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Diagnostic Yield and Treatment Impact of Targeted Exome Sequencing in Early-Onset Epilepsy.

Demos M, Guella I, DeGuzman C, McKenzie MB, Buerki SE, Evans DM, Toyota EB, Boelman C, Huh LL, Datta A, Michoulas A, Selby K, Bjornson BH, Horvath G, Lopez-Rangel E, van Karnebeek CDM, Salvarinova R, Slade E, Eydoux P, Adam S, Van Allen MI, Nelson TN, Bolbocean C, Connolly MB, Farrer MJ.

Front Neurol. 2019 May 21;10:434. doi: 10.3389/fneur.2019.00434. eCollection 2019.


A systematic review of deep brain stimulation for the treatment of drug-resistant epilepsy in childhood.

Yan H, Toyota E, Anderson M, Abel TJ, Donner E, Kalia SK, Drake J, Rutka JT, Ibrahim GM.

J Neurosurg Pediatr. 2018 Nov 30;23(3):274-284. doi: 10.3171/2018.9.PEDS18417. Review.


Assessing an Interactive Online Tool to Support Parents' Genomic Testing Decisions.

Adam S, Birch PH, Coe RR, Bansback N, Jones AL, Connolly MB, Demos MK, Toyota EB, Farrer MJ, Friedman JM.

J Genet Couns. 2018 Jul 23. doi: 10.1007/s10897-018-0281-1. [Epub ahead of print]


An Infant With Epilepsy and Recurrent Hemiplegia due to Compound Heterozygous Variants in ATP1A2.

Wilbur C, Buerki SE, Guella I, Toyota EB, Evans DM, McKenzie MB, Datta A, Michoulas A, Adam S, Van Allen MI, Nelson TN, Farrer MJ, Connolly MB, Demos M.

Pediatr Neurol. 2017 Oct;75:87-90. doi: 10.1016/j.pediatrneurol.2017.06.003. Epub 2017 Jun 8.


De Novo Mutations in YWHAG Cause Early-Onset Epilepsy.

Guella I, McKenzie MB, Evans DM, Buerki SE, Toyota EB, Van Allen MI; Epilepsy Genomics Study, Suri M, Elmslie F; Deciphering Developmental Disorders Study, Simon MEH, van Gassen KLI, Héron D, Keren B, Nava C, Connolly MB, Demos M, Farrer MJ.

Am J Hum Genet. 2017 Aug 3;101(2):300-310. doi: 10.1016/j.ajhg.2017.07.004.


De novo FGF12 mutation in 2 patients with neonatal-onset epilepsy.

Guella I, Huh L, McKenzie MB, Toyota EB, Bebin EM, Thompson ML, Cooper GM, Evans DM, Buerki SE, Adam S, Van Allen MI, Nelson TN, Connolly MB, Farrer MJ, Demos M.

Neurol Genet. 2016 Nov 10;2(6):e120. eCollection 2016 Dec.


Effect of the orthoquinone moiety in 9,10-phenanthrenequinone on its ability to induce apoptosis in HCT-116 and HL-60 cells.

Hatae N, Nakamura J, Okujima T, Ishikura M, Abe T, Hibino S, Choshi T, Okada C, Yamada H, Uno H, Toyota E.

Bioorg Med Chem Lett. 2013 Aug 15;23(16):4637-40. doi: 10.1016/j.bmcl.2013.06.015. Epub 2013 Jun 15.


Expression, purification, and refolding of active recombinant human E-selectin lectin and EGF domains in Escherichia coli.

Kawano S, Iyaguchi D, Okada C, Sasaki Y, Toyota E.

Protein J. 2013 Jun;32(5):386-91. doi: 10.1007/s10930-013-9496-z.


[Clinical evaluation of a line probe assay kit for the identification of Mycobacterium species and detection of drug-resistant Mycobacterium tuberculosis].

Matsumoto T, Ogata H, Toyota E, Suzuki K, Saito T, Fujita A, Suetake T, Chikamatsu K, Mizuno K, Mitarai S.

