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Items: 27


Automated On-tip Affinity Capture Coupled with Mass Spectrometry to Characterize Intact Antibody-Drug Conjugates from Blood.

Li KS, Chu PY, Fourie-O'Donohue A, Srikumar N, Kozak KR, Liu Y, Tran JC.

J Am Soc Mass Spectrom. 2018 Jul;29(7):1532-1537. doi: 10.1007/s13361-018-1961-7. Epub 2018 May 29.


Identification of Small-Molecule Noncovalent Binders Utilizing SAMDI Technology.

VanderPorten EC, Scholle MD, Sherrill J, Tran JC, Liu Y.

SLAS Discov. 2017 Dec;22(10):1211-1217. doi: 10.1177/2472555217712761. Epub 2017 Jun 5.


Automated Affinity Capture and On-Tip Digestion to Accurately Quantitate in Vivo Deamidation of Therapeutic Antibodies.

Tran JC, Tran D, Hilderbrand A, Andersen N, Huang T, Reif K, Hotzel I, Stefanich EG, Liu Y, Wang J.

Anal Chem. 2016 Dec 6;88(23):11521-11526. Epub 2016 Nov 11.


Automated Functional Imaging by 2D Speckle Tracking Echocardiography Reveals High Incidence of Abnormal Longitudinal Strain in a Cohort of Pediatric Oncology Patients.

Tran JC, Ruble K, Loeb DM, Chen AR, Thompson WR.

Pediatr Blood Cancer. 2016 Jun;63(6):1075-80. doi: 10.1002/pbc.25938. Epub 2016 Feb 10.


Mass Spectrometry and Antibody-Based Characterization of Blood Vessels from Brachylophosaurus canadensis.

Cleland TP, Schroeter ER, Zamdborg L, Zheng W, Lee JE, Tran JC, Bern M, Duncan MB, Lebleu VS, Ahlf DR, Thomas PM, Kalluri R, Kelleher NL, Schweitzer MH.

J Proteome Res. 2015 Dec 4;14(12):5252-62. doi: 10.1021/acs.jproteome.5b00675. Epub 2015 Nov 23.


Online matrix removal platform for coupling gel-based separations to whole protein electrospray ionization mass spectrometry.

Kim KH, Compton PD, Tran JC, Kelleher NL.

J Proteome Res. 2015 May 1;14(5):2199-206. doi: 10.1021/pr501331q. Epub 2015 Apr 15.


Optimizing capillary electrophoresis for top-down proteomics of 30-80 kDa proteins.

Li Y, Compton PD, Tran JC, Ntai I, Kelleher NL.

Proteomics. 2014 May;14(10):1158-64. doi: 10.1002/pmic.201300381. Epub 2014 Apr 10.


Large-scale top-down proteomics of the human proteome: membrane proteins, mitochondria, and senescence.

Catherman AD, Durbin KR, Ahlf DR, Early BP, Fellers RT, Tran JC, Thomas PM, Kelleher NL.

Mol Cell Proteomics. 2013 Dec;12(12):3465-73. doi: 10.1074/mcp.M113.030114. Epub 2013 Sep 10.


Top down proteomics of human membrane proteins from enriched mitochondrial fractions.

Catherman AD, Li M, Tran JC, Durbin KR, Compton PD, Early BP, Thomas PM, Kelleher NL.

Anal Chem. 2013 Feb 5;85(3):1880-8. doi: 10.1021/ac3031527. Epub 2013 Jan 23.


Evaluation of the compact high-field orbitrap for top-down proteomics of human cells.

Ahlf DR, Compton PD, Tran JC, Early BP, Thomas PM, Kelleher NL.

J Proteome Res. 2012 Aug 3;11(8):4308-14. doi: 10.1021/pr3004216. Epub 2012 Jul 13.


A protease for 'middle-down' proteomics.

Wu C, Tran JC, Zamdborg L, Durbin KR, Li M, Ahlf DR, Early BP, Thomas PM, Sweedler JV, Kelleher NL.

Nat Methods. 2012 Jun 17;9(8):822-4. doi: 10.1038/nmeth.2074.


Nano-LC FTICR tandem mass spectrometry for top-down proteomics: routine baseline unit mass resolution of whole cell lysate proteins up to 72 kDa.

Tipton JD, Tran JC, Catherman AD, Ahlf DR, Durbin KR, Lee JE, Kellie JF, Kelleher NL, Hendrickson CL, Marshall AG.

Anal Chem. 2012 Mar 6;84(5):2111-7. doi: 10.1021/ac202651v. Epub 2012 Feb 22.


Robust analysis of the yeast proteome under 50 kDa by molecular-mass-based fractionation and top-down mass spectrometry.

Kellie JF, Catherman AD, Durbin KR, Tran JC, Tipton JD, Norris JL, Witkowski CE 2nd, Thomas PM, Kelleher NL.

