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Items: 1 to 50 of 60

1.

Dishevelled-3 conformation dynamics analyzed by FRET-based biosensors reveals a key role of casein kinase 1.

Harnoš J, Cañizal MCA, Jurásek M, Kumar J, Holler C, Schambony A, Hanáková K, Bernatík O, Zdráhal Z, Gömöryová K, Gybeľ T, Radaszkiewicz TW, Kravec M, Trantírek L, Ryneš J, Dave Z, Fernández-Llamazares AI, Vácha R, Tripsianes K, Hoffmann C, Bryja V.

Nat Commun. 2019 Apr 18;10(1):1804. doi: 10.1038/s41467-019-09651-7.

2.

Fibroblast growth factor receptor influences primary cilium length through an interaction with intestinal cell kinase.

Kunova Bosakova M, Nita A, Gregor T, Varecha M, Gudernova I, Fafilek B, Barta T, Basheer N, Abraham SP, Balek L, Tomanova M, Fialova Kucerova J, Bosak J, Potesil D, Zieba J, Song J, Konik P, Park S, Duran I, Zdrahal Z, Smajs D, Jansen G, Fu Z, Ko HW, Hampl A, Trantirek L, Krakow D, Krejci P.

Proc Natl Acad Sci U S A. 2019 Feb 19. pii: 201800338. doi: 10.1073/pnas.1800338116. [Epub ahead of print]

3.

In-Cell NMR Spectroscopy of Nucleic Acids in Human Cells.

Viskova P, Krafcik D, Trantirek L, Foldynova-Trantirkova S.

Curr Protoc Nucleic Acid Chem. 2019 Mar;76(1):e71. doi: 10.1002/cpnc.71. Epub 2018 Nov 29.

PMID:
30489693
4.

The PTH/PTHrP-SIK3 pathway affects skeletogenesis through altered mTOR signaling.

Csukasi F, Duran I, Barad M, Barta T, Gudernova I, Trantirek L, Martin JH, Kuo CY, Woods J, Lee H, Cohn DH, Krejci P, Krakow D.

Sci Transl Med. 2018 Sep 19;10(459). pii: eaat9356. doi: 10.1126/scitranslmed.aat9356.

PMID:
30232230
5.

The inositol phosphatase SHIP2 enables sustained ERK activation downstream of FGF receptors by recruiting Src kinases.

Fafilek B, Balek L, Bosakova MK, Varecha M, Nita A, Gregor T, Gudernova I, Krenova J, Ghosh S, Piskacek M, Jonatova L, Cernohorsky NH, Zieba JT, Kostas M, Haugsten EM, Wesche J, Erneux C, Trantirek L, Krakow D, Krejci P.

Sci Signal. 2018 Sep 18;11(548). pii: eaap8608. doi: 10.1126/scisignal.aap8608.

PMID:
30228226
6.

Analysis of binding interfaces of the human scaffold protein AXIN1 by peptide microarrays.

Harnoš J, Ryneš J, Víšková P, Foldynová-Trantírková S, Bajard-Ešner L, Trantírek L, Bryja V.

J Biol Chem. 2018 Oct 19;293(42):16337-16347. doi: 10.1074/jbc.RA118.005127. Epub 2018 Aug 30.

PMID:
30166345
7.

Nanodiamonds as "artificial proteins": Regulation of a cell signalling system using low nanomolar solutions of inorganic nanocrystals.

Balek L, Buchtova M, Kunova Bosakova M, Varecha M, Foldynova-Trantirkova S, Gudernova I, Vesela I, Havlik J, Neburkova J, Turner S, Krzyscik MA, Zakrzewska M, Klimaschewski L, Claus P, Trantirek L, Cigler P, Krejci P.

Biomaterials. 2018 Sep;176:106-121. doi: 10.1016/j.biomaterials.2018.05.030. Epub 2018 May 21.

8.

Advances in the cellular structural biology of nucleic acids.

Giassa IC, Rynes J, Fessl T, Foldynova-Trantirkova S, Trantirek L.

FEBS Lett. 2018 Jun;592(12):1997-2011. doi: 10.1002/1873-3468.13054. Epub 2018 May 2. Review.

9.

Inhibitor repurposing reveals ALK, LTK, FGFR, RET and TRK kinases as the targets of AZD1480.

Gudernova I, Balek L, Varecha M, Kucerova JF, Kunova Bosakova M, Fafilek B, Palusova V, Uldrijan S, Trantirek L, Krejci P.