Kekkaku. 2013 Mar;88(3):291-6. Japanese.


Doctor's delay in endobronchial tuberculosis.

Tamura A, Higaki N, Kusaka K, Akashi S, Suzuki J, Shimada M, Suzuki J, Kawashima M, Suzuki J, Oshima N, Masuda K, Matsui H, Yamane A, Nagai H, Nagayama N, Toyota E, Akagawa S, Hebisawa A, Shoji S, Ohta K.

Kekkaku. 2013 Jan;88(1):9-13.


Disulfiram, a drug widely used to control alcoholism, suppresses the self-renewal of glioblastoma and over-rides resistance to temozolomide.

Triscott J, Lee C, Hu K, Fotovati A, Berns R, Pambid M, Luk M, Kast RE, Kong E, Toyota E, Yip S, Toyota B, Dunn SE.

Oncotarget. 2012 Oct;3(10):1112-23.


Superiority of nebulized corticosteroids over dry powder inhalers in certain patients with cough variant asthma or cough-predominant asthma.

Kamimura M, Izumi S, Hamamoto Y, Morita A, Toyota E, Kobayashi N, Kudo K.

Allergol Int. 2012 Sep;61(3):411-7. doi: 10.2332/allergolint.11-OA-0357. Epub 2012 May 25.


Association of SLC11A1 (NRAMP1) polymorphisms with pulmonary Mycobacterium avium complex infection.

Sapkota BR, Hijikata M, Matsushita I, Tanaka G, Ieki R, Kobayashi N, Toyota E, Nagai H, Kurashima A, Tokunaga K, Keicho N.

Hum Immunol. 2012 May;73(5):529-36. doi: 10.1016/j.humimm.2012.02.008. Epub 2012 Feb 16.


Inter-rater agreement in the assessment of abnormal chest X-ray findings for tuberculosis between two Asian countries.

Sakurada S, Hang NT, Ishizuka N, Toyota E, Hung le D, Chuc PT, Lien LT, Thuong PH, Bich PT, Keicho N, Kobayashi N.

BMC Infect Dis. 2012 Feb 1;12:31. doi: 10.1186/1471-2334-12-31.


Comprehensive multicenter evaluation of a new line probe assay kit for identification of Mycobacterium species and detection of drug-resistant Mycobacterium tuberculosis.

Mitarai S, Kato S, Ogata H, Aono A, Chikamatsu K, Mizuno K, Toyota E, Sejimo A, Suzuki K, Yoshida S, Saito T, Moriya A, Fujita A, Sato S, Matsumoto T, Ano H, Suetake T, Kondo Y, Kirikae T, Mori T.

J Clin Microbiol. 2012 Mar;50(3):884-90. doi: 10.1128/JCM.05638-11. Epub 2012 Jan 11.


[Evaluation of tuberculosis treatment including levofloxacin (LVFX) in cases who could not continue standard regimen].

Kunogi M, Kawabe Y, Suzuki J, Shimada M, Kaneko Y, Matsui Y, Kawashima M, Ohshima N, Ariga H, Masuda K, Matsui H, Tamura A, Nagai H, Akagawa S, Nagayama N, Toyota E, Machida K, Nakajima Y.

Kekkaku. 2011 Sep;86(9):773-9. Japanese.


Evaluation of a simple loop-mediated isothermal amplification test kit for the diagnosis of tuberculosis.

Mitarai S, Okumura M, Toyota E, Yoshiyama T, Aono A, Sejimo A, Azuma Y, Sugahara K, Nagasawa T, Nagayama N, Yamane A, Yano R, Kokuto H, Morimoto K, Ueyama M, Kubota M, Yi R, Ogata H, Kudoh S, Mori T.

Int J Tuberc Lung Dis. 2011 Sep;15(9):1211-7, i. doi: 10.5588/ijtld.10.0629.


[A case of tuberculous pleurisy developing contralateral effusion during anti-tuberculosis chemotherapy].