Anal Chem. 2012 Jan 3;84(1):209-15. doi: 10.1021/ac202384v. Epub 2011 Dec 14.


Intact proteome fractionation strategies compatible with mass spectrometry.

Doucette AA, Tran JC, Wall MJ, Fitzsimmons S.

Expert Rev Proteomics. 2011 Dec;8(6):787-800. doi: 10.1586/epr.11.67. Review.


Mapping intact protein isoforms in discovery mode using top-down proteomics.

Tran JC, Zamdborg L, Ahlf DR, Lee JE, Catherman AD, Durbin KR, Tipton JD, Vellaichamy A, Kellie JF, Li M, Wu C, Sweet SM, Early BP, Siuti N, LeDuc RD, Compton PD, Thomas PM, Kelleher NL.

Nature. 2011 Oct 30;480(7376):254-8. doi: 10.1038/nature10575.


Analysis of intact protein isoforms by mass spectrometry.

Tipton JD, Tran JC, Catherman AD, Ahlf DR, Durbin KR, Kelleher NL.

J Biol Chem. 2011 Jul 22;286(29):25451-8. doi: 10.1074/jbc.R111.239442. Epub 2011 Jun 1. Review.


Dietary exposure of Hong Kong adults to nitrate and nitrite from vegetable intake.

Chen MY, Chung SW, Tran JC, Tong KS, Ho YY, Chan CH, Xiao Y.

Food Addit Contam Part B Surveill. 2011;4(2):94-8. doi: 10.1080/19393210.2011.574158. Epub 2011 May 23.


Nitrate and nitrite levels in commonly consumed vegetables in Hong Kong.

Chung SW, Tran JC, Tong KS, Chen MY, Xiao Y, Ho YY, Chan CH.

Food Addit Contam Part B Surveill. 2011;4(1):34-41. doi: 10.1080/19393210.2011.557784.


Intact mass detection, interpretation, and visualization to automate Top-Down proteomics on a large scale.

Durbin KR, Tran JC, Zamdborg L, Sweet SM, Catherman AD, Lee JE, Li M, Kellie JF, Kelleher NL.

Proteomics. 2010 Oct;10(20):3589-97. doi: 10.1002/pmic.201000177.


The emerging process of Top Down mass spectrometry for protein analysis: biomarkers, protein-therapeutics, and achieving high throughput.

Kellie JF, Tran JC, Lee JE, Ahlf DR, Thomas HM, Ntai I, Catherman AD, Durbin KR, Zamdborg L, Vellaichamy A, Thomas PM, Kelleher NL.

Mol Biosyst. 2010 Sep;6(9):1532-9. doi: 10.1039/c000896f. Epub 2010 Mar 29.


Size-sorting combined with improved nanocapillary liquid chromatography-mass spectrometry for identification of intact proteins up to 80 kDa.

Vellaichamy A, Tran JC, Catherman AD, Lee JE, Kellie JF, Sweet SM, Zamdborg L, Thomas PM, Ahlf DR, Durbin KR, Valaskovic GA, Kelleher NL.

Anal Chem. 2010 Feb 15;82(4):1234-44. doi: 10.1021/ac9021083.


A robust two-dimensional separation for top-down tandem mass spectrometry of the low-mass proteome.

Lee JE, Kellie JF, Tran JC, Tipton JD, Catherman AD, Thomas HM, Ahlf DR, Durbin KR, Vellaichamy A, Ntai I, Marshall AG, Kelleher NL.

J Am Soc Mass Spectrom. 2009 Dec;20(12):2183-91. doi: 10.1016/j.jasms.2009.08.001. Epub 2009 Aug 12.


Multiplexed size separation of intact proteins in solution phase for mass spectrometry.

Tran JC, Doucette AA.

Anal Chem. 2009 Aug 1;81(15):6201-9. doi: 10.1021/ac900729r.


Evaluation of a solution isoelectric focusing protocol as an alternative to ion exchange chromatography for charge-based proteome prefractionation.

Tran JC, Wall MJ, Doucette AA.

J Chromatogr B Analyt Technol Biomed Life Sci. 2009 Mar 15;877(8-9):807-13. doi: 10.1016/j.jchromb.2009.02.024. Epub 2009 Feb 13.


Rapid and effective focusing in a carrier ampholyte solution isoelectric focusing system: a proteome prefractionation tool.

Tran JC, Doucette AA.

J Proteome Res. 2008 Apr;7(4):1761-6. doi: 10.1021/pr700677u. Epub 2008 Feb 20.


Gel-eluted liquid fraction entrapment electrophoresis: an electrophoretic method for broad molecular weight range proteome separation.

Tran JC, Doucette AA.

Anal Chem. 2008 Mar 1;80(5):1568-73. doi: 10.1021/ac702197w. Epub 2008 Jan 30.


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