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Items: 1 to 50 of 183

1.

Synthesis and Preliminary Evaluations of a Triazole-cored Antagonist ([18F]N2B-0518) as PET Imaging Probe for GluN2B Subunit in the Brain.

Fu H, Tang W, Chen Z, Belov VV, Zhang G, Shao T, Zhang X, Yu Q, Rong J, Deng X, Han W, Myers S, Giffenig P, Wang L, Josephson L, Shao Y, Davenport A, Daunais J, Papisov MI, Yuan H, Li Z, Traynelis SF, Liang SH.

ACS Chem Neurosci. 2019 Jan 30. doi: 10.1021/acschemneuro.8b00591. [Epub ahead of print]

PMID:
30698943
2.

Structural elements of a pH-sensitive inhibitor binding site in NMDA receptors.

Regan MC, Zhu Z, Yuan H, Myers SJ, Menaldino DS, Tahirovic YA, Liotta DC, Traynelis SF, Furukawa H.

Nat Commun. 2019 Jan 18;10(1):321. doi: 10.1038/s41467-019-08291-1.

3.

Unique Biology and Single-Channel Properties of GluN2A- and GluN2C-Containing Triheteromeric N-Methyl-D-Aspartate Receptors.

Bhattacharya S, Traynelis SF.

J Exp Neurosci. 2018 Nov 19;12:1179069518810423. doi: 10.1177/1179069518810423. eCollection 2018.

4.

The GluN2B-Glu413Gly NMDA receptor variant arising from a de novo GRIN2B mutation promotes ligand-unbinding and domain opening.

Wells G, Yuan H, McDaniel MJ, Kusumoto H, Snyder JP, Liotta DC, Traynelis SF.

Proteins. 2018 Dec;86(12):1265-1276. doi: 10.1002/prot.25595. Epub 2018 Oct 5.

PMID:
30168177
5.

Triheteromeric GluN1/GluN2A/GluN2C NMDARs with Unique Single-Channel Properties Are the Dominant Receptor Population in Cerebellar Granule Cells.

Bhattacharya S, Khatri A, Swanger SA, DiRaddo JO, Yi F, Hansen KB, Yuan H, Traynelis SF.

Neuron. 2018 Jul 25;99(2):315-328.e5. doi: 10.1016/j.neuron.2018.06.010. Epub 2018 Jun 28.

PMID:
30056832
6.

Synaptic Receptor Diversity Revealed Across Space and Time.

Swanger SA, Traynelis SF.

Trends Neurosci. 2018 Aug;41(8):486-488. doi: 10.1016/j.tins.2018.06.001.

PMID:
30053950
7.

Structure, function, and allosteric modulation of NMDA receptors.

Hansen KB, Yi F, Perszyk RE, Furukawa H, Wollmuth LP, Gibb AJ, Traynelis SF.

J Gen Physiol. 2018 Aug 6;150(8):1081-1105. doi: 10.1085/jgp.201812032. Epub 2018 Jul 23. Review.

8.

A structurally derived model of subunit-dependent NMDA receptor function.

Gibb AJ, Ogden KK, McDaniel MJ, Vance KM, Kell SA, Butch C, Burger P, Liotta DC, Traynelis SF.

J Physiol. 2018 Sep;596(17):4057-4089. doi: 10.1113/JP276093. Epub 2018 Aug 1.

9.

Allosteric Modulation of Ionotropic Glutamate Receptors Special Issue.

Carruthers NI, Lovenberg TW, Traynelis SF.

ACS Med Chem Lett. 2018 May 10;9(5):398-399. doi: 10.1021/acsmedchemlett.8b00174. eCollection 2018 May 10.

PMID:
29795747
10.

An NMDAR positive and negative allosteric modulator series share a binding site and are interconverted by methyl groups.

Perszyk R, Katzman BM, Kusumoto H, Kell SA, Epplin MP, Tahirovic YA, Moore RL, Menaldino D, Burger P, Liotta DC, Traynelis SF.

Elife. 2018 May 24;7. pii: e34711. doi: 10.7554/eLife.34711.

11.

Structural Mechanism of Functional Modulation by Gene Splicing in NMDA Receptors.

Regan MC, Grant T, McDaniel MJ, Karakas E, Zhang J, Traynelis SF, Grigorieff N, Furukawa H.

Neuron. 2018 May 2;98(3):521-529.e3. doi: 10.1016/j.neuron.2018.03.034. Epub 2018 Apr 12.

PMID:
29656875
12.

A novel missense mutation in GRIN2A causes a nonepileptic neurodevelopmental disorder.

