan L, Zhang S, Bathgate RA, Tregear GW, Wade JD.

Biochemistry. 2011 Oct 4;50(39):8352-61. doi: 10.1021/bi201093m. Epub 2011 Sep 8.

PMID:
21866895
4.

Relaxin remodels fibrotic healing following myocardial infarction.

Samuel CS, Cendrawan S, Gao XM, Ming Z, Zhao C, Kiriazis H, Xu Q, Tregear GW, Bathgate RA, Du XJ.

Lab Invest. 2011 May;91(5):675-90. doi: 10.1038/labinvest.2010.198. Epub 2011 Jan 10.

5.

The chemically synthesized human relaxin-2 analog, B-R13/17K H2, is an RXFP1 antagonist.

Hossain MA, Samuel CS, Binder C, Hewitson TD, Tregear GW, Wade JD, Bathgate RA.

Amino Acids. 2010 Jul;39(2):409-16. doi: 10.1007/s00726-009-0454-1. Epub 2009 Dec 31.

PMID:
20043231
6.

Aberrant protein expression in plasma and kidney tissue during experimental obstructive nephropathy.

Giannakis E, Samuel CS, Hewitson TD, Boon WM, Macris M, Reeve S, Lawrence J, Ian Smith A, Tregear GW, Wade JD.

Proteomics Clin Appl. 2009 Oct;3(10):1211-24. doi: 10.1002/prca.200900021. Epub 2009 Aug 4.

PMID:
21136945
7.

Use of a temporary "solubilizing" peptide tag for the Fmoc solid-phase synthesis of human insulin glargine via use of regioselective disulfide bond formation.

Hossain MA, Belgi A, Lin F, Zhang S, Shabanpoor F, Chan L, Belyea C, Truong HT, Blair AR, Andrikopoulos S, Tregear GW, Wade JD.

Bioconjug Chem. 2009 Jul;20(7):1390-6. doi: 10.1021/bc900181a.

PMID:
19552405
8.

Evaluation of relaxin's antifibrotic action by SELDI-TOF mass spectrometry-based profiling of relaxin knockout mice, a model of progressive fibrosis.

Giannakis E, Macris M, Chan L, Tregear GW, Samuel CS, Wade JD.

Ann N Y Acad Sci. 2009 Apr;1160:350-2. doi: 10.1111/j.1749-6632.2009.03957.x.

PMID:
19416218
9.

Investigations into the inhibitory effects of relaxin on renal myofibroblast differentiation.

Samuel CS, Mookerjee I, Halls ML, Summers RJ, Chew E, Bathgate RA, Tregear GW, Hewitson TD.

Ann N Y Acad Sci. 2009 Apr;1160:294-9. doi: 10.1111/j.1749-6632.2008.03823.x. Review.

PMID:
19416207
10.

Reversal of cardiac fibrosis and related dysfunction by relaxin.

Du XJ, Xu Q, Lekgabe E, Gao XM, Kiriazis H, Moore XL, Dart AM, Tregear GW, Bathgate RA, Samuel CS.

Ann N Y Acad Sci. 2009 Apr;1160:278-84. doi: 10.1111/j.1749-6632.2008.03780.x.

PMID:
19416203
11.

Relaxin family peptides and receptors in mammalian brain.

Gundlach AL, Ma S, Sang Q, Shen PJ, Piccenna L, Sedaghat K, Smith CM, Bathgate RA, Lawrence AJ, Tregear GW, Wade JD, Finkelstein DI, Bonaventure P, Liu C, Lovenberg TW, Sutton SW.

Ann N Y Acad Sci. 2009 Apr;1160:226-35. doi: 10.1111/j.1749-6632.2009.03956.x. Review.

PMID:
19416194
12.

Modeling the primary hormone-binding site of RXFP1 and RXFP2.

Scott DJ, Tregear GW, Bathgate RA.

Ann N Y Acad Sci. 2009 Apr;1160:74-7. doi: 10.1111/j.1749-6632.2009.03950.x.

PMID:
19416162
13.

The chemical synthesis of relaxin and related peptides.

Wade JD, Lin F, Hossain MA, Shabanpoor F, Zhang S, Tregear GW.

Ann N Y Acad Sci. 2009 Apr;1160:11-5. doi: 10.1111/j.1749-6632.2009.03951.x.

PMID:
19416151
14.

