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Items: 1 to 50 of 104

1.

Review about the multi-target profile of resveratrol and its implication in the SGK1 inhibition.

Catalogna G, Moraca F, D'Antona L, Dattilo V, Perrotti G, Lupia A, Costa G, Ortuso F, Iuliano R, Trapasso F, Amato R, Alcaro S, Perrotti N.

Eur J Med Chem. 2019 Dec 1;183:111675. doi: 10.1016/j.ejmech.2019.111675. Epub 2019 Sep 5.

PMID:
31539779
2.

Functional characterization of p.Pro409His variant in HNF1A, a hypomorphic mutation involved in pancreatic β-cell dysfunction.

Nocera D, Menniti M, Belviso S, Bond HM, Lanzillotta D, Spoleti CB, Guagliardi MR, Malatesta P, Trapasso F, Irace C, Perrotti N, Iuliano R.

Acta Diabetol. 2019 Aug;56(8):883-888. doi: 10.1007/s00592-019-01298-6. Epub 2019 Apr 9.

PMID:
30963309
3.

Fhit-Fdxr interaction in the mitochondria: modulation of reactive oxygen species generation and apoptosis in cancer cells.

Druck T, Cheung DG, Park D, Trapasso F, Pichiorri F, Gaspari M, Palumbo T, Aqeilan RI, Gaudio E, Okumura H, Iuliano R, Raso C, Green K, Huebner K, Croce CM.

Cell Death Dis. 2019 Feb 15;10(3):147. doi: 10.1038/s41419-019-1414-7.

4.

Retraction: The Receptor-Type Protein Tyrosine Phosphatase J Antagonizes the Biochemical and Biological Effects of RET-Derived Oncoproteins.

Iervolino A, Iuliano R, Trapasso F, Viglietto G, Melillo RM, Carlomagno F, Santoro M, Fusco A.

Cancer Res. 2018 Dec 15;78(24):6907. doi: 10.1158/0008-5472.CAN-18-3456. No abstract available.

PMID:
30552125
5.

T-Cell Leukemia/Lymphoma 1 (TCL1): An Oncogene Regulating Multiple Signaling Pathways.

Paduano F, Gaudio E, Mensah AA, Pinton S, Bertoni F, Trapasso F.

Front Oncol. 2018 Aug 13;8:317. doi: 10.3389/fonc.2018.00317. eCollection 2018.

6.

Design, Synthesis, Biological Activity, and Structural Analysis of Lactam-Constrained PTPRJ Agonist Peptides.

Sala M, Spensiero A, Scala MC, Pepe G, Bilotta A, Paduano F, D'Agostino S, Lanzillotta D, Bertamino A, Novellino E, Trapasso F, Gomez-Monterrey IM, Campiglia P.

ChemMedChem. 2018 Aug 20;13(16):1673-1680. doi: 10.1002/cmdc.201800147. Epub 2018 Jul 4.

PMID:
29888867
7.

The receptor protein tyrosine phosphatase PTPRJ negatively modulates the CD98hc oncoprotein in lung cancer cells.

D'Agostino S, Lanzillotta D, Varano M, Botta C, Baldrini A, Bilotta A, Scalise S, Dattilo V, Amato R, Gaudio E, Paduano F, Palmieri C, Iuliano R, Perrotti N, Indiveri C, Fusco A, Gaspari M, Trapasso F.

Oncotarget. 2018 May 4;9(34):23334-23348. doi: 10.18632/oncotarget.25101. eCollection 2018 May 4.

8.

TCL1A interacts with TP63 and enhances the survival of Raji Burkitt lymphoma cell line.

Gaudio E, Paduano F, Pinton S, D'Agostino S, Rocca R, Costa G, Ngankeu A, Aqeilan RI, Croce CM, Bertoni F, Alcaro S, Trapasso F.

