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Induction of store-operated calcium entry (SOCE) suppresses glioblastoma growth by inhibiting the Hippo pathway transcriptional coactivators YAP/TAZ.

Liu Z, Wei Y, Zhang L, Yee PP, Johnson M, Zhang X, Gulley M, Atkinson JM, Trebak M, Wang HG, Li W.

Oncogene. 2018 Aug 6. doi: 10.1038/s41388-018-0425-7. [Epub ahead of print]


Mitochondrial Ca2+ signaling.

Pathak T, Trebak M.

Pharmacol Ther. 2018 Jul 20. pii: S0163-7258(18)30120-7. doi: 10.1016/j.pharmthera.2018.07.001. [Epub ahead of print] Review.


Slow Traffic Makes for Bad Circulation: The Case of β1 Subunit of BK Channels in Hypertension.

Johnson M, Trebak M.

Hypertension. 2018 Jul 16. pii: HYPERTENSIONAHA.118.11237. doi: 10.1161/HYPERTENSIONAHA.118.11237. [Epub ahead of print] No abstract available.


Pore properties of Orai1 calcium channel dimers and their activation by the STIM1 ER calcium sensor.

Cai X, Nwokonko RM, Loktionova NA, Abdulqadir R, Baraniak JH Jr, Wang Y, Trebak M, Zhou Y, Gill DL.

J Biol Chem. 2018 Aug 17;293(33):12962-12974. doi: 10.1074/jbc.RA118.003424. Epub 2018 Jun 28.


Oncogenic KRAS suppresses store-operated Ca2+ entry and ICRAC through ERK pathway-dependent remodelling of STIM expression in colorectal cancer cell lines.

Pierro C, Zhang X, Kankeu C, Trebak M, Bootman MD, Roderick HL.

Cell Calcium. 2018 Jun;72:70-80. doi: 10.1016/j.ceca.2018.03.002. Epub 2018 Mar 14.


Cross-linking of Orai1 channels by STIM proteins.

Zhou Y, Nwokonko RM, Cai X, Loktionova NA, Abdulqadir R, Xin P, Niemeyer BA, Wang Y, Trebak M, Gill DL.

Proc Natl Acad Sci U S A. 2018 Apr 10;115(15):E3398-E3407. doi: 10.1073/pnas.1720810115. Epub 2018 Mar 26.


Revisiting the physiological effects of methylene blue as a treatment of cyanide intoxication.

Haouzi P, Gueguinou M, Sonobe T, Judenherc-Haouzi A, Tubbs N, Trebak M, Cheung J, Bouillaud F.

Clin Toxicol (Phila). 2018 Sep;56(9):828-840. doi: 10.1080/15563650.2018.1429615. Epub 2018 Feb 16.


Crosslink between calcium and sodium signalling.

Verkhratsky A, Trebak M, Perocchi F, Khananshvili D, Sekler I.

Exp Physiol. 2018 Feb 1;103(2):157-169. doi: 10.1113/EP086534. Epub 2018 Jan 16. Review.


Cardiovascular and Hemostatic Disorders: Role of STIM and Orai Proteins in Vascular Disorders.

Tanwar J, Trebak M, Motiani RK.

Adv Exp Med Biol. 2017;993:425-452. doi: 10.1007/978-3-319-57732-6_22. Review.


ORAI Calcium Channels.

Trebak M, Putney JW Jr.

Physiology (Bethesda). 2017 Jul;32(4):332-342. doi: 10.1152/physiol.00011.2017. Review.


Golgi-Associated Protein Kinase C-ε Is Delivered to Phagocytic Cups: Role of Phosphatidylinositol 4-Phosphate.

Hanes CM, D'Amico AE, Ueyama T, Wong AC, Zhang X, Hynes WF, Barroso MM, Cady NC, Trebak M, Saito N, Lennartz MR.

J Immunol. 2017 Jul 1;199(1):271-277. doi: 10.4049/jimmunol.1700243. Epub 2017 May 24.


Mitochondria control store-operated Ca2+ entry through Na+ and redox signals.

Ben-Kasus Nissim T, Zhang X, Elazar A, Roy S, Stolwijk JA, Zhou Y, Motiani RK, Gueguinou M, Hempel N, Hershfinkel M, Gill DL, Trebak M, Sekler I.

EMBO J. 2017 Mar 15;36(6):797-815. doi: 10.15252/embj.201592481. Epub 2017 Feb 20.