Fernández-Marmiesse A, Kusumoto H, Rekarte S, Roca I, Zhang J, Myers SJ, Traynelis SF, Couce ML, Gutierrez-Solana L, Yuan H.

Mov Disord. 2018 Jul;33(6):992-999. doi: 10.1002/mds.27315. Epub 2018 Apr 11.

PMID:
29644724
13.

NMDA receptor blockade ameliorates abnormalities of spike firing of subthalamic nucleus neurons in a parkinsonian nonhuman primate.

Bhattacharya S, Ma Y, Dunn AR, Bradner JM, Scimemi A, Miller GW, Traynelis SF, Wichmann T.

J Neurosci Res. 2018 Jul;96(7):1324-1335. doi: 10.1002/jnr.24230. Epub 2018 Mar 25.

14.

AMPA-Type Glutamate Receptor Conductance Changes and Plasticity: Still a Lot of Noise.

Benke T, Traynelis SF.

Neurochem Res. 2018 Feb 23. doi: 10.1007/s11064-018-2491-1. [Epub ahead of print]

PMID:
29476449
15.

Glutamatergic Tuning of Hyperactive Striatal Projection Neurons Controls the Motor Response to Dopamine Replacement in Parkinsonian Primates.

Singh A, Jenkins MA, Burke KJ Jr, Beck G, Jenkins A, Scimemi A, Traynelis SF, Papa SM.

Cell Rep. 2018 Jan 23;22(4):941-952. doi: 10.1016/j.celrep.2017.12.095. Epub 2018 Jan 28.

16.

De novo mutations in GRIN1 cause extensive bilateral polymicrogyria.

Fry AE, Fawcett KA, Zelnik N, Yuan H, Thompson BAN, Shemer-Meiri L, Cushion TD, Mugalaasi H, Sims D, Stoodley N, Chung SK, Rees MI, Patel CV, Brueton LA, Layet V, Giuliano F, Kerr MP, Banne E, Meiner V, Lerman-Sagie T, Helbig KL, Kofman LH, Knight KM, Chen W, Kannan V, Hu C, Kusumoto H, Zhang J, Swanger SA, Shaulsky GH, Mirzaa GM, Muir AM, Mefford HC, Dobyns WB, Mackenzie AB, Mullins JGL, Lemke JR, Bahi-Buisson N, Traynelis SF, Iago HF, Pilz DT.

Brain. 2018 Mar 1;141(3):698-712. doi: 10.1093/brain/awx358.

17.

The Bioactive Protein-Ligand Conformation of GluN2C-Selective Positive Allosteric Modulators Bound to the NMDA Receptor.

Kaiser TM, Kell SA, Kusumoto H, Shaulsky G, Bhattacharya S, Epplin MP, Strong KL, Miller EJ, Cox BD, Menaldino DS, Liotta DC, Traynelis SF, Burger PB.

Mol Pharmacol. 2018 Feb;93(2):141-156. doi: 10.1124/mol.117.110940. Epub 2017 Dec 14.

18.

A Novel Negative Allosteric Modulator Selective for GluN2C/2D-Containing NMDA Receptors Inhibits Synaptic Transmission in Hippocampal Interneurons.

Swanger SA, Vance KM, Acker TM, Zimmerman SS, DiRaddo JO, Myers SJ, Bundgaard C, Mosley CA, Summer SL, Menaldino DS, Jensen HS, Liotta DC, Traynelis SF.

ACS Chem Neurosci. 2018 Feb 21;9(2):306-319. doi: 10.1021/acschemneuro.7b00329. Epub 2017 Nov 2.

PMID:
29043770
19.

Selective Cell-Surface Expression of Triheteromeric NMDA Receptors.

Yi F, Traynelis SF, Hansen KB.

Methods Mol Biol. 2017;1677:145-162. doi: 10.1007/978-1-4939-7321-7_7.

PMID:
28986871
20.

NMDA Receptors in the Central Nervous System.

Hansen KB, Yi F, Perszyk RE, Menniti FS, Traynelis SF.

Methods Mol Biol. 2017;1677:1-80. doi: 10.1007/978-1-4939-7321-7_1.

PMID:
28986865
21.

The Structure-Activity Relationship of a Tetrahydroisoquinoline Class of N-Methyl-d-Aspartate Receptor Modulators that Potentiates GluN2B-Containing N-Methyl-d-Aspartate Receptors.

Strong KL, Epplin MP, Bacsa J, Butch CJ, Burger PB, Menaldino DS, Traynelis SF, Liotta DC.

J Med Chem. 2017 Jul 13;60(13):5556-5585. doi: 10.1021/acs.jmedchem.7b00239. Epub 2017 Jun 26.

