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Items: 20


Technological challenges and milestones for writing genomes.

Ostrov N, Beal J, Ellis T, Gordon DB, Karas BJ, Lee HH, Lenaghan SC, Schloss JA, Stracquadanio G, Trefzer A, Bader JS, Church GM, Coelho CM, Efcavitch JW, Güell M, Mitchell LA, Nielsen AAK, Peck B, Smith AC, Stewart CN Jr, Tekotte H.

Science. 2019 Oct 18;366(6463):310-312. doi: 10.1126/science.aay0339. No abstract available.


Two C++ libraries for counting trees on a phylogenetic terrace.

Biczok R, Bozsoky P, Eisenmann P, Ernst J, Ribizel T, Scholz F, Trefzer A, Weber F, Hamann M, Stamatakis A.

Bioinformatics. 2018 Oct 1;34(19):3399-3401. doi: 10.1093/bioinformatics/bty384.


Metabolic Engineering toward Sustainable Production of Nylon-6.

Turk SC, Kloosterman WP, Ninaber DK, Kolen KP, Knutova J, Suir E, Schürmann M, Raemakers-Franken PC, Müller M, de Wildeman SM, Raamsdonk LM, van der Pol R, Wu L, Temudo MF, van der Hoeven RA, Akeroyd M, van der Stoel RE, Noorman HJ, Bovenberg RA, Trefzer AC.

ACS Synth Biol. 2016 Jan 15;5(1):65-73. doi: 10.1021/acssynbio.5b00129. Epub 2015 Nov 11.


Systematic transfer of prokaryotic sensors and circuits to mammalian cells.

Stanton BC, Siciliano V, Ghodasara A, Wroblewska L, Clancy K, Trefzer AC, Chesnut JD, Weiss R, Voigt CA.

ACS Synth Biol. 2014 Dec 19;3(12):880-91. doi: 10.1021/sb5002856. Epub 2014 Nov 20.


Genome-wide gene expression changes in an industrial clavulanic acid overproduction strain of Streptomyces clavuligerus.

Medema MH, Alam MT, Heijne WH, van den Berg MA, Müller U, Trefzer A, Bovenberg RA, Breitling R, Takano E.

Microb Biotechnol. 2011 Mar;4(2):300-5. doi: 10.1111/j.1751-7915.2010.00226.x. Epub 2010 Nov 2.


The sequence of a 1.8-mb bacterial linear plasmid reveals a rich evolutionary reservoir of secondary metabolic pathways.

Medema MH, Trefzer A, Kovalchuk A, van den Berg M, Müller U, Heijne W, Wu L, Alam MT, Ronning CM, Nierman WC, Bovenberg RA, Breitling R, Takano E.

Genome Biol Evol. 2010 Jul 12;2:212-24. doi: 10.1093/gbe/evq013.


Biocatalytic conversion of avermectin to 4''-oxo-avermectin: improvement of cytochrome p450 monooxygenase specificity by directed evolution.

Trefzer A, Jungmann V, Molnár I, Botejue A, Buckel D, Frey G, Hill DS, Jörg M, Ligon JM, Mason D, Moore D, Pachlatko JP, Richardson TH, Spangenberg P, Wall MA, Zirkle R, Stege JT.

Appl Environ Microbiol. 2007 Jul;73(13):4317-25. Epub 2007 May 4.


Streptomyces genetics: a genomic perspective.

Paradkar A, Trefzer A, Chakraburtty R, Stassi D.

Crit Rev Biotechnol. 2003;23(1):1-27. Review.


Rationally designed glycosylated premithramycins: hybrid aromatic polyketides using genes from three different biosynthetic pathways.

Trefzer A, Blanco G, Remsing L, Künzel E, Rix U, Lipata F, Braña AF, Méndez C, Rohr J, Bechthold A, Salas JA.

J Am Chem Soc. 2002 May 29;124(21):6056-62.


Biosynthetic gene cluster of simocyclinone, a natural multihybrid antibiotic.

Trefzer A, Pelzer S, Schimana J, Stockert S, Bihlmaier C, Fiedler HP, Welzel K, Vente A, Bechthold A.

Antimicrob Agents Chemother. 2002 May;46(5):1174-82.


Elucidation of the function of two glycosyltransferase genes (lanGT1 and lanGT4) involved in landomycin biosynthesis and generation of new oligosaccharide antibiotics.

Trefzer A, Fischer C, Stockert S, Westrich L, Künzel E, Girreser U, Rohr J, Bechthold A.

Chem Biol. 2001 Dec;8(12):1239-52.


Biosynthesis of the orthosomycin antibiotic avilamycin A: deductions from the molecular analysis of the avi biosynthetic gene cluster of Streptomyces viridochromogenes Tü57 and production of new antibiotics.

Weitnauer G, Mühlenweg A, Trefzer A, Hoffmeister D, Süssmuth RD, Jung G, Welzel K, Vente A, Girreser U, Bechthold A.

Chem Biol. 2001 Jun;8(6):569-81.


Identification of a sugar flexible glycosyltransferase from Streptomyces olivaceus, the producer of the antitumor polyketide elloramycin.

Blanco G, Patallo EP, Braña AF, Trefzer A, Bechthold A, Rohr J, Méndez C, Salas JA.

Chem Biol. 2001 Mar;8(3):253-63.


An ATP-binding cassette transporter and two rRNA methyltransferases are involved in resistance to avilamycin in the producer organism Streptomyces viridochromogenes Tü57.

Weitnauer G, Gaisser S, Trefzer A, Stockert S, Westrich L, Quiros LM, Mendez C, Salas JA, Bechthold A.

Antimicrob Agents Chemother. 2001 Mar;45(3):690-5.


The NDP-sugar co-substrate concentration and the enzyme expression level influence the substrate specificity of glycosyltransferases: cloning and characterization of deoxysugar biosynthetic genes of the urdamycin biosynthetic gene cluster.

Hoffmeister D, Ichinose K, Domann S, Faust B, Trefzer A, Dräger G, Kirschning A, Fischer C, Künzel E, Bearden D, Rohr J, Bechthold A.

Chem Biol. 2000 Nov;7(11):821-31.


Function of glycosyltransferase genes involved in urdamycin A biosynthesis.

Trefzer A, Hoffmeister D, Künzel E, Stockert S, Weitnauer G, Westrich L, Rix U, Fuchser J, Bindseil KU, Rohr J, Bechthold A.

Chem Biol. 2000 Feb;7(2):133-42.


Genes and enzymes involved in deoxysugar biosynthesis in bacteria.

Trefzer A, Salas JA, Bechthold A.

Nat Prod Rep. 1999 Jun;16(3):283-99. Review. No abstract available.


Cloning of an avilamycin biosynthetic gene cluster from Streptomyces viridochromogenes Tü57.

Gaisser S, Trefzer A, Stockert S, Kirschning A, Bechthold A.

J Bacteriol. 1997 Oct;179(20):6271-8.


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