Br J Haematol. 2018 Nov;183(3):509-512. doi: 10.1111/bjh.14989. Epub 2017 Oct 19. No abstract available.

PMID:
29048125
9.

Fhit interaction with ferredoxin reductase triggers generation of reactive oxygen species and apoptosis of cancer cells.

Trapasso F, Pichiorri F, Gaspari M, Palumbo T, Aqeilan RI, Gaudio E, Okumura H, Iuliano R, Di Leva G, Fabbri M, Birk DE, Raso C, Green-Church K, Spagnoli LG, Venuta S, Huebner K, Croce CM.

J Biol Chem. 2017 Aug 25;292(34):14279. doi: 10.1074/jbc.A117.709062. No abstract available.

10.

A novel splice variant of the protein tyrosine phosphatase PTPRJ that encodes for a soluble protein involved in angiogenesis.

Bilotta A, Dattilo V, D'Agostino S, Belviso S, Scalise S, Bilotta M, Gaudio E, Paduano F, Perrotti N, Florio T, Fusco A, Iuliano R, Trapasso F.

Oncotarget. 2017 Feb 7;8(6):10091-10102. doi: 10.18632/oncotarget.14350.

11.

The Fhit protein: an opportunity to overcome chemoresistance.

Gaudio E, Paduano F, Croce CM, Trapasso F.

Aging (Albany NY). 2016 Nov 12;8(11):3147-3150. doi: 10.18632/aging.101123. No abstract available.

12.

The rat tyrosine phosphatase η increases cell adhesion by activating c-Src through dephosphorylation of its inhibitory phosphotyrosine residue.

Le Pera I, Iuliano R, Florio T, Susini C, Trapasso F, Santoro M, Chiariotti L, Schettini G, Viglietto G, Fusco A.

Oncogene. 2016 Oct 13;35(41):5456. doi: 10.1038/onc.2016.138. Epub 2016 Jul 18. No abstract available.

PMID:
27425594
13.

A Fhit-mimetic peptide suppresses annexin A4-mediated chemoresistance to paclitaxel in lung cancer cells.

Gaudio E, Paduano F, Ngankeu A, Ortuso F, Lovat F, Pinton S, D'Agostino S, Zanesi N, Aqeilan RI, Campiglia P, Novellino E, Alcaro S, Croce CM, Trapasso F.

Oncotarget. 2016 May 24;7(21):29927-36. doi: 10.18632/oncotarget.9179.

14.

SI113, a SGK1 inhibitor, potentiates the effects of radiotherapy, modulates the response to oxidative stress and induces cytotoxic autophagy in human glioblastoma multiforme cells.

Talarico C, Dattilo V, D'Antona L, Barone A, Amodio N, Belviso S, Musumeci F, Abbruzzese C, Bianco C, Trapasso F, Schenone S, Alcaro S, Ortuso F, Florio T, Paggi MG, Perrotti N, Amato R.

Oncotarget. 2016 Mar 29;7(13):15868-84. doi: 10.18632/oncotarget.7520.

15.

The R3 receptor-like protein tyrosine phosphatase subfamily inhibits insulin signalling by dephosphorylating the insulin receptor at specific sites.

Shintani T, Higashi S, Takeuchi Y, Gaudio E, Trapasso F, Fusco A, Noda M.

J Biochem. 2015 Sep;158(3):235-43. doi: 10.1093/jb/mvv045. Epub 2015 Jun 10.

PMID:
26063811
16.

SI113, a specific inhibitor of the Sgk1 kinase activity that counteracts cancer cell proliferation.

D'Antona L, Amato R, Talarico C, Ortuso F, Menniti M, Dattilo V, Iuliano R, Gigliotti F, Artese A, Costa G, Schenone S, Musumeci F, Abbruzzese C, Botta L, Trapasso F, Alcaro S, Paggi MG, Perrotti N.

Cell Physiol Biochem. 2015;35(5):2006-18. doi: 10.1159/000374008. Epub 2015 Mar 27.

