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Items: 1 to 50 of 99

1.

Succinimide-Based Conjugates Improve IsoDGR Cyclopeptide Affinity to αvβ3 without Promoting Integrin Allosteric Activation.

Nardelli F, Paissoni C, Quilici G, Gori A, Traversari C, Valentinis B, Sacchi A, Corti A, Curnis F, Ghitti M, Musco G.

J Med Chem. 2018 Sep 13;61(17):7474-7485. doi: 10.1021/acs.jmedchem.8b00745. Epub 2018 Jun 26.

PMID:
29883545
2.

Monocyte-derived IL-1 and IL-6 are differentially required for cytokine-release syndrome and neurotoxicity due to CAR T cells.

Norelli M, Camisa B, Barbiera G, Falcone L, Purevdorj A, Genua M, Sanvito F, Ponzoni M, Doglioni C, Cristofori P, Traversari C, Bordignon C, Ciceri F, Ostuni R, Bonini C, Casucci M, Bondanza A.

Nat Med. 2018 Jun;24(6):739-748. doi: 10.1038/s41591-018-0036-4. Epub 2018 May 28.

PMID:
29808007
3.

Extracellular NGFR Spacers Allow Efficient Tracking and Enrichment of Fully Functional CAR-T Cells Co-Expressing a Suicide Gene.

Casucci M, Falcone L, Camisa B, Norelli M, Porcellini S, Stornaiuolo A, Ciceri F, Traversari C, Bordignon C, Bonini C, Bondanza A.

Front Immunol. 2018 Mar 21;9:507. doi: 10.3389/fimmu.2018.00507. eCollection 2018.

4.

The administration of drugs inhibiting cholesterol/oxysterol synthesis is safe and increases the efficacy of immunotherapeutic regimens in tumor-bearing mice.

Lanterna C, Musumeci A, Raccosta L, Corna G, Moresco M, Maggioni D, Fontana R, Doglioni C, Bordignon C, Traversari C, Russo V.

Cancer Immunol Immunother. 2016 Nov;65(11):1303-1315. Epub 2016 Aug 12.

PMID:
27520505
5.

24-Hydroxycholesterol participates in pancreatic neuroendocrine tumor development.

Soncini M, Corna G, Moresco M, Coltella N, Restuccia U, Maggioni D, Raccosta L, Lin CY, Invernizzi F, Crocchiolo R, Doglioni C, Traversari C, Bachi A, Bernardi R, Bordignon C, Gustafsson JÅ, Russo V.

Proc Natl Acad Sci U S A. 2016 Oct 11;113(41):E6219-E6227. Epub 2016 Sep 26.

6.

T Cells as Antigen Carriers for Anti-tumor Vaccination.

Traversari C, Russo V.

Methods Mol Biol. 2016;1393:97-104. doi: 10.1007/978-1-4939-3338-9_9.

PMID:
27033219
7.

Tracking genetically engineered lymphocytes long-term reveals the dynamics of T cell immunological memory.

Oliveira G, Ruggiero E, Stanghellini MT, Cieri N, D'Agostino M, Fronza R, Lulay C, Dionisio F, Mastaglio S, Greco R, Peccatori J, Aiuti A, Ambrosi A, Biasco L, Bondanza A, Lambiase A, Traversari C, Vago L, von Kalle C, Schmidt M, Bordignon C, Ciceri F, Bonini C.

Sci Transl Med. 2015 Dec 9;7(317):317ra198. doi: 10.1126/scitranslmed.aac8265. Erratum in: Sci Transl Med. 2015 Dec 23;7(319):319er9. D'Agostino, Mattio [corrected to D'Agostino, Mattia].

PMID:
26659572
8.

The tumor vessel targeting agent NGR-TNF controls the different stages of the tumorigenic process in transgenic mice by distinct mechanisms.

