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Items: 49


Resistance to the Tat Inhibitor Didehydro-Cortistatin A Is Mediated by Heightened Basal HIV-1 Transcription.

Mousseau G, Aneja R, Clementz MA, Mediouni S, Lima NS, Haregot A, Kessing CF, Jablonski JA, Thenin-Houssier S, Nagarsheth N, Trautmann L, Valente ST.

MBio. 2019 Jul 2;10(4). pii: e01750-18. doi: 10.1128/mBio.01750-18.


Neurosyphilis During Acute HIV Infection: A CNS Immunologic and Virologic Characterization.

Chan P, Dumrongpisutikul N, Subra C, Colby DJ, Kroon E, Fletcher J, Sacdalan C, Phanuphak N, Valcour V, Ananworanich J, Trautmann L, Spudich S.

J Acquir Immune Defic Syndr. 2019 Oct 1;82(2):e34-e37. doi: 10.1097/QAI.0000000000002114. No abstract available.


Role of T Lymphocytes in HIV Neuropathogenesis.

Subra C, Trautmann L.

Curr HIV/AIDS Rep. 2019 Jun;16(3):236-243. doi: 10.1007/s11904-019-00445-6. Review.


Safety and efficacy of VRC01 broadly neutralising antibodies in adults with acutely treated HIV (RV397): a phase 2, randomised, double-blind, placebo-controlled trial.

Crowell TA, Colby DJ, Pinyakorn S, Sacdalan C, Pagliuzza A, Intasan J, Benjapornpong K, Tangnaree K, Chomchey N, Kroon E, de Souza MS, Tovanabutra S, Rolland M, Eller MA, Paquin-Proulx D, Bolton DL, Tokarev A, Thomas R, Takata H, Trautmann L, Krebs SJ, Modjarrad K, McDermott AB, Bailer RT, Doria-Rose N, Patel B, Gorelick RJ, Fullmer BA, Schuetz A, Grandin PV, O'Connell RJ, Ledgerwood JE, Graham BS, Tressler R, Mascola JR, Chomont N, Michael NL, Robb ML, Phanuphak N, Ananworanich J; RV397 Study Group.

Lancet HIV. 2019 May;6(5):e297-e306. doi: 10.1016/S2352-3018(19)30053-0. Epub 2019 Apr 15.


Modeling HIV-1 Latency Using Primary CD4+ T Cells from Virally Suppressed HIV-1-Infected Individuals on Antiretroviral Therapy.

Takata H, Kessing C, Sy A, Lima N, Sciumbata J, Mori L, Jones RB, Chomont N, Michael NL, Valente S, Trautmann L.

J Virol. 2019 May 15;93(11). pii: e02248-18. doi: 10.1128/JVI.02248-18. Print 2019 Jun 1.


Rapid HIV RNA rebound after antiretroviral treatment interruption in persons durably suppressed in Fiebig I acute HIV infection.

Colby DJ, Trautmann L, Pinyakorn S, Leyre L, Pagliuzza A, Kroon E, Rolland M, Takata H, Buranapraditkun S, Intasan J, Chomchey N, Muir R, Haddad EK, Tovanabutra S, Ubolyam S, Bolton DL, Fullmer BA, Gorelick RJ, Fox L, Crowell TA, Trichavaroj R, O'Connell R, Chomont N, Kim JH, Michael NL, Robb ML, Phanuphak N, Ananworanich J; RV411 study group.

Nat Med. 2018 Jul;24(7):923-926. doi: 10.1038/s41591-018-0026-6. Epub 2018 Jun 11.


Lymphoid tissue fibrosis is associated with impaired vaccine responses.

Kityo C, Makamdop KN, Rothenberger M, Chipman JG, Hoskuldsson T, Beilman GJ, Grzywacz B, Mugyenyi P, Ssali F, Akondy RS, Anderson J, Schmidt TE, Reimann T, Callisto SP, Schoephoerster J, Schuster J, Muloma P, Ssengendo P, Moysi E, Petrovas C, Lanciotti R, Zhang L, Arévalo MT, Rodriguez B, Ross TM, Trautmann L, Sekaly RP, Lederman MM, Koup RA, Ahmed R, Reilly C, Douek DC, Schacker TW.

