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Items: 1 to 50 of 110


Mechanism of the E2 to E1 transition in Ca2+ pump revealed by crystal structures of gating residue mutants.

Tsunekawa N, Ogawa H, Tsueda J, Akiba T, Toyoshima C.

Proc Natl Acad Sci U S A. 2018 Dec 11;115(50):12722-12727. doi: 10.1073/pnas.1815472115. Epub 2018 Nov 27.


Suppressor mutation analysis combined with 3D modeling explains cohesin's capacity to hold and release DNA.

Xu X, Kanai R, Nakazawa N, Wang L, Toyoshima C, Yanagida M.

Proc Natl Acad Sci U S A. 2018 May 22;115(21):E4833-E4842. doi: 10.1073/pnas.1803564115. Epub 2018 May 7.


Distinct pH dependencies of Na+/K+ selectivity at the two faces of Na,K-ATPase.

Cornelius F, Tsunekawa N, Toyoshima C.

J Biol Chem. 2018 Feb 9;293(6):2195-2205. doi: 10.1074/jbc.RA117.000700. Epub 2017 Dec 15.


Protein-phospholipid interplay revealed with crystals of a calcium pump.

Norimatsu Y, Hasegawa K, Shimizu N, Toyoshima C.

Nature. 2017 May 11;545(7653):193-198. doi: 10.1038/nature22357. Epub 2017 May 3.


Mn2+ transport by Ca2+ -ATPase of sarcoplasmic reticulum.

Yonekura SI, Toyoshima C.

FEBS Lett. 2016 Dec;590(24):4650. doi: 10.1002/1873-3468.12524. No abstract available.


Mn(2+) transport by Ca(2+) -ATPase of sarcoplasmic reticulum.

Yonekura S, Toyoshima C.

FEBS Lett. 2016 Jul;590(14):2086-95. doi: 10.1002/1873-3468.12244. Epub 2016 Jun 23. Erratum in: FEBS Lett. 2016 Dec;590(24):4650.


Traumatic ventricular septal rupture associated with rapid progression of heart failure despite low Qp/Qs ratio: a case report.

Murakawa K, Yoshida S, Okada T, Toyoshima C, Yuyama R, Minato N, Shiojima I.

J Cardiothorac Surg. 2016 Apr 12;11(1):57. doi: 10.1186/s13019-016-0457-4.


Sequential substitution of K(+) bound to Na(+),K(+)-ATPase visualized by X-ray crystallography.

Ogawa H, Cornelius F, Hirata A, Toyoshima C.

Nat Commun. 2015 Aug 10;6:8004. doi: 10.1038/ncomms9004.


Functional analysis of SERCA1b, a highly expressed SERCA1 variant in myotonic dystrophy type 1 muscle.

Zhao Y, Ogawa H, Yonekura S, Mitsuhashi H, Mitsuhashi S, Nishino I, Toyoshima C, Ishiura S.

Biochim Biophys Acta. 2015 Oct;1852(10 Pt A):2042-7. doi: 10.1016/j.bbadis.2015.07.006. Epub 2015 Jul 11.


Biselyngbyasides, cytotoxic marine macrolides, are novel and potent inhibitors of the Ca(2+) pumps with a unique mode of binding.

Morita M, Ogawa H, Ohno O, Yamori T, Suenaga K, Toyoshima C.

FEBS Lett. 2015 Jun 4;589(13):1406-11. doi: 10.1016/j.febslet.2015.04.056. Epub 2015 May 6.


General and specific lipid-protein interactions in Na,K-ATPase.

Cornelius F, Habeck M, Kanai R, Toyoshima C, Karlish SJ.

Biochim Biophys Acta. 2015 Sep;1848(9):1729-43. doi: 10.1016/j.bbamem.2015.03.012. Epub 2015 Mar 16. Review.


Electron crystallography of ultrathin 3D protein crystals: atomic model with charges.

Yonekura K, Kato K, Ogasawara M, Tomita M, Toyoshima C.

Proc Natl Acad Sci U S A. 2015 Mar 17;112(11):3368-73. doi: 10.1073/pnas.1500724112. Epub 2015 Feb 17.


Stimulation, inhibition, or stabilization of Na,K-ATPase caused by specific lipid interactions at distinct sites.

Habeck M, Haviv H, Katz A, Kapri-Pardes E, Ayciriex S, Shevchenko A, Ogawa H, Toyoshima C, Karlish SJ.

J Biol Chem. 2015 Feb 20;290(8):4829-42. doi: 10.1074/jbc.M114.611384. Epub 2014 Dec 22.


ATPase-dependent auto-phosphorylation of the open condensin hinge diminishes DNA binding.

Akai Y, Kanai R, Nakazawa N, Ebe M, Toyoshima C, Yanagida M.

Open Biol. 2014 Dec;4(12). pii: 140193. doi: 10.1098/rsob.140193.


Design, synthesis and structure-activity relationship studies of novel sirtuin 2 (SIRT2) inhibitors with a benzamide skeleton.

