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Items: 25

1.

Correction to "Structural Basis for Potency and Promiscuity in Poly(ADP-ribose) Polymerase (PARP) and Tankyrase Inhibitors".

Thorsell AG, Ekblad T, Karlberg T, Löw M, Pinto AF, Trésaugues L, Moche M, Cohen MS, Schüler H.

J Med Chem. 2019 Jun 27;62(12):5922. doi: 10.1021/acs.jmedchem.9b00852. Epub 2019 Jun 19. No abstract available.

PMID:
31242737
2.

Creation of a Novel Class of Potent and Selective MutT Homologue 1 (MTH1) Inhibitors Using Fragment-Based Screening and Structure-Based Drug Design.

Rahm F, Viklund J, Trésaugues L, Ellermann M, Giese A, Ericsson U, Forsblom R, Ginman T, Günther J, Hallberg K, Lindström J, Persson LB, Silvander C, Talagas A, Díaz-Sáez L, Fedorov O, Huber KVM, Panagakou I, Siejka P, Gorjánácz M, Bauser M, Andersson M.

J Med Chem. 2018 Mar 22;61(6):2533-2551. doi: 10.1021/acs.jmedchem.7b01884. Epub 2018 Mar 7.

PMID:
29485874
3.

Irreversible inhibition of cytosolic thioredoxin reductase 1 as a mechanistic basis for anticancer therapy.

Stafford WC, Peng X, Olofsson MH, Zhang X, Luci DK, Lu L, Cheng Q, Trésaugues L, Dexheimer TS, Coussens NP, Augsten M, Ahlzén HM, Orwar O, Östman A, Stone-Elander S, Maloney DJ, Jadhav A, Simeonov A, Linder S, Arnér ESJ.

Sci Transl Med. 2018 Feb 14;10(428). pii: eaaf7444. doi: 10.1126/scitranslmed.aaf7444.

PMID:
29444979
4.

Novel Class of Potent and Cellularly Active Inhibitors Devalidates MTH1 as Broad-Spectrum Cancer Target.

Ellermann M, Eheim A, Rahm F, Viklund J, Guenther J, Andersson M, Ericsson U, Forsblom R, Ginman T, Lindström J, Silvander C, Trésaugues L, Giese A, Bunse S, Neuhaus R, Weiske J, Quanz M, Glasauer A, Nowak-Reppel K, Bader B, Irlbacher H, Meyer H, Queisser N, Bauser M, Haegebarth A, Gorjánácz M.

ACS Chem Biol. 2017 Aug 18;12(8):1986-1992. doi: 10.1021/acschembio.7b00370. Epub 2017 Jul 12.

5.

Structural Basis for Potency and Promiscuity in Poly(ADP-ribose) Polymerase (PARP) and Tankyrase Inhibitors.

Thorsell AG, Ekblad T, Karlberg T, Löw M, Pinto AF, Trésaugues L, Moche M, Cohen MS, Schüler H.

J Med Chem. 2017 Feb 23;60(4):1262-1271. doi: 10.1021/acs.jmedchem.6b00990. Epub 2016 Dec 21. Erratum in: J Med Chem. 2019 Jun 27;62(12):5922.

6.

Crystal Structures of Type-II Inositol Polyphosphate 5-Phosphatase INPP5B with Synthetic Inositol Polyphosphate Surrogates Reveal New Mechanistic Insights for the Inositol 5-Phosphatase Family.

Mills SJ, Silvander C, Cozier G, Trésaugues L, Nordlund P, Potter BV.

Biochemistry. 2016 Mar 8;55(9):1384-97. doi: 10.1021/acs.biochem.5b00838. Epub 2016 Feb 29.

7.

The structure and catalytic mechanism of human sphingomyelin phosphodiesterase like 3a--an acid sphingomyelinase homologue with a novel nucleotide hydrolase activity.

Lim SM, Yeung K, Trésaugues L, Ling TH, Nordlund P.