J Clin Invest. 2018 Jul 2;128(7):2763-2773. doi: 10.1172/JCI97377. Epub 2018 May 21.


Wake me up before you go: a strategy to reduce the latent HIV reservoir.

Chomont N, Okoye AA, Favre D, Trautmann L.

AIDS. 2018 Jan 28;32(3):293-298. doi: 10.1097/QAD.0000000000001695. No abstract available.


In Vivo Suppression of HIV Rebound by Didehydro-Cortistatin A, a "Block-and-Lock" Strategy for HIV-1 Treatment.

Kessing CF, Nixon CC, Li C, Tsai P, Takata H, Mousseau G, Ho PT, Honeycutt JB, Fallahi M, Trautmann L, Garcia JV, Valente ST.

Cell Rep. 2017 Oct 17;21(3):600-611. doi: 10.1016/j.celrep.2017.09.080.


T Cell Immunity and Zika Virus Vaccine Development.

Lima NS, Rolland M, Modjarrad K, Trautmann L.

Trends Immunol. 2017 Aug;38(8):594-605. doi: 10.1016/ Epub 2017 Jun 1. Review.


Delayed differentiation of potent effector CD8+ T cells reducing viremia and reservoir seeding in acute HIV infection.

Takata H, Buranapraditkun S, Kessing C, Fletcher JL, Muir R, Tardif V, Cartwright P, Vandergeeten C, Bakeman W, Nichols CN, Pinyakorn S, Hansasuta P, Kroon E, Chalermchai T, O'Connell R, Kim J, Phanuphak N, Robb ML, Michael NL, Chomont N, Haddad EK, Ananworanich J, Trautmann L; RV254/SEARCH010 and the RV304/SEARCH013 Study Groups.

Sci Transl Med. 2017 Feb 15;9(377). pii: eaag1809. doi: 10.1126/scitranslmed.aag1809.


High Number of Activated CD8+ T Cells Targeting HIV Antigens Are Present in Cerebrospinal Fluid in Acute HIV Infection.

Kessing CF, Spudich S, Valcour V, Cartwright P, Chalermchai T, Fletcher JL, Takata H, Nichols C, Josey BJ, Slike B, Krebs SJ, Sailsuta N, Lerdlum S, Jagodzinski L, Tipsuk S, Suttichom D, Rattanamanee S, Zetterberg H, Hellmuth J, Phanuphak N, Robb ML, Michael NL, Ananworanich J, Trautmann L.

J Acquir Immune Defic Syndr. 2017 May 1;75(1):108-117. doi: 10.1097/QAI.0000000000001301.


Altered Memory Circulating T Follicular Helper-B Cell Interaction in Early Acute HIV Infection.

Muir R, Metcalf T, Tardif V, Takata H, Phanuphak N, Kroon E, Colby DJ, Trichavaroj R, Valcour V, Robb ML, Michael NL, Ananworanich J, Trautmann L, Haddad EK; RV254/SEARCH010 RV304/SEARCH 013 Study Groups.

PLoS Pathog. 2016 Jul 27;12(7):e1005777. doi: 10.1371/journal.ppat.1005777. eCollection 2016 Jul.


Kill: boosting HIV-specific immune responses.

Trautmann L.

Curr Opin HIV AIDS. 2016 Jul;11(4):409-16. doi: 10.1097/COH.0000000000000286. Review.


Reversible Reprogramming of Circulating Memory T Follicular Helper Cell Function during Chronic HIV Infection.

Cubas R, van Grevenynghe J, Wills S, Kardava L, Santich BH, Buckner CM, Muir R, Tardif V, Nichols C, Procopio F, He Z, Metcalf T, Ghneim K, Locci M, Ancuta P, Routy JP, Trautmann L, Li Y, McDermott AB, Koup RA, Petrovas C, Migueles SA, Connors M, Tomaras GD, Moir S, Crotty S, Haddad EK.