Ishii T, Matsui Y, Nagayama N, Higaki N, Tone K, Kusaka K, Senoo M, Ariga H, Ohshima N, Masuda K, Matsui H, Teramoto S, Yamane A, Tamura A, Nagai H, Akagawa S, Toyota E, Shoji S, Nakajima Y.

Kekkaku. 2011 Jul;86(7):723-7. Japanese.


[Tuberculosis screening of foreigners in European, North-American, and Oceanian countries].

Toyota E, Ito K.

Kekkaku. 2011 Jul;86(7):685-95. Japanese.


[A case of cold abscess of the chest wall due to thoracic drainage for tuberculous pleuritis].

Komiya K, Ariga H, Nagayama N, Matsui Y, Oshima N, Masuda K, Matsui H, Teramoto S, Tamura A, Toyota E, Nagai H, Akagawa S, Nakajima Y.

Kekkaku. 2010 Aug;85(8):673-7. Japanese.


[Clinical investigation among elderly patients with tuberculosis].

Toyota E, Machida K, Nagayama N, Yamane A, Komiya K, Ito S, Suzuki J, Kashizaki F, Shimada M, Matsui Y, Kawashima M, Ohshima N, Suzuki J, Ariga H, Masuda K, Matsui H, Tamura A, Teramoto S, Nagai H, Akagawa S, Shoji S, Hebisawa A, Nakajima Y.

Kekkaku. 2010 Aug;85(8):655-60. Japanese.


[Review of pulmonary Mycobacterium xenopi infection cases: 11 cases of our own and 18 other cases reported in Japan].

Matsui Y, Tamura A, Nagayama N, Akashi S, Araki K, Kimura H, Shimada M, Suzuki J, Kashizaki F, Kawashima M, Ariga H, Suzuki J, Ohshima N, Masuda K, Matsui H, Teramoto S, Yamane A, Nagai H, Akagawa S, Toyota E, Shouji S, Nakajima Y.

Kekkaku. 2010 Aug;85(8):647-53. Review. Japanese.


Atlantic cod trypsin-catalyzed peptide synthesis with inverse substrates as acyl donor components.

Fuchise T, Kishimura H, Yang ZH, Kojoma M, Toyota E, Sekizaki H.

Chem Pharm Bull (Tokyo). 2010 Apr;58(4):484-7.


[Prevention of tuberculosis in medically high-risked patients].

Sasaki Y, Toyota E.

Kekkaku. 2010 Jan;85(1):47-60. Japanese. No abstract available.


Identification of katG mutations associated with high-level isoniazid resistance in Mycobacterium tuberculosis.

Ando H, Kondo Y, Suetake T, Toyota E, Kato S, Mori T, Kirikae T.

Antimicrob Agents Chemother. 2010 May;54(5):1793-9. doi: 10.1128/AAC.01691-09. Epub 2010 Mar 8.


Structural basis for the design of novel Schiff base metal chelate inhibitors of trypsin.

Iyaguchi D, Kawano S, Takada K, Toyota E.

Bioorg Med Chem. 2010 Mar 15;18(6):2076-2080. doi: 10.1016/j.bmc.2010.02.016. Epub 2010 Feb 15.


Diagnosis of myocardial viability by fluorodeoxyglucose distribution at the border zone of a low uptake region.

Toyota E, Sone T, Yoshikawa K, Mimura H, Hayashida A, Wada N, Obase K, Imai K, Saito K, Maehama T, Fukunaga M, Yoshida K.

Yonsei Med J. 2010 Mar;51(2):178-86. doi: 10.3349/ymj.2010.51.2.178. Epub 2010 Feb 12.


[Two cases of tuberculosis after treatment of rheumatoid arthritis with infliximab].

Takasaka N, Toyota E, Shimada M, Ariga H, Teramoto S, Akagawa S.

Nihon Kokyuki Gakkai Zasshi. 2010 Jan;48(1):60-5. Japanese.


The value of fiberoptic bronchoscopy in culture-positive pulmonary tuberculosis patients whose pre-bronchoscopic sputum specimens were negative both for smear and PCR analyses.

