Format
Sort by
Items per page

Send to

Choose Destination

Search results

Items: 1 to 50 of 280

1.

Differential effects of BTK inhibitors ibrutinib and zanubrutinib on NK cell effector function in patients with mantle cell lymphoma.

Flinsenberg TWH, Tromedjo CC, Hu N, Liu Y, Guo Y, Thia KYT, Noori T, Song X, Aw Yeang HX, Tantalo DG, Handunnetti S, Seymour JF, Roberts AW, Ritchie D, Koldej R, Neeson PJ, Wang L, Trapani JA, Tam CS, Voskoboinik I.

Haematologica. 2019 Jun 6. pii: haematol.2019.220590. doi: 10.3324/haematol.2019.220590. [Epub ahead of print]

2.

Perforin inhibition protects from lethal endothelial damage during fulminant viral hepatitis.

Welz M, Eickhoff S, Abdullah Z, Trebicka J, Gartlan KH, Spicer JA, Demetris AJ, Akhlaghi H, Anton M, Manske K, Zehn D, Nieswandt B, Kurts C, Trapani JA, Knolle P, Wohlleber D, Kastenmüller W.

Nat Commun. 2018 Nov 15;9(1):4805. doi: 10.1038/s41467-018-07213-x.

3.

Dual PD-1 and CTLA-4 Checkpoint Blockade Promotes Antitumor Immune Responses through CD4+Foxp3- Cell-Mediated Modulation of CD103+ Dendritic Cells.

Beavis PA, Henderson MA, Giuffrida L, Davenport AJ, Petley EV, House IG, Lai J, Sek K, Milenkovski N, John LB, Mardiana S, Slaney CY, Trapani JA, Loi S, Kershaw MH, Haynes NM, Darcy PK.

Cancer Immunol Res. 2018 Sep;6(9):1069-1081. doi: 10.1158/2326-6066.CIR-18-0291. Epub 2018 Jul 17.

PMID:
30018045
4.

Tumor immune evasion arises through loss of TNF sensitivity.

Kearney CJ, Vervoort SJ, Hogg SJ, Ramsbottom KM, Freeman AJ, Lalaoui N, Pijpers L, Michie J, Brown KK, Knight DA, Sutton V, Beavis PA, Voskoboinik I, Darcy PK, Silke J, Trapani JA, Johnstone RW, Oliaro J.

Sci Immunol. 2018 May 18;3(23). pii: eaar3451. doi: 10.1126/sciimmunol.aar3451.

PMID:
29776993
5.

Down-regulation of a pro-apoptotic pathway regulated by PCAF/ADA3 in early stage gastric cancer.

Brasacchio D, Busuttil RA, Noori T, Johnstone RW, Boussioutas A, Trapani JA.

Cell Death Dis. 2018 May 1;9(5):442. doi: 10.1038/s41419-018-0470-8.

6.

Bi-Allelic Mutations in STXBP2 Reveal a Complementary Role for STXBP1 in Cytotoxic Lymphocyte Killing.

Lopez JA, Noori T, Minson A, Li Jovanoska L, Thia K, Hildebrand MS, Akhlaghi H, Darcy PK, Kershaw MH, Brown NJ, Grigg A, Trapani JA, Voskoboinik I.

Front Immunol. 2018 Mar 15;9:529. doi: 10.3389/fimmu.2018.00529. eCollection 2018.

7.

Chimeric antigen receptor T cells form nonclassical and potent immune synapses driving rapid cytotoxicity.

Davenport AJ, Cross RS, Watson KA, Liao Y, Shi W, Prince HM, Beavis PA, Trapani JA, Kershaw MH, Ritchie DS, Darcy PK, Neeson PJ, Jenkins MR.

Proc Natl Acad Sci U S A. 2018 Feb 27;115(9):E2068-E2076. doi: 10.1073/pnas.1716266115. Epub 2018 Feb 12. Erratum in: Proc Natl Acad Sci U S A. 2019 May 28;116(22):11075-11076.

8.

Perforin proteostasis is regulated through its C2 domain: supra-physiological cell death mediated by T431D-perforin.

Brennan AJ, Law RHP, Conroy PJ, Noori T, Lukoyanova N, Saibil H, Yagita H, Ciccone A, Verschoor S, Whisstock JC, Trapani JA, Voskoboinik I.

Cell Death Differ. 2018 Aug;25(8):1517-1529. doi: 10.1038/s41418-018-0057-z. Epub 2018 Feb 7.

PMID:
29416110
9.

Adaptive reprogramming of NK cells in X-linked lymphoproliferative syndrome.