J Immunol. 2015 Dec 15;195(12):5625-36. doi: 10.4049/jimmunol.1501524. Epub 2015 Nov 6.


Enhanced Influenza Virus-Like Particle Vaccination with a Structurally Optimized RIG-I Agonist as Adjuvant.

Beljanski V, Chiang C, Kirchenbaum GA, Olagnier D, Bloom CE, Wong T, Haddad EK, Trautmann L, Ross TM, Hiscott J.

J Virol. 2015 Oct;89(20):10612-24. doi: 10.1128/JVI.01526-15. Epub 2015 Aug 12.


The Tat Inhibitor Didehydro-Cortistatin A Prevents HIV-1 Reactivation from Latency.

Mousseau G, Kessing CF, Fromentin R, Trautmann L, Chomont N, Valente ST.

MBio. 2015 Jul 7;6(4):e00465. doi: 10.1128/mBio.00465-15.


Sequence-Specific Modifications Enhance the Broad-Spectrum Antiviral Response Activated by RIG-I Agonists.

Chiang C, Beljanski V, Yin K, Olagnier D, Ben Yebdri F, Steel C, Goulet ML, DeFilippis VR, Streblow DN, Haddad EK, Trautmann L, Ross T, Lin R, Hiscott J.

J Virol. 2015 Aug;89(15):8011-25. doi: 10.1128/JVI.00845-15. Epub 2015 May 27.


SRSF1 RNA Recognition Motifs Are Strong Inhibitors of HIV-1 Replication.

Paz S, Lu ML, Takata H, Trautmann L, Caputi M.

J Virol. 2015 Jun;89(12):6275-86. doi: 10.1128/JVI.00693-15. Epub 2015 Apr 8.


Immune activation alters cellular and humoral responses to yellow fever 17D vaccine.

Muyanja E, Ssemaganda A, Ngauv P, Cubas R, Perrin H, Srinivasan D, Canderan G, Lawson B, Kopycinski J, Graham AS, Rowe DK, Smith MJ, Isern S, Michael S, Silvestri G, Vanderford TH, Castro E, Pantaleo G, Singer J, Gillmour J, Kiwanuka N, Nanvubya A, Schmidt C, Birungi J, Cox J, Haddad EK, Kaleebu P, Fast P, Sekaly RP, Trautmann L, Gaucher D.

J Clin Invest. 2014 Jul;124(7):3147-58. doi: 10.1172/JCI75429. Epub 2014 Jun 9. Erratum in: J Clin Invest. 2014 Oct 1;124(10):4669. Gaucher, Denis [Added].


Cell-based flow cytometry assay to measure cytotoxic activity.

Noto A, Ngauv P, Trautmann L.

J Vis Exp. 2013 Dec 17;(82):e51105. doi: 10.3791/51105.


Identification of a vibration regime favorable for bone healing and muscle in estrogen-deficient rats.

Komrakova M, Sehmisch S, Tezval M, Ammon J, Lieberwirth P, Sauerhoff C, Trautmann L, Wicke M, Dullin C, Stuermer KM, Stuermer EK.

Calcif Tissue Int. 2013 Jun;92(6):509-20. doi: 10.1007/s00223-013-9706-x. Epub 2013 Feb 17.


Developing Combined HIV Vaccine Strategies for a Functional Cure.

Noto A, Trautmann L.

Vaccines (Basel). 2013 Oct 28;1(4):481-96. doi: 10.3390/vaccines1040481. Review.


Beyond surface markers with a universal cell secretion assay.

Trautmann L.

Cytometry A. 2013 Feb;83(2):177-8. doi: 10.1002/cyto.a.22200. Epub 2012 Sep 20. No abstract available.


Profound metabolic, functional, and cytolytic differences characterize HIV-specific CD8 T cells in primary and chronic HIV infection.

Trautmann L, Mbitikon-Kobo FM, Goulet JP, Peretz Y, Shi Y, Van Grevenynghe J, Procopio FA, Boulassel MR, Routy JP, Chomont N, Haddad EK, Sekaly RP.

