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Items: 1 to 50 of 100

1.

Baseline IL22 expression in atopic dermatitis patients stratifies tissue responses to fezakinumab.

Brunner PM, Pavel AB, Khattri S, Leonard A, Malik K, Rose S, On SJ, Vekaria AS, Traidl-Hoffmann C, Singer GK, Baum D, Gilleaudeau P, Sullivan-Whalen M, Fuentes-Duculan J, Li X, Zheng X, Estrada Y, Garcet S, Wen HC, Gonzalez J, Coats I, Cueto I, Neumann AU, Lebwohl MG, Krueger JG, Guttman-Yassky E.

J Allergy Clin Immunol. 2018 Aug 16. pii: S0091-6749(18)31141-2. doi: 10.1016/j.jaci.2018.07.028. [Epub ahead of print]

PMID:
30121291
2.

The role of environmental factors in allergy: A critical reappraisal.

Gilles S, Akdis C, Lauener R, Schmid-Grendelmeier P, Bieber T, Schäppi G, Traidl-Hoffmann C.

Exp Dermatol. 2018 Aug 12. doi: 10.1111/exd.13769. [Epub ahead of print] Review.

PMID:
30099779
3.

Relations between epidermal barrier dysregulation and staphylococci-dominated microbiome dysbiosis in atopic dermatitis.

Altunbulakli C, Reiger M, Neumann AU, Garzorz-Stark N, Fleming M, Huelpuesch C, Castro-Giner F, Eyerich K, Akdis CA, Traidl-Hoffmann C.

J Allergy Clin Immunol. 2018 Jul 23. pii: S0091-6749(18)31053-4. doi: 10.1016/j.jaci.2018.07.005. [Epub ahead of print] No abstract available.

PMID:
30048670
4.

Artemisia pollen is the main vector for airborne endotoxin.

Oteros J, Bartusel E, Alessandrini F, Núñez A, Moreno DA, Behrendt H, Schmidt-Weber C, Traidl-Hoffmann C, Buters J.

J Allergy Clin Immunol. 2018 Aug 9. pii: S0091-6749(18)30999-0. doi: 10.1016/j.jaci.2018.05.040. [Epub ahead of print]

PMID:
30012513
5.

[The significance of climate and environment protection for health under special consideration of skin barrier damages and allergic sequelae].

Heuson C, Traidl-Hoffmann C.

Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz. 2018 Jun;61(6):684-696. doi: 10.1007/s00103-018-2742-y. Review. German.

PMID:
29789892
6.

Context matters: TH2 polarization resulting from pollen composition and not from protein-intrinsic allergenicity.

Aglas L, Gilles S, Bauer R, Huber S, Araujo GR, Mueller G, Scheiblhofer S, Amisi M, Dang HH, Briza P, Bohle B, Horejs-Hoeck J, Traidl-Hoffmann C, Ferreira F.

J Allergy Clin Immunol. 2018 May 18. pii: S0091-6749(18)30711-5. doi: 10.1016/j.jaci.2018.05.004. [Epub ahead of print] No abstract available.

7.

Cutaneous Barriers and Skin Immunity: Differentiating A Connected Network.

Eyerich S, Eyerich K, Traidl-Hoffmann C, Biedermann T.

Trends Immunol. 2018 Apr;39(4):315-327. doi: 10.1016/j.it.2018.02.004. Epub 2018 Mar 15. Review.

PMID:
29551468
8.

Efficacy and safety of fezakinumab (an IL-22 monoclonal antibody) in adults with moderate-to-severe atopic dermatitis inadequately controlled by conventional treatments: A randomized, double-blind, phase 2a trial.

Guttman-Yassky E, Brunner PM, Neumann AU, Khattri S, Pavel AB, Malik K, Singer GK, Baum D, Gilleaudeau P, Sullivan-Whalen M, Rose S, Jim On S, Li X, Fuentes-Duculan J, Estrada Y, Garcet S, Traidl-Hoffmann C, Krueger JG, Lebwohl MG.

J Am Acad Dermatol. 2018 May;78(5):872-881.e6. doi: 10.1016/j.jaad.2018.01.016. Epub 2018 Jan 17.

9.

STAT1 Gain-of-Function and Dominant Negative STAT3 Mutations Impair IL-17 and IL-22 Immunity Associated with CMC.