Crosstalk between calcium and reactive oxygen species signaling in cancer.

Hempel N, Trebak M.

Cell Calcium. 2017 May;63:70-96. doi: 10.1016/j.ceca.2017.01.007. Epub 2017 Jan 18. Review.


The STIM1-binding site nexus remotely controls Orai1 channel gating.

Zhou Y, Cai X, Loktionova NA, Wang X, Nwokonko RM, Wang X, Wang Y, Rothberg BS, Trebak M, Gill DL.

Nat Commun. 2016 Dec 8;7:13725. doi: 10.1038/ncomms13725.


Calcium Signaling Is Dispensable for Receptor Regulation of Endothelial Barrier Function.

Stolwijk JA, Zhang X, Gueguinou M, Zhang W, Matrougui K, Renken C, Trebak M.

J Biol Chem. 2016 Oct 28;291(44):22894-22912. Epub 2016 Sep 13.


The Orai1 Store-operated Calcium Channel Functions as a Hexamer.

Cai X, Zhou Y, Nwokonko RM, Loktionova NA, Wang X, Xin P, Trebak M, Wang Y, Gill DL.

J Biol Chem. 2016 Dec 9;291(50):25764-25775. Epub 2016 Oct 25.


Essential Role of Smooth Muscle STIM1 in Hypertension and Cardiovascular Dysfunction.

Kassan M, Ait-Aissa K, Radwan E, Mali V, Haddox S, Gabani M, Zhang W, Belmadani S, Irani K, Trebak M, Matrougui K.

Arterioscler Thromb Vasc Biol. 2016 Sep;36(9):1900-9. doi: 10.1161/ATVBAHA.116.307869. Epub 2016 Jul 28.


Transient Receptor Potential Canonical 7 (TRPC7), a Calcium (Ca(2+)) Permeable Non-selective Cation Channel.

Zhang X, Spinelli AM, Masiello T, Trebak M.

Adv Exp Med Biol. 2016;898:251-64. doi: 10.1007/978-3-319-26974-0_11. Review.


Low-Voltage-Activated CaV3.1 Calcium Channels Shape T Helper Cell Cytokine Profiles.

Wang H, Zhang X, Xue L, Xing J, Jouvin MH, Putney JW, Anderson MP, Trebak M, Kinet JP.

Immunity. 2016 Apr 19;44(4):782-94. doi: 10.1016/j.immuni.2016.01.015. Epub 2016 Mar 29.


Orai channel-mediated Ca2+ signals in vascular and airway smooth muscle.

Spinelli AM, Trebak M.

Am J Physiol Cell Physiol. 2016 Mar 15;310(6):C402-13. doi: 10.1152/ajpcell.00355.2015. Epub 2015 Dec 30. Review.


Francisella tularensis Catalase Restricts Immune Function by Impairing TRPM2 Channel Activity.

Shakerley NL, Chandrasekaran A, Trebak M, Miller BA, Melendez JA.

J Biol Chem. 2016 Feb 19;291(8):3871-81. doi: 10.1074/jbc.M115.706879. Epub 2015 Dec 17.


Multiple types of calcium channels arising from alternative translation initiation of the Orai1 message.

Desai PN, Zhang X, Wu S, Janoshazi A, Bolimuntha S, Putney JW, Trebak M.

Sci Signal. 2015 Jul 28;8(387):ra74. doi: 10.1126/scisignal.aaa8323.


Smooth muscle CaMKIIδ promotes allergen-induced airway hyperresponsiveness and inflammation.

Spinelli AM, Liu Y, Sun LY, González-Cobos JC, Backs J, Trebak M, Singer HA.

Pflugers Arch. 2015 Dec;467(12):2541-54. doi: 10.1007/s00424-015-1713-5. Epub 2015 Jun 20.


A sacrificial process for fabrication of biodegradable polymer membranes with submicron thickness.

Beardslee LA, Stolwijk J, Khaladj DA, Trebak M, Halman J, Torrejon KY, Niamsiri N, Bergkvist M.

J Biomed Mater Res B Appl Biomater. 2016 Aug;104(6):1192-201. doi: 10.1002/jbm.b.33464. Epub 2015 Jun 16.


Novel Protein Kinase C-Mediated Control of Orai1 Function in Invasive Melanoma.

Hooper R, Zhang X, Webster M, Go C, Kedra J, Marchbank K, Gill DL, Weeraratna AT, Trebak M, Soboloff J.