Blood. 2012 Oct 25;120(17):3466-77. doi: 10.1182/blood-2012-04-422550. Epub 2012 Sep 6.


Foxo3a: an integrator of immune dysfunction during HIV infection.

van Grevenynghe J, Cubas RA, DaFonseca S, Metcalf T, Tremblay CL, Trautmann L, Sekaly RP, Schatzle J, Haddad EK.

Cytokine Growth Factor Rev. 2012 Aug-Oct;23(4-5):215-21. doi: 10.1016/j.cytogfr.2012.05.008. Epub 2012 Jun 27. Review.


Clonotype and repertoire changes drive the functional improvement of HIV-specific CD8 T cell populations under conditions of limited antigenic stimulation.

Janbazian L, Price DA, Canderan G, Filali-Mouhim A, Asher TE, Ambrozak DR, Scheinberg P, Boulassel MR, Routy JP, Koup RA, Douek DC, Sekaly RP, Trautmann L.

J Immunol. 2012 Feb 1;188(3):1156-67. doi: 10.4049/jimmunol.1102610. Epub 2011 Dec 30.


Ex vivo measurement of the cytotoxic capacity of human primary antigen-specific CD8 T cells.

Mbitikon-Kobo FM, Bonneville M, Sekaly RP, Trautmann L.

J Immunol Methods. 2012 Jan 31;375(1-2):252-7. doi: 10.1016/j.jim.2011.09.008. Epub 2011 Oct 5.


Solving vaccine mysteries: a systems biology perspective.

Trautmann L, Sekaly RP.

Nat Immunol. 2011 Jul 19;12(8):729-31. doi: 10.1038/ni.2078. No abstract available.


New approaches to design HIV-1 T-cell vaccines.

Perrin H, Canderan G, Sékaly RP, Trautmann L.

Curr Opin HIV AIDS. 2010 Sep;5(5):368-76. doi: 10.1097/COH.0b013e32833d2cc0. Review.


Programmed death-1-induced interleukin-10 production by monocytes impairs CD4+ T cell activation during HIV infection.

Said EA, Dupuy FP, Trautmann L, Zhang Y, Shi Y, El-Far M, Hill BJ, Noto A, Ancuta P, Peretz Y, Fonseca SG, Van Grevenynghe J, Boulassel MR, Bruneau J, Shoukry NH, Routy JP, Douek DC, Haddad EK, Sekaly RP.

Nat Med. 2010 Apr;16(4):452-9. doi: 10.1038/nm.2106. Epub 2010 Mar 7.


HIV reservoir size and persistence are driven by T cell survival and homeostatic proliferation.

Chomont N, El-Far M, Ancuta P, Trautmann L, Procopio FA, Yassine-Diab B, Boucher G, Boulassel MR, Ghattas G, Brenchley JM, Schacker TW, Hill BJ, Douek DC, Routy JP, Haddad EK, Sékaly RP.

Nat Med. 2009 Aug;15(8):893-900. doi: 10.1038/nm.1972. Epub 2009 Jun 21.


Early interferon therapy for hepatitis C virus infection rescues polyfunctional, long-lived CD8+ memory T cells.

Badr G, Bédard N, Abdel-Hakeem MS, Trautmann L, Willems B, Villeneuve JP, Haddad EK, Sékaly RP, Bruneau J, Shoukry NH.

J Virol. 2008 Oct;82(20):10017-31. doi: 10.1128/JVI.01083-08. Epub 2008 Jul 30.


T-cell exhaustion in HIV infection.

El-Far M, Halwani R, Said E, Trautmann L, Doroudchi M, Janbazian L, Fonseca S, van Grevenynghe J, Yassine-Diab B, Sékaly RP, Haddad EK.

Curr HIV/AIDS Rep. 2008 Feb;5(1):13-9. Review.


Transcription factor FOXO3a controls the persistence of memory CD4(+) T cells during HIV infection.

van Grevenynghe J, Procopio FA, He Z, Chomont N, Riou C, Zhang Y, Gimmig S, Boucher G, Wilkinson P, Shi Y, Yassine-Diab B, Said EA, Trautmann L, El Far M, Balderas RS, Boulassel MR, Routy JP, Haddad EK, Sekaly RP.

