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Dysfunctional missense variant of OAT10/SLC22A13 decreases gout risk and serum uric acid levels.

Higashino T, Morimoto K, Nakaoka H, Toyoda Y, Kawamura Y, Shimizu S, Nakamura T, Hosomichi K, Nakayama A, Ooyama K, Ooyama H, Shimizu T, Ueno M, Ito T, Tamura T, Naito M, Nakashima H, Kawaguchi M, Takao M, Kawai Y, Osada N, Ichida K, Yamamoto K, Suzuki H, Shinomiya N, Inoue I, Takada T, Matsuo H.

Ann Rheum Dis. 2019 Nov 28. pii: annrheumdis-2019-216044. doi: 10.1136/annrheumdis-2019-216044. [Epub ahead of print] No abstract available.


Familial early-onset hyperuricemia and gout associated with a newly identified dysfunctional variant in urate transporter ABCG2.

Toyoda Y, Pavelcová K, Klein M, Suzuki H, Takada T, Stiburkova B.

Arthritis Res Ther. 2019 Oct 28;21(1):219. doi: 10.1186/s13075-019-2007-7. No abstract available.


Bronchial-arterial-circulation-sparing lung preservation: A new organ protection approach for lung transplantation.

Tane S, Noda K, Toyoda Y, Shigemura N.

Transplantation. 2019 Sep 24. doi: 10.1097/TP.0000000000002984. [Epub ahead of print]


Quantitative Evaluation of Reactivity and Toxicity of Acyl Glucuronides by [35S]Cysteine Trapping.

Harada H, Toyoda Y, Abe Y, Endo T, Takeda H.

Chem Res Toxicol. 2019 Oct 21;32(10):1955-1964. doi: 10.1021/acs.chemrestox.9b00111. Epub 2019 Sep 20.


Structural Transformation and Melting in Gold Shock Compressed to 355 GPa.

Sharma SM, Turneaure SJ, Winey JM, Li Y, Rigg P, Schuman A, Sinclair N, Toyoda Y, Wang X, Weir N, Zhang J, Gupta YM.

Phys Rev Lett. 2019 Jul 26;123(4):045702. doi: 10.1103/PhysRevLett.123.045702.


α-Amylase expressed in human small intestinal epithelial cells is essential for cell proliferation and differentiation.

Date K, Yamazaki T, Toyoda Y, Hoshi K, Ogawa H.

J Cell Biochem. 2019 Sep 3. doi: 10.1002/jcb.29357. [Epub ahead of print]


Long-term survival after surgical resection for recurrent hepatic and pulmonary metastases of intrahepatic cholangiocarcinoma: a case report.

Yamada M, Arimoto A, Toyoda Y, Watanabe S, Aizu K, Sato F, Fujieda A, Yamaguchi R.

Surg Case Rep. 2019 Aug 20;5(1):135. doi: 10.1186/s40792-019-0693-7.


Computed tomography angiography is not accurate in predicting surgical prosthetic aortic valve implant size.

Boova R, Banerjee S, Kashem A, Das A, Zimmerman H, Jennings R, Minakata K, Toyoda Y.

Surgery. 2019 Aug 7. pii: S0039-6060(19)30410-6. doi: 10.1016/j.surg.2019.06.022. [Epub ahead of print]


A long-term survival case after resection of the pancreatic metastasis from lung cancer.

Kageyama Y, Yamaguchi R, Watanabe S, Aizu K, Sato F, Fujieda H, Yamada M, Toyoda Y, Iwata T.

Int J Surg Case Rep. 2019;61:222-225. doi: 10.1016/j.ijscr.2019.07.060. Epub 2019 Jul 25.


Towards identification of bioactive compounds in cold vacuum extracted double cherry blossom (Gosen-Sakura) leaves.

Shibato J, Takenoya F, Hirabayashi T, Kimura A, Iwasaki Y, Toyoda Y, Hori M, Tamogami S, Rakwal R, Shioda S.

Plant Signal Behav. 2019;14(10):e1644594. doi: 10.1080/15592324.2019.1644594. Epub 2019 Jul 25.