Hiller J, Hagl B, Effner R, Puel A, Schaller M, Mascher B, Eyerich S, Eyerich K, Jansson AF, Ring J, Casanova JL, Renner ED, Traidl-Hoffmann C.

J Invest Dermatol. 2018 Mar;138(3):711-714. doi: 10.1016/j.jid.2017.09.035. Epub 2017 Oct 18. No abstract available.

PMID:
29054602
10.

Perception of climate change in patients with chronic lung disease.

Götschke J, Mertsch P, Bischof M, Kneidinger N, Matthes S, Renner ED, Schultz K, Traidl-Hoffmann C, Duchna HW, Behr J, Schmude J, Huber RM, Milger K.

PLoS One. 2017 Oct 18;12(10):e0186632. doi: 10.1371/journal.pone.0186632. eCollection 2017.

11.

Lung function improvement and airways inflammation reduction in asthmatic children after a rehabilitation program at moderate altitude.

Bersuch E, Gräf F, Renner ED, Jung A, Traidl-Hoffmann C, Lauener R, Roduit C.

Pediatr Allergy Immunol. 2017 Dec;28(8):768-775. doi: 10.1111/pai.12808. Epub 2017 Nov 2.

PMID:
28981975
12.

Pro-Inflammatory versus Immunomodulatory Effects of Silver Nanoparticles in the Lung: The Critical Role of Dose, Size and Surface Modification.

Alessandrini F, Vennemann A, Gschwendtner S, Neumann AU, Rothballer M, Seher T, Wimmer M, Kublik S, Traidl-Hoffmann C, Schloter M, Wiemann M, Schmidt-Weber CB.

Nanomaterials (Basel). 2017 Sep 29;7(10). pii: E300. doi: 10.3390/nano7100300.

13.

Toll-like receptor 7/8 agonists stimulate plasmacytoid dendritic cells to initiate TH17-deviated acute contact dermatitis in human subjects.

Garzorz-Stark N, Lauffer F, Krause L, Thomas J, Atenhan A, Franz R, Roenneberg S, Boehner A, Jargosch M, Batra R, Mueller NS, Haak S, Groß C, Groß O, Traidl-Hoffmann C, Theis FJ, Schmidt-Weber CB, Biedermann T, Eyerich S, Eyerich K.

J Allergy Clin Immunol. 2018 Apr;141(4):1320-1333.e11. doi: 10.1016/j.jaci.2017.07.045. Epub 2017 Sep 19.

14.

When does atopic dermatitis warrant systemic therapy? Recommendations from an expert panel of the International Eczema Council.

Simpson EL, Bruin-Weller M, Flohr C, Ardern-Jones MR, Barbarot S, Deleuran M, Bieber T, Vestergaard C, Brown SJ, Cork MJ, Drucker AM, Eichenfield LF, Foelster-Holst R, Guttman-Yassky E, Nosbaum A, Reynolds NJ, Silverberg JI, Schmitt J, Seyger MMB, Spuls PI, Stalder JF, Su JC, Takaoka R, Traidl-Hoffmann C, Thyssen JP, van der Schaft J, Wollenberg A, Irvine AD, Paller AS.

J Am Acad Dermatol. 2017 Oct;77(4):623-633. doi: 10.1016/j.jaad.2017.06.042. Epub 2017 Aug 10.

15.

Primary skin manifestation of plasmoblastic lymphoma in an AIDS patient with long-term survival.

Todorova A, Zink A, Spinner CD, Schielein M, Vogelmann R, Weirich G, Rudelius M, Andres C, Traidl-Hoffmann C.

J Eur Acad Dermatol Venereol. 2017 Oct;31(10):e428-e429. doi: 10.1111/jdv.14323. Epub 2017 Jul 3. No abstract available.

PMID:
28499061
16.

[Allergy - an environmental disease].

Traidl-Hoffmann C.

Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz. 2017 Jun;60(6):584-591. doi: 10.1007/s00103-017-2547-4. Review. German.

PMID:
28466132
17.

Clinical phenotypes and endophenotypes of atopic dermatitis: Where are we, and where should we go?

Bieber T, D'Erme AM, Akdis CA, Traidl-Hoffmann C, Lauener R, Schäppi G, Schmid-Grendelmeier P.