Mol Cell Biol. 2015 Aug;35(16):2790-8.


Augmented EGF receptor tyrosine kinase activity impairs vascular function by NADPH oxidase-dependent mechanism in type 2 diabetic mouse.

Kassan M, Ait-Aissa K, Ali M, Trebak M, Matrougui K.

Biochim Biophys Acta. 2015 Oct;1853(10 Pt A):2404-10. doi: 10.1016/j.bbamcr.2015.05.032. Epub 2015 May 31.


STIM and Orai proteins as novel targets for cancer therapy. A Review in the Theme: Cell and Molecular Processes in Cancer Metastasis.

Vashisht A, Trebak M, Motiani RK.

Am J Physiol Cell Physiol. 2015 Oct 1;309(7):C457-69. doi: 10.1152/ajpcell.00064.2015. Epub 2015 May 27. Review.


Calcium signals tune the fidelity of transcriptional responses.

Zhou Y, Trebak M, Gill DL.

Mol Cell. 2015 Apr 16;58(2):197-9. doi: 10.1016/j.molcel.2015.04.003.


Vascular balloon injury and intraluminal administration in rat carotid artery.

Zhang W, Trebak M.

J Vis Exp. 2014 Dec 23;(94). doi: 10.3791/52045.


Leukotriene-C4 synthase, a critical enzyme in the activation of store-independent Orai1/Orai3 channels, is required for neointimal hyperplasia.

Zhang W, Zhang X, González-Cobos JC, Stolwijk JA, Matrougui K, Trebak M.

J Biol Chem. 2015 Feb 20;290(8):5015-27. doi: 10.1074/jbc.M114.625822. Epub 2014 Dec 24.


Impedance analysis of GPCR-mediated changes in endothelial barrier function: overview and fundamental considerations for stable and reproducible measurements.

Stolwijk JA, Matrougui K, Renken CW, Trebak M.

Pflugers Arch. 2015 Oct;467(10):2193-218. doi: 10.1007/s00424-014-1674-0. Epub 2014 Dec 24.


Emergence of Orai3 activity during cardiac hypertrophy.

Saliba Y, Keck M, Marchand A, Atassi F, Ouillé A, Cazorla O, Trebak M, Pavoine C, Lacampagne A, Hulot JS, Farès N, Fauconnier J, Lompré AM.

Cardiovasc Res. 2015 Mar 1;105(3):248-59. doi: 10.1093/cvr/cvu207. Epub 2014 Sep 11.


Differential role for stromal interacting molecule 1 in the regulation of vascular function.

Kassan M, Zhang W, Aissa KA, Stolwijk J, Trebak M, Matrougui K.

Pflugers Arch. 2015 Jun;467(6):1195-202. doi: 10.1007/s00424-014-1556-5. Epub 2014 Jun 27.


Transient receptor potential canonical 7: a diacylglycerol-activated non-selective cation channel.

Zhang X, Trebak M.

Handb Exp Pharmacol. 2014;222:189-204. doi: 10.1007/978-3-642-54215-2_8. Review.


Nuclear factor kappa B inhibition improves conductance artery function in type 2 diabetic mice.

Kassan M, Choi SK, Galán M, Trebak M, Belmadani S, Matrougui K.

Diabetes Metab Res Rev. 2015 Jan;31(1):39-49. doi: 10.1002/dmrr.2542.


Mechanism of endoplasmic reticulum stress-induced vascular endothelial dysfunction.

Galán M, Kassan M, Kadowitz PJ, Trebak M, Belmadani S, Matrougui K.

Biochim Biophys Acta. 2014 Jun;1843(6):1063-75. doi: 10.1016/j.bbamcr.2014.02.009. Epub 2014 Feb 24.


Complex role of STIM1 in the activation of store-independent Orai1/3 channels.

Zhang X, Zhang W, González-Cobos JC, Jardin I, Romanin C, Matrougui K, Trebak M.

J Gen Physiol. 2014 Mar;143(3):345-59. doi: 10.1085/jgp.201311084.


Enhanced p22phox expression impairs vascular function through p38 and ERK1/2 MAP kinase-dependent mechanisms in type 2 diabetic mice.

Kassan M, Choi SK, Galán M, Lee YH, Trebak M, Matrougui K.

Am J Physiol Heart Circ Physiol. 2014 Apr 1;306(7):H972-80. doi: 10.1152/ajpheart.00872.2013. Epub 2014 Jan 31.