Apocrine adenocarcinoma in the setting of apocrine hidrocystoma of the leg.

Toyoda Y, Franck P, Brownstone ND, Lieberman M, Magro CM, Otterburn DM.

Dermatol Online J. 2019 Jun 15;25(6). pii: 13030/qt1jn1n606.


The novel inhibitor PRI-724 for Wnt/β-catenin/CBP signaling ameliorates bleomycin-induced pulmonary fibrosis in mice.

Okazaki H, Sato S, Koyama K, Morizumi S, Abe S, Azuma M, Chen Y, Goto H, Aono Y, Ogawa H, Kagawa K, Nishimura H, Kawano H, Toyoda Y, Uehara H, Kouji H, Nishioka Y.

Exp Lung Res. 2019 Sep;45(7):188-199. doi: 10.1080/01902148.2019.1638466. Epub 2019 Jul 12.


Mediastinal Lymphoma Presenting in Cardiogenic Shock with Superior Vena Cava Syndrome in a Primigravida at Full Term: Salvage Resection after Prolonged Extracorporeal Life Support.

Carro SE, Essex DW, Alsammak M, Bains A, Toyoda Y, Keshavamurthy S.

Case Rep Oncol. 2019 Jun 4;12(2):401-410. doi: 10.1159/000499195. eCollection 2019 May-Aug.


Publisher Correction: Hydrostatic pressure and the actomyosin cortex drive mitotic cell rounding.

Stewart MP, Helenius J, Toyoda Y, Ramanathan SP, Muller DJ, Hyman AA.

Nature. 2019 Jul;571(7764):E5. doi: 10.1038/s41586-019-1327-8.


Clinical features of interstitial pneumonia associated with systemic lupus erythematosus.

Toyoda Y, Koyama K, Kawano H, Nishimura H, Kagawa K, Morizumi S, Naito N, Sato S, Yamashita Y, Takahashi N, Goto H, Azuma M, Nishioka Y.

Respir Investig. 2019 Sep;57(5):435-443. doi: 10.1016/j.resinv.2019.04.005. Epub 2019 Jun 21.


Development, validation, and comparison of gene analysis methods for detecting EGFR mutation from non-small cell lung cancer patients-derived circulating free DNA.

Hanibuchi M, Kanoh A, Kuramoto T, Saito T, Tobiume M, Saijo A, Kozai H, Kondo M, Morizumi S, Yoneda H, Kagawa K, Ogino H, Sato S, Kawano H, Otsuka K, Toyoda Y, Nokihara H, Goto H, Nishioka Y.

Oncotarget. 2019 Jun 4;10(38):3654-3666. doi: 10.18632/oncotarget.26951. eCollection 2019 Jun 4.


[A Case of Stevens-Johnson Syndrome Induced by Chemotherapy for Metastatic Colon Cancer].

Fukata T, Ito Y, Miyagaki H, Nishida H, Toyoda Y, Shingai T, Takayama O, Yoshioka S, Hojo S, Fukuzaki T, Ohigashi H.

Gan To Kagaku Ryoho. 2019 Apr;46(4):748-750. Japanese.


The laser shock station in the dynamic compression sector. I.

Wang X, Rigg P, Sethian J, Sinclair N, Weir N, Williams B, Zhang J, Hawreliak J, Toyoda Y, Gupta Y, Li Y, Broege D, Bromage J, Earley R, Guy D, Zuegel J.

Rev Sci Instrum. 2019 May;90(5):053901. doi: 10.1063/1.5088367.


Cholangiographic Tumor Classification for Simple Patient Selection Prior to Hepatopancreatoduodenectomy for Cholangiocarcinoma.

Toyoda Y, Ebata T, Mizuno T, Yokoyama Y, Igami T, Yamaguchi J, Onoe S, Watanabe N, Nagino M.

Ann Surg Oncol. 2019 Sep;26(9):2971-2979. doi: 10.1245/s10434-019-07457-x. Epub 2019 May 17.


Microstructured hydrogel scaffolds containing differential density interfaces promote rapid cellular invasion and vascularization.

