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Items: 46

1.

Inhibitory killer cell immunoglobulin-like receptors strengthen CD8+ T cell-mediated control of HIV-1, HCV, and HTLV-1.

Boelen L, Debebe B, Silveira M, Salam A, Makinde J, Roberts CH, Wang ECY, Frater J, Gilmour J, Twigger K, Ladell K, Miners KL, Jayaraman J, Traherne JA, Price DA, Qi Y, Martin MP, Macallan DC, Thio CL, Astemborski J, Kirk G, Donfield SM, Buchbinder S, Khakoo SI, Goedert JJ, Trowsdale J, Carrington M, Kollnberger S, Asquith B.

Sci Immunol. 2018 Nov 9;3(29). pii: eaao2892. doi: 10.1126/sciimmunol.aao2892.

PMID:
30413420
2.

A novel antibody combination to identify KIR2DS2high NK cells in KIR2DL3/L2/S2 heterozygous donors.

Blunt MD, Rettman P, Bastidas-Legarda LY, Fulton R, Capizzuto V, Naiyer MM, Traherne JA, Khakoo SI.

HLA. 2018 Nov 1. doi: 10.1111/tan.13413. [Epub ahead of print]

PMID:
30381896
3.

Report from the Killer-cell Immunoglobulin-like Receptors (KIR) component of the 17th International HLA and Immunogenetics Workshop.

Misra MK, Augusto DG, Martin GM, Nemat-Gorgani N, Sauter J, Hofmann JA, Traherne JA, González-Quezada B, Gorodezky C, Bultitude WP, Marin W, Vierra-Green C, Anderson KM, Balas A, Caro-Oleas JL, Cisneros E, Colucci F, Dandekar R, Elfishawi SM, Fernández-Viña MA, Fouda M, González-Fernández R, Große A, Herrero-Mata MJ, Hollenbach SQ, Marsh SGE, Mentzer A, Middleton D, Moffett A, Moreno-Hidalgo MA, Mossallam GI, Nakimuli A, Oksenberg JR, Oppenheimer SJ, Parham P, Petzl-Erler ML, Planelles D, Sánchez-García F, Sánchez-Gordo F, Schmidt AH, Trowsdale J, Vargas LB, Vicario JL, Vilches C, Norman PJ, Hollenbach JA.

Hum Immunol. 2018 Dec;79(12):825-833. doi: 10.1016/j.humimm.2018.10.003. Epub 2018 Oct 12. Review.

PMID:
30321631
4.

High-Resolution Genetic and Phenotypic Analysis of KIR2DL1 Alleles and Their Association with Pre-Eclampsia.

Huhn O, Chazara O, Ivarsson MA, Retière C, Venkatesan TC, Norman PJ, Hilton HG, Jayaraman J, Traherne JA, Trowsdale J, Ito M, Kling C, Parham P, Ghadially H, Moffett A, Sharkey AM, Colucci F.

J Immunol. 2018 Nov 1;201(9):2593-2601. doi: 10.4049/jimmunol.1800860. Epub 2018 Sep 24.

PMID:
30249807
5.

Novel KIR genotypes and gene copy number variations in northeastern Thais.

Chaisri S, Traherne JA, Jayaraman J, Romphruk A, Trowsdale J, Leelayuwat C.

Immunology. 2018 Mar;153(3):380-386. doi: 10.1111/imm.12847. Epub 2017 Oct 23.

PMID:
28950036
6.

Genome-wide association study identifies distinct genetic contributions to prognosis and susceptibility in Crohn's disease.

Lee JC, Biasci D, Roberts R, Gearry RB, Mansfield JC, Ahmad T, Prescott NJ, Satsangi J, Wilson DC, Jostins L, Anderson CA; UK IBD Genetics Consortium, Traherne JA, Lyons PA, Parkes M, Smith KG.

Nat Genet. 2017 Feb;49(2):262-268. doi: 10.1038/ng.3755. Epub 2017 Jan 9.

7.

Deciphering the killer-cell immunoglobulin-like receptor system at super-resolution for natural killer and T-cell biology.

Béziat V, Hilton HG, Norman PJ, Traherne JA.

Immunology. 2017 Mar;150(3):248-264. doi: 10.1111/imm.12684. Epub 2016 Dec 14. Review.