Sakai T, Matsumoto Y, Ishikawa M, Sugita K, Hashimoto Y, Wakai N, Kitao A, Morishita E, Toyoshima C, Hayashi T, Akiyama T.

Bioorg Med Chem. 2015 Jan 15;23(2):328-39. doi: 10.1016/j.bmc.2014.11.027. Epub 2014 Dec 2.


5-Hydroxymethylcytosine plays a critical role in glioblastomagenesis by recruiting the CHTOP-methylosome complex.

Takai H, Masuda K, Sato T, Sakaguchi Y, Suzuki T, Suzuki T, Koyama-Nasu R, Nasu-Nishimura Y, Katou Y, Ogawa H, Morishita Y, Kozuka-Hata H, Oyama M, Todo T, Ino Y, Mukasa A, Saito N, Toyoshima C, Shirahige K, Akiyama T.

Cell Rep. 2014 Oct 9;9(1):48-60. doi: 10.1016/j.celrep.2014.08.071. Epub 2014 Oct 2.


Crystal structure of a Na+-bound Na+,K+-ATPase preceding the E1P state.

Kanai R, Ogawa H, Vilsen B, Cornelius F, Toyoshima C.

Nature. 2013 Oct 10;502(7470):201-6. doi: 10.1038/nature12578. Epub 2013 Oct 2.


New crystal structures of PII-type ATPases: excitement continues.

Toyoshima C, Cornelius F.

Curr Opin Struct Biol. 2013 Aug;23(4):507-14. doi: 10.1016/ Epub 2013 Jul 18. Review.


Crystal structures of the calcium pump and sarcolipin in the Mg2+-bound E1 state.

Toyoshima C, Iwasawa S, Ogawa H, Hirata A, Tsueda J, Inesi G.

Nature. 2013 Mar 14;495(7440):260-4. doi: 10.1038/nature11899. Epub 2013 Mar 3.


Neutral phospholipids stimulate Na,K-ATPase activity: a specific lipid-protein interaction.

Haviv H, Habeck M, Kanai R, Toyoshima C, Karlish SJ.

J Biol Chem. 2013 Apr 5;288(14):10073-81. doi: 10.1074/jbc.M112.446997. Epub 2013 Feb 21.


A structural view on the functional importance of the sugar moiety and steroid hydroxyls of cardiotonic steroids in binding to Na,K-ATPase.

Cornelius F, Kanai R, Toyoshima C.

J Biol Chem. 2013 Mar 1;288(9):6602-16. doi: 10.1074/jbc.M112.442137. Epub 2013 Jan 22.


A new method for establishing stable cell lines and its use for large-scale production of human guanylyl cyclase-B receptor and of the extracellular domain.

Okamoto N, Ogawa H, Toyoshima C.

Biochem Biophys Res Commun. 2012 Sep 21;426(2):260-5. doi: 10.1016/j.bbrc.2012.08.077. Epub 2012 Aug 23.


First crystal structures of Na+,K+-ATPase: new light on the oldest ion pump.

Toyoshima C, Kanai R, Cornelius F.

Structure. 2011 Dec 7;19(12):1732-8. doi: 10.1016/j.str.2011.10.016. Review.


Metal fluoride complexes of Na,K-ATPase: characterization of fluoride-stabilized phosphoenzyme analogues and their interaction with cardiotonic steroids.

Cornelius F, Mahmmoud YA, Toyoshima C.

J Biol Chem. 2011 Aug 26;286(34):29882-92. doi: 10.1074/jbc.M111.259663. Epub 2011 Jun 27.


Trinitrophenyl derivatives bind differently from parent adenine nucleotides to Ca2+-ATPase in the absence of Ca2+.

Toyoshima C, Yonekura S, Tsueda J, Iwasawa S.

Proc Natl Acad Sci U S A. 2011 Feb 1;108(5):1833-8. doi: 10.1073/pnas.1017659108. Epub 2011 Jan 14.


Detection of parasternal metastatic lymph nodes by sentinel lymph node methods in a patient with recurrence in the conserved breast.

Yamashita T, Fujita T, Hayashi H, Ando Y, Hato Y, Horio A, Toyoshima C, Yamada M, Iwata H.

Breast Cancer. 2014 Mar;21(2):246-8. doi: 10.1007/s12282-010-0248-z. Epub 2011 Jan 7.


Relationship between Ca2+-affinity and shielding of bulk water in the Ca2+-pump from molecular dynamics simulations.

Sugita Y, Ikeguchi M, Toyoshima C.

Proc Natl Acad Sci U S A. 2010 Dec 14;107(50):21465-9. doi: 10.1073/pnas.1015819107. Epub 2010 Nov 23.


Crystal structure of the sodium-potassium pump (Na+,K+-ATPase) with bound potassium and ouabain.

Ogawa H, Shinoda T, Cornelius F, Toyoshima C.

Proc Natl Acad Sci U S A. 2009 Aug 18;106(33):13742-7. doi: 10.1073/pnas.0907054106. Epub 2009 Aug 3.


Nucleotide recognition by CopA, a Cu+-transporting P-type ATPase.

Tsuda T, Toyoshima C.