Tamura A, Shimada M, Matsui Y, Kawashima M, Suzuki J, Ariga H, Ohshima N, Masuda K, Matsui H, Nagai H, Nagayama N, Toyota E, Akagawa S, Hebisawa A.

Intern Med. 2010;49(2):95-102. Epub 2010 Jan 15.


Activator of G protein signaling 8 (AGS8) is required for hypoxia-induced apoptosis of cardiomyocytes: role of G betagamma and connexin 43 (CX43).

Sato M, Jiao Q, Honda T, Kurotani R, Toyota E, Okumura S, Takeya T, Minamisawa S, Lanier SM, Ishikawa Y.

J Biol Chem. 2009 Nov 6;284(45):31431-40. doi: 10.1074/jbc.M109.014068. Epub 2009 Sep 1.


Prevalence and risk factors for tuberculosis infection among hospital workers in Hanoi, Viet Nam.

Lien LT, Hang NT, Kobayashi N, Yanai H, Toyota E, Sakurada S, Thuong PH, Cuong VC, Nanri A, Mizoue T, Matsushita I, Harada N, Higuchi K, Tuan LA, Keicho N.

PLoS One. 2009 Aug 27;4(8):e6798. doi: 10.1371/journal.pone.0006798.


A structural comparison of three isoforms of anionic trypsin from chum salmon (Oncorhynchus keta).

Toyota E, Iyaguchi D, Sekizaki H, Tateyama M, Ng KK.

Acta Crystallogr D Biol Crystallogr. 2009 Jul;65(Pt 7):717-23. doi: 10.1107/S0907444909012165. Epub 2009 Jun 20.


C-reactive protein predicts non-target lesion revascularization and cardiac events following percutaneous coronary intervention in patients with angina pectoris.

Imai K, Okura H, Kume T, Yamada R, Miyamoto Y, Kawamoto T, Neishi Y, Watanabe N, Toyota E, Yoshida K.

J Cardiol. 2009 Jun;53(3):388-95. doi: 10.1016/j.jjcc.2009.01.005. Epub 2009 Feb 20.


Development of cardiac dysfunction induced by repetitive transient myocardial ischemia is inhibited by edaravone in conscious rats.

Toyota E, Miyamoto Y, Imai K, Neishi Y, Kawamoto T, Okura H, Yoshida K.

Clin Exp Pharmacol Physiol. 2009 Sep;36(9):e20-5. doi: 10.1111/j.1440-1681.2009.05178.x. Epub 2009 Mar 26.


Identification of MICA as a susceptibility gene for pulmonary Mycobacterium avium complex infection.

Shojima J, Tanaka G, Keicho N, Tamiya G, Ando S, Oka A, Inoue Y, Suzuki K, Sakatani M, Okada M, Kobayashi N, Toyota E, Kudo K, Kajiki A, Nagai H, Kurashima A, Oketani N, Hayakawa H, Takemura T, Nakata K, Ito H, Morita T, Matsushita I, Hijikata M, Sakurada S, Sasazuki T, Inoko H.

J Infect Dis. 2009 Jun 1;199(11):1707-15. doi: 10.1086/598982.


Cloning, expression, purification and preliminary crystallographic studies of the adenylate/uridylate-rich element-binding protein HuR complexed with its target RNA.

Iyaguchi D, Yao M, Tanaka I, Toyota E.

Acta Crystallogr Sect F Struct Biol Cryst Commun. 2009 Mar 1;65(Pt 3):285-7. doi: 10.1107/S174430910900400X. Epub 2009 Feb 26.


[Usefulness of bronchofiberscopy for the diagnosis of pulmonary non-tuberculous mycobacteriosis--an analysis mainly on pulmonary M. avium complex disease].

Tamura A, Muraki K, Shimada M, Suzuki J, Kashizaki F, Matsui Y, Kawashima M, Suzuki J, Ariga H, Ohshima N, Masuda K, Matsui H, Nagai H, Akagawa S, Nagayama N, Toyota E, Machida K, Kurashima A, Nakajima Y, Yotsumoto H, Hebisawa A.