8.

qKAT: a high-throughput qPCR method for KIR gene copy number and haplotype determination.

Jiang W, Johnson C, Simecek N, López-Álvarez MR, Di D, Trowsdale J, Traherne JA.

Genome Med. 2016 Sep 29;8(1):99.

9.

Defining KIR and HLA Class I Genotypes at Highest Resolution via High-Throughput Sequencing.

Norman PJ, Hollenbach JA, Nemat-Gorgani N, Marin WM, Norberg SJ, Ashouri E, Jayaraman J, Wroblewski EE, Trowsdale J, Rajalingam R, Oksenberg JR, Chiaroni J, Guethlein LA, Traherne JA, Ronaghi M, Parham P.

Am J Hum Genet. 2016 Aug 4;99(2):375-91. doi: 10.1016/j.ajhg.2016.06.023.

10.

LILRA6 copy number variation correlates with susceptibility to atopic dermatitis.

López-Álvarez MR, Jiang W, Jones DC, Jayaraman J, Johnson C, Cookson WO, Moffatt MF, Trowsdale J, Traherne JA.

Immunogenetics. 2016 Oct;68(9):743-7. doi: 10.1007/s00251-016-0924-z. Epub 2016 Jun 22.

11.

Critical Role of CD2 Co-stimulation in Adaptive Natural Killer Cell Responses Revealed in NKG2C-Deficient Humans.

Liu LL, Landskron J, Ask EH, Enqvist M, Sohlberg E, Traherne JA, Hammer Q, Goodridge JP, Larsson S, Jayaraman J, Oei VYS, Schaffer M, Taskén K, Ljunggren HG, Romagnani C, Trowsdale J, Malmberg KJ, Béziat V.

Cell Rep. 2016 May 3;15(5):1088-1099. doi: 10.1016/j.celrep.2016.04.005. Epub 2016 Apr 21.

12.

STAT4-associated natural killer cell tolerance following liver transplantation.

Jamil KM, Hydes TJ, Cheent KS, Cassidy SA, Traherne JA, Jayaraman J, Trowsdale J, Alexander GJ, Little AM, McFarlane H, Heneghan MA, Purbhoo MA, Khakoo SI.

Gut. 2017 Feb;66(2):352-361. doi: 10.1136/gutjnl-2015-309395. Epub 2016 Feb 17.

13.

KIR haplotypes are associated with late-onset type 1 diabetes in European-American families.

Traherne JA, Jiang W, Valdes AM, Hollenbach JA, Jayaraman J, Lane JA, Johnson C, Trowsdale J, Noble JA.

Genes Immun. 2016 Jan-Feb;17(1):8-12. doi: 10.1038/gene.2015.44. Epub 2015 Oct 22.

14.

Imputation of KIR Types from SNP Variation Data.

Vukcevic D, Traherne JA, Næss S, Ellinghaus E, Kamatani Y, Dilthey A, Lathrop M, Karlsen TH, Franke A, Moffatt M, Cookson W, Trowsdale J, McVean G, Sawcer S, Leslie S.

Am J Hum Genet. 2015 Oct 1;97(4):593-607. doi: 10.1016/j.ajhg.2015.09.005.

15.

The interaction of genetic determinants in the outcome of HCV infection: evidence for discrete immunological pathways.

Hydes TJ, Moesker B, Traherne JA, Ashraf S, Alexander GJ, Dimitrov BD, Woelk CH, Trowsdale J, Khakoo SI.

Tissue Antigens. 2015 Oct;86(4):267-75. doi: 10.1111/tan.12650.

16.

Surveillance of cell and tissue perturbation by receptors in the LRC.

Trowsdale J, Jones DC, Barrow AD, Traherne JA.

Immunol Rev. 2015 Sep;267(1):117-36. doi: 10.1111/imr.12314. Review.

PMID:
26284474
17.

2DL1, 2DL2 and 2DL3 all contribute to KIR phenotype variability on human NK cells.

Dunphy SE, Guinan KJ, Chorcora CN, Jayaraman J, Traherne JA, Trowsdale J, Pende D, Middleton D, Gardiner CM.

Genes Immun. 2015 Jul-Aug;16(5):301-10. doi: 10.1038/gene.2015.15. Epub 2015 May 7.

PMID:
25950617
18.