Oncotarget. 2017 Nov 27;8(65):109319-109331. doi: 10.18632/oncotarget.22674. eCollection 2017 Dec 12.

10.

Evaluation of the Stability of DNA i-Motifs in the Nuclei of Living Mammalian Cells.

Dzatko S, Krafcikova M, Hänsel-Hertsch R, Fessl T, Fiala R, Loja T, Krafcik D, Mergny JL, Foldynova-Trantirkova S, Trantirek L.

Angew Chem Int Ed Engl. 2018 Feb 19;57(8):2165-2169. doi: 10.1002/anie.201712284. Epub 2018 Jan 29.

11.

Metabolic stress regulates ERK activity by controlling KSR-RAF heterodimerization.

Verlande A, Krafčíková M, Potěšil D, Trantírek L, Zdráhal Z, Elkalaf M, Trnka J, Souček K, Rauch N, Rauch J, Kolch W, Uldrijan S.

EMBO Rep. 2018 Feb;19(2):320-336. doi: 10.15252/embr.201744524. Epub 2017 Dec 20.

12.

Clustered abasic lesions profoundly change the structure and stability of human telomeric G-quadruplexes.

Kejnovská I, Bednárová K, Renciuk D, Dvoráková Z, Školáková P, Trantírek L, Fiala R, Vorlícková M, Sagi J.

Nucleic Acids Res. 2017 May 5;45(8):4294-4305. doi: 10.1093/nar/gkx191.

13.

Structure of a Stable G-Hairpin.

Gajarský M, Živković ML, Stadlbauer P, Pagano B, Fiala R, Amato J, Tomáška L, Šponer J, Plavec J, Trantírek L.

J Am Chem Soc. 2017 Mar 15;139(10):3591-3594. doi: 10.1021/jacs.6b10786. Epub 2017 Mar 2.

PMID:
28217994
14.

One reporter for in-cell activity profiling of majority of protein kinase oncogenes.

Gudernova I, Foldynova-Trantirkova S, Ghannamova BE, Fafilek B, Varecha M, Balek L, Hruba E, Jonatova L, Jelinkova I, Kunova Bosakova M, Trantirek L, Mayer J, Krejci P.

Elife. 2017 Feb 15;6. pii: e21536. doi: 10.7554/eLife.21536.

15.

Membrane-Depolarizing Channel Blockers Induce Selective Glioma Cell Death by Impairing Nutrient Transport and Unfolded Protein/Amino Acid Responses.

Niklasson M, Maddalo G, Sramkova Z, Mutlu E, Wee S, Sekyrova P, Schmidt L, Fritz N, Dehnisch I, Kyriatzis G, Krafcikova M, Carson BB, Feenstra JM, Marinescu VD, Segerman A, Haraldsson M, Gustavsson AL, Hammarström LG, Jenmalm Jensen A, Uhrbom L, Altelaar AF, Linnarsson S, Uhlén P, Trantirek L, Vincent CT, Nelander S, Enger PØ, Andäng M.

Cancer Res. 2017 Apr 1;77(7):1741-1752. doi: 10.1158/0008-5472.CAN-16-2274. Epub 2017 Jan 13.

16.

G-quadruplex formation in the Oct4 promoter positively regulates Oct4 expression.

Renčiuk D, Ryneš J, Kejnovská I, Foldynová-Trantírková S, Andäng M, Trantírek L, Vorlíčková M.

Biochim Biophys Acta Gene Regul Mech. 2017 Feb;1860(2):175-183. doi: 10.1016/j.bbagrm.2016.11.002. Epub 2016 Nov 15.

PMID:
27863263
17.

Microenvironmental interactions between endothelial and lymphoma cells: a role for the canonical WNT pathway in Hodgkin lymphoma.

Linke F, Harenberg M, Nietert MM, Zaunig S, von Bonin F, Arlt A, Szczepanowski M, Weich HA, Lutz S, Dullin C, Janovská P, Krafčíková M, Trantírek L, Ovesná P, Klapper W, Beissbarth T, Alves F, Bryja V, Trümper L, Wilting J, Kube D.

Leukemia. 2017 Feb;31(2):361-372. doi: 10.1038/leu.2016.232. Epub 2016 Aug 18.

PMID:
27535218
18.

An inactivating mutation in intestinal cell kinase, ICK, impairs hedgehog signalling and causes short rib-polydactyly syndrome.