Porcellini S, Asperti C, Valentinis B, Tiziano E, Mangia P, Bordignon C, Rizzardi GP, Traversari C.

Oncoimmunology. 2015 Jul 1;4(10):e1041700. eCollection 2015 Oct.

9.

Haploidentical HSCT: a 15-year experience at San Raffaele.

Bonini C, Peccatori J, Stanghellini MT, Vago L, Bondanza A, Cieri N, Greco R, Bernardi M, Corti C, Oliveira G, Zappone E, Traversari C, Bordignon C, Ciceri F.

Bone Marrow Transplant. 2015 Jun;50 Suppl 2:S67-71. doi: 10.1038/bmt.2015.99.

PMID:
26039212
10.

Anti-metastatic activity of the tumor vascular targeting agent NGR-TNF.

Di Matteo P, Mangia P, Tiziano E, Valentinis B, Porcellini S, Doglioni C, Sanvito F, Bordignon C, Rizzardi GP, Traversari C.

Clin Exp Metastasis. 2015 Mar;32(3):289-300. doi: 10.1007/s10585-015-9704-7. Epub 2015 Feb 4.

PMID:
25648442
11.

LXR-dependent and -independent effects of oxysterols on immunity and tumor growth.

Traversari C, Sozzani S, Steffensen KR, Russo V.

Eur J Immunol. 2014 Jul;44(7):1896-903. doi: 10.1002/eji.201344292. Epub 2014 May 22. Review.

12.

Oxysterols recruit tumor-supporting neutrophils within the tumor microenvironment: The many facets of tumor-derived oxysterols.

Raccosta L, Fontana R, Traversari C, Russo V.

Oncoimmunology. 2013 Nov 1;2(11):e26469. Epub 2013 Oct 10.

13.

The oxysterol-CXCR2 axis plays a key role in the recruitment of tumor-promoting neutrophils.

Raccosta L, Fontana R, Maggioni D, Lanterna C, Villablanca EJ, Paniccia A, Musumeci A, Chiricozzi E, Trincavelli ML, Daniele S, Martini C, Gustafsson JA, Doglioni C, Feo SG, Leiva A, Ciampa MG, Mauri L, Sensi C, Prinetti A, Eberini I, Mora JR, Bordignon C, Steffensen KR, Sonnino S, Sozzani S, Traversari C, Russo V.

J Exp Med. 2013 Aug 26;210(9):1711-28. doi: 10.1084/jem.20130440. Epub 2013 Jul 29.

14.

NGR-TNF, a novel vascular-targeting agent, does not induce cytokine recruitment of proangiogenic bone marrow-derived cells.

Di Matteo P, Hackl C, Jedeszko C, Valentinis B, Bordignon C, Traversari C, Kerbel RS, Rizzardi GP.

Br J Cancer. 2013 Jul 23;109(2):360-9. doi: 10.1038/bjc.2013.347. Epub 2013 Jul 4.

15.

Clinical and immunologic responses in melanoma patients vaccinated with MAGE-A3-genetically modified lymphocytes.

Russo V, Pilla L, Lunghi F, Crocchiolo R, Greco R, Ciceri F, Maggioni D, Fontana R, Mukenge S, Rivoltini L, Rigamonti G, Mercuri SR, Nicoletti R, Maschio AD, Gianolli L, Fazio F, Marchianò A, Florio AD, Maio M, Salomoni M, Gallo-Stampino C, Fiacco MD, Lambiase A, Coulie PG, Patuzzo R, Parmiani G, Traversari C, Bordignon C, Santinami M, Bregni M.

Int J Cancer. 2013 Jun 1;132(11):2557-66. doi: 10.1002/ijc.27939. Epub 2012 Dec 13.

16.

De novo design of a tumor-penetrating peptide.

Alberici L, Roth L, Sugahara KN, Agemy L, Kotamraju VR, Teesalu T, Bordignon C, Traversari C, Rizzardi GP, Ruoslahti E.