17.

Interleukin 27 polymorphisms in HCV RNA positive patients: is there an impact on response to interferon therapy?

Zicca E, Quirino A, Marascio N, Nucara S, Fabiani F, Trapasso F, Perrotti N, Strazzulla A, Torti C, Liberto MC, Focà A.

BMC Infect Dis. 2014;14 Suppl 5:S5. doi: 10.1186/1471-2334-14-S5-S5. Epub 2014 Sep 5.

18.

In silico identification and biological evaluation of novel selective serum/glucocorticoid-inducible kinase 1 inhibitors based on the pyrazolo-pyrimidine scaffold.

Ortuso F, Amato R, Artese A, D'antona L, Costa G, Talarico C, Gigliotti F, Bianco C, Trapasso F, Schenone S, Musumeci F, Botta L, Perrotti N, Alcaro S.

J Chem Inf Model. 2014 Jul 28;54(7):1828-32. doi: 10.1021/ci500235f. Epub 2014 Jun 13.

PMID:
24896223
19.

Fhit delocalizes annexin a4 from plasma membrane to cytosol and sensitizes lung cancer cells to paclitaxel.

Gaudio E, Paduano F, Spizzo R, Ngankeu A, Zanesi N, Gaspari M, Ortuso F, Lovat F, Rock J, Hill GA, Kaou M, Cuda G, Aqeilan RI, Alcaro S, Croce CM, Trapasso F.

PLoS One. 2013 Nov 6;8(11):e78610. doi: 10.1371/journal.pone.0078610. eCollection 2013.

20.

Discovery of PTPRJ agonist peptides that effectively inhibit in vitro cancer cell proliferation and tube formation.

Ortuso F, Paduano F, Carotenuto A, Gomez-Monterrey I, Bilotta A, Gaudio E, Sala M, Artese A, Vernieri E, Dattilo V, Iuliano R, Brancaccio D, Bertamino A, Musella S, Alcaro S, Grieco P, Perrotti N, Croce CM, Novellino E, Fusco A, Campiglia P, Trapasso F.

ACS Chem Biol. 2013 Jul 19;8(7):1497-506. doi: 10.1021/cb3007192. Epub 2013 May 13.

PMID:
23627474
21.

The role of microRNAs in cancer susceptibility.

Iuliano R, Vismara MF, Dattilo V, Trapasso F, Baudi F, Perrotti N.

Biomed Res Int. 2013;2013:591931. doi: 10.1155/2013/591931. Epub 2013 Mar 19. Review.

22.

Future research and collaboration: the "SINERGIE" project on HCV (South Italian Network for Rational Guidelines and International Epidemiology).

Torti C, Zazzi M, Abenavoli L, Trapasso F, Cesario F, Corigliano D, Cosco L, Costa C, Curia RL, De Rosa M, Foti G, Giraldi C, Leone R, Liberto MC, Lucchino D, Marascio N, Masciari R, Matera G, Pisani V, Serrao N, Surace L, Zicca E, Castelli F, Ciccozzi M, Puoti M, Focà A; SINERGIE Study Group.

BMC Infect Dis. 2012;12 Suppl 2:S9. doi: 10.1186/1471-2334-12-S2-S9. Epub 2012 Nov 12. Review.

23.

Natural history and clinical response: "it's the virus, stupid, or is it the host?".

Nucara S, Caroleo B, Guadagnino V, Perrotti N, Trapasso F.

BMC Infect Dis. 2012;12 Suppl 2:S6. doi: 10.1186/1471-2334-12-S2-S6. Epub 2012 Nov 12. Review.

24.

Heat shock protein 70 regulates Tcl1 expression in leukemia and lymphomas.

Gaudio E, Paduano F, Ngankeu A, Lovat F, Fabbri M, Sun HL, Gasparini P, Efanov A, Peng Y, Zanesi N, Shuaib MA, Rassenti LZ, Kipps TJ, Li C, Aqeilan RI, Lesinski GB, Trapasso F, Croce CM.