Celie KB, Toyoda Y, Dong X, Morrison KA, Zhang P, Asanbe O, Jin JL, Hooper RC, Zanotelli MR, Kaymakcalan O, Bender RJ, Spector JA.

Acta Biomater. 2019 Jun;91:144-158. doi: 10.1016/j.actbio.2019.04.027. Epub 2019 Apr 18.


Functional Characterization of Clinically-Relevant Rare Variants in ABCG2 Identified in a Gout and Hyperuricemia Cohort.

Toyoda Y, Mančíková A, Krylov V, Morimoto K, Pavelcová K, Bohatá J, Pavelka K, Pavlíková M, Suzuki H, Matsuo H, Takada T, Stiburkova B.

Cells. 2019 Apr 18;8(4). pii: E363. doi: 10.3390/cells8040363.


Massive Air Embolism Caused by a Central Venous Catheter During Extracorporeal Membrane Oxygenation.

Kumar A, Keshavamurthy S, Abraham JG, Toyoda Y.

J Extra Corpor Technol. 2019 Mar;51(1):9-11.


Inhibitors of Human ABCG2: From Technical Background to Recent Updates With Clinical Implications.

Toyoda Y, Takada T, Suzuki H.

Front Pharmacol. 2019 Mar 5;10:208. doi: 10.3389/fphar.2019.00208. eCollection 2019. Review.


[A Case of Extended Mediastinal and Retroperitoneal Emphysema after Transanal Local Excision of an Early Lower Rectal Adenocarcinoma].

Shingai T, Fukuzaki T, Okimura S, Ito Y, Taniguchi Y, Fukata T, Nishida H, Toyoda Y, Takayama O, Yoshioka S, Hojo S, Ohigashi H.

Gan To Kagaku Ryoho. 2018 Dec;45(13):1973-1975. Japanese.


[A Case of an Elderly with Locoregional Recurrence of ER-Negative HER2-Positive Breast Cancer Successfully Treated with Local Therapy].

Yoshioka S, Hojo S, Toyoda Y, Ito Y, Fukata T, Miyagaki H, Nishida H, Shingai T, Takayama O, Fukuzaki T, Ohigashi H.

Gan To Kagaku Ryoho. 2018 Dec;45(13):2232-2234. Japanese.


Blockade of platelet-derived growth factor receptor-β, not receptor-α ameliorates bleomycin-induced pulmonary fibrosis in mice.

Kishi M, Aono Y, Sato S, Koyama K, Azuma M, Abe S, Kawano H, Kishi J, Toyoda Y, Okazaki H, Ogawa H, Uehara H, Nishioka Y.

PLoS One. 2018 Dec 31;13(12):e0209786. doi: 10.1371/journal.pone.0209786. eCollection 2018.


Fatal Invasive Pulmonary Aspergillosis Associated with Nonspecific Interstitial Pneumonia: An Autopsy Case Report.

Matsuyama H, Miyoshi S, Sugino K, Ota H, Toyoda Y, Nihonyanagi Y, Shibuya K, Homma S.

Intern Med. 2018;57(24):3619-3624. doi: 10.2169/internalmedicine.1144-18. Epub 2018 Dec 15.


The Tyrosine Kinase Inhibitor TAS-115 Attenuates Bleomycin-induced Lung Fibrosis in Mice.

Koyama K, Goto H, Morizumi S, Kagawa K, Nishimura H, Sato S, Kawano H, Toyoda Y, Ogawa H, Homma S, Nishioka Y.

Am J Respir Cell Mol Biol. 2019 Apr;60(4):478-487. doi: 10.1165/rcmb.2018-0098OC.


d-Allulose is a substrate of glucose transporter type 5 (GLUT5) in the small intestine.

Kishida K, Martinez G, Iida T, Yamada T, Ferraris RP, Toyoda Y.

Food Chem. 2019 Mar 30;277:604-608. doi: 10.1016/j.foodchem.2018.11.003. Epub 2018 Nov 2.


Ligand binding to human prostaglandin E receptor EP4 at the lipid-bilayer interface.