Opat S, Hearps AC, Thia K, Yuen A, Rogers B, Chachage M, Moore G, Shortt J, Ryland G, Blombery P, Schwarer AP, Noori T, Trapani JA, Jaworowski A, Voskoboinik I.

Blood. 2018 Feb 8;131(6):699-702. doi: 10.1182/blood-2017-08-803668. Epub 2017 Dec 12. No abstract available.

10.

Agonist immunotherapy restores T cell function following MEK inhibition improving efficacy in breast cancer.

Dushyanthen S, Teo ZL, Caramia F, Savas P, Mintoff CP, Virassamy B, Henderson MA, Luen SJ, Mansour M, Kershaw MH, Trapani JA, Neeson PJ, Salgado R, McArthur GA, Balko JM, Beavis PA, Darcy PK, Loi S.

Nat Commun. 2017 Sep 19;8(1):606. doi: 10.1038/s41467-017-00728-9.

11.

Late-Onset Non-HLH Presentations of Growth Arrest, Inflammatory Arachnoiditis, and Severe Infectious Mononucleosis, in Siblings with Hypomorphic Defects in UNC13D.

Gray PE, Shadur B, Russell S, Mitchell R, Buckley M, Gallagher K, Andrews I, Thia K, Trapani JA, Kirk EP, Voskoboinik I.

Front Immunol. 2017 Aug 9;8:944. doi: 10.3389/fimmu.2017.00944. eCollection 2017.

12.

CMTM6 maintains the expression of PD-L1 and regulates anti-tumour immunity.

Burr ML, Sparbier CE, Chan YC, Williamson JC, Woods K, Beavis PA, Lam EYN, Henderson MA, Bell CC, Stolzenburg S, Gilan O, Bloor S, Noori T, Morgens DW, Bassik MC, Neeson PJ, Behren A, Darcy PK, Dawson SJ, Voskoboinik I, Trapani JA, Cebon J, Lehner PJ, Dawson MA.

Nature. 2017 Sep 7;549(7670):101-105. doi: 10.1038/nature23643. Epub 2017 Aug 16.

13.

Regulation of perforin activation and pre-synaptic toxicity through C-terminal glycosylation.

House IG, House CM, Brennan AJ, Gilan O, Dawson MA, Whisstock JC, Law RH, Trapani JA, Voskoboinik I.

EMBO Rep. 2017 Oct;18(10):1775-1785. doi: 10.15252/embr.201744351. Epub 2017 Aug 14.

14.

Granzyme A Deficiency Breaks Immune Tolerance and Promotes Autoimmune Diabetes Through a Type I Interferon-Dependent Pathway.

Mollah ZUA, Quah HS, Graham KL, Jhala G, Krishnamurthy B, Dharma JFM, Chee J, Trivedi PM, Pappas EG, Mackin L, Chu EPF, Akazawa S, Fynch S, Hodson C, Deans AJ, Trapani JA, Chong MMW, Bird PI, Brodnicki TC, Thomas HE, Kay TWH.

Diabetes. 2017 Dec;66(12):3041-3050. doi: 10.2337/db17-0517. Epub 2017 Jul 21.

15.

Substituted arylsulphonamides as inhibitors of perforin-mediated lysis.

Spicer JA, Miller CK, O'Connor PD, Jose J, Huttunen KM, Jaiswal JK, Denny WA, Akhlaghi H, Browne KA, Trapani JA.

Eur J Med Chem. 2017 Sep 8;137:139-155. doi: 10.1016/j.ejmech.2017.05.048. Epub 2017 May 26.

16.

Immunotherapy of cancer.

Trapani JA, Darcy PK.

Aust Fam Physician. 2017;46(4):194-199.

17.

HDAC Inhibitor Panobinostat Engages Host Innate Immune Defenses to Promote the Tumoricidal Effects of Trastuzumab in HER2+ Tumors.

Medon M, Vidacs E, Vervoort SJ, Li J, Jenkins MR, Ramsbottom KM, Trapani JA, Smyth MJ, Darcy PK, Atadja PW, Henderson MA, Johnstone RW, Haynes NM.

Cancer Res. 2017 May 15;77(10):2594-2606. doi: 10.1158/0008-5472.CAN-16-2247. Epub 2017 Mar 1.

18.

Real-time visualization of perforin nanopore assembly.

Leung C, Hodel AW, Brennan AJ, Lukoyanova N, Tran S, House CM, Kondos SC, Whisstock JC, Dunstone MA, Trapani JA, Voskoboinik I, Saibil HR, Hoogenboom BW.