22.

Corrigendum to "Human GRIN2B variants in neurodevelopmental disorders" [J Pharmacol Sci 132 (2) 115-121].

Hu C, Chen W, Myers SJ, Yuan H, Traynelis SF.

J Pharmacol Sci. 2017 Apr;133(4):280. doi: 10.1016/j.jphs.2017.04.001. Epub 2017 Apr 12. No abstract available.

23.

GRIN2B encephalopathy: novel findings on phenotype, variant clustering, functional consequences and treatment aspects.

Platzer K, Yuan H, Schütz H, Winschel A, Chen W, Hu C, Kusumoto H, Heyne HO, Helbig KL, Tang S, Willing MC, Tinkle BT, Adams DJ, Depienne C, Keren B, Mignot C, Frengen E, Strømme P, Biskup S, Döcker D, Strom TM, Mefford HC, Myers CT, Muir AM, LaCroix A, Sadleir L, Scheffer IE, Brilstra E, van Haelst MM, van der Smagt JJ, Bok LA, Møller RS, Jensen UB, Millichap JJ, Berg AT, Goldberg EM, De Bie I, Fox S, Major P, Jones JR, Zackai EH, Abou Jamra R, Rolfs A, Leventer RJ, Lawson JA, Roscioli T, Jansen FE, Ranza E, Korff CM, Lehesjoki AE, Courage C, Linnankivi T, Smith DR, Stanley C, Mintz M, McKnight D, Decker A, Tan WH, Tarnopolsky MA, Brady LI, Wolff M, Dondit L, Pedro HF, Parisotto SE, Jones KL, Patel AD, Franz DN, Vanzo R, Marco E, Ranells JD, Di Donato N, Dobyns WB, Laube B, Traynelis SF, Lemke JR.

J Med Genet. 2017 Jul;54(7):460-470. doi: 10.1136/jmedgenet-2016-104509. Epub 2017 Apr 4.

24.

A Rare Variant Identified Within the GluN2B C-Terminus in a Patient with Autism Affects NMDA Receptor Surface Expression and Spine Density.

Liu S, Zhou L, Yuan H, Vieira M, Sanz-Clemente A, Badger JD 2nd, Lu W, Traynelis SF, Roche KW.

J Neurosci. 2017 Apr 12;37(15):4093-4102. doi: 10.1523/JNEUROSCI.0827-16.2017. Epub 2017 Mar 10.

25.

GRIN1 mutation associated with intellectual disability alters NMDA receptor trafficking and function.

Chen W, Shieh C, Swanger SA, Tankovic A, Au M, McGuire M, Tagliati M, Graham JM, Madan-Khetarpal S, Traynelis SF, Yuan H, Pierson TM.

J Hum Genet. 2017 Jun;62(6):589-597. doi: 10.1038/jhg.2017.19. Epub 2017 Feb 23.

26.

A de novo loss-of-function GRIN2A mutation associated with childhood focal epilepsy and acquired epileptic aphasia.

Gao K, Tankovic A, Zhang Y, Kusumoto H, Zhang J, Chen W, XiangWei W, Shaulsky GH, Hu C, Traynelis SF, Yuan H, Jiang Y.

PLoS One. 2017 Feb 9;12(2):e0170818. doi: 10.1371/journal.pone.0170818. eCollection 2017.

27.

Functional Evaluation of a De Novo GRIN2A Mutation Identified in a Patient with Profound Global Developmental Delay and Refractory Epilepsy.

Chen W, Tankovic A, Burger PB, Kusumoto H, Traynelis SF, Yuan H.

Mol Pharmacol. 2017 Apr;91(4):317-330. doi: 10.1124/mol.116.106781. Epub 2017 Jan 26.

28.

Molecular Mechanism of Disease-Associated Mutations in the Pre-M1 Helix of NMDA Receptors and Potential Rescue Pharmacology.

Ogden KK, Chen W, Swanger SA, McDaniel MJ, Fan LZ, Hu C, Tankovic A, Kusumoto H, Kosobucki GJ, Schulien AJ, Su Z, Pecha J, Bhattacharya S, Petrovski S, Cohen AE, Aizenman E, Traynelis SF, Yuan H.

PLoS Genet. 2017 Jan 17;13(1):e1006536. doi: 10.1371/journal.pgen.1006536. eCollection 2017 Jan.

29.

Development of Radiolabeled Ligands Targeting the Glutamate Binding Site of the N-Methyl-d-aspartate Receptor as Potential Imaging Agents for Brain.