Blood. 2013 Jan 10;121(2):351-9. doi: 10.1182/blood-2012-09-457374. Epub 2012 Nov 15.

25.

Isolation and functional characterization of peptide agonists of PTPRJ, a tyrosine phosphatase receptor endowed with tumor suppressor activity.

Paduano F, Ortuso F, Campiglia P, Raso C, Iaccino E, Gaspari M, Gaudio E, Mangone G, Carotenuto A, Bilotta A, Narciso D, Palmieri C, Agosti V, Artese A, Gomez-Monterrey I, Sala M, Cuda G, Iuliano R, Perrotti N, Scala G, Viglietto G, Alcaro S, Croce CM, Novellino E, Fusco A, Trapasso F.

ACS Chem Biol. 2012 Oct 19;7(10):1666-76. doi: 10.1021/cb300281t. Epub 2012 Jul 10.

PMID:
22759068
26.

HIPK2 controls cytokinesis and prevents tetraploidization by phosphorylating histone H2B at the midbody.

Rinaldo C, Moncada A, Gradi A, Ciuffini L, D'Eliseo D, Siepi F, Prodosmo A, Giorgi A, Pierantoni GM, Trapasso F, Guarguaglini G, Bartolazzi A, Cundari E, Schininà ME, Fusco A, Soddu S.

Mol Cell. 2012 Jul 13;47(1):87-98. doi: 10.1016/j.molcel.2012.04.029. Epub 2012 May 31.

27.

Protein tyrosine phosphatase PTPRJ is negatively regulated by microRNA-328.

Paduano F, Dattilo V, Narciso D, Bilotta A, Gaudio E, Menniti M, Agosti V, Palmieri C, Perrotti N, Fusco A, Trapasso F, Iuliano R.

FEBS J. 2013 Jan;280(2):401-12. doi: 10.1111/j.1742-4658.2012.08624.x. Epub 2012 May 30.

28.

Tcl1 interacts with Atm and enhances NF-κB activation in hematologic malignancies.

Gaudio E, Spizzo R, Paduano F, Luo Z, Efanov A, Palamarchuk A, Leber AS, Kaou M, Zanesi N, Bottoni A, Costinean S, Rassenti LZ, Nakamura T, Kipps TJ, Aqeilan RI, Pekarsky Y, Trapasso F, Croce CM.

Blood. 2012 Jan 5;119(1):180-7. doi: 10.1182/blood-2011-08-374561. Epub 2011 Nov 7.

29.

Design, synthesis, biophysical and biological studies of trisubstituted naphthalimides as G-quadruplex ligands.

Peduto A, Pagano B, Petronzi C, Massa A, Esposito V, Virgilio A, Paduano F, Trapasso F, Fiorito F, Florio S, Giancola C, Galeone A, Filosa R.

Bioorg Med Chem. 2011 Nov 1;19(21):6419-29. doi: 10.1016/j.bmc.2011.08.062. Epub 2011 Sep 1.

PMID:
21944546
30.

Identification of a new mutation in the gene coding for hairless protein responsible for alopecia universalis: The importance of direct gene sequencing.

Nucara S, Colao E, Mangone G, Baudi F, Fabiani F, Nocera D, Passafaro G, Longo T, Laria AE, Malatesta P, Amato R, Trapasso F, Perrotti N.

Dermatol Online J. 2011 Jan 15;17(1):3.

31.

Role of PTPRJ genotype in papillary thyroid carcinoma risk.

Iuliano R, Palmieri D, He H, Iervolino A, Borbone E, Pallante P, Cianflone A, Nagy R, Alder H, Calin GA, Trapasso F, Giordano C, Croce CM, de la Chapelle A, Fusco A.