Paige Taylor S, Kunova Bosakova M, Varecha M, Balek L, Barta T, Trantirek L, Jelinkova I, Duran I, Vesela I, Forlenza KN, Martin JH, Hampl A; University of Washington Center for Mendelian Genomics, Bamshad M, Nickerson D, Jaworski ML, Song J, Ko HW, Cohn DH, Krakow D, Krejci P.

Hum Mol Genet. 2016 Sep 15;25(18):3998-4011. doi: 10.1093/hmg/ddw240. Epub 2016 Jul 27.

19.

Erratum to: Impact of nucleic acid self-alignment in a strong magnetic field on the interpretation of indirect spin-spin interactions.

Vavrinská A, Zelinka J, Šebera J, Sychrovský V, Fiala R, Boelens R, Sklenář V, Trantírek L.

J Biomol NMR. 2016 May;65(1):49. No abstract available.

20.

Notch stimulates growth by direct regulation of genes involved in the control of glycolysis and the tricarboxylic acid cycle.

Slaninova V, Krafcikova M, Perez-Gomez R, Steffal P, Trantirek L, Bray SJ, Krejci A.

Open Biol. 2016 Feb;6(2):150155. doi: 10.1098/rsob.150155.

21.

Impact of nucleic acid self-alignment in a strong magnetic field on the interpretation of indirect spin-spin interactions.

Vavrinská A, Zelinka J, Šebera J, Sychrovský V, Fiala R, Boelens R, Sklenář V, Trantírek L.

J Biomol NMR. 2016 Jan;64(1):53-62. doi: 10.1007/s10858-015-0005-x. Epub 2015 Dec 19. Erratum in: J Biomol NMR. 2016 May;65(1):49.

22.

Hairpins participating in folding of human telomeric sequence quadruplexes studied by standard and T-REMD simulations.

Stadlbauer P, Kührová P, Banáš P, Koča J, Bussi G, Trantírek L, Otyepka M, Šponer J.

Nucleic Acids Res. 2015 Nov 16;43(20):9626-44. doi: 10.1093/nar/gkv994. Epub 2015 Oct 3.

23.

Diverse effects of naturally occurring base lesions on the structure and stability of the human telomere DNA quadruplex.

Konvalinová H, Dvořáková Z, Renčiuk D, Bednářová K, Kejnovská I, Trantírek L, Vorlíčková M, Sagi J.

Biochimie. 2015 Nov;118:15-25. doi: 10.1016/j.biochi.2015.07.013. Epub 2015 Jul 15. Review.

PMID:
26188111
24.

Unique C. elegans telomeric overhang structures reveal the evolutionarily conserved properties of telomeric DNA.

Školáková P, Foldynová-Trantírková S, Bednářová K, Fiala R, Vorlíčková M, Trantírek L.

Nucleic Acids Res. 2015 May 19;43(9):4733-45. doi: 10.1093/nar/gkv296. Epub 2015 Apr 8.

25.

Instability restricts signaling of multiple fibroblast growth factors.

Buchtova M, Chaloupkova R, Zakrzewska M, Vesela I, Cela P, Barathova J, Gudernova I, Zajickova R, Trantirek L, Martin J, Kostas M, Otlewski J, Damborsky J, Kozubik A, Wiedlocha A, Krejci P.

Cell Mol Life Sci. 2015 Jun;72(12):2445-59. doi: 10.1007/s00018-015-1856-8. Epub 2015 Feb 18.

PMID:
25854632
26.

A novel variant of FGFR3 causes proportionate short stature.

Kant SG, Cervenkova I, Balek L, Trantirek L, Santen GW, de Vries MC, van Duyvenvoorde HA, van der Wielen MJ, Verkerk AJ, Uitterlinden AG, Hannema SE, Wit JM, Oostdijk W, Krejci P, Losekoot M.

Eur J Endocrinol. 2015 Jun;172(6):763-70. doi: 10.1530/EJE-14-0945. Epub 2015 Mar 16.

PMID:
25777271
27.

In-cell NMR and EPR spectroscopy of biomacromolecules.

Hänsel R, Luh LM, Corbeski I, Trantirek L, Dötsch V.

Angew Chem Int Ed Engl. 2014 Sep 22;53(39):10300-14. doi: 10.1002/anie.201311320. Epub 2014 Jul 28. Review.

PMID:
25070284
28.

