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Items: 49


Chemical activation of estrogen and aryl hydrocarbon receptor signaling pathways and their interaction in toxicology and metabolism.

Tarnow P, Tralau T, Luch A.

Expert Opin Drug Metab Toxicol. 2019 Mar;15(3):219-229. doi: 10.1080/17425255.2019.1569627. Epub 2019 Jan 27. Review.


Skin toxicology and 3Rs-Current challenges for public health protection.

Riebeling C, Luch A, Tralau T.

Exp Dermatol. 2018 May;27(5):526-536. doi: 10.1111/exd.13536. Review.


Framework for the quantitative weight-of-evidence analysis of 'omics data for regulatory purposes.

Bridges J, Sauer UG, Buesen R, Deferme L, Tollefsen KE, Tralau T, van Ravenzwaay B, Poole A, Pemberton M.

Regul Toxicol Pharmacol. 2017 Dec;91 Suppl 1:S46-S60. doi: 10.1016/j.yrtph.2017.10.010. Epub 2017 Oct 14. Review.


Framework for the quality assurance of 'omics technologies considering GLP requirements.

Kauffmann HM, Kamp H, Fuchs R, Chorley BN, Deferme L, Ebbels T, Hackermüller J, Perdichizzi S, Poole A, Sauer UG, Tollefsen KE, Tralau T, Yauk C, van Ravenzwaay B.

Regul Toxicol Pharmacol. 2017 Dec;91 Suppl 1:S27-S35. doi: 10.1016/j.yrtph.2017.10.007. Epub 2017 Oct 5. Review.


Applying 'omics technologies in chemicals risk assessment: Report of an ECETOC workshop.

Buesen R, Chorley BN, da Silva Lima B, Daston G, Deferme L, Ebbels T, Gant TW, Goetz A, Greally J, Gribaldo L, Hackermüller J, Hubesch B, Jennen D, Johnson K, Kanno J, Kauffmann HM, Laffont M, McMullen P, Meehan R, Pemberton M, Perdichizzi S, Piersma AH, Sauer UG, Schmidt K, Seitz H, Sumida K, Tollefsen KE, Tong W, Tralau T, van Ravenzwaay B, Weber RJM, Worth A, Yauk C, Poole A.

Regul Toxicol Pharmacol. 2017 Dec;91 Suppl 1:S3-S13. doi: 10.1016/j.yrtph.2017.09.002. Epub 2017 Sep 25. Review.


The challenge of the application of 'omics technologies in chemicals risk assessment: Background and outlook.

Sauer UG, Deferme L, Gribaldo L, Hackermüller J, Tralau T, van Ravenzwaay B, Yauk C, Poole A, Tong W, Gant TW.

Regul Toxicol Pharmacol. 2017 Dec;91 Suppl 1:S14-S26. doi: 10.1016/j.yrtph.2017.09.020. Epub 2017 Sep 18. Review.


Embryonic stem cells and the next generation of developmental toxicity testing.

Kugler J, Huhse B, Tralau T, Luch A.

Expert Opin Drug Metab Toxicol. 2017 Aug;13(8):833-841. doi: 10.1080/17425255.2017.1351548. Epub 2017 Jul 12. Review.


A Novel Dual-Color Luciferase Reporter Assay for Simultaneous Detection of Estrogen and Aryl Hydrocarbon Receptor Activation.

Tarnow P, Bross S, Wollenberg L, Nakajima Y, Ohmiya Y, Tralau T, Luch A.

Chem Res Toxicol. 2017 Jul 17;30(7):1436-1447. doi: 10.1021/acs.chemrestox.7b00076. Epub 2017 Jul 3.


Application of proteomics in the elucidation of chemical-mediated allergic contact dermatitis.

Höper T, Mussotter F, Haase A, Luch A, Tralau T.

Toxicol Res (Camb). 2017 Jun 13;6(5):595-610. doi: 10.1039/c7tx00058h. eCollection 2017 Sep 1. Review.


Toxification of polycyclic aromatic hydrocarbons by commensal bacteria from human skin.

Sowada J, Lemoine L, Schön K, Hutzler C, Luch A, Tralau T.

Arch Toxicol. 2017 Jun;91(6):2331-2341. doi: 10.1007/s00204-017-1964-3. Epub 2017 Apr 4.


The human microbiome, from Achilles armour to Nessus' shirt.

Tralau T, Luch A.