Toyoda Y, Morimoto K, Suno R, Horita S, Yamashita K, Hirata K, Sekiguchi Y, Yasuda S, Shiroishi M, Shimizu T, Urushibata Y, Kajiwara Y, Inazumi T, Hotta Y, Asada H, Nakane T, Shiimura Y, Nakagita T, Tsuge K, Yoshida S, Kuribara T, Hosoya T, Sugimoto Y, Nomura N, Sato M, Hirokawa T, Kinoshita M, Murata T, Takayama K, Yamamoto M, Narumiya S, Iwata S, Kobayashi T.

Nat Chem Biol. 2019 Jan;15(1):18-26. doi: 10.1038/s41589-018-0131-3. Epub 2018 Dec 3.


Systemic Sarcoidosis Presenting with Renal Involvement Caused by Various Sarcoidosis-associated Pathophysiological Conditions.

Ueda S, Murakami T, Ogino H, Matsuura M, Tamaki M, Kishi S, Hann M, Toyoda Y, Nagai K, Bando Y, Abe H, Nishioka Y, Doi T.

Intern Med. 2019 Mar 1;58(5):679-684. doi: 10.2169/internalmedicine.1558-18. Epub 2018 Nov 19.


The clinical features of older patients with lung cancer in comparison with their younger counterparts.

Ogino H, Hanibuchi M, Sakaguchi S, Toyoda Y, Tezuka T, Kawano H, Kakiuchi S, Otsuka K, Saijo A, Azuma M, Nokihara H, Goto H, Nishioka Y.

Respir Investig. 2019 Jan;57(1):40-48. doi: 10.1016/j.resinv.2018.10.003. Epub 2018 Nov 15.


A multicenter, open-label, phase II trial of S-1 plus carboplatin in advanced non-small cell lung cancer patients with interstitial lung disease.

Hanibuchi M, Kakiuchi S, Atagi S, Ogushi F, Shimizu E, Haku T, Toyoda Y, Azuma M, Kondo M, Kawano H, Otsuka K, Sakaguchi S, Nokihara H, Goto H, Nishioka Y.

Lung Cancer. 2018 Nov;125:93-99. doi: 10.1016/j.lungcan.2018.09.007. Epub 2018 Sep 12.


Transcatheter aortic valve implantation in a patient with aplastic anemia.

Kawai Y, Toyoda Y, Kimura H, Horigome M, Tsuda Y, Takemura T.

J Cardiol Cases. 2017 Sep 5;16(6):213-215. doi: 10.1016/j.jccase.2017.08.003. eCollection 2017 Dec.


Artificial Lungs for Lung Failure: JACC Technology Corner.

Naito N, Cook K, Toyoda Y, Shigemura N.

J Am Coll Cardiol. 2018 Oct 2;72(14):1640-1652. doi: 10.1016/j.jacc.2018.07.049. Review.


Case series of seven women with uterine fibroids associated with venous thromboembolism and chronic thromboembolic disease.

Lacharite-Roberge AS, Raza F, Bashir R, Dass CA, Moser GW, Auger WR, Toyoda Y, Forfia PR, Vaidya A.

Pulm Circ. 2019 Jan-Mar;9(1):2045894018803873. doi: 10.1177/2045894018803873. Epub 2018 Sep 11.


Extracellular glucose level regulates dependence on GRP78 for cell surface localization of multipass transmembrane proteins in HeLa cells.

Toyoda Y, Akarlar B, Sarov M, Ozlu N, Saitoh S.

FEBS Lett. 2018 Oct;592(19):3295-3304. doi: 10.1002/1873-3468.13232. Epub 2018 Sep 8.


Early arterial access for resuscitative endovascular balloon occlusion of the aorta is related to survival outcome in trauma.

Matsumura Y, Matsumoto J, Kondo H, Idoguchi K, Ishida T, Okada Y, Kon Y, Oka K, Ishida K, Toyoda Y, Funabiki T; DIRECT-IABO Investigators.

J Trauma Acute Care Surg. 2018 Sep;85(3):507-511. doi: 10.1097/TA.0000000000002004.