FEBS J. 2016 Mar;283(6):1107-23. doi: 10.1111/febs.13655. Epub 2016 Feb 5.

8.

Structural Basis for the Specificity of Human NUDT16 and Its Regulation by Inosine Monophosphate.

Trésaugues L, Lundbäck T, Welin M, Flodin S, Nyman T, Silvander C, Gräslund S, Nordlund P.

PLoS One. 2015 Jun 29;10(6):e0131507. doi: 10.1371/journal.pone.0131507. eCollection 2015.

9.

Structural basis for phosphoinositide substrate recognition, catalysis, and membrane interactions in human inositol polyphosphate 5-phosphatases.

Trésaugues L, Silvander C, Flodin S, Welin M, Nyman T, Gräslund S, Hammarström M, Berglund H, Nordlund P.

Structure. 2014 May 6;22(5):744-55. doi: 10.1016/j.str.2014.01.013. Epub 2014 Apr 3.

10.

Structural insights into substrate recognition in proton-dependent oligopeptide transporters.

Guettou F, Quistgaard EM, Trésaugues L, Moberg P, Jegerschöld C, Zhu L, Jong AJ, Nordlund P, Löw C.

EMBO Rep. 2013 Sep;14(9):804-10. doi: 10.1038/embor.2013.107. Epub 2013 Jul 19.

11.

Substrate specificity and oligomerization of human GMP synthetase.

Welin M, Lehtiö L, Johansson A, Flodin S, Nyman T, Trésaugues L, Hammarström M, Gräslund S, Nordlund P.

J Mol Biol. 2013 Nov 15;425(22):4323-33. doi: 10.1016/j.jmb.2013.06.032. Epub 2013 Jun 28.

12.

Structural basis for substrate transport in the GLUT-homology family of monosaccharide transporters.

Quistgaard EM, Löw C, Moberg P, Trésaugues L, Nordlund P.

Nat Struct Mol Biol. 2013 Jun;20(6):766-8. doi: 10.1038/nsmb.2569. Epub 2013 Apr 28.

PMID:
23624861
13.

Structural and dynamic insights into substrate binding and catalysis of human lipocalin prostaglandin D synthase.

Lim SM, Chen D, Teo H, Roos A, Jansson AE, Nyman T, Trésaugues L, Pervushin K, Nordlund P.

J Lipid Res. 2013 Jun;54(6):1630-43. doi: 10.1194/jlr.M035410. Epub 2013 Mar 22.

14.

A synthetic polyphosphoinositide headgroup surrogate in complex with SHIP2 provides a rationale for drug discovery.

Mills SJ, Persson C, Cozier G, Thomas MP, Trésaugues L, Erneux C, Riley AM, Nordlund P, Potter BV.

ACS Chem Biol. 2012 May 18;7(5):822-8. doi: 10.1021/cb200494d. Epub 2012 Feb 27.

15.

Structural and functional studies of the human phosphoribosyltransferase domain containing protein 1.

Welin M, Egeblad L, Johansson A, Stenmark P, Wang L, Flodin S, Nyman T, Trésaugues L, Kotenyova T, Johansson I, Eriksson S, Eklund H, Nordlund P.

FEBS J. 2010 Dec;277(23):4920-30. doi: 10.1111/j.1742-4658.2010.07897.x. Epub 2010 Nov 5.

16.

The crystal structure of the Dachshund domain of human SnoN reveals flexibility in the putative protein interaction surface.

Nyman T, Trésaugues L, Welin M, Lehtiö L, Flodin S, Persson C, Johansson I, Hammarström M, Nordlund P.

PLoS One. 2010 Sep 23;5(9):e12907. doi: 10.1371/journal.pone.0012907.

17.

Structural studies of tri-functional human GART.

Welin M, Grossmann JG, Flodin S, Nyman T, Stenmark P, Trésaugues L, Kotenyova T, Johansson I, Nordlund P, Lehtiö L.