Structure and activity in the relaxin family of peptides.

Tregear GW, Bathgate RA, Hossain MA, Lin F, Zhang S, Shabanpoor F, Scott DJ, Ma S, Gundlach AL, Samuel CS, Wade JD.

Ann N Y Acad Sci. 2009 Apr;1160:5-10. doi: 10.1111/j.1749-6632.2009.03955.x.

PMID:
19416150
15.

Solid phase synthesis and structural analysis of novel A-chain dicarba analogs of human relaxin-3 (INSL7) that exhibit full biological activity.

Hossain MA, Rosengren KJ, Zhang S, Bathgate RA, Tregear GW, van Lierop BJ, Robinson AJ, Wade JD.

Org Biomol Chem. 2009 Apr 21;7(8):1547-53. doi: 10.1039/b821882j. Epub 2009 Feb 24.

PMID:
19343240
16.

Relaxin reverses airway remodeling and airway dysfunction in allergic airways disease.

Royce SG, Miao YR, Lee M, Samuel CS, Tregear GW, Tang ML.

Endocrinology. 2009 Jun;150(6):2692-9. doi: 10.1210/en.2008-1457. Epub 2009 Feb 12.

PMID:
19213838
17.

The structural and functional role of the B-chain C-terminal arginine in the relaxin-3 peptide antagonist, R3(BDelta23-27)R/I5.

Hossain MA, Bathgate RA, Rosengren KJ, Shabanpoor F, Zhang S, Lin F, Tregear GW, Wade JD.

Chem Biol Drug Des. 2009 Jan;73(1):46-52. doi: 10.1111/j.1747-0285.2008.00756.x.

PMID:
19152634
18.

Relaxin inhibits renal myofibroblast differentiation via RXFP1, the nitric oxide pathway, and Smad2.

Mookerjee I, Hewitson TD, Halls ML, Summers RJ, Mathai ML, Bathgate RA, Tregear GW, Samuel CS.

FASEB J. 2009 Apr;23(4):1219-29. doi: 10.1096/fj.08-120857. Epub 2008 Dec 10.

PMID:
19073841
19.

Effect of helix-promoting strategies on the biological activity of novel analogues of the B-chain of INSL3.

Shabanpoor F, Hughes RA, Zhang S, Bathgate RA, Layfield S, Hossain MA, Tregear GW, Separovic F, Wade JD.

Amino Acids. 2010 Jan;38(1):121-31. doi: 10.1007/s00726-008-0219-2. Epub 2008 Dec 7.

PMID:
19067106
20.

Relaxin family peptide receptor-1 protects against airway fibrosis during homeostasis but not against fibrosis associated with chronic allergic airways disease.

Samuel CS, Royce SG, Chen B, Cao H, Gossen JA, Tregear GW, Tang ML.

Endocrinology. 2009 Mar;150(3):1495-502. doi: 10.1210/en.2008-1062. Epub 2008 Oct 30.

PMID:
18974264
21.

Synthesis, conformation, and activity of human insulin-like peptide 5 (INSL5).

Akhter Hossain M, Bathgate RA, Kong CK, Shabanpoor F, Zhang S, Haugaard-Jönsson LM, Rosengren KJ, Tregear GW, Wade JD.

Chembiochem. 2008 Jul 21;9(11):1816-22. doi: 10.1002/cbic.200800113.

22.

Identification of the N-linked glycosylation sites of the human relaxin receptor and effect of glycosylation on receptor function.

Yan Y, Scott DJ, Wilkinson TN, Ji J, Tregear GW, Bathgate RA.

Biochemistry. 2008 Jul 1;47(26):6953-68. doi: 10.1021/bi800535b. Epub 2008 Jun 6.

PMID:
18533687
23.

The A-chain of human relaxin family peptides has distinct roles in the binding and activation of the different relaxin family peptide receptors.

Hossain MA, Rosengren KJ, Haugaard-Jönsson LM, Zhang S, Layfield S, Ferraro T, Daly NL, Tregear GW, Wade JD, Bathgate RA.

J Biol Chem. 2008 Jun 20;283(25):17287-97. doi: 10.1074/jbc.M801911200. Epub 2008 Apr 22.

24.

Endogenous relaxin does not affect chronic pressure overload-induced cardiac hypertrophy and fibrosis.