Triplex intermediates in folding of human telomeric quadruplexes probed by microsecond-scale molecular dynamics simulations.

Stadlbauer P, Trantírek L, Cheatham TE 3rd, Koča J, Sponer J.

Biochimie. 2014 Oct;105:22-35. doi: 10.1016/j.biochi.2014.07.009. Epub 2014 Jul 17.

29.

Functional analysis of dishevelled-3 phosphorylation identifies distinct mechanisms driven by casein kinase 1ϵ and frizzled5.

Bernatík O, Šedová K, Schille C, Ganji RS, Červenka I, Trantírek L, Schambony A, Zdráhal Z, Bryja V.

J Biol Chem. 2014 Aug 22;289(34):23520-33. doi: 10.1074/jbc.M114.590638. Epub 2014 Jul 3.

30.

Expression of FGF19 in human embryonic stem cells.

Krejci P, Kunova M, Kubikova I, Trantirek L, Kozubik A, Dvorak P.

Stem Cells. 2013 Nov;31(11):2582-4. doi: 10.1002/stem.1493. No abstract available.

31.

High-resolution insight into G-overhang architecture.

Hänsel R, Löhr F, Trantirek L, Dötsch V.

J Am Chem Soc. 2013 Feb 20;135(7):2816-24. doi: 10.1021/ja312403b. Epub 2013 Feb 5.

PMID:
23339582
32.

Influence of the O-phosphorylation of serine, threonine and tyrosine in proteins on the amidic ¹⁵N chemical shielding anisotropy tensors.

Emmer J, Vavrinská A, Sychrovský V, Benda L, Kříž Z, Koča J, Boelens R, Sklenář V, Trantírek L.

J Biomol NMR. 2013 Jan;55(1):59-70. doi: 10.1007/s10858-012-9686-6. Epub 2012 Dec 1.

PMID:
23202985
33.

Pyramidalization of the glycosidic nitrogen provides the way for efficient cleavage of the N-glycosidic bond of 8-OxoG with the hOGG1 DNA repair protein.

Šebera J, Trantírek L, Tanaka Y, Sychrovský V.

J Phys Chem B. 2012 Oct 18;116(41):12535-44. doi: 10.1021/jp309098d. Epub 2012 Oct 9.

PMID:
22989268
34.

Investigation of quadruplex structure under physiological conditions using in-cell NMR.

Hänsel R, Foldynová-Trantírková S, Dötsch V, Trantírek L.

Top Curr Chem. 2013;330:47-65. doi: 10.1007/128_2012_332. Review.

PMID:
22760824
35.

Towards characterization of DNA structure under physiological conditions in vivo at the single-molecule level using single-pair FRET.

Fessl T, Adamec F, Polívka T, Foldynová-Trantírková S, Vácha F, Trantírek L.

Nucleic Acids Res. 2012 Sep;40(16):e121. doi: 10.1093/nar/gks333. Epub 2012 Apr 28.

36.

Guanine bases in DNA G-quadruplex adopt nonplanar geometries owing to solvation and base pairing.

Sychrovský V, Sochorová Vokáčová Z, Trantírek L.

J Phys Chem A. 2012 Apr 26;116(16):4144-51. doi: 10.1021/jp2110049. Epub 2012 Apr 18.

PMID:
22471881
37.

NMR cross-correlated relaxation rates reveal ion coordination sites in DNA.

Fiala R, Spacková N, Foldynová-Trantírková S, Sponer J, Sklenár V, Trantírek L.

J Am Chem Soc. 2011 Sep 7;133(35):13790-3. doi: 10.1021/ja202397p. Epub 2011 Aug 12.

PMID:
21819145
38.

The parallel G-quadruplex structure of vertebrate telomeric repeat sequences is not the preferred folding topology under physiological conditions.

Hänsel R, Löhr F, Foldynová-Trantírková S, Bamberg E, Trantírek L, Dötsch V.

Nucleic Acids Res. 2011 Jul;39(13):5768-75. doi: 10.1093/nar/gkr174. Epub 2011 Mar 30.

39.

Evaluating the effects of the nonplanarity of nucleic acid bases on NMR, IR, and vibrational circular dichroism spectra: a density functional theory computational study.

Vokácová Z, Trantírek L, Sychrovský V.

J Phys Chem A. 2010 Sep 23;114(37):10202-8. doi: 10.1021/jp102329t.

PMID:
20795684
40.