Cancer Res. 2013 Jan 15;73(2):804-12. doi: 10.1158/0008-5472.CAN-12-1668. Epub 2012 Nov 14.

17.

Thymidine kinase suicide gene-mediated ganciclovir ablation of autologous gene-modified rhesus hematopoiesis.

Barese CN, Krouse AE, Metzger ME, King CA, Traversari C, Marini FC, Donahue RE, Dunbar CE.

Mol Ther. 2012 Oct;20(10):1932-43. doi: 10.1038/mt.2012.166. Epub 2012 Aug 21.

18.

Control of the immune system by oxysterols and cancer development.

Traversari C, Russo V.

Curr Opin Pharmacol. 2012 Dec;12(6):729-35. doi: 10.1016/j.coph.2012.07.003. Epub 2012 Jul 24. Review.

PMID:
22832233
19.

Molecular dynamics reveal that isoDGR-containing cyclopeptides are true αvβ3 antagonists unable to promote integrin allostery and activation.

Ghitti M, Spitaleri A, Valentinis B, Mari S, Asperti C, Traversari C, Rizzardi GP, Musco G.

Angew Chem Int Ed Engl. 2012 Jul 27;51(31):7702-5. doi: 10.1002/anie.201202032. Epub 2012 Jun 20.

PMID:
22718573
20.

T-cell suicide gene therapy prompts thymic renewal in adults after hematopoietic stem cell transplantation.

Vago L, Oliveira G, Bondanza A, Noviello M, Soldati C, Ghio D, Brigida I, Greco R, Lupo Stanghellini MT, Peccatori J, Fracchia S, Del Fiacco M, Traversari C, Aiuti A, Del Maschio A, Bordignon C, Ciceri F, Bonini C.

Blood. 2012 Aug 30;120(9):1820-30. doi: 10.1182/blood-2012-01-405670. Epub 2012 Jun 18.

21.

A dual role for genetically modified lymphocytes in cancer immunotherapy.

Russo V, Bondanza A, Ciceri F, Bregni M, Bordignon C, Traversari C, Bonini C.

Trends Mol Med. 2012 Apr;18(4):193-200. doi: 10.1016/j.molmed.2011.12.003. Epub 2012 Jan 7. Review.

PMID:
22230382
22.

Enhanced expression of CD13 in vessels of inflammatory and neoplastic tissues.

Di Matteo P, Arrigoni GL, Alberici L, Corti A, Gallo-Stampino C, Traversari C, Doglioni C, Rizzardi GP.

J Histochem Cytochem. 2011 Jan;59(1):47-59. doi: 10.1369/jhc.2010.956644.

23.

Use of metadynamics in the design of isoDGR-based αvβ3 antagonists to fine-tune the conformational ensemble.

Spitaleri A, Ghitti M, Mari S, Alberici L, Traversari C, Rizzardi GP, Musco G.

Angew Chem Int Ed Engl. 2011 Feb 18;50(8):1832-6. doi: 10.1002/anie.201007091. Epub 2011 Jan 18. No abstract available.

PMID:
21328650
24.

An efficient strategy to induce and maintain in vitro human T cells specific for autologous non-small cell lung carcinoma.

Canderan G, Gruarin P, Montagna D, Fontana R, Campi G, Melloni G, Traversari C, Dellabona P, Casorati G.

PLoS One. 2010 Aug 9;5(8):e12014. doi: 10.1371/journal.pone.0012014. Erratum in: PLoS One. 2011;6(1).doi: 10.1371/annotation/df559170-4836-4bc7-a16d-44c7c6339cda. Campi, Gabriele [added].

25.

Phase II study of NGR-hTNF, a selective vascular targeting agent, in patients with metastatic colorectal cancer after failure of standard therapy.