Arch Toxicol. 2017 Jul;91(7):2699-2701. doi: 10.1007/s00204-017-1951-8. Epub 2017 Mar 29. No abstract available.


An oxidative N-demethylase reveals PAS transition from ubiquitous sensor to enzyme.

Ortmayer M, Lafite P, Menon BR, Tralau T, Fisher K, Denkhaus L, Scrutton NS, Rigby SE, Munro AW, Hay S, Leys D.

Nature. 2016 Nov 24;539(7630):593-597. doi: 10.1038/nature20159. Epub 2016 Nov 16.


The Q-rich/PST domain of the AHR regulates both ligand-induced nuclear transport and nucleocytoplasmic shuttling.

Tkachenko A, Henkler F, Brinkmann J, Sowada J, Genkinger D, Kern C, Tralau T, Luch A.

Sci Rep. 2016 Aug 18;6:32009. doi: 10.1038/srep32009.


Combination of Metabolomics with Cellular Assays Reveals New Biomarkers and Mechanistic Insights on Xenoestrogenic Exposures in MCF-7 Cells.

Potratz S, Tarnow P, Jungnickel H, Baumann S, von Bergen M, Tralau T, Luch A.

Chem Res Toxicol. 2017 Apr 17;30(4):883-892. doi: 10.1021/acs.chemrestox.6b00106. Epub 2016 Aug 29.


CpG sites with continuously increasing or decreasing methylation from early to late human fetal brain development.

Schneider E, Dittrich M, Böck J, Nanda I, Müller T, Seidmann L, Tralau T, Galetzka D, El Hajj N, Haaf T.

Gene. 2016 Oct 30;592(1):110-118. doi: 10.1016/j.gene.2016.07.058. Epub 2016 Jul 25.


Epigenetic dysregulation in the developing Down syndrome cortex.

El Hajj N, Dittrich M, Böck J, Kraus TF, Nanda I, Müller T, Seidmann L, Tralau T, Galetzka D, Schneider E, Haaf T.

Epigenetics. 2016 Aug 2;11(8):563-78. doi: 10.1080/15592294.2016.1192736. Epub 2016 May 31.


Biology-inspired microphysiological system approaches to solve the prediction dilemma of substance testing.

Marx U, Andersson TB, Bahinski A, Beilmann M, Beken S, Cassee FR, Cirit M, Daneshian M, Fitzpatrick S, Frey O, Gaertner C, Giese C, Griffith L, Hartung T, Heringa MB, Hoeng J, de Jong WH, Kojima H, Kuehnl J, Leist M, Luch A, Maschmeyer I, Sakharov D, Sips AJ, Steger-Hartmann T, Tagle DA, Tonevitsky A, Tralau T, Tsyb S, van de Stolpe A, Vandebriel R, Vulto P, Wang J, Wiest J, Rodenburg M, Roth A.

ALTEX. 2016;33(3):272-321. doi: 10.14573/altex.1603161. Epub 2016 May 15. Review.


Estrogenic Activity of Mineral Oil Aromatic Hydrocarbons Used in Printing Inks.

Tarnow P, Hutzler C, Grabiger S, Schön K, Tralau T, Luch A.

PLoS One. 2016 Jan 15;11(1):e0147239. doi: 10.1371/journal.pone.0147239. eCollection 2016.


Non-animal models of epithelial barriers (skin, intestine and lung) in research, industrial applications and regulatory toxicology.

Gordon S, Daneshian M, Bouwstra J, Caloni F, Constant S, Davies DE, Dandekar G, Guzman CA, Fabian E, Haltner E, Hartung T, Hasiwa N, Hayden P, Kandarova H, Khare S, Krug HF, Kneuer C, Leist M, Lian G, Marx U, Metzger M, Ott K, Prieto P, Roberts MS, Roggen EL, Tralau T, van den Braak C, Walles H, Lehr CM.

ALTEX. 2015;32(4):327-78. doi: 10.14573/altex.1510051.


G protein-coupled receptor 30 ligand G-1 increases aryl hydrocarbon receptor signalling by inhibition of tubulin assembly and cell cycle arrest in human MCF-7 cells.

Tarnow P, Tralau T, Luch A.

Arch Toxicol. 2016 Aug;90(8):1939-48. doi: 10.1007/s00204-015-1615-5. Epub 2015 Oct 16.


A medical-toxicological view of tattooing.