A KIR B centromeric region present in Africans but not Europeans protects pregnant women from pre-eclampsia.

Nakimuli A, Chazara O, Hiby SE, Farrell L, Tukwasibwe S, Jayaraman J, Traherne JA, Trowsdale J, Colucci F, Lougee E, Vaughan RW, Elliott AM, Byamugisha J, Kaleebu P, Mirembe F, Nemat-Gorgani N, Parham P, Norman PJ, Moffett A.

Proc Natl Acad Sci U S A. 2015 Jan 20;112(3):845-50. doi: 10.1073/pnas.1413453112. Epub 2015 Jan 5.

19.

High-density mapping of the MHC identifies a shared role for HLA-DRB1*01:03 in inflammatory bowel diseases and heterozygous advantage in ulcerative colitis.

Goyette P, Boucher G, Mallon D, Ellinghaus E, Jostins L, Huang H, Ripke S, Gusareva ES, Annese V, Hauser SL, Oksenberg JR, Thomsen I, Leslie S; International Inflammatory Bowel Disease Genetics Consortium; Australia and New Zealand IBDGC; Belgium IBD Genetics Consortium; Italian Group for IBD Genetic Consortium; NIDDK Inflammatory Bowel Disease Genetics Consortium; United Kingdom IBDGC; Wellcome Trust Case Control Consortium; Quebec IBD Genetics Consortium, Daly MJ, Van Steen K, Duerr RH, Barrett JC, McGovern DP, Schumm LP, Traherne JA, Carrington MN, Kosmoliaptsis V, Karlsen TH, Franke A, Rioux JD.

Nat Genet. 2015 Feb;47(2):172-9. doi: 10.1038/ng.3176. Epub 2015 Jan 5.

20.

Refinement of the MHC risk map in a scandinavian primary sclerosing cholangitis population.

Næss S, Lie BA, Melum E, Olsson M, Hov JR, Croucher PJ, Hampe J, Thorsby E, Bergquist A, Traherne JA, Schrumpf E, Boberg KM, Schreiber S, Franke A, Karlsen TH.

PLoS One. 2014 Dec 18;9(12):e114486. doi: 10.1371/journal.pone.0114486. eCollection 2014.

21.

Killer immunoglobulin-like receptor gene repertoire influences viral load of primary human cytomegalovirus infection in renal transplant patients.

Jones DC, Peacock S, Hughes D, Traherne JA, Allen RL, Barnardo MC, Friend P, Taylor CJ, Fuggle S, Trowsdale J, Young NT.

Genes Immun. 2014 Dec;15(8):562-8. doi: 10.1038/gene.2014.53. Epub 2014 Sep 25.

PMID:
25253288
22.

KIR diversity in Māori and Polynesians: populations in which HLA-B is not a significant KIR ligand.

Nemat-Gorgani N, Edinur HA, Hollenbach JA, Traherne JA, Dunn PP, Chambers GK, Parham P, Norman PJ.

Immunogenetics. 2014 Nov;66(11):597-611. doi: 10.1007/s00251-014-0794-1. Epub 2014 Aug 21.

23.

A hybrid qPCR/SNP array approach allows cost efficient assessment of KIR gene copy numbers in large samples.

Pontikos N, Smyth DJ, Schuilenburg H, Howson JM, Walker NM, Burren OS, Guo H, Onengut-Gumuscu S, Chen WM, Concannon P, Rich SS, Jayaraman J, Jiang W, Traherne JA, Trowsdale J, Todd JA, Wallace C.

BMC Genomics. 2014 Apr 11;15:274. doi: 10.1186/1471-2164-15-274.

24.

Killer-cell Immunoglobulin-like Receptor gene linkage and copy number variation analysis by droplet digital PCR.

Roberts CH, Jiang W, Jayaraman J, Trowsdale J, Holland MJ, Traherne JA.

Genome Med. 2014 Mar 5;6(3):20. doi: 10.1186/gm537. eCollection 2014.

25.

TAPBPR isoforms exhibit altered association with MHC class I.

Porter KM, Hermann C, Traherne JA, Boyle LH.

Immunology. 2014 Jun;142(2):289-99. doi: 10.1111/imm.12253.

26.

Copy number and nucleotide variation of the LILR family of myelomonocytic cell activating and inhibitory receptors.