Nat Med. 2008 Mar;14(3):266-74. doi: 10.1038/nm1728. Epub 2008 Mar 2.


Programmed death 1: a critical regulator of T-cell function and a strong target for immunotherapies for chronic viral infections.

Trautmann L, Said EA, Halwani R, Janbazian L, Chomont N, El-Far M, Breton G, Haddad EK, Sekaly RP.

Curr Opin HIV AIDS. 2007 May;2(3):219-27. doi: 10.1097/COH.0b013e3280ebb5c9.


Drug resistance mutations and the cellular immune response: a valuable synergy for the development of novel immune therapies.

Chomont N, Trautmann L, Routy JP, Sékaly RP.

Curr Opin HIV AIDS. 2007 Mar;2(2):116-22. doi: 10.1097/COH.0b013e3280287a4d.


[Inhibition of the PD-1 pathway restores the effector function of HIV-specific T cells].

Trautmann L, Chomont N, Sékaly RP.

Med Sci (Paris). 2007 Jan;23(1):24-5. French. No abstract available.


The duration of exposure to HIV modulates the breadth and the magnitude of HIV-specific memory CD4+ T cells.

Younes SA, Trautmann L, Yassine-Diab B, Kalfayan LH, Kernaleguen AE, Cameron TO, Boulassel R, Stern LJ, Routy JP, Grossman Z, Dumont AR, Sekaly RP.

J Immunol. 2007 Jan 15;178(2):788-97.


Upregulation of PD-1 expression on HIV-specific CD8+ T cells leads to reversible immune dysfunction.

Trautmann L, Janbazian L, Chomont N, Said EA, Gimmig S, Bessette B, Boulassel MR, Delwart E, Sepulveda H, Balderas RS, Routy JP, Haddad EK, Sekaly RP.

Nat Med. 2006 Oct;12(10):1198-202. Epub 2006 Aug 20. Erratum in: Nat Med. 2006 Nov;12(11):1329.


Simulations of string vibrations with boundary conditions of third kind using the functional transformation method.

Trautmann L, Petrausch S, Bauer M.

J Acoust Soc Am. 2005 Sep;118(3 Pt 1):1763-75.


Selection of T cell clones expressing high-affinity public TCRs within Human cytomegalovirus-specific CD8 T cell responses.

Trautmann L, Rimbert M, Echasserieau K, Saulquin X, Neveu B, Dechanet J, Cerundolo V, Bonneville M.

J Immunol. 2005 Nov 1;175(9):6123-32.


Direct killing of Epstein-Barr virus (EBV)-infected B cells by CD4 T cells directed against the EBV lytic protein BHRF1.

Landais E, Saulquin X, Scotet E, Trautmann L, Peyrat MA, Yates JL, Kwok WW, Bonneville M, Houssaint E.

Blood. 2004 Feb 15;103(4):1408-16. Epub 2003 Oct 16.


Dominant TCR V alpha usage by virus and tumor-reactive T cells with wide affinity ranges for their specific antigens.

Trautmann L, Labarrière N, Jotereau F, Karanikas V, Gervois N, Connerotte T, Coulie P, Bonneville M.

Eur J Immunol. 2002 Nov;32(11):3181-90.


+1 Frameshifting as a novel mechanism to generate a cryptic cytotoxic T lymphocyte epitope derived from human interleukin 10.

Saulquin X, Scotet E, Trautmann L, Peyrat MA, Halary F, Bonneville M, Houssaint E.

J Exp Med. 2002 Feb 4;195(3):353-8.


[The clinical work site system as a central component of a clinical information system].

Trautmann L, Scherer A, Geib D, Gräber S.

Stud Health Technol Inform. 2000;77:936-40. German. No abstract available.


[Experiences with an enzyme-immunoassay for hepatitis B antigen detection in blood donors (author's transl)].

Seidl S, Kühner J, Trautmann L, Pade K.

Klin Wochenschr. 1978 May 15;56(10):521-4. German.


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