A case of pulmonary pleomorphic carcinoma with malignant phenotypes induced by ZEB1-associated epithelial-mesenchymal transition.

Kondo M, Ogino H, Ogawa H, Afroj T, Toyoda Y, Sakaguchi S, Tsuboi M, Bando Y, Goto H, Tsuneyama K, Nishioka Y.

Respir Med Case Rep. 2018 Aug 3;25:119-121. doi: 10.1016/j.rmcr.2018.07.008. eCollection 2018.


Identification of ABCG2 as an Exporter of Uremic Toxin Indoxyl Sulfate in Mice and as a Crucial Factor Influencing CKD Progression.

Takada T, Yamamoto T, Matsuo H, Tan JK, Ooyama K, Sakiyama M, Miyata H, Yamanashi Y, Toyoda Y, Higashino T, Nakayama A, Nakashima A, Shinomiya N, Ichida K, Ooyama H, Fujimori S, Suzuki H.

Sci Rep. 2018 Jul 24;8(1):11147. doi: 10.1038/s41598-018-29208-w.


Effect of Acute Exacerbation of Idiopathic Pulmonary Fibrosis on Lung Transplantation Outcome.

Dotan Y, Vaidy A, Shapiro WB, Zhao H, Dass C, Toyoda Y, Marchetti N, Shenoy K, Cordova FC, Criner GJ, Mamary AJ.

Chest. 2018 Oct;154(4):818-826. doi: 10.1016/j.chest.2018.06.027. Epub 2018 Jun 30.


Early arterial access for REBOA is related to survival outcome in trauma.

Matsumura Y, Matsumoto J, Kondo H, Idoguchi K, Ishida T, Okada Y, Kon Y, Oka K, Ishida K, Toyoda Y, Funabiki T; DIRECT-IABO investigators.

J Trauma Acute Care Surg. 2018 Jun 12. doi: 10.1097/TA.0000000000002004. [Epub ahead of print]


Increase in incidental detection of thyroid cancer in Osaka, Japan.

Toyoda Y, Tabuchi T, Nakata K, Morishima T, Nakayama T, Miyashiro I, Hojo S, Yoshioka S.

Cancer Sci. 2018 Jul;109(7):2310-2314. doi: 10.1111/cas.13645. Epub 2018 Jun 9.


Thymidine catabolism promotes NADPH oxidase-derived reactive oxygen species (ROS) signalling in KB and yumoto cells.

Tabata S, Yamamoto M, Goto H, Hirayama A, Ohishi M, Kuramoto T, Mitsuhashi A, Ikeda R, Haraguchi M, Kawahara K, Shinsato Y, Minami K, Saijo A, Toyoda Y, Hanibuchi M, Nishioka Y, Sone S, Esumi H, Tomita M, Soga T, Furukawa T, Akiyama SI.

Sci Rep. 2018 Apr 30;8(1):6760. doi: 10.1038/s41598-018-25189-y.


Are human ATP-binding cassette transporter C11 and earwax associated with the incidence of cholesteatoma?

Nakagawa H, Toyoda Y, Albrecht T, Tsukamoto M, Praetorius M, Ishikawa T, Kamiya K, Kusunoki T, Ikeda K, Sertel S.

Med Hypotheses. 2018 May;114:19-22. doi: 10.1016/j.mehy.2018.02.030. Epub 2018 Feb 24.


A case of interstitial pneumonia associated with anti-PL-7 antibody in a patient with rheumatoid arthritis.

Kozai H, Toyoda Y, Goto H, Kishi J, Tobiume M, Yamashita Y, Nishimura H, Kondo M, Kawano H, Nishioka Y.

J Med Invest. 2018;65(1.2):147-150. doi: 10.2152/jmi.65.147.


In Search of a Murine Model of Radiation-Induced Periprosthetic Capsular Fibrosis.

Lin AJ, Karinja SJ, Bernstein JL, Jin J, Toyoda Y, Miller AJ, Zanzonico PB, Spector JA.

Ann Plast Surg. 2018 Apr;80(4 Suppl 4):S204-S210. doi: 10.1097/SAP.0000000000001362.


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