López-Álvarez MR, Jones DC, Jiang W, Traherne JA, Trowsdale J.

Immunogenetics. 2014 Feb;66(2):73-83. doi: 10.1007/s00251-013-0742-5. Epub 2013 Nov 21.

27.

Killer cell immunoglobulin-like receptor (KIR) genes and their HLA-C ligands in a Ugandan population.

Nakimuli A, Chazara O, Farrell L, Hiby SE, Tukwasibwe S, Knee O, Jayaraman J, Traherne JA, Elliott AM, Kaleebu P, Mirembe F, Moffett A.

Immunogenetics. 2013 Nov;65(11):765-75. doi: 10.1007/s00251-013-0724-7. Epub 2013 Aug 24.

28.

Influence of KIR gene copy number on natural killer cell education.

Béziat V, Traherne JA, Liu LL, Jayaraman J, Enqvist M, Larsson S, Trowsdale J, Malmberg KJ.

Blood. 2013 Jun 6;121(23):4703-7. doi: 10.1182/blood-2012-10-461442. Epub 2013 May 1.

29.

Copy number variation leads to considerable diversity for B but not A haplotypes of the human KIR genes encoding NK cell receptors.

Jiang W, Johnson C, Jayaraman J, Simecek N, Noble J, Moffatt MF, Cookson WO, Trowsdale J, Traherne JA.

Genome Res. 2012 Oct;22(10):1845-54. doi: 10.1101/gr.137976.112. Epub 2012 Sep 4.

30.

Electrostatic modifications of the human leukocyte antigen-DR P9 peptide-binding pocket and susceptibility to primary sclerosing cholangitis.

Hov JR, Kosmoliaptsis V, Traherne JA, Olsson M, Boberg KM, Bergquist A, Schrumpf E, Bradley JA, Taylor CJ, Lie BA, Trowsdale J, Karlsen TH.

Hepatology. 2011 Jun;53(6):1967-76. doi: 10.1002/hep.24299. Epub 2011 May 13.

31.

Genetic variation, Fcγ receptors, KIRs and infection: the evolution of autoimmunity.

Espeli M, Niederer HA, Traherne JA, Trowsdale J, Smith KG.

Curr Opin Immunol. 2010 Dec;22(6):715-22. doi: 10.1016/j.coi.2010.10.003. Epub 2010 Nov 1. Review.

PMID:
21050737
32.

Mechanisms of copy number variation and hybrid gene formation in the KIR immune gene complex.

Traherne JA, Martin M, Ward R, Ohashi M, Pellett F, Gladman D, Middleton D, Carrington M, Trowsdale J.

Hum Mol Genet. 2010 Mar 1;19(5):737-51. doi: 10.1093/hmg/ddp538. Epub 2009 Dec 3.

33.

ULBP6/RAET1L is an additional human NKG2D ligand.

Eagle RA, Traherne JA, Hair JR, Jafferji I, Trowsdale J.

Eur J Immunol. 2009 Nov;39(11):3207-16. doi: 10.1002/eji.200939502.

34.

Cellular expression, trafficking, and function of two isoforms of human ULBP5/RAET1G.

Eagle RA, Flack G, Warford A, Martínez-Borra J, Jafferji I, Traherne JA, Ohashi M, Boyle LH, Barrow AD, Caillat-Zucman S, Young NT, Trowsdale J.

PLoS One. 2009;4(2):e4503. doi: 10.1371/journal.pone.0004503. Epub 2009 Feb 18. Erratum in: PLoS ONE. 2009;4(3). doi: 10.1371/annotation/8501cd33-6c9e-437c-9ea1-f96fbb4140d6. PLoS ONE. 2009;4(3). doi: 10.1371/annotation/34238ee8-5128-4f1d-9ae2-6906c9764e49.

35.

SIGLEC16 encodes a DAP12-associated receptor expressed in macrophages that evolved from its inhibitory counterpart SIGLEC11 and has functional and non-functional alleles in humans.

Cao H, Lakner U, de Bono B, Traherne JA, Trowsdale J, Barrow AD.

Eur J Immunol. 2008 Aug;38(8):2303-15. doi: 10.1002/eji.200738078.

36.

Human MHC architecture and evolution: implications for disease association studies.

Traherne JA.