Santoro A, Rimassa L, Sobrero AF, Citterio G, Sclafani F, Carnaghi C, Pessino A, Caprioni F, Andretta V, Tronconi MC, Finocchiaro G, Rossoni G, Zanoni A, Miggiano C, Rizzardi GP, Traversari C, Caligaris-Cappio F, Lambiase A, Bordignon C.

Eur J Cancer. 2010 Oct;46(15):2746-52. doi: 10.1016/j.ejca.2010.07.012. Epub 2010 Aug 12.

PMID:
20708923
26.

Critical role of flanking residues in NGR-to-isoDGR transition and CD13/integrin receptor switching.

Curnis F, Cattaneo A, Longhi R, Sacchi A, Gasparri AM, Pastorino F, Di Matteo P, Traversari C, Bachi A, Ponzoni M, Rizzardi GP, Corti A.

J Biol Chem. 2010 Mar 19;285(12):9114-23. doi: 10.1074/jbc.M109.044297. Epub 2010 Jan 11.

27.

2D TR-NOESY experiments interrogate and rank ligand-receptor interactions in living human cancer cells.

Mari S, Invernizzi C, Spitaleri A, Alberici L, Ghitti M, Bordignon C, Traversari C, Rizzardi GP, Musco G.

Angew Chem Int Ed Engl. 2010 Feb 1;49(6):1071-4. doi: 10.1002/anie.200905941. No abstract available.

PMID:
20058288
28.

Tumor-mediated liver X receptor-alpha activation inhibits CC chemokine receptor-7 expression on dendritic cells and dampens antitumor responses.

Villablanca EJ, Raccosta L, Zhou D, Fontana R, Maggioni D, Negro A, Sanvito F, Ponzoni M, Valentinis B, Bregni M, Prinetti A, Steffensen KR, Sonnino S, Gustafsson JA, Doglioni C, Bordignon C, Traversari C, Russo V.

Nat Med. 2010 Jan;16(1):98-105. doi: 10.1038/nm.2074. Epub 2009 Dec 27.

PMID:
20037595
29.

Infusion of suicide-gene-engineered donor lymphocytes after family haploidentical haemopoietic stem-cell transplantation for leukaemia (the TK007 trial): a non-randomised phase I-II study.

Ciceri F, Bonini C, Stanghellini MT, Bondanza A, Traversari C, Salomoni M, Turchetto L, Colombi S, Bernardi M, Peccatori J, Pescarollo A, Servida P, Magnani Z, Perna SK, Valtolina V, Crippa F, Callegaro L, Spoldi E, Crocchiolo R, Fleischhauer K, Ponzoni M, Vago L, Rossini S, Santoro A, Todisco E, Apperley J, Olavarria E, Slavin S, Weissinger EM, Ganser A, Stadler M, Yannaki E, Fassas A, Anagnostopoulos A, Bregni M, Stampino CG, Bruzzi P, Bordignon C.

Lancet Oncol. 2009 May;10(5):489-500. doi: 10.1016/S1470-2045(09)70074-9. Epub 2009 Apr 1.

PMID:
19345145
30.

Critical role of indoleamine 2,3-dioxygenase in tumor resistance to repeated treatments with targeted IFNgamma.

Gasparri AM, Jachetti E, Colombo B, Sacchi A, Curnis F, Rizzardi GP, Traversari C, Bellone M, Corti A.

Mol Cancer Ther. 2008 Dec;7(12):3859-66. doi: 10.1158/1535-7163.MCT-08-0538.

31.

Peripheral blood lymphocytes genetically modified to express the self/tumor antigen MAGE-A3 induce antitumor immune responses in cancer patients.

Fontana R, Bregni M, Cipponi A, Raccosta L, Rainelli C, Maggioni D, Lunghi F, Ciceri F, Mukenge S, Doglioni C, Colau D, Coulie PG, Bordignon C, Traversari C, Russo V.

Blood. 2009 Feb 19;113(8):1651-60. doi: 10.1182/blood-2008-07-168666. Epub 2008 Dec 12.