Kekkaku. 2008 Dec;83(12):785-91. Japanese.


[Clinical research on multi-drug resistant and extensive drug-resistant tuberculosis in Japan].

Toyota E, Kawabe Y, Yotsumoto H, Sakatani M, Tsuyuguchi K, Maekura R, Fujikawa K, Takashima T, Ogawa K, Yoshiyama T, Sugie T.

Kekkaku. 2008 Dec;83(12):773-7. Japanese.


Quantitative measurement of mitral valve coaptation in functional mitral regurgitation: In vivo experimental study by real-time three-dimensional echocardiography.

Yamada R, Watanabe N, Kume T, Tsukiji M, Kawamoto T, Neishi Y, Hayashida A, Toyota E, Okura H, Yoshida K.

J Cardiol. 2009 Feb;53(1):94-101. doi: 10.1016/j.jjcc.2008.09.005. Epub 2008 Nov 8.


[Clinical analysis on tuberculosis cases among foreigners in our hospital].

Suzuki M, Hojo M, Kobayashi N, Shinohara Y, Takasaki J, Yoshizawa A, Sugiyama H, Kudo K, Toyota E.

Kekkaku. 2008 Oct;83(10):661-6. Japanese.


C-Reactive protein predicts severity, progression, and prognosis of asymptomatic aortic valve stenosis.

Imai K, Okura H, Kume T, Yamada R, Miyamoto Y, Kawamoto T, Watanabe N, Neishi Y, Toyota E, Yoshida K.

Am Heart J. 2008 Oct;156(4):713-8. doi: 10.1016/j.ahj.2008.04.011. Epub 2008 Sep 9.


Images in cardiovascular medicine. Fibrin clot visualized by optical coherence tomography.

Kume T, Okura H, Kawamoto T, Akasaka T, Toyota E, Watanabe N, Neishi Y, Sadahira Y, Yoshida K.

Circulation. 2008 Jul 22;118(4):426-7. doi: 10.1161/CIRCULATIONAHA.107.749564. No abstract available.


Trypsin-catalyzed synthesis of dipeptide containing alpha-aminoisobutyric acid using p- and m-(amidinomethyl)phenyl esters as acyl donor.

Sekizaki H, Itoh K, Shibuya A, Toyota E, Kojoma M, Tanizawa K.

Chem Pharm Bull (Tokyo). 2008 May;56(5):688-91.


Mechanism of increasing systolic coronary flow velocity in patients with aortic regurgitation.

Kume T, Kawamoto T, Okura H, Watanabe N, Toyota E, Neishi Y, Sukmawan R, Yamada R, Akasaka T, Yoshida K.

J Heart Valve Dis. 2008 Jan;17(1):89-93.


Local release of catecholamines from the hearts of patients with tako-tsubo-like left ventricular dysfunction.

Kume T, Kawamoto T, Okura H, Toyota E, Neishi Y, Watanabe N, Hayashida A, Okahashi N, Yoshimura Y, Saito K, Nezuo S, Yamada R, Yoshida K.

Circ J. 2008 Jan;72(1):106-8.


Crystallization and preliminary x-ray studies of the unliganded wild-type bovine thrombin.

Iyaguchi D, Yao M, Watanabe N, Tanaka I, Toyota E.

Protein Pept Lett. 2007;14(9):923-4.


Histological characteristics of plaque with ultrasonic attenuation: a comparison between intravascular ultrasound and histology.

Yamada R, Okura H, Kume T, Neishi Y, Kawamoto T, Watanabe N, Toyota E, Yoshida K.

J Cardiol. 2007 Oct;50(4):223-8.


The relationship between coronary plaque characteristics and small embolic particles during coronary stent implantation.

Kawamoto T, Okura H, Koyama Y, Toda I, Taguchi H, Tamita K, Yamamuro A, Yoshimura Y, Neishi Y, Toyota E, Yoshida K.

J Am Coll Cardiol. 2007 Oct 23;50(17):1635-40.

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