Int J Immunogenet. 2008 Jun;35(3):179-92. doi: 10.1111/j.1744-313X.2008.00765.x. Epub 2008 Apr 8. Review.

37.

Variation analysis and gene annotation of eight MHC haplotypes: the MHC Haplotype Project.

Horton R, Gibson R, Coggill P, Miretti M, Allcock RJ, Almeida J, Forbes S, Gilbert JG, Halls K, Harrow JL, Hart E, Howe K, Jackson DK, Palmer S, Roberts AN, Sims S, Stewart CA, Traherne JA, Trevanion S, Wilming L, Rogers J, de Jong PJ, Elliott JF, Sawcer S, Todd JA, Trowsdale J, Beck S.

Immunogenetics. 2008 Jan;60(1):1-18. doi: 10.1007/s00251-007-0262-2. Epub 2008 Jan 10.

38.

Splice variation in the cytoplasmic domains of myelin oligodendrocyte glycoprotein affects its cellular localisation and transport.

Boyle LH, Traherne JA, Plotnek G, Ward R, Trowsdale J.

J Neurochem. 2007 Sep;102(6):1853-1862. doi: 10.1111/j.1471-4159.2007.04687.x. Epub 2007 Jun 15.

39.

Analysis of the BTNL2 truncating splice site mutation in tuberculosis, leprosy and Crohn's disease.

Johnson CM, Traherne JA, Jamieson SE, Tremelling M, Bingham S, Parkes M, Blackwell JM, Trowsdale J.

Tissue Antigens. 2007 Mar;69(3):236-41.

PMID:
17493147
40.

The LRC haplotype project: a resource for killer immunoglobulin-like receptor-linked association studies.

Horton R, Coggill P, Miretti MM, Sambrook JG, Traherne JA, Ward R, Sims S, Palmer S, Sehra H, Harrow J, Rogers J, Carrington M, Trowsdale J, Beck S.

Tissue Antigens. 2006 Nov;68(5):450-2.

41.

Regulation of NKG2D ligand gene expression.

Eagle RA, Traherne JA, Ashiru O, Wills MR, Trowsdale J.

Hum Immunol. 2006 Mar;67(3):159-69. Epub 2006 Apr 17.

PMID:
16698438
42.

Genetic analysis of completely sequenced disease-associated MHC haplotypes identifies shuffling of segments in recent human history.

Traherne JA, Horton R, Roberts AN, Miretti MM, Hurles ME, Stewart CA, Ashurst JL, Atrazhev AM, Coggill P, Palmer S, Almeida J, Sims S, Wilming LG, Rogers J, de Jong PJ, Carrington M, Elliott JF, Sawcer S, Todd JA, Trowsdale J, Beck S.

PLoS Genet. 2006 Jan;2(1):e9. Epub 2006 Jan 27.

43.

Association of the truncating splice site mutation in BTNL2 with multiple sclerosis is secondary to HLA-DRB1*15.

Traherne JA, Barcellos LF, Sawcer SJ, Compston A, Ramsay PP, Hauser SL, Oksenberg JR, Trowsdale J.

Hum Mol Genet. 2006 Jan 1;15(1):155-61. Epub 2005 Dec 1.

PMID:
16321988
44.

LD mapping of maternally and non-maternally derived alleles and atopy in FcepsilonRI-beta.

Traherne JA, Hill MR, Hysi P, D'Amato M, Broxholme J, Mott R, Moffatt MF, Cookson WO.

Hum Mol Genet. 2003 Oct 15;12(20):2577-85. Epub 2003 Aug 27.

PMID:
12944417
45.

Extent and distribution of linkage disequilibrium in three genomic regions.

Abecasis GR, Noguchi E, Heinzmann A, Traherne JA, Bhattacharyya S, Leaves NI, Anderson GG, Zhang Y, Lench NJ, Carey A, Cardon LR, Moffatt MF, Cookson WO.

Am J Hum Genet. 2001 Jan;68(1):191-197. Epub 2000 Nov 13.

46.

Single nucleotide polymorphism and linkage disequilibrium within the TCR alpha/delta locus.

Moffatt MF, Traherne JA, Abecasis GR, Cookson WO.

Hum Mol Genet. 2000 Apr 12;9(7):1011-9.

PMID:
10767325

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