32.

IL-7 and IL-15 allow the generation of suicide gene-modified alloreactive self-renewing central memory human T lymphocytes.

Kaneko S, Mastaglio S, Bondanza A, Ponzoni M, Sanvito F, Aldrighetti L, Radrizzani M, La Seta-Catamancio S, Provasi E, Mondino A, Nagasawa T, Fleischhauer K, Russo V, Traversari C, Ciceri F, Bordignon C, Bonini C.

Blood. 2009 Jan 29;113(5):1006-15. doi: 10.1182/blood-2008-05-156059. Epub 2008 Oct 31.

33.

Isoaspartate-glycine-arginine: a new tumor vasculature-targeting motif.

Curnis F, Sacchi A, Gasparri A, Longhi R, Bachi A, Doglioni C, Bordignon C, Traversari C, Rizzardi GP, Corti A.

Cancer Res. 2008 Sep 1;68(17):7073-82. doi: 10.1158/0008-5472.CAN-08-1272.

34.

Selected natural and synthetic retinoids impair CCR7- and CXCR4-dependent cell migration in vitro and in vivo.

Villablanca EJ, Zhou D, Valentinis B, Negro A, Raccosta L, Mauri L, Prinetti A, Sonnino S, Bordignon C, Traversari C, Russo V.

J Leukoc Biol. 2008 Sep;84(3):871-9. doi: 10.1189/jlb.0108047. Epub 2008 May 30.

PMID:
18515328
35.

Structural basis for the interaction of isoDGR with the RGD-binding site of alphavbeta3 integrin.

Spitaleri A, Mari S, Curnis F, Traversari C, Longhi R, Bordignon C, Corti A, Rizzardi GP, Musco G.

J Biol Chem. 2008 Jul 11;283(28):19757-68. doi: 10.1074/jbc.M710273200. Epub 2008 May 13.

36.

Human recombinant heat shock protein 70 affects the maturation pathways of dendritic cells in vitro and has an in vivo adjuvant activity.

Valentinis B, Capobianco A, Esposito F, Bianchi A, Rovere-Querini P, Manfredi AA, Traversari C.

J Leukoc Biol. 2008 Jul;84(1):199-206. doi: 10.1189/jlb.0807548. Epub 2008 May 2.

PMID:
18456818
37.

Lymphocytes genetically modified to express tumor antigens target DCs in vivo and induce antitumor immunity.

Russo V, Cipponi A, Raccosta L, Rainelli C, Fontana R, Maggioni D, Lunghi F, Mukenge S, Ciceri F, Bregni M, Bordignon C, Traversari C.

J Clin Invest. 2007 Oct;117(10):3087-96.

38.

Abrogation of prostaglandin E2/EP4 signaling impairs the development of rag1+ lymphoid precursors in the thymus of zebrafish embryos.

Villablanca EJ, Pistocchi A, Court FA, Cotelli F, Bordignon C, Allende ML, Traversari C, Russo V.

J Immunol. 2007 Jul 1;179(1):357-64.

39.

The suicide gene therapy challenge: how to improve a successful gene therapy approach.

Bonini C, Bondanza A, Perna SK, Kaneko S, Traversari C, Ciceri F, Bordignon C.

Mol Ther. 2007 Jul;15(7):1248-52. Epub 2007 May 8. Review.

40.

The potential immunogenicity of the TK suicide gene does not prevent full clinical benefit associated with the use of TK-transduced donor lymphocytes in HSCT for hematologic malignancies.

Traversari C, Marktel S, Magnani Z, Mangia P, Russo V, Ciceri F, Bonini C, Bordignon C.

Blood. 2007 Jun 1;109(11):4708-15. Epub 2007 Feb 27.

41.

Antitumor effects of HSV-TK-engineered donor lymphocytes after allogeneic stem-cell transplantation.