Nat Nanotechnol. 2017 May;12(5):467-473. doi: 10.1038/nnano.2016.303. Epub 2017 Feb 6.

PMID:
28166206
19.

Targeting the adenosine 2A receptor enhances chimeric antigen receptor T cell efficacy.

Beavis PA, Henderson MA, Giuffrida L, Mills JK, Sek K, Cross RS, Davenport AJ, John LB, Mardiana S, Slaney CY, Johnstone RW, Trapani JA, Stagg J, Loi S, Kats L, Gyorki D, Kershaw MH, Darcy PK.

J Clin Invest. 2017 Mar 1;127(3):929-941. doi: 10.1172/JCI89455. Epub 2017 Feb 6.

20.

Benzenesulphonamide inhibitors of the cytolytic protein perforin.

Spicer JA, Miller CK, O'Connor PD, Jose J, Huttunen KM, Jaiswal JK, Denny WA, Akhlaghi H, Browne KA, Trapani JA.

Bioorg Med Chem Lett. 2017 Feb 15;27(4):1050-1054. doi: 10.1016/j.bmcl.2016.12.057. Epub 2016 Dec 23.

21.

A Multifunctional Role for Adjuvant Anti-4-1BB Therapy in Augmenting Antitumor Response by Chimeric Antigen Receptor T Cells.

Mardiana S, John LB, Henderson MA, Slaney CY, von Scheidt B, Giuffrida L, Davenport AJ, Trapani JA, Neeson PJ, Loi S, Haynes NM, Kershaw MH, Beavis PA, Darcy PK.

Cancer Res. 2017 Mar 15;77(6):1296-1309. doi: 10.1158/0008-5472.CAN-16-1831. Epub 2017 Jan 12.

22.

Epigenetic control of mitochondrial cell death through PACS1-mediated regulation of BAX/BAK oligomerization.

Brasacchio D, Alsop AE, Noori T, Lufti M, Iyer S, Simpson KJ, Bird PI, Kluck RM, Johnstone RW, Trapani JA.

Cell Death Differ. 2017 Jun;24(6):961-970. doi: 10.1038/cdd.2016.119. Epub 2017 Jan 6.

23.

Dual-specific Chimeric Antigen Receptor T Cells and an Indirect Vaccine Eradicate a Variety of Large Solid Tumors in an Immunocompetent, Self-antigen Setting.

Slaney CY, von Scheidt B, Davenport AJ, Beavis PA, Westwood JA, Mardiana S, Tscharke DC, Ellis S, Prince HM, Trapani JA, Johnstone RW, Smyth MJ, Teng MW, Ali A, Yu Z, Rosenberg SA, Restifo NP, Neeson P, Darcy PK, Kershaw MH.

Clin Cancer Res. 2017 May 15;23(10):2478-2490. doi: 10.1158/1078-0432.CCR-16-1860. Epub 2016 Dec 13.

24.

Missense mutations in the perforin (PRF1) gene as a cause of hereditary cancer predisposition.

Chaudhry MS, Gilmour KC, House IG, Layton M, Panoskaltsis N, Sohal M, Trapani JA, Voskoboinik I.

Oncoimmunology. 2016 Jun 2;5(7):e1179415. doi: 10.1080/2162402X.2016.1179415. eCollection 2016 Jul.

25.

Recognition of the Major Histocompatibility Complex (MHC) Class Ib Molecule H2-Q10 by the Natural Killer Cell Receptor Ly49C.

Sullivan LC, Berry R, Sosnin N, Widjaja JM, Deuss FA, Balaji GR, LaGruta NL, Mirams M, Trapani JA, Rossjohn J, Brooks AG, Andrews DM.

J Biol Chem. 2016 Sep 2;291(36):18740-52. doi: 10.1074/jbc.M116.737130. Epub 2016 Jul 6.

26.

A role for multiple chimeric antigen receptor-expressing leukocytes in antigen-specific responses to cancer.

Yong CS, John LB, Devaud C, Prince MH, Johnstone RW, Trapani JA, Darcy PK, Kershaw MH.

Oncotarget. 2016 Jun 7;7(23):34582-98. doi: 10.18632/oncotarget.9149.

27.

A genome scale RNAi screen identifies GLI1 as a novel gene regulating vorinostat sensitivity.

Falkenberg KJ, Newbold A, Gould CM, Luu J, Trapani JA, Matthews GM, Simpson KJ, Johnstone RW.

Cell Death Differ. 2016 Jul;23(7):1209-18. doi: 10.1038/cdd.2015.175. Epub 2016 Feb 12.

28.

Serglycin determines secretory granule repertoire and regulates natural killer cell and cytotoxic T lymphocyte cytotoxicity.