Breast cancer-specific mutations in CK1epsilon inhibit Wnt/beta-catenin and activate the Wnt/Rac1/JNK and NFAT pathways to decrease cell adhesion and promote cell migration.

Foldynová-Trantírková S, Sekyrová P, Tmejová K, Brumovská E, Bernatík O, Blankenfeldt W, Krejcí P, Kozubík A, Dolezal T, Trantírek L, Bryja V.

Breast Cancer Res. 2010;12(3):R30. doi: 10.1186/bcr2581. Epub 2010 May 27.

41.

NF449 is a novel inhibitor of fibroblast growth factor receptor 3 (FGFR3) signaling active in chondrocytes and multiple myeloma cells.

Krejci P, Murakami S, Prochazkova J, Trantirek L, Chlebova K, Ouyang Z, Aklian A, Smutny J, Bryja V, Kozubik A, Wilcox WR.

J Biol Chem. 2010 Jul 2;285(27):20644-53. doi: 10.1074/jbc.M109.083626. Epub 2010 May 3.

42.

Unusual interstrand Pt(S,S-diaminocyclohexane)-GG crosslink formed by rearrangement of a classical intrastrand crosslink within a DNA duplex.

Kubícek K, Monnet J, Scintilla S, Kopecná J, Arnesano F, Trantírek L, Chopard C, Natile G, Kozelka J.

Chem Asian J. 2010 Feb 1;5(2):244-7. doi: 10.1002/asia.200900655. No abstract available.

PMID:
20033981
43.

Evaluation of parameters critical for observing nucleic acids inside living Xenopus laevis oocytes by in-cell NMR spectroscopy.

Hänsel R, Foldynová-Trantírková S, Löhr F, Buck J, Bongartz E, Bamberg E, Schwalbe H, Dötsch V, Trantírek L.

J Am Chem Soc. 2009 Nov 4;131(43):15761-8. doi: 10.1021/ja9052027.

PMID:
19824671
44.

Revisiting the planarity of nucleic acid bases: Pyramidilization at glycosidic nitrogen in purine bases is modulated by orientation of glycosidic torsion.

Sychrovsky V, Foldynova-Trantirkova S, Spackova N, Robeyns K, Van Meervelt L, Blankenfeldt W, Vokacova Z, Sponer J, Trantirek L.

Nucleic Acids Res. 2009 Nov;37(21):7321-31. doi: 10.1093/nar/gkp783.

45.

A cost-effective amino-acid-type selective isotope labeling of proteins expressed in Leishmania tarentolae.

Foldynová-Trantirková S, Matulová J, Dötsch V, Löhr F, Cirstea I, Alexandov K, Breitling R, Lukes J, Trantírek L.

J Biomol Struct Dyn. 2009 Jun;26(6):755-61.

PMID:
19385703
46.

Effect of local sugar and base geometry on 13C and 15N magnetic shielding anisotropy in DNA nucleosides.

Brumovská E, Sychrovský V, Vokácová Z, Sponer J, Schneider B, Trantírek L.

J Biomol NMR. 2008 Nov;42(3):209-23. doi: 10.1007/s10858-008-9278-7. Epub 2008 Oct 14.

PMID:
18853259
47.

Structure and function of the native and recombinant mitochondrial MRP1/MRP2 complex from Trypanosoma brucei.

Zíková A, Kopecná J, Schumacher MA, Stuart K, Trantírek L, Lukes J.

Int J Parasitol. 2008 Jul;38(8-9):901-12. doi: 10.1016/j.ijpara.2007.12.009. Epub 2008 Jan 26.

48.

NMR (13)C-relaxation study of base and sugar dynamics in GCAA RNA hairpin tetraloop.

Trantírek L, Caha E, Kaderávek P, Fiala R.

J Biomol Struct Dyn. 2007 Dec;25(3):243-52.

PMID:
17937486
49.

Crystal structures of T. brucei MRP1/MRP2 guide-RNA binding complex reveal RNA matchmaking mechanism.

Schumacher MA, Karamooz E, Zíková A, Trantírek L, Lukes J.

Cell. 2006 Aug 25;126(4):701-11.

50.

Structural study of elements of Tetrahymena telomerase RNA stem-loop IV domain important for function.

Richards RJ, Wu H, Trantirek L, O'Connor CM, Collins K, Feigon J.

RNA. 2006 Aug;12(8):1475-85. Epub 2006 Jun 29.

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