Redox control of the senescence regulator interleukin-1α and the secretory phenotype.

McCarthy DA, Clark RR, Bartling TR, Trebak M, Melendez JA.

J Biol Chem. 2013 Nov 8;288(45):32149-59. doi: 10.1074/jbc.M113.493841. Epub 2013 Sep 23.


Redox-control of the alarmin, Interleukin-1α.

McCarthy DA, Ranganathan A, Subbaram S, Flaherty NL, Patel N, Trebak M, Hempel N, Melendez JA.

Redox Biol. 2013 Apr 17;1:218-25. doi: 10.1016/j.redox.2013.03.001. eCollection 2013.


Urotensin-II promotes vascular smooth muscle cell proliferation through store-operated calcium entry and EGFR transactivation.

Rodríguez-Moyano M, Díaz I, Dionisio N, Zhang X, Avila-Medina J, Calderón-Sánchez E, Trebak M, Rosado JA, Ordóñez A, Smani T.

Cardiovasc Res. 2013 Nov 1;100(2):297-306. doi: 10.1093/cvr/cvt196. Epub 2013 Aug 9.


Emerging roles for native Orai Ca2+ channels in cardiovascular disease.

Ruhle B, Trebak M.

Curr Top Membr. 2013;71:209-35. doi: 10.1016/B978-0-12-407870-3.00009-3. Review.


CD4+CD25+Foxp3 regulatory T cells and vascular dysfunction in hypertension.

Kassan M, Wecker A, Kadowitz P, Trebak M, Matrougui K.

J Hypertens. 2013 Oct;31(10):1939-43. doi: 10.1097/HJH.0b013e328362feb7. Review.


Mechanisms of STIM1 activation of store-independent leukotriene C4-regulated Ca2+ channels.

Zhang X, González-Cobos JC, Schindl R, Muik M, Ruhle B, Motiani RK, Bisaillon JM, Zhang W, Fahrner M, Barroso M, Matrougui K, Romanin C, Trebak M.

Mol Cell Biol. 2013 Sep;33(18):3715-23. doi: 10.1128/MCB.00554-13. Epub 2013 Jul 22.


Emerging roles of Orai3 in pathophysiology.

Motiani RK, Stolwijk JA, Newton RL, Zhang X, Trebak M.

Channels (Austin). 2013 Sep-Oct;7(5):392-401. doi: 10.4161/chan.24960. Epub 2013 May 21. Review.


PKC-ε pseudosubstrate and catalytic activity are necessary for membrane delivery during IgG-mediated phagocytosis.

Wood TR, Chow RY, Hanes CM, Zhang X, Kashiwagi K, Shirai Y, Trebak M, Loegering DJ, Saito N, Lennartz MR.

J Leukoc Biol. 2013 Jul;94(1):109-22. doi: 10.1189/jlb.1212634. Epub 2013 May 13.


STIM1 and Orai1 mediate CRAC channel activity and are essential for human glioblastoma invasion.

Motiani RK, Hyzinski-García MC, Zhang X, Henkel MM, Abdullaev IF, Kuo YH, Matrougui K, Mongin AA, Trebak M.

Pflugers Arch. 2013 Sep;465(9):1249-60. doi: 10.1007/s00424-013-1254-8. Epub 2013 Mar 21.


STIM1 controls endothelial barrier function independently of Orai1 and Ca2+ entry.

Shinde AV, Motiani RK, Zhang X, Abdullaev IF, Adam AP, González-Cobos JC, Zhang W, Matrougui K, Vincent PA, Trebak M.

Sci Signal. 2013 Mar 19;6(267):ra18. doi: 10.1126/scisignal.2003425.


miR-424/322 regulates vascular smooth muscle cell phenotype and neointimal formation in the rat.

Merlet E, Atassi F, Motiani RK, Mougenot N, Jacquet A, Nadaud S, Capiod T, Trebak M, Lompré AM, Marchand A.

Cardiovasc Res. 2013 Jun 1;98(3):458-68. doi: 10.1093/cvr/cvt045. Epub 2013 Feb 26.


Enhanced NF-κB activity impairs vascular function through PARP-1-, SP-1-, and COX-2-dependent mechanisms in type 2 diabetes.

Kassan M, Choi SK, Galán M, Bishop A, Umezawa K, Trebak M, Belmadani S, Matrougui K.

Diabetes. 2013 Jun;62(6):2078-87. doi: 10.2337/db12-1374. Epub 2013 Jan 24.

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