EMBO J. 2009 Jun 17;28(12):1782-91. doi: 10.1038/emboj.2009.143. Epub 2009 May 28.


Crystal structure of the sodium-potassium pump at 2.4 A resolution.

Shinoda T, Ogawa H, Cornelius F, Toyoshima C.

Nature. 2009 May 21;459(7245):446-50. doi: 10.1038/nature07939.


Reaction cycle of Thermotoga maritima copper ATPase and conformational characterization of catalytically deficient mutants.

Hatori Y, Lewis D, Toyoshima C, Inesi G.

Biochemistry. 2009 Jun 9;48(22):4871-80. doi: 10.1021/bi900338n.


How Ca2+-ATPase pumps ions across the sarcoplasmic reticulum membrane.

Toyoshima C.

Biochim Biophys Acta. 2009 Jun;1793(6):941-6. doi: 10.1016/j.bbamcr.2008.10.008. Epub 2008 Oct 29. Review.


Intermediate phosphorylation reactions in the mechanism of ATP utilization by the copper ATPase (CopA) of Thermotoga maritima.

Hatori Y, Hirata A, Toyoshima C, Lewis D, Pilankatta R, Inesi G.

J Biol Chem. 2008 Aug 15;283(33):22541-9. doi: 10.1074/jbc.M802735200. Epub 2008 Jun 18.


Structural aspects of ion pumping by Ca2+-ATPase of sarcoplasmic reticulum.

Toyoshima C.

Arch Biochem Biophys. 2008 Aug 1;476(1):3-11. doi: 10.1016/ Epub 2008 Apr 18. Review.


How processing of aspartylphosphate is coupled to lumenal gating of the ion pathway in the calcium pump.

Toyoshima C, Norimatsu Y, Iwasawa S, Tsuda T, Ogawa H.

Proc Natl Acad Sci U S A. 2007 Dec 11;104(50):19831-6. Epub 2007 Dec 5.


Critical role of Val-304 in conformational transitions that allow Ca2+ occlusion and phosphoenzyme turnover in the Ca2+ transport ATPase.

Xu C, Prasad AM, Inesi G, Toyoshima C.

J Biol Chem. 2008 Feb 8;283(6):3297-304. Epub 2007 Dec 5.


Interaction sites among phospholamban, sarcolipin, and the sarco(endo)plasmic reticulum Ca(2+)-ATPase.

Morita T, Hussain D, Asahi M, Tsuda T, Kurzydlowski K, Toyoshima C, Maclennan DH.

Biochem Biophys Res Commun. 2008 Apr 25;369(1):188-94. Epub 2007 Nov 29. Review.


Conformational fluctuations of the Ca2+-ATPase in the native membrane environment. Effects of pH, temperature, catalytic substrates, and thapsigargin.

Inesi G, Lewis D, Toyoshima C, Hirata A, de Meis L.

J Biol Chem. 2008 Jan 11;283(2):1189-96. Epub 2007 Nov 9.


Domain organization and movements in heavy metal ion pumps: papain digestion of CopA, a Cu+-transporting ATPase.

Hatori Y, Majima E, Tsuda T, Toyoshima C.

J Biol Chem. 2007 Aug 31;282(35):25213-21. Epub 2007 Jul 6.


Interdomain communication in calcium pump as revealed in the crystal structures with transmembrane inhibitors.

Takahashi M, Kondou Y, Toyoshima C.

Proc Natl Acad Sci U S A. 2007 Apr 3;104(14):5800-5. Epub 2007 Mar 26.


Ion pumping by calcium ATPase of sarcoplasmic reticulum.

Toyoshima C.

Adv Exp Med Biol. 2007;592:295-303. Review. No abstract available.


Structural changes in the cytoplasmic domain of phospholamban by phosphorylation at Ser16: a molecular dynamics study.

Sugita Y, Miyashita N, Yoda T, Ikeguchi M, Toyoshima C.

Biochemistry. 2006 Oct 3;45(39):11752-61.


Role of the Rho GTPase-activating protein RICS in neurite outgrowth.

Nasu-Nishimura Y, Hayashi T, Ohishi T, Okabe T, Ohwada S, Hasegawa Y, Senda T, Toyoshima C, Nakamura T, Akiyama T.

Genes Cells. 2006 Jun;11(6):607-14.


Structural role of countertransport revealed in Ca(2+) pump crystal structure in the absence of Ca(2+).

Obara K, Miyashita N, Xu C, Toyoshima I, Sugita Y, Inesi G, Toyoshima C.

Proc Natl Acad Sci U S A. 2005 Oct 11;102(41):14489-96. Epub 2005 Sep 6.


[Structure and functions of a calcium pump].

Sugita Y, Toyoshima C.

Tanpakushitsu Kakusan Koso. 2005 Aug;50(10 Suppl):1271-7. Review. Japanese. No abstract available.


Functional and structural roles of critical amino acids within the"N", "P", and "A" domains of the Ca2+ ATPase (SERCA) headpiece.

Ma H, Lewis D, Xu C, Inesi G, Toyoshima C.

Biochemistry. 2005 Jun 7;44(22):8090-100.


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