Sutton VR, Brennan AJ, Ellis S, Danne J, Thia K, Jenkins MR, Voskoboinik I, Pejler G, Johnstone RW, Andrews DM, Trapani JA.

FEBS J. 2016 Mar;283(5):947-61. doi: 10.1111/febs.13649. Epub 2016 Jan 22.

29.

Diarylthiophenes as inhibitors of the pore-forming protein perforin.

Miller CK, Huttunen KM, Denny WA, Jaiswal JK, Ciccone A, Browne KA, Trapani JA, Spicer JA.

Bioorg Med Chem Lett. 2016 Jan 15;26(2):355-360. doi: 10.1016/j.bmcl.2015.12.003. Epub 2015 Dec 7.

30.

In memoriam: Prof Christopher J Froelich (1951-2015).

Metkar SS, Pardo J, Anderluh G, Salvesen G, Trapani JA, Simon MM.

Cell Death Differ. 2016 Jan;23(1):3-4. doi: 10.1038/cdd.2015.141. No abstract available.

31.

CAR-T cells are serial killers.

Davenport AJ, Jenkins MR, Ritchie DS, Prince HM, Trapani JA, Kershaw MH, Darcy PK, Neeson PJ.

Oncoimmunology. 2015 Jun 1;4(12):e1053684. eCollection 2015 Dec.

32.

Analysis of Perforin Assembly by Quartz Crystal Microbalance Reveals a Role for Cholesterol and Calcium-independent Membrane Binding.

Stewart SE, Bird CH, Tabor RF, D'Angelo ME, Piantavigna S, Whisstock JC, Trapani JA, Martin LL, Bird PI.

J Biol Chem. 2015 Dec 25;290(52):31101-12. doi: 10.1074/jbc.M115.683078. Epub 2015 Nov 5.

33.

Induction of potent NK cell-dependent anti-myeloma cytotoxic T cells in response to combined mapatumumab and bortezomib.

Neeson PJ, Hsu AK, Chen YR, Halse HM, Loh J, Cordy R, Fielding K, Davis J, Noske J, Davenport AJ, Lindqvist-Gigg CA, Humphreys R, Tai T, Prince HM, Trapani JA, Smyth MJ, Ritchie DS.

Oncoimmunology. 2015 May 27;4(9):e1038011. eCollection 2015 Sep.

34.

Perforin-dependent cytotoxicity: 'Kiss of death' or prolonged embrace with darker elocation-idnseque11es?

Trapani JA, Voskoboinik I, Jenkins MR.

Oncoimmunology. 2015 Apr 14;4(9):e1036215. eCollection 2015 Sep.

35.

Structural Basis for Ca2+-mediated Interaction of the Perforin C2 Domain with Lipid Membranes.

Yagi H, Conroy PJ, Leung EW, Law RH, Trapani JA, Voskoboinik I, Whisstock JC, Norton RS.

J Biol Chem. 2015 Oct 16;290(42):25213-26. doi: 10.1074/jbc.M115.668384. Epub 2015 Aug 25.

36.

B cell-derived circulating granzyme B is a feature of acute infectious mononucleosis.

Hagn M, Panikkar A, Smith C, Balfour HH Jr, Khanna R, Voskoboinik I, Trapani JA.

Clin Transl Immunology. 2015 Jun 26;4(6):e38. doi: 10.1038/cti.2015.10. eCollection 2015 Jun.

37.

Perforin and granzymes: function, dysfunction and human pathology.

Voskoboinik I, Whisstock JC, Trapani JA.

Nat Rev Immunol. 2015 Jun;15(6):388-400. Review.

PMID:
25998963
38.

Heterozygosity for the common perforin mutation, p.A91V, impairs the cytotoxicity of primary natural killer cells from healthy individuals.

House IG, Thia K, Brennan AJ, Tothill R, Dobrovic A, Yeh WZ, Saffery R, Chatterton Z, Trapani JA, Voskoboinik I.

Immunol Cell Biol. 2015 Jul;93(6):575-80. doi: 10.1038/icb.2015.1. Epub 2015 Mar 17.

PMID:
25776844
39.

Failed CTL/NK cell killing and cytokine hypersecretion are directly linked through prolonged synapse time.

Jenkins MR, Rudd-Schmidt JA, Lopez JA, Ramsbottom KM, Mannering SI, Andrews DM, Voskoboinik I, Trapani JA.

J Exp Med. 2015 Mar 9;212(3):307-17. doi: 10.1084/jem.20140964. Epub 2015 Mar 2.

40.