J Allergy Clin Immunol. 2017 Apr;139(4S):S58-S64. doi: 10.1016/j.jaci.2017.01.008.

18.

Estimating the abundance of airborne pollen and fungal spores at variable elevations using an aircraft: how high can they fly?

Damialis A, Kaimakamis E, Konoglou M, Akritidis I, Traidl-Hoffmann C, Gioulekas D.

Sci Rep. 2017 Mar 16;7:44535. doi: 10.1038/srep44535.

19.

Pollen of common ragweed (Ambrosia artemisiifolia L.): Illumina-based de novo sequencing and differential transcript expression upon elevated NO2/O3.

Zhao F, Durner J, Winkler JB, Traidl-Hoffmann C, Strom TM, Ernst D, Frank U.

Environ Pollut. 2017 May;224:503-514. doi: 10.1016/j.envpol.2017.02.032. Epub 2017 Mar 8.

PMID:
28284545
20.

Cytochrome P450s in human immune cells regulate IL-22 and c-Kit via an AHR feedback loop.

Effner R, Hiller J, Eyerich S, Traidl-Hoffmann C, Brockow K, Triggiani M, Behrendt H, Schmidt-Weber CB, Buters JT.

Sci Rep. 2017 Mar 9;7:44005. doi: 10.1038/srep44005.

21.

Anti-inflammatory effects of the petasin phyto drug Ze339 are mediated by inhibition of the STAT pathway.

Steiert SA, Zissler UM, Chaker AM, Esser-von-Bieren J, Dittlein D, Guerth F, Jakwerth CA, Piontek G, Zahner C, Drewe J, Traidl-Hoffmann C, Schmidt-Weber CB, Gilles S.

Biofactors. 2017 May 6;43(3):388-399. doi: 10.1002/biof.1349. Epub 2017 Jan 31.

PMID:
28139053
22.

Performing Skin Microbiome Research: A Method to the Madness.

Kong HH, Andersson B, Clavel T, Common JE, Jackson SA, Olson ND, Segre JA, Traidl-Hoffmann C.

J Invest Dermatol. 2017 Mar;137(3):561-568. doi: 10.1016/j.jid.2016.10.033. Epub 2017 Jan 4. Review.

23.

Pollen and UV-B radiation strongly affect the inflammasome response in human primary keratinocytes.

Dittlein DC, Gilles-Stein S, Hiller J, Beck I, Overbeek SA, Durner J, Ernst D, Frank U, Groß O, Traidl-Hoffmann C.

Exp Dermatol. 2016 Dec;25(12):991-993. doi: 10.1111/exd.13120. Epub 2016 Nov 3. No abstract available.

PMID:
27306558
24.

K+ Efflux-Independent NLRP3 Inflammasome Activation by Small Molecules Targeting Mitochondria.

Groß CJ, Mishra R, Schneider KS, Médard G, Wettmarshausen J, Dittlein DC, Shi H, Gorka O, Koenig PA, Fromm S, Magnani G, Ćiković T, Hartjes L, Smollich J, Robertson AAB, Cooper MA, Schmidt-Supprian M, Schuster M, Schroder K, Broz P, Traidl-Hoffmann C, Beutler B, Kuster B, Ruland J, Schneider S, Perocchi F, Groß O.

Immunity. 2016 Oct 18;45(4):761-773. doi: 10.1016/j.immuni.2016.08.010. Epub 2016 Sep 27.

25.

Phytotherapie in der Dermatologie - natürlich gut?!

Traidl-Hoffmann C.

J Dtsch Dermatol Ges. 2016 Sep;14(9):867-9. doi: 10.1111/ddg.13123. No abstract available.

PMID:
27607026
26.

Cellular and molecular immunologic mechanisms in patients with atopic dermatitis.

Werfel T, Allam JP, Biedermann T, Eyerich K, Gilles S, Guttman-Yassky E, Hoetzenecker W, Knol E, Simon HU, Wollenberg A, Bieber T, Lauener R, Schmid-Grendelmeier P, Traidl-Hoffmann C, Akdis CA.

J Allergy Clin Immunol. 2016 Aug;138(2):336-49. doi: 10.1016/j.jaci.2016.06.010. Review.

PMID:
27497276
27.

Heterozygous STAT1 gain-of-function mutations underlie an unexpectedly broad clinical phenotype.