Endocr Relat Cancer. 2010 Oct 29;17(4):1001-6. doi: 10.1677/ERC-10-0143. Print 2010 Dec.

32.

Rational design, synthesis, biophysical and antiproliferative evaluation of fluorenone derivatives with DNA G-quadruplex binding properties.

Alcaro S, Artese A, Iley JN, Missailidis S, Ortuso F, Parrotta L, Pasceri R, Paduano F, Sissi C, Trapasso F, Vigorita MG.

ChemMedChem. 2010 Apr 6;5(4):575-83. doi: 10.1002/cmdc.200900541.

PMID:
20135671
33.

MicroRNAs in mouse models of lymphoid malignancies.

Zanesi N, Pekarsky Y, Trapasso F, Calin G, Croce CM.

J Nucleic Acids Investig. 2010;1(1):36-40.

34.

The role of G-CSF in the treatment of advanced tumors.

Bottoni U, Trapasso F.

Cancer Biol Ther. 2009 Sep;8(18):1744-6. Epub 2009 Sep 7. No abstract available.

PMID:
19652549
35.

Targeted disruption of the murine homeodomain-interacting protein kinase-2 causes growth deficiency in vivo and cell cycle arrest in vitro.

Trapasso F, Aqeilan RI, Iuliano R, Visone R, Gaudio E, Ciuffini L, Alder H, Paduano F, Pierantoni GM, Soddu S, Croce CM, Fusco A.

DNA Cell Biol. 2009 Apr;28(4):161-7. doi: 10.1089/dna.2008.0778. Retraction in: DNA Cell Biol. 2014 Mar;33(3):189.

PMID:
19364276
36.

The eighth fibronectin type III domain of protein tyrosine phosphatase receptor J influences the formation of protein complexes and cell localization.

Iuliano R, Raso C, Quintiero A, Pera IL, Pichiorri F, Palumbo T, Palmieri D, Pattarozzi A, Florio T, Viglietto G, Trapasso F, Croce CM, Fusco A.

J Biochem. 2009 Mar;145(3):377-85. doi: 10.1093/jb/mvn175. Epub 2009 Jan 3.

PMID:
19122201
37.

Fhit tumor suppressor: guardian of the preneoplastic genome.

Pichiorri F, Palumbo T, Suh SS, Okamura H, Trapasso F, Ishii H, Huebner K, Croce CM.

Future Oncol. 2008 Dec;4(6):815-24. doi: 10.2217/14796694.4.6.815. Review.

38.

BRCA1 5083del19 mutant allele selectively up-regulates periostin expression in vitro and in vivo.

Quaresima B, Romeo F, Faniello MC, Di Sanzo M, Liu CG, Lavecchia A, Taccioli C, Gaudio E, Baudi F, Trapasso F, Croce CM, Cuda G, Costanzo F.

Clin Cancer Res. 2008 Nov 1;14(21):6797-803. doi: 10.1158/1078-0432.CCR-07-5208.

39.

Molecular parameters of genome instability: roles of fragile genes at common fragile sites.

Pichiorri F, Ishii H, Okumura H, Trapasso F, Wang Y, Huebner K.

J Cell Biochem. 2008 Aug 1;104(5):1525-33. doi: 10.1002/jcb.21560. Review.

PMID:
18393361
40.

ARLTS1 - a novel tumor suppressor gene.

Yendamuri S, Trapasso F, Calin GA.

Cancer Lett. 2008 Jun 8;264(1):11-20. doi: 10.1016/j.canlet.2008.02.021. Epub 2008 Mar 28. Review.

PMID:
18375053
41.

Fhit interaction with ferredoxin reductase triggers generation of reactive oxygen species and apoptosis of cancer cells.

Trapasso F, Pichiorri F, Gaspari M, Palumbo T, Aqeilan RI, Gaudio E, Okumura H, Iuliano R, Di Leva G, Fabbri M, Birk DE, Raso C, Green-Church K, Spagnoli LG, Venuta S, Huebner K, Croce CM.