CAR-T Cells Inflict Sequential Killing of Multiple Tumor Target Cells.

Davenport AJ, Jenkins MR, Cross RS, Yong CS, Prince HM, Ritchie DS, Trapani JA, Kershaw MH, Darcy PK, Neeson PJ.

Cancer Immunol Res. 2015 May;3(5):483-94. doi: 10.1158/2326-6066.CIR-15-0048. Epub 2015 Feb 24.

41.

Conformational changes during pore formation by the perforin-related protein pleurotolysin.

Lukoyanova N, Kondos SC, Farabella I, Law RH, Reboul CF, Caradoc-Davies TT, Spicer BA, Kleifeld O, Traore DA, Ekkel SM, Voskoboinik I, Trapani JA, Hatfaludi T, Oliver K, Hotze EM, Tweten RK, Whisstock JC, Topf M, Saibil HR, Dunstone MA.

PLoS Biol. 2015 Feb 5;13(2):e1002049. doi: 10.1371/journal.pbio.1002049. eCollection 2015 Feb.

42.

A natural genetic variant of granzyme B confers lethality to a common viral infection.

Andoniou CE, Sutton VR, Wikstrom ME, Fleming P, Thia KY, Matthews AY, Kaiserman D, Schuster IS, Coudert JD, Eldi P, Chaudhri G, Karupiah G, Bird PI, Trapani JA, Degli-Esposti MA.

PLoS Pathog. 2014 Dec 11;10(12):e1004526. doi: 10.1371/journal.ppat.1004526. eCollection 2014 Dec.

43.

A colorimetric assay that specifically measures Granzyme B proteolytic activity: hydrolysis of Boc-Ala-Ala-Asp-S-Bzl.

Hagn M, Sutton VR, Trapani JA.

J Vis Exp. 2014 Nov 28;(93):e52419. doi: 10.3791/52419.

44.

A radio-resistant perforin-expressing lymphoid population controls allogeneic T cell engraftment, activation, and onset of graft-versus-host disease in mice.

Davis JE, Harvey M, Gherardin NA, Koldej R, Huntington N, Neeson P, Trapani JA, Ritchie DS.

Biol Blood Marrow Transplant. 2015 Feb;21(2):242-9. doi: 10.1016/j.bbmt.2014.11.003. Epub 2014 Nov 12.

45.

TRAIL+ NK cells control CD4+ T cell responses during chronic viral infection to limit autoimmunity.

Schuster IS, Wikstrom ME, Brizard G, Coudert JD, Estcourt MJ, Manzur M, O'Reilly LA, Smyth MJ, Trapani JA, Hill GR, Andoniou CE, Degli-Esposti MA.

Immunity. 2014 Oct 16;41(4):646-56. doi: 10.1016/j.immuni.2014.09.013.

46.

A method for detecting intracellular perforin in mouse lymphocytes.

Brennan AJ, House IG, Oliaro J, Ramsbottom KM, Hagn M, Yagita H, Trapani JA, Voskoboinik I.

J Immunol. 2014 Dec 1;193(11):5744-50. doi: 10.4049/jimmunol.1402207. Epub 2014 Oct 27.

47.

Granzyme H is a novel protease expressed by human mast cells.

Rönnberg E, Calounova G, Sutton VR, Trapani JA, Rollman O, Hagforsen E, Pejler G.

Int Arch Allergy Immunol. 2014;165(1):68-74. doi: 10.1159/000368403. Epub 2014 Oct 21.

PMID:
25342632
48.

The preclinical pharmacokinetic disposition of a series of perforin-inhibitors as potential immunosuppressive agents.

Bull MR, Spicer JA, Huttunen KM, Denny WA, Ciccone A, Browne KA, Trapani JA, Helsby NA.

Eur J Drug Metab Pharmacokinet. 2015 Dec;40(4):417-25. doi: 10.1007/s13318-014-0220-y. Epub 2014 Aug 26.

PMID:
25155444
49.

Familial haemophagocytic lymphohistiocytosis: Australian experience and perspectives.

Voskoboinik I, Thia K, Trapani JA.

Intern Med J. 2014 Aug;44(8):826-7. doi: 10.1111/imj.12493. No abstract available.

PMID:
25081055
50.

NK cell intrinsic regulation of MIP-1α by granzyme M.

Baschuk N, Wang N, Watt SV, Halse H, House C, Bird PI, Strugnell R, Trapani JA, Smyth MJ, Andrews DM.

Cell Death Dis. 2014 Mar 13;5:e1115. doi: 10.1038/cddis.2014.74.

Supplemental Content

Loading ...
Support Center