Tamborini L, Chen Y, Foss CA, Pinto A, Horti AG, Traynelis SF, De Micheli C, Mease RC, Hansen KB, Conti P, Pomper MG.

J Med Chem. 2016 Dec 22;59(24):11110-11119. Epub 2016 Dec 6.

30.

The role of glutamate transport and SLC7A11 expression in tumor-associate seizures and survival in patients with malignant gliomas.

Keen JR, Swanger SA, Traynelis SF, Olson JJ.

Ann Transl Med. 2016 Oct;4(Suppl 1):S18. No abstract available.

31.

Mechanistic Insight into NMDA Receptor Dysregulation by Rare Variants in the GluN2A and GluN2B Agonist Binding Domains.

Swanger SA, Chen W, Wells G, Burger PB, Tankovic A, Bhattacharya S, Strong KL, Hu C, Kusumoto H, Zhang J, Adams DR, Millichap JJ, Petrovski S, Traynelis SF, Yuan H.

Am J Hum Genet. 2016 Dec 1;99(6):1261-1280. doi: 10.1016/j.ajhg.2016.10.002. Epub 2016 Nov 10.

32.

Human GRIN2B variants in neurodevelopmental disorders.

Hu C, Chen W, Myers SJ, Yuan H, Traynelis SF.

J Pharmacol Sci. 2016 Oct;132(2):115-121. doi: 10.1016/j.jphs.2016.10.002. Epub 2016 Oct 19. Review.

33.

GluN2D-Containing N-methyl-d-Aspartate Receptors Mediate Synaptic Transmission in Hippocampal Interneurons and Regulate Interneuron Activity.

Perszyk RE, DiRaddo JO, Strong KL, Low CM, Ogden KK, Khatri A, Vargish GA, Pelkey KA, Tricoire L, Liotta DC, Smith Y, McBain CJ, Traynelis SF.

Mol Pharmacol. 2016 Dec;90(6):689-702. Epub 2016 Sep 13.

34.

GRIN2D Recurrent De Novo Dominant Mutation Causes a Severe Epileptic Encephalopathy Treatable with NMDA Receptor Channel Blockers.

Li D, Yuan H, Ortiz-Gonzalez XR, Marsh ED, Tian L, McCormick EM, Kosobucki GJ, Chen W, Schulien AJ, Chiavacci R, Tankovic A, Naase C, Brueckner F, von Stülpnagel-Steinbeis C, Hu C, Kusumoto H, Hedrich UB, Elsen G, Hörtnagel K, Aizenman E, Lemke JR, Hakonarson H, Traynelis SF, Falk MJ.

Am J Hum Genet. 2016 Oct 6;99(4):802-816. doi: 10.1016/j.ajhg.2016.07.013. Epub 2016 Sep 8.

35.

Altered motility of plaque-associated microglia in a model of Alzheimer's disease.

Gyoneva S, Swanger SA, Zhang J, Weinshenker D, Traynelis SF.

Neuroscience. 2016 Aug 25;330:410-20. doi: 10.1016/j.neuroscience.2016.05.061. Epub 2016 Jun 7.

36.

Pharmacology of dextromethorphan: Relevance to dextromethorphan/quinidine (Nuedexta®) clinical use.

Taylor CP, Traynelis SF, Siffert J, Pope LE, Matsumoto RR.

Pharmacol Ther. 2016 Aug;164:170-82. doi: 10.1016/j.pharmthera.2016.04.010. Epub 2016 Apr 29. Review.

37.

Pharmacology and Structural Analysis of Ligand Binding to the Orthosteric Site of Glutamate-Like GluD2 Receptors.

Kristensen AS, Hansen KB, Naur P, Olsen L, Kurtkaya NL, Dravid SM, Kvist T, Yi F, Pøhlsgaard J, Clausen RP, Gajhede M, Kastrup JS, Traynelis SF.

Mol Pharmacol. 2016 Feb;89(2):253-62. doi: 10.1124/mol.115.100909. Epub 2015 Dec 10.

38.

NMDA Receptors Containing the GluN2D Subunit Control Neuronal Function in the Subthalamic Nucleus.

Swanger SA, Vance KM, Pare JF, Sotty F, Fog K, Smith Y, Traynelis SF.

J Neurosci. 2015 Dec 2;35(48):15971-83. doi: 10.1523/JNEUROSCI.1702-15.2015.

39.

Randomized, Placebo-Controlled, Double-Blind Pilot Study of D-Cycloserine in Chronic Stroke.

Butler AJ, Kallos J, Housley SN, LaPlaca MC, Traynelis SF, Wolf SL.