Xu Q, Lekgabe ED, Gao XM, Ming Z, Tregear GW, Dart AM, Bathgate RA, Samuel CS, Du XJ.

Endocrinology. 2008 Feb;149(2):476-82. Epub 2007 Nov 8.

PMID:
17991721
25.

Relaxin plays an important role in the regulation of airway structure and function.

Samuel CS, Royce SG, Burton MD, Zhao C, Tregear GW, Tang ML.

Endocrinology. 2007 Sep;148(9):4259-66. Epub 2007 Jun 21.

PMID:
17584966
26.

Defining the LGR8 residues involved in binding insulin-like peptide 3.

Scott DJ, Wilkinson TN, Zhang S, Ferraro T, Wade JD, Tregear GW, Bathgate RA.

Mol Endocrinol. 2007 Jul;21(7):1699-712. Epub 2007 May 1.

PMID:
17473281
27.

Improved chemical synthesis and demonstration of the relaxin receptor binding affinity and biological activity of mouse relaxin.

Samuel CS, Lin F, Hossain MA, Zhao C, Ferraro T, Bathgate RA, Tregear GW, Wade JD.

Biochemistry. 2007 May 8;46(18):5374-81. Epub 2007 Apr 11.

PMID:
17425335
28.

Relaxin antagonizes hypertrophy and apoptosis in neonatal rat cardiomyocytes.

Moore XL, Tan SL, Lo CY, Fang L, Su YD, Gao XM, Woodcock EA, Summers RJ, Tregear GW, Bathgate RA, Du XJ.

Endocrinology. 2007 Apr;148(4):1582-9. Epub 2007 Jan 4.

PMID:
17204550
29.

Endogenous relaxin is a naturally occurring modulator of experimental renal tubulointerstitial fibrosis.

Hewitson TD, Mookerjee I, Masterson R, Zhao C, Tregear GW, Becker GJ, Samuel CS.

Endocrinology. 2007 Feb;148(2):660-9. Epub 2006 Nov 9.

PMID:
17095590
30.

Relaxin-3 in GABA projection neurons of nucleus incertus suggests widespread influence on forebrain circuits via G-protein-coupled receptor-135 in the rat.

Ma S, Bonaventure P, Ferraro T, Shen PJ, Burazin TC, Bathgate RA, Liu C, Tregear GW, Sutton SW, Gundlach AL.

Neuroscience. 2007 Jan 5;144(1):165-90. Epub 2006 Oct 30.

PMID:
17071007
31.

Characterization of novel splice variants of LGR7 and LGR8 reveals that receptor signaling is mediated by their unique low density lipoprotein class A modules.

Scott DJ, Layfield S, Yan Y, Sudo S, Hsueh AJ, Tregear GW, Bathgate RA.

J Biol Chem. 2006 Nov 17;281(46):34942-54. Epub 2006 Sep 8.

32.

The effects of relaxin and estrogen deficiency on collagen deposition and hypertrophy of nonreproductive organs.

Lekgabe ED, Royce SG, Hewitson TD, Tang ML, Zhao C, Moore XL, Tregear GW, Bathgate RA, Du XJ, Samuel CS.

Endocrinology. 2006 Dec;147(12):5575-83. Epub 2006 Aug 24.

PMID:
16935837
33.
34.

Leucine-rich repeat-containing G-protein-coupled receptor 8 in mature glomeruli of developing and adult rat kidney and inhibition by insulin-like peptide-3 of glomerular cell proliferation.

Fu P, Shen PJ, Zhao CX, Scott DJ, Samuel CS, Wade JD, Tregear GW, Bathgate RA, Gundlach AL.

J Endocrinol. 2006 May;189(2):397-408.

PMID:
16648305
35.

Relaxin-3: improved synthesis strategy and demonstration of its high-affinity interaction with the relaxin receptor LGR7 both in vitro and in vivo.

Bathgate RA, Lin F, Hanson NF, Otvos L Jr, Guidolin A, Giannakis C, Bastiras S, Layfield SL, Ferraro T, Ma S, Zhao C, Gundlach AL, Samuel CS, Tregear GW, Wade JD.

Biochemistry. 2006 Jan 24;45(3):1043-53.

PMID:
16411781
36.

Solution structure and novel insights into the determinants of the receptor specificity of human relaxin-3.

Rosengren KJ, Lin F, Bathgate RA, Tregear GW, Daly NL, Wade JD, Craik DJ.