Nucleic Acids Res. 2010 Nov;38(20):7308-19. doi: 10.1093/nar/gkq595. Epub 2010 Jul 14.

18.

Structures of BIR domains from human NAIP and cIAP2.

Herman MD, Moche M, Flodin S, Welin M, Trésaugues L, Johansson I, Nilsson M, Nordlund P, Nyman T.

Acta Crystallogr Sect F Struct Biol Cryst Commun. 2009 Nov 1;65(Pt 11):1091-6. doi: 10.1107/S1744309109038597. Epub 2009 Oct 24.

19.

Completing the family portrait of the anti-apoptotic Bcl-2 proteins: crystal structure of human Bfl-1 in complex with Bim.

Herman MD, Nyman T, Welin M, Lehtiö L, Flodin S, Trésaugues L, Kotenyova T, Flores A, Nordlund P.

FEBS Lett. 2008 Oct 29;582(25-26):3590-4. doi: 10.1016/j.febslet.2008.09.028. Epub 2008 Sep 21.

20.

The crystal structure of human cleavage and polyadenylation specific factor-5 reveals a dimeric Nudix protein with a conserved catalytic site.

Trésaugues L, Stenmark P, Schüler H, Flodin S, Welin M, Nyman T, Hammarström M, Moche M, Gräslund S, Nordlund P.

Proteins. 2008 Dec;73(4):1047-52. doi: 10.1002/prot.22198. No abstract available.

PMID:
18767156
21.

Cloning, production, and purification of proteins for a medium-scale structural genomics project.

Quevillon-Cheruel S, Collinet B, Trésaugues L, Minard P, Henckes G, Aufrère R, Blondeau K, Zhou CZ, Liger D, Bettache N, Poupon A, Aboulfath I, Leulliot N, Janin J, van Tilbeurgh H.

Methods Mol Biol. 2007;363:21-37.

PMID:
17272835
22.

Structural characterization of Set1 RNA recognition motifs and their role in histone H3 lysine 4 methylation.

Trésaugues L, Dehé PM, Guérois R, Rodriguez-Gil A, Varlet I, Salah P, Pamblanco M, Luciano P, Quevillon-Cheruel S, Sollier J, Leulliot N, Couprie J, Tordera V, Zinn-Justin S, Chàvez S, van Tilbeurgh H, Géli V.

J Mol Biol. 2006 Jun 23;359(5):1170-81. Epub 2006 May 9.

PMID:
16787775
23.

HalX: an open-source LIMS (Laboratory Information Management System) for small- to large-scale laboratories.

Prilusky J, Oueillet E, Ulryck N, Pajon A, Bernauer J, Krimm I, Quevillon-Cheruel S, Leulliot N, Graille M, Liger D, Trésaugues L, Sussman JL, Janin J, van Tilbeurgh H, Poupon A.

Acta Crystallogr D Biol Crystallogr. 2005 Jun;61(Pt 6):671-8. Epub 2005 May 26.

PMID:
15930618
24.

High-throughput crystal-optimization strategies in the South Paris Yeast Structural Genomics Project: one size fits all?

Leulliot N, Trésaugues L, Bremang M, Sorel I, Ulryck N, Graille M, Aboulfath I, Poupon A, Liger D, Quevillon-Cheruel S, Janin J, van Tilbeurgh H.

Acta Crystallogr D Biol Crystallogr. 2005 Jun;61(Pt 6):664-70. Epub 2005 May 26.

PMID:
15930617
25.

Refolding strategies from inclusion bodies in a structural genomics project.

Trésaugues L, Collinet B, Minard P, Henckes G, Aufrère R, Blondeau K, Liger D, Zhou CZ, Janin J, Van Tilbeurgh H, Quevillon-Cheruel S.

J Struct Funct Genomics. 2004;5(3):195-204.

PMID:
15263835

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