Laux P, Tralau T, Tentschert J, Blume A, Dahouk SA, Bäumler W, Bernstein E, Bocca B, Alimonti A, Colebrook H, de Cuyper C, Dähne L, Hauri U, Howard PC, Janssen P, Katz L, Klitzman B, Kluger N, Krutak L, Platzek T, Scott-Lang V, Serup J, Teubner W, Schreiver I, Wilkniß E, Luch A.

Lancet. 2016 Jan 23;387(10016):395-402. doi: 10.1016/S0140-6736(15)60215-X. Epub 2015 Jul 23. Review.


Moving from rats to cellular omics in regulatory toxicology: great challenge toward sustainability or "up-shit-creek without a paddle"?

Tralau T, Luch A.

Arch Toxicol. 2015 Jun;89(6):819-21. doi: 10.1007/s00204-015-1511-z. Epub 2015 Mar 28. No abstract available.


Regulatory toxicology in the twenty-first century: challenges, perspectives and possible solutions.

Tralau T, Oelgeschläger M, Gürtler R, Heinemeyer G, Herzler M, Höfer T, Itter H, Kuhl T, Lange N, Lorenz N, Müller-Graf C, Pabel U, Pirow R, Ritz V, Schafft H, Schneider H, Schulz T, Schumacher D, Zellmer S, Fleur-Böl G, Greiner M, Lahrssen-Wiederholt M, Lampen A, Luch A, Schönfelder G, Solecki R, Wittkowski R, Hensel A.

Arch Toxicol. 2015 Jun;89(6):823-50. doi: 10.1007/s00204-015-1510-0. Epub 2015 Mar 28. Review.


Insights on the human microbiome and its xenobiotic metabolism: what is known about its effects on human physiology?

Tralau T, Sowada J, Luch A.

Expert Opin Drug Metab Toxicol. 2015 Mar;11(3):411-25. doi: 10.1517/17425255.2015.990437. Epub 2014 Dec 5. Review.


Degradation of benzo[a]pyrene by bacterial isolates from human skin.

Sowada J, Schmalenberger A, Ebner I, Luch A, Tralau T.

FEMS Microbiol Ecol. 2014 Apr;88(1):129-39. doi: 10.1111/1574-6941.12276. Epub 2014 Jan 21.


The evolution of our understanding of endo-xenobiotic crosstalk and cytochrome P450 regulation and the therapeutic implications.

Tralau T, Luch A.

Expert Opin Drug Metab Toxicol. 2013 Dec;9(12):1541-54. doi: 10.1517/17425255.2013.828692. Epub 2013 Aug 13. Review.


Effects of triclocarban on the transcription of estrogen, androgen and aryl hydrocarbon receptor responsive genes in human breast cancer cells.

Tarnow P, Tralau T, Hunecke D, Luch A.

Toxicol In Vitro. 2013 Aug;27(5):1467-75. doi: 10.1016/j.tiv.2013.03.003. Epub 2013 Mar 21.


Risk assessment of nanomaterials in cosmetics: a European union perspective.

Henkler F, Tralau T, Tentschert J, Kneuer C, Haase A, Platzek T, Luch A, Götz ME.

Arch Toxicol. 2012 Nov;86(11):1641-6. doi: 10.1007/s00204-012-0944-x. Epub 2012 Oct 2.


"Drugs on oxygen": an update and perspective on the role of cytochrome P450 testing in pharmacology.

Tralau T, Luch A.

Expert Opin Drug Metab Toxicol. 2012 Nov;8(11):1357-62. doi: 10.1517/17425255.2012.722620. Epub 2012 Sep 13.


Wind of change challenges toxicological regulators.

Tralau T, Riebeling C, Pirow R, Oelgeschläger M, Seiler A, Liebsch M, Luch A.

Environ Health Perspect. 2012 Nov;120(11):1489-94. doi: 10.1289/ehp.1104782. Epub 2012 Aug 7.


Drug-mediated toxicity: illuminating the 'bad' in the test tube by means of cellular assays?

Tralau T, Luch A.

Trends Pharmacol Sci. 2012 Jul;33(7):353-64. doi: 10.1016/ Epub 2012 May 1. Review.


Developmental toxicity testing in the 21st century: the sword of Damocles shattered by embryonic stem cell assays?

Seiler A, Oelgeschläger M, Liebsch M, Pirow R, Riebeling C, Tralau T, Luch A.

Arch Toxicol. 2011 Nov;85(11):1361-72. doi: 10.1007/s00204-011-0767-1. Epub 2011 Oct 19. Review.