Ciceri F, Bonini C, Marktel S, Zappone E, Servida P, Bernardi M, Pescarollo A, Bondanza A, Peccatori J, Rossini S, Magnani Z, Salomoni M, Benati C, Ponzoni M, Callegaro L, Corradini P, Bregni M, Traversari C, Bordignon C.

Blood. 2007 Jun 1;109(11):4698-707. Epub 2007 Feb 27.

42.

A gene encoding an antigen recognized by cytolytic T lymphocytes on a human melanoma.

van der Bruggen P, Traversari C, Chomez P, Lurquin C, De Plaen E, Van den Eynde BJ, Knuth A, Boon T.

J Immunol. 2007 Mar 1;178(5):2617-21. No abstract available.

43.

CD8(+) T lymphocytes isolated from renal cancer patients recognize tumour cells through an HLA- and TCR/CD3-independent pathway.

Lionello I, Mangia P, Gattinoni L, Pende D, Cippone A, Sensi M, Rigatti P, Traversari C.

Cancer Immunol Immunother. 2007 Jul;56(7):1065-76. Epub 2006 Dec 29.

PMID:
17195078
44.

Generation of tumour-specific cytotoxic T-cell clones from histocompatibility leucocyte antigen-identical siblings of patients with melanoma.

Gottlieb DJ, Li YC, Lionello I, Tanzarella S, Marangolo M, Bradstock KF, Russo V, Traversari C.

Br J Cancer. 2006 Jul 17;95(2):181-8. Epub 2006 Jul 4.

45.

Suicide gene therapy of graft-versus-host disease induced by central memory human T lymphocytes.

Bondanza A, Valtolina V, Magnani Z, Ponzoni M, Fleischhauer K, Bonyhadi M, Traversari C, Sanvito F, Toma S, Radrizzani M, La Seta-Catamancio S, Ciceri F, Bordignon C, Bonini C.

Blood. 2006 Mar 1;107(5):1828-36. Epub 2005 Nov 17.

46.

An anti-CD45RO/RB monoclonal antibody modulates T cell responses via induction of apoptosis and generation of regulatory T cells.

Gregori S, Mangia P, Bacchetta R, Tresoldi E, Kolbinger F, Traversari C, Carballido JM, de Vries JE, Korthäuer U, Roncarolo MG.

J Exp Med. 2005 Apr 18;201(8):1293-305.

47.

Direct effects of polymyxin B on human dendritic cells maturation. The role of IkappaB-alpha/NF-kappaB and ERK1/2 pathways and adhesion.

Valentinis B, Bianchi A, Zhou D, Cipponi A, Catalanotti F, Russo V, Traversari C.

J Biol Chem. 2005 Apr 8;280(14):14264-71. Epub 2005 Jan 25.

48.

Intratumor heterogeneity of cancer/testis antigens expression in human cutaneous melanoma is methylation-regulated and functionally reverted by 5-aza-2'-deoxycytidine.

Sigalotti L, Fratta E, Coral S, Tanzarella S, Danielli R, Colizzi F, Fonsatti E, Traversari C, Altomonte M, Maio M.

Cancer Res. 2004 Dec 15;64(24):9167-71.

49.

HMGB1 is an endogenous immune adjuvant released by necrotic cells.

Rovere-Querini P, Capobianco A, Scaffidi P, Valentinis B, Catalanotti F, Giazzon M, Dumitriu IE, Müller S, Iannacone M, Traversari C, Bianchi ME, Manfredi AA.

EMBO Rep. 2004 Aug;5(8):825-30. Epub 2004 Jul 23.

50.

Prognostic significance of cancer-testis gene expression in resected non-small cell lung cancer patients.

Melloni G, Ferreri AJ, Russo V, Gattinoni L, Arrigoni G, Ceresoli GL, Zannini P, Traversari C.

Oncol Rep. 2004 Jul;12(1):145-51.

PMID:
15201976

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