Toubiana J, Okada S, Hiller J, Oleastro M, Lagos Gomez M, Aldave Becerra JC, Ouachée-Chardin M, Fouyssac F, Girisha KM, Etzioni A, Van Montfrans J, Camcioglu Y, Kerns LA, Belohradsky B, Blanche S, Bousfiha A, Rodriguez-Gallego C, Meyts I, Kisand K, Reichenbach J, Renner ED, Rosenzweig S, Grimbacher B, van de Veerdonk FL, Traidl-Hoffmann C, Picard C, Marodi L, Morio T, Kobayashi M, Lilic D, Milner JD, Holland S, Casanova JL, Puel A; International STAT1 Gain-of-Function Study Group.

Blood. 2016 Jun 23;127(25):3154-64. doi: 10.1182/blood-2015-11-679902. Epub 2016 Apr 25.

28.

Pollen derived low molecular compounds enhance the human allergen specific immune response in vivo.

Gilles-Stein S, Beck I, Chaker A, Bas M, McIntyre M, Cifuentes L, Petersen A, Gutermuth J, Schmidt-Weber C, Behrendt H, Traidl-Hoffmann C.

Clin Exp Allergy. 2016 Oct;46(10):1355-65. doi: 10.1111/cea.12739. Epub 2016 May 18.

PMID:
27061126
29.

Global Allergy Forum and 3rd Davos Declaration 2015: Atopic dermatitis/Eczema: challenges and opportunities toward precision medicine.

Bieber T, Akdis C, Lauener R, Traidl-Hoffmann C, Schmid-Grendelmeier P, Schäppi G, Allam JP, Apfelbacher C, Augustin M, Beck L, Biedermann T, Braun-Fahrländer C, Chew FT, Clavel T, Crameri R, Darsow U, Deleuran M, Dittlein D, Duchna HW, Eichenfeld L, Eyerich K, Frei R, Gelmetti C, Gieler U, Gilles S, Glatz M, Grando K, Green J, Gutermuth J, Guttman-Yassky E, Hanifin J, Hijnen D, Hoetzenecker W, Irvine A, Kalweit A, Katoh N, Knol E, Koren H, Möhrenschlager M, Münch D, Novak N, O'Mahony L, Paller AS, Rhyner C, Roduit C, Schiesser K, Schröder J, Simon D, Simon HU, Sokolowska M, Spuls P, Stalder JF, Straub D, Szalai Z, Taieb A, Takaoka R, Todd G, Todorova A, Vestergaard C, Werfel T, Wollenberg A, Ring J.

Allergy. 2016 May;71(5):588-92. doi: 10.1111/all.12857. Epub 2016 Mar 8. No abstract available.

PMID:
27023268
30.

Pollen-Associated Microbiome Correlates with Pollution Parameters and the Allergenicity of Pollen.

Obersteiner A, Gilles S, Frank U, Beck I, Häring F, Ernst D, Rothballer M, Hartmann A, Traidl-Hoffmann C, Schmid M.

PLoS One. 2016 Feb 24;11(2):e0149545. doi: 10.1371/journal.pone.0149545. eCollection 2016.

31.

Canakinumab in adults with steroid-refractory pyoderma gangrenosum.

Kolios AG, Maul JT, Meier B, Kerl K, Traidl-Hoffmann C, Hertl M, Zillikens D, Röcken M, Ring J, Facchiano A, Mondino C, Yawalkar N, Contassot E, Navarini AA, French LE.

Br J Dermatol. 2015 Nov;173(5):1216-23. doi: 10.1111/bjd.14037. Epub 2015 Oct 16.

32.

Low molecular weight components of pollen alter bronchial epithelial barrier functions.

Blume C, Swindle EJ, Gilles S, Traidl-Hoffmann C, Davies DE.

Tissue Barriers. 2015 Jul 15;3(3):e1062316. doi: 10.1080/15476286.2015.1062316. eCollection 2015 Jul-Sep.

33.

Automatic and Online Pollen Monitoring.

Oteros J, Pusch G, Weichenmeier I, Heimann U, Möller R, Röseler S, Traidl-Hoffmann C, Schmidt-Weber C, Buters JT.

Int Arch Allergy Immunol. 2015;167(3):158-66. doi: 10.1159/000436968. Epub 2015 Aug 19.