Rehabil Res Pract. 2015;2015:534239. doi: 10.1155/2015/534239. Epub 2015 Oct 26.

40.

A novel class of negative allosteric modulators of NMDA receptor function.

Katzman BM, Perszyk RE, Yuan H, Tahirovic YA, Sotimehin AE, Traynelis SF, Liotta DC.

Bioorg Med Chem Lett. 2015 Dec 1;25(23):5583-8. doi: 10.1016/j.bmcl.2015.10.046. Epub 2015 Oct 19.

PMID:
26525866
41.

The First 50 Years of Molecular Pharmacology.

Brown JH, Catterall WA, Conn PJ, Cull-Candy SG, Dingledine R, Harden TK, Insel PA, Milligan G, Traynelis SF.

Mol Pharmacol. 2015 Jul;88(1):139-40. doi: 10.1124/mol.115.099564. Epub 2015 May 5. Review.

PMID:
25943115
42.

Ionotropic GABA and Glutamate Receptor Mutations and Human Neurologic Diseases.

Yuan H, Low CM, Moody OA, Jenkins A, Traynelis SF.

Mol Pharmacol. 2015 Jul;88(1):203-17. doi: 10.1124/mol.115.097998. Epub 2015 Apr 22. Review.

43.

The genetics of neuropsychiatric diseases: looking in and beyond the exome.

Heinzen EL, Neale BM, Traynelis SF, Allen AS, Goldstein DB.

Annu Rev Neurosci. 2015 Jul 8;38:47-68. doi: 10.1146/annurev-neuro-071714-034136. Epub 2015 Apr 2. Review.

PMID:
25840007
44.

Correction to "Design, synthesis, and structure-activity relationship of a novel series of GluN2C-selective potentiators".

Zimmerman SS, Khatri A, Garnier-Amblard EC, Mullasseril P, Kurtkaya NL, Gyoneva S, Hansen KB, Traynelis SF, Liotta DC.

J Med Chem. 2015 Mar 26;58(6):2862. doi: 10.1021/acs.jmedchem.5b00199. Epub 2015 Mar 4. No abstract available.

45.

Context-dependent GluN2B-selective inhibitors of NMDA receptor function are neuroprotective with minimal side effects.

Yuan H, Myers SJ, Wells G, Nicholson KL, Swanger SA, Lyuboslavsky P, Tahirovic YA, Menaldino DS, Ganesh T, Wilson LJ, Liotta DC, Snyder JP, Traynelis SF.

Neuron. 2015 Mar 18;85(6):1305-1318. doi: 10.1016/j.neuron.2015.02.008. Epub 2015 Feb 26.

46.

Channel-mediated astrocytic glutamate modulates hippocampal synaptic plasticity by activating postsynaptic NMDA receptors.

Park H, Han KS, Seo J, Lee J, Dravid SM, Woo J, Chun H, Cho S, Bae JY, An H, Koh W, Yoon BE, Berlinguer-Palmini R, Mannaioni G, Traynelis SF, Bae YC, Choi SY, Lee CJ.

Mol Brain. 2015 Feb 3;8:7. doi: 10.1186/s13041-015-0097-y.

47.

NMDA receptor modulators: an updated patent review (2013-2014).

Strong KL, Jing Y, Prosser AR, Traynelis SF, Liotta DC.

Expert Opin Ther Pat. 2014 Dec;24(12):1349-66. doi: 10.1517/13543776.2014.972938. Epub 2014 Oct 29. Review.

48.

Glutamate receptors: mechanistic twists and turns.

Hansen KB, Traynelis SF.

Nat Chem Biol. 2014 Sep;10(9):698-9. doi: 10.1038/nchembio.1614. No abstract available.

PMID:
25271345
49.

Structural determinants and mechanism of action of a GluN2C-selective NMDA receptor positive allosteric modulator.

Khatri A, Burger PB, Swanger SA, Hansen KB, Zimmerman S, Karakas E, Liotta DC, Furukawa H, Snyder JP, Traynelis SF.

Mol Pharmacol. 2014 Nov;86(5):548-60. doi: 10.1124/mol.114.094516. Epub 2014 Sep 9.

50.

Correction to Synthesis and Structure Activity Relationship of Tetrahydroisoquinoline-Based Potentiators of GluN2C and GluN2D Containing N-Methyl-d-aspartate Receptors.

Santangelo Freel RM, Ogden KK, Strong KL, Khatri A, Chepiga KM, Jensen HS, Traynelis SF, Liotta DC.

J Med Chem. 2014 Jun 12;57(11):4975. doi: 10.1021/jm500710w. Epub 2014 May 30. No abstract available.

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