J Biol Chem. 2008 May 16;283(20):13736-44. doi: 10.1074/jbc.M709062200. Epub 2008 Mar 3. Retraction in: J Biol Chem. 2017 Aug 25;292(34):14279.

42.

Tumor suppressor functions of ARLTS1 in lung cancers.

Yendamuri S, Trapasso F, Ferracin M, Cesari R, Sevignani C, Shimizu M, Rattan S, Kuroki T, Dumon KR, Bullrich F, Liu CG, Negrini M, Williams NN, Kaiser LR, Croce CM, Calin GA.

Cancer Res. 2007 Aug 15;67(16):7738-45.

43.

Targeted deletion of Wwox reveals a tumor suppressor function.

Aqeilan RI, Trapasso F, Hussain S, Costinean S, Marshall D, Pekarsky Y, Hagan JP, Zanesi N, Kaou M, Stein GS, Lian JB, Croce CM.

Proc Natl Acad Sci U S A. 2007 Mar 6;104(10):3949-54. Epub 2007 Feb 27.

44.

Physical association with WWOX suppresses c-Jun transcriptional activity.

Gaudio E, Palamarchuk A, Palumbo T, Trapasso F, Pekarsky Y, Croce CM, Aqeilan RI.

Cancer Res. 2006 Dec 15;66(24):11585-9.

45.

Fhit modulates the DNA damage checkpoint response.

Ishii H, Mimori K, Inoue H, Inageta T, Ishikawa K, Semba S, Druck T, Trapasso F, Tani K, Vecchione A, Croce CM, Mori M, Huebner K.

Cancer Res. 2006 Dec 1;66(23):11287-92.

46.

Alterations of the tumor suppressor gene ARLTS1 in ovarian cancer.

Petrocca F, Iliopoulos D, Qin HR, Nicoloso MS, Yendamuri S, Wojcik SE, Shimizu M, Di Leva G, Vecchione A, Trapasso F, Godwin AK, Negrini M, Calin GA, Croce CM.

Cancer Res. 2006 Nov 1;66(21):10287-91.

47.

Biological functions of mammalian Nit1, the counterpart of the invertebrate NitFhit Rosetta stone protein, a possible tumor suppressor.

Semba S, Han SY, Qin HR, McCorkell KA, Iliopoulos D, Pekarsky Y, Druck T, Trapasso F, Croce CM, Huebner K.

J Biol Chem. 2006 Sep 22;281(38):28244-53. Epub 2006 Jul 24.

48.

Genetic ablation of Ptprj, a mouse cancer susceptibility gene, results in normal growth and development and does not predispose to spontaneous tumorigenesis.

Trapasso F, Drusco A, Costinean S, Alder H, Aqeilan RI, Iuliano R, Gaudio E, Raso C, Zanesi N, Croce CM, Fusco A.

DNA Cell Biol. 2006 Jun;25(6):376-82.

PMID:
16792508
49.

The receptor-type protein tyrosine phosphatase J antagonizes the biochemical and biological effects of RET-derived oncoproteins.

Iervolino A, Iuliano R, Trapasso F, Viglietto G, Melillo RM, Carlomagno F, Santoro M, Fusco A.

Cancer Res. 2006 Jun 15;66(12):6280-7. Retraction in: Cancer Res. 2018 Dec 15;78(24):6907.

50.

Preclinical assessment of FHIT gene replacement therapy in human leukemia using a chimeric adenovirus, Ad5/F35.

Pichiorri F, Trapasso F, Palumbo T, Aqeilan RI, Drusco A, Blaser BW, Iliopoulos D, Caligiuri MA, Huebner K, Croce CM.

Clin Cancer Res. 2006 Jun 1;12(11 Pt 1):3494-501. Erratum in: Clin Cancer Res. 2016 Dec 15;22(24):6304.

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