34.

The effects of short- and long-term air pollutants on plant phenology and leaf characteristics.

Jochner S, Markevych I, Beck I, Traidl-Hoffmann C, Heinrich J, Menzel A.

Environ Pollut. 2015 Nov;206:382-9. doi: 10.1016/j.envpol.2015.07.040. Epub 2015 Aug 4.

PMID:
26253312
35.

Pollen-derived nonallergenic substances enhance Th2-induced IgE production in B cells.

Oeder S, Alessandrini F, Wirz OF, Braun A, Wimmer M, Frank U, Hauser M, Durner J, Ferreira F, Ernst D, Mempel M, Gilles S, Buters JT, Behrendt H, Traidl-Hoffmann C, Schmidt-Weber C, Akdis M, Gutermuth J.

Allergy. 2015 Nov;70(11):1450-60. doi: 10.1111/all.12707. Epub 2015 Aug 28.

PMID:
26214762
36.

Common ragweed (Ambrosia artemisiifolia L.): allergenicity and molecular characterization of pollen after plant exposure to elevated NO2.

Zhao F, Elkelish A, Durner J, Lindermayr C, Winkler JB, Ruёff F, Behrendt H, Traidl-Hoffmann C, Holzinger A, Kofler W, Braun P, von Toerne C, Hauck SM, Ernst D, Frank U.

Plant Cell Environ. 2016 Jan;39(1):147-64. doi: 10.1111/pce.12601. Epub 2015 Sep 19.

PMID:
26177592
37.

Green tea in dermatology--myths and facts.

Zink A, Traidl-Hoffmann C.

J Dtsch Dermatol Ges. 2015 Aug;13(8):768-75. doi: 10.1111/ddg.12737. Epub 2015 Jul 14. Review.

PMID:
26177066
38.

In Vitro Evidence for Immune-Modulatory Properties of Non-Digestible Oligosaccharides: Direct Effect on Human Monocyte Derived Dendritic Cells.

Lehmann S, Hiller J, van Bergenhenegouwen J, Knippels LM, Garssen J, Traidl-Hoffmann C.

PLoS One. 2015 Jul 6;10(7):e0132304. doi: 10.1371/journal.pone.0132304. eCollection 2015.

39.

Particulate matter from both heavy fuel oil and diesel fuel shipping emissions show strong biological effects on human lung cells at realistic and comparable in vitro exposure conditions.

Oeder S, Kanashova T, Sippula O, Sapcariu SC, Streibel T, Arteaga-Salas JM, Passig J, Dilger M, Paur HR, Schlager C, Mülhopt S, Diabaté S, Weiss C, Stengel B, Rabe R, Harndorf H, Torvela T, Jokiniemi JK, Hirvonen MR, Schmidt-Weber C, Traidl-Hoffmann C, BéruBé KA, Wlodarczyk AJ, Prytherch Z, Michalke B, Krebs T, Prévôt AS, Kelbg M, Tiggesbäumker J, Karg E, Jakobi G, Scholtes S, Schnelle-Kreis J, Lintelmann J, Matuschek G, Sklorz M, Klingbeil S, Orasche J, Richthammer P, Müller L, Elsasser M, Reda A, Gröger T, Weggler B, Schwemer T, Czech H, Rüger CP, Abbaszade G, Radischat C, Hiller K, Buters JT, Dittmar G, Zimmermann R.

PLoS One. 2015 Jun 3;10(6):e0126536. doi: 10.1371/journal.pone.0126536. eCollection 2015.

40.

Pollen-derived adenosine is a necessary cofactor for ragweed allergy.

Wimmer M, Alessandrini F, Gilles S, Frank U, Oeder S, Hauser M, Ring J, Ferreira F, Ernst D, Winkler JB, Schmitt-Kopplin P, Ohnmacht C, Behrendt H, Schmidt-Weber C, Traidl-Hoffmann C, Gutermuth J.

Allergy. 2015 Aug;70(8):944-54. doi: 10.1111/all.12642. Epub 2015 May 28.

PMID:
25939785
41.

Non-allergenic factors from pollen modulate T helper cell instructing notch ligands on dendritic cells.

Gilles S, Beck I, Lange S, Ring J, Behrendt H, Traidl-Hoffmann C.