J Biol Chem. 2006 Mar 3;281(9):5845-51. Epub 2005 Dec 19.

37.

Relaxin receptor activation in the basolateral amygdala impairs memory consolidation.

Ma S, Roozendaal B, Burazin TC, Tregear GW, McGaugh JL, Gundlach AL.

Eur J Neurosci. 2005 Oct;22(8):2117-22.

PMID:
16262650
38.

Endogenous relaxin regulates collagen deposition in an animal model of allergic airway disease.

Mookerjee I, Solly NR, Royce SG, Tregear GW, Samuel CS, Tang ML.

Endocrinology. 2006 Feb;147(2):754-61. Epub 2005 Oct 27.

PMID:
16254028
39.

The relaxin gene knockout mouse: a model of progressive scleroderma.

Samuel CS, Zhao C, Yang Q, Wang H, Tian H, Tregear GW, Amento EP.

J Invest Dermatol. 2005 Oct;125(4):692-9.

40.

Coevolution of the relaxin-like peptides and their receptors.

Wilkinson TN, Speed TP, Tregear GW, Bathgate RA.

Ann N Y Acad Sci. 2005 May;1041:534-9.

PMID:
15956757
41.

Evolution of the relaxin-like peptide family: from neuropeptide to reproduction.

Wilkinson TN, Speed TP, Tregear GW, Bathgate RA.

Ann N Y Acad Sci. 2005 May;1041:530-3.

PMID:
15956756
42.

Detection, localization, and action of the INSL3 receptor, LGR8, in rat kidney.

Fu P, Shen PJ, Zhao CX, Scott DJ, Samuel CS, Wade JD, Tregear GW, Bathgate RA, Gundlach AL.

Ann N Y Acad Sci. 2005 May;1041:516-9.

PMID:
15956754
43.

Restricted expression of LGR8 in intralaminar thalamic nuclei of rat brain suggests a role in sensorimotor systems.

Shen PJ, Fu P, Phelan KD, Scott DJ, Layfield S, Tregear GW, Bathgate RA, Gundlach AL.

Ann N Y Acad Sci. 2005 May;1041:510-5.

PMID:
15956753
44.

Insulin-relaxin family peptide signaling and receptors in mouse brain membranes and neuronal cells.

Ortinau S, Lin F, Wade JD, Tregear GW, Bathgate RA, Gundlach AL.

Ann N Y Acad Sci. 2005 May;1041:211-5.

PMID:
15956710
45.

Localization of LGR7 (relaxin receptor) mRNA and protein in rat forebrain: correlation with relaxin binding site distribution.

Burazin TC, Johnson KJ, Ma S, Bathgate RA, Tregear GW, Gundlach AL.

Ann N Y Acad Sci. 2005 May;1041:205-10.

PMID:
15956709
46.

Investigating the role of relaxin in the regulation of airway fibrosis in animal models of acute and chronic allergic airway disease.

Mookerjee I, Tang ML, Solly N, Tregear GW, Samuel CS.

Ann N Y Acad Sci. 2005 May;1041:194-6.

PMID:
15956707
47.

Relaxin modulates fibroblast function, collagen production, and matrix metalloproteinase-2 expression by cardiac fibroblasts.

Mookerjee I, Unemori EN, DU XJ, Tregear GW, Samuel CS.

Ann N Y Acad Sci. 2005 May;1041:190-3.

PMID:
15956706
48.

Relaxin regulates collagen overproduction associated with experimental progressive renal fibrosis.

Samuel CS, Mookerjee I, Masterson R, Tregear GW, Hewitson TD.

Ann N Y Acad Sci. 2005 May;1041:182-4.

PMID:
15956704
49.

The relaxin gene-knockout mouse: a model of progressive fibrosis.

Samuel CS, Zhao C, Bathgate RA, DU XJ, Summers RJ, Amento EP, Walker LL, McBurnie M, Zhao L, Tregear GW.

Ann N Y Acad Sci. 2005 May;1041:173-81.

PMID:
15956703
50.

The chemistry and biology of human relaxin-3.

Tregear GW, Bathgate RA, Layfield S, Ferraro T, Gundlach A, Ma S, Lin F, Hanson NF, Summers RJ, Rosengren J, Craik DJ, Wade JD.

Ann N Y Acad Sci. 2005 May;1041:40-6.

PMID:
15956686

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