Allergic contact dermatitis: epidemiology, molecular mechanisms, in vitro methods and regulatory aspects. Current knowledge assembled at an international workshop at BfR, Germany.

Peiser M, Tralau T, Heidler J, Api AM, Arts JH, Basketter DA, English J, Diepgen TL, Fuhlbrigge RC, Gaspari AA, Johansen JD, Karlberg AT, Kimber I, Lepoittevin JP, Liebsch M, Maibach HI, Martin SF, Merk HF, Platzek T, Rustemeyer T, Schnuch A, Vandebriel RJ, White IR, Luch A.

Cell Mol Life Sci. 2012 Mar;69(5):763-81. doi: 10.1007/s00018-011-0846-8. Epub 2011 Oct 14. Review.


Chemical toxicity testing in vitro using cytochrome P450-expressing cell lines, such as human CYP1B1.

Landsiedel R, Fabian E, Tralau T, Luch A.

Nat Protoc. 2011 May;6(5):677-87. doi: 10.1038/nprot.2011.316. Epub 2011 Apr 28.


Why two are not enough: degradation of p-toluenesulfonate by a bacterial community from a pristine site in Moorea, French Polynesia.

Tralau T, Yang EC, Tralau C, Cook AM, Küpper FC.

FEMS Microbiol Lett. 2011 Mar;316(2):123-9. doi: 10.1111/j.1574-6968.2010.02207.x. Epub 2011 Jan 24.


Structural studies on the full-length LysR-type regulator TsaR from Comamonas testosteroni T-2 reveal a novel open conformation of the tetrameric LTTR fold.

Monferrer D, Tralau T, Kertesz MA, Dix I, Solà M, Usón I.

Mol Microbiol. 2010 Mar;75(5):1199-214. doi: 10.1111/j.1365-2958.2010.07043.x. Epub 2010 Jan 5.


An internal reaction chamber in dimethylglycine oxidase provides efficient protection from exposure to toxic formaldehyde.

Tralau T, Lafite P, Levy C, Combe JP, Scrutton NS, Leys D.

J Biol Chem. 2009 Jun 26;284(26):17826-34. doi: 10.1074/jbc.M109.006262. Epub 2009 Apr 15.


High crystallizability under air-exclusion conditions of the full-length LysR-type transcriptional regulator TsaR from Comamonas testosteroni T-2 and data-set analysis for a MIRAS structure-solution approach.

Monferrer D, Tralau T, Kertesz MA, Panjikar S, Usón I.

Acta Crystallogr Sect F Struct Biol Cryst Commun. 2008 Aug 1;64(Pt 8):764-9. doi: 10.1107/S1744309108019738. Epub 2008 Jul 31.


Transcriptomic analysis of the sulfate starvation response of Pseudomonas aeruginosa.

Tralau T, Vuilleumier S, Thibault C, Campbell BJ, Hart CA, Kertesz MA.

J Bacteriol. 2007 Oct;189(19):6743-50. Epub 2007 Aug 3.


Circadian rhythmicity during prolonged chemostat cultivation of Neurospora crassa.

Tralau T, Lanthaler K, Robson GD, Crosthwaite SK.

Fungal Genet Biol. 2007 Aug;44(8):754-63. Epub 2006 Dec 29.


Congenital nephrosis, mesangial sclerosis, and distinct eye abnormalities with microcoria: an autosomal recessive syndrome.

Zenker M, Tralau T, Lennert T, Pitz S, Mark K, Madlon H, Dötsch J, Reis A, Müntefering H, Neumann LM.

Am J Med Genet A. 2004 Oct 1;130A(2):138-45. Review.


Human laminin beta2 deficiency causes congenital nephrosis with mesangial sclerosis and distinct eye abnormalities.

Zenker M, Aigner T, Wendler O, Tralau T, Müntefering H, Fenski R, Pitz S, Schumacher V, Royer-Pokora B, Wühl E, Cochat P, Bouvier R, Kraus C, Mark K, Madlon H, Dötsch J, Rascher W, Maruniak-Chudek I, Lennert T, Neumann LM, Reis A.

Hum Mol Genet. 2004 Nov 1;13(21):2625-32. Epub 2004 Sep 14.


Human leukocyte elastase and cathepsin G are specific inhibitors of C5a-dependent neutrophil enzyme release and chemotaxis.

Tralau T, Meyer-Hoffert U, Schröder JM, Wiedow O.

Exp Dermatol. 2004 May;13(5):316-25.


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