World Allergy Organ J. 2015 Jan 20;8(1):2. doi: 10.1186/s40413-014-0054-8. eCollection 2015.

42.

Ambrosia artemisiifolia (ragweed) in Germany - current presence, allergological relevance and containment procedures.

Buters J, Alberternst B, Nawrath S, Wimmer M, Traidl-Hoffmann C, Starfinger U, Behrendt H, Schmidt-Weber C, Bergmann KC.

Allergo J Int. 2015;24:108-120. Epub 2015 Jul 11. Review.

43.

[The Working Group on Allergology in the DDG].

Traidl-Hoffmann C, Treudler R, Pryzbilla B, Kapp A, Zuberbier T, Werfel T.

J Dtsch Dermatol Ges. 2014 Nov;12 Suppl 4:46-8. doi: 10.1111/ddg.12485. German. No abstract available.

PMID:
25366449
44.

Outbreak of Microsporum audouinii in Munich--the return of infectious fungi in Germany.

Zink A, Papanagiotou V, Todorova A, Seidl HP, Niedermeier A, Ring J, Traidl-Hoffmann C.

Mycoses. 2014 Dec;57(12):765-70. doi: 10.1111/myc.12242. Epub 2014 Sep 1.

PMID:
25175409
45.

Acute transverse myelitis and psoriasiform dermatitis associated with Sjoegren's syndrome: a case report.

Kurz C, Wunderlich S, Spieler D, Schwaiger BJ, Andres C, Traidl-Hoffmann C, Ilg R.

BMC Res Notes. 2014 Aug 29;7:580. doi: 10.1186/1756-0500-7-580.

46.

Regulatory T cells and immune regulation of allergic diseases: roles of IL-10 and TGF-β.

Palomares O, Martín-Fontecha M, Lauener R, Traidl-Hoffmann C, Cavkaytar O, Akdis M, Akdis CA.

Genes Immun. 2014 Dec;15(8):511-20. doi: 10.1038/gene.2014.45. Epub 2014 Jul 24. Review.

PMID:
25056447
47.

Global Allergy Forum and Second Davos Declaration 2013 Allergy: Barriers to cure--challenges and actions to be taken.

Ring J, Akdis C, Lauener R, Schäppi G, Traidl-Hoffmann C, Akdis M, Ammann W, Behrendt H, Bieber T, Biedermann T, Bienenstock J, Blaser K, Braun-Fahrländer C, Brockow K, Buters J, Crameri R, Darsow U, Denburg JA, Eyerich K, Frei R, Galli SJ, Gutermuth J, Holt P, Koren H, Leung D, Müller U, Muraro A, Ollert M, O'Mahony L, Pawankar R, Platts-Mills T, Rhyner C, Rosenwasser LJ, Schmid-Grendelmeier P, Schmidt-Weber CB, Schmutz W, Simon D, Simon HU, Sofiev M, van Hage M, van Ree R.

Allergy. 2014 Aug;69(8):978-82. doi: 10.1111/all.12406. No abstract available.

PMID:
25041525
48.

Intraindividual genome expression analysis reveals a specific molecular signature of psoriasis and eczema.

Quaranta M, Knapp B, Garzorz N, Mattii M, Pullabhatla V, Pennino D, Andres C, Traidl-Hoffmann C, Cavani A, Theis FJ, Ring J, Schmidt-Weber CB, Eyerich S, Eyerich K.

Sci Transl Med. 2014 Jul 9;6(244):244ra90. doi: 10.1126/scitranslmed.3008946.

49.

Ragweed (Ambrosia artemisiifolia) pollen allergenicity: SuperSAGE transcriptomic analysis upon elevated CO2 and drought stress.

El Kelish A, Zhao F, Heller W, Durner J, Winkler JB, Behrendt H, Traidl-Hoffmann C, Horres R, Pfeifer M, Frank U, Ernst D.

BMC Plant Biol. 2014 Jun 27;14:176. doi: 10.1186/1471-2229-14-176.

50.

The environment-pathogen-host axis in communicable and non-communicable diseases: recent advances in experimental and clinical research.

Gilles S, Traidl-Hoffmann C.

J Dtsch Dermatol Ges. 2014 May;12(5):395-9. doi: 10.